4.6 Article

Selenium supplementation provides potent neuroprotection following cerebral ischemia in mice

Related references

Note: Only part of the references are listed.
Article Cell Biology

Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging

Odette Leiter et al.

Summary: Exercise enhances adult hippocampal neurogenesis through the systemic release of the antioxidant selenium transport protein, SEPP1, providing a potential therapeutic approach for cognitive decline associated with hippocampal injury and aging.

CELL METABOLISM (2022)

Article Clinical Neurology

Trimethylamine N-Oxide and Stroke Recurrence Depends on Ischemic Stroke Subtypes

Jie Xu et al.

Summary: Elevated TMAO levels are associated with an increased risk of stroke recurrence, particularly in patients with small artery occlusion subtype.

STROKE (2022)

Article Biochemistry & Molecular Biology

Regulation of a New Type of Selenium-Rich Royal Jelly on Gut Microbiota Profile in Mice

Xuepeng Chi et al.

Summary: This study demonstrated that selenium-rich royal jelly (SRJ) can enhance antioxidant capacity in the liver and kidney of mice, as well as alter the composition of gut microbiota. SRJ treatment increased the levels of glutathione peroxidase and total antioxidant activity, while also affecting the ratio of different bacterial families in the gut. Additionally, SRJ showed potential in optimizing the functional network of gut microbiota and improving the interactions between gut microbiota and the host.

BIOLOGICAL TRACE ELEMENT RESEARCH (2022)

Article Biochemistry & Molecular Biology

Brazil nut supplementation does not affect trimethylamine-n-oxide plasma levels in patients with coronary artery disease

Karen Salve Coutinho-Wolino et al.

Summary: This study aimed to assess the effect of Brazil nut supplementation on TMAO levels and GPx activity in patients with CAD. It found that a 3-month Brazil nut supplementation did not change TMAO levels, but potentially increased GPx activity.

JOURNAL OF FOOD BIOCHEMISTRY (2022)

Article Clinical Neurology

Pertussis toxin-induced inflammatory response exacerbates intracerebral haemorrhage and ischaemic stroke in mice

Ming Zou et al.

Summary: The study found that using pertussis toxin can exacerbate brain injury in mouse models of ICH and ischemic stroke, manifesting as worsened neurological deficits, increased hemorrhage lesions, enhanced inflammatory response, and further disruption of the integrity of the blood-brain barrier.

STROKE AND VASCULAR NEUROLOGY (2022)

Review Cell Biology

The Influence of Gut Dysbiosis in the Pathogenesis and Management of Ischemic Stroke

Saravana Babu Chidambaram et al.

Summary: Recent research has shown that gut dysbiosis affects ischemic stroke pathogenesis and treatment outcomes. The bidirectional gut-brain interactions involve signals transmitted through microbial metabolites, bacterial components, immune cells, and bacterial translocation. Restoring a healthy gut microbiome improves stroke treatment outcomes.

CELLS (2022)

Article Medicine, General & Internal

Correlation between dietary selenium intake and stroke in the National Health and Nutrition Examination Survey 2003-2018

Wenrui Shi et al.

Summary: This study examined the correlation between dietary selenium intake and the risk of stroke in adults through a retrospective analysis. The results showed a negative and non-linear correlation between dietary selenium intake and the risk of stroke. Additionally, this correlation varied across different population subgroups.

ANNALS OF MEDICINE (2022)

Letter Biochemistry & Molecular Biology

PKCα phosphorylation of GLT-1 at Ser562/563 induces glutamate excitotoxicity in ischemia in mice

Yuqing Wang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

Review Nutrition & Dietetics

Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases

Rannapaula Lawrynhuk Urbano Ferreira et al.

Summary: Selenium plays a crucial role in various bodily functions and maintaining a healthy gut microbiota. Its symbiotic relationship with gut bacteria helps in improving the bioavailability of selenocompounds and balancing microbial flora to prevent health damage associated with dysbiosis. However, selenium deficiency can lead to a phenotype of gut microbiota that is more susceptible to certain diseases, highlighting the importance of adequate selenium intake for both human and bacterial health.

FRONTIERS IN NUTRITION (2021)

Article Clinical Neurology

Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019

Valery L. Feigin et al.

Summary: Regularly updated data on stroke including incidence, prevalence, mortality, disability, risk factors, and trends are crucial for evidence-based care planning. The Global Burden of Diseases Study provides comprehensive measurement of these metrics. From 1990 to 2019, while age-standardized rates improved, the number of strokes and deaths increased. Low-income countries had the highest stroke-related mortality and DALY rates, with high body-mass index being the fastest-growing risk factor.

LANCET NEUROLOGY (2021)

Article Gastroenterology & Hepatology

Rapid gut dysbiosis induced by stroke exacerbates brain infarction in turn

Kaiyu Xu et al.

