Journal
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
Volume 59, Issue -, Pages 91-97Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jtice.2015.08.003
Keywords
Bacterial carrier; Lycopene; Targeted delivery; HER2/neu
Categories
Funding
- Ministry of Science and Technology, Taiwan [102-2221-E-039-014-MY3, 104-2622-E-035-011-CC1, 104-2221-E- 035-072]
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Lycopene is a potent antioxidant and has an anti-carcinogenic activity. However, it still remains technically challenging to formulate lipophilic lycopene as an anticancer drug. This issue was addressed by development of a bacterial carrier for targeted delivery of lycopene. First, Escherichia call was engineered for lycopene synthesis by pathway engineering. A HER2/neu-affinity domain was subsequently displayed on the surface of the lycopene producer, rendering the strain selectively invasive. Finally, the bacterial carrier was fabricated by permeabilizing the constructed strain to facilitate release of the lycopene cargo. As a result of multiple infections with the bacterial carrier, the growth of HER2/neu-positive breast cancer cells was completely arrested. The result indicates that our proposed strategy is promising and may open up a new avenue of targeted cancer therapy using chemopreventive chemicals. (C) 2015 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.
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