Summary: Stroke is a leading cause of death and disability worldwide, and neuroprotective approaches have been unsuccessful in clinical trials. This study reveals a reciprocal relationship between stroke and gut dysbiosis, with acute ischemic stroke triggering dysbiosis of the gut microbiome, exacerbating brain infarction. Administering certain treatments was able to alleviate post-stroke brain infarction, illustrating the translational value of the brain-gut axis in stroke treatment.
Article Clinical Neurology

Reactive Oxygen Species Scavenger in Acute Intracerebral Hemorrhage Patients A Multicenter, Randomized Controlled Trial

Moinay Kim et al.

Summary: Administering ROS scavengers to patients with acute ICH significantly reduced PHE volume, shortened time to reach target Richmond Agitation Sedation Scale, and reduced length of stay in the intensive care unit.

STROKE (2021)

Article Biochemistry & Molecular Biology

Methionine restriction alleviates age-associated cognitive decline via fibroblast growth factor 21

Bo Ren et al.

Summary: Methionine restriction has shown protective effects against age-related cognitive decline in mice through preserving synaptic ultrastructure, increasing mitochondrial biogenesis, and reducing brain MDA levels. The role of FGF21 in this process is crucial.

REDOX BIOLOGY (2021)

Article Multidisciplinary Sciences

Infarct growth precedes cerebral thrombosis following experimental stroke in mice

Vanessa Gob et al.

Summary: Ischemic stroke is a major cause of disability and death worldwide. Successful recanalization of occluded vessels is the primary therapeutic aim, but the presence of cerebral thrombi does not necessarily lead to secondary infarct growth during ischemic stroke.

SCIENTIFIC REPORTS (2021)

Article Biochemistry & Molecular Biology

Fibroblast growth factor 21 attenuates iron overload-induced liver injury and fibrosis by inhibiting ferroptosis

Aimin Wu et al.

Summary: Iron overload-induced ferroptosis in hepatocytes is promoted by excessive HO-1 expression, while FGF21 protein can protect against this process by inhibiting ferroptosis and preventing liver damage. These findings suggest that activating FGF21 could be an effective strategy for potential treatment of iron overload-induced ferroptosis-related diseases like hereditary haemochromatosis.

REDOX BIOLOGY (2021)

Article Endocrinology & Metabolism

More than motor impairment: A spatiotemporal analysis of cognitive impairment and associated neuropathological changes following cortical photothrombotic stroke

Sonia Sanchez-Bezanilla et al.

Summary: The study found that cognitive function remains impaired post-stroke, while there is modest spontaneous motor recovery over an 84-day period. Reduced neuronal loss and decreased neuroinflammation in the peri-infarct region may explain the spontaneous motor recovery, whereas persistent neuronal loss with increased neuroinflammation and amyloid-beta accumulation in the hippocampus likely contribute to the persistent cognitive dysfunction.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2021)

Article Biology

Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice

Jason D. Plummer et al.

Summary: The study found that selenium supplementation can lead to healthspan benefits similar to methionine restriction, including protection against obesity in mice and alterations in various plasma hormone levels.

ELIFE (2021)

Article Clinical Neurology

Plasma from healthy donors protects blood-brain barrier integrity via FGF21 and improves the recovery in a mouse model of cerebral ischaemia

Muyassar Mamtilahun et al.

Summary: The study demonstrated that healthy adult plasma treatment can improve neurobehavioral recovery, reduce infarct volume, brain edema, and atrophy after stroke, as well as protect the structural and functional integrity of the blood-brain barrier.

STROKE AND VASCULAR NEUROLOGY (2021)

Article Microbiology

Gut microbes impact stroke severity via the trimethylamine N-oxide pathway

Weifei Zhu et al.

Summary: Clinical studies have shown associations between gut-microbiota-derived metabolite TMAO and stroke risk, but a causal role had not been proven. This study demonstrates that gut microbes impact stroke severity through choline and TMAO production, with traits being transmissible. The microbial cutC gene is identified as a key factor in TMA/TMAO production, cerebral infarct size, and functional impairment post-stroke.

CELL HOST & MICROBE (2021)

Article Medicine, Research & Experimental

Selenium attenuates ischemia/reperfusion injury-induced damage to the blood-brain barrier in hyperglycemia through PI3K/AKT/mTOR pathway-mediated autophagy inhibition

Biao Yang et al.

Summary: The study found that selenium can inhibit autophagy by regulating the PI3K/AKT/mTOR signaling pathway, significantly preventing BBB damage following cerebral I/R injury in hyperglycemic conditions.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

Article Biochemistry & Molecular Biology

Thalamic reticular nucleus impairments and abnormal prefrontal control of dopamine system in a developmental model of schizophrenia: prevention by N-acetylcysteine

Xiyu Zhu et al.

Summary: Thalamic abnormalities involving disruptions to parvalbumin neurons in the thalamic reticular nucleus have been associated with dopamine dysregulation in schizophrenia. Early oxidative stress accumulation in the TRN may shape the later onset of schizophrenia pathophysiology, serving as a potential target for early intervention to prevent impairments. In a rat model, impaired parvalbumin neurons correlated with increased oxidative stress markers, leading to abnormal prefrontal control of VTA dopamine neuron activity.

MOLECULAR PSYCHIATRY (2021)

Article Clinical Neurology

Characterization of Selenium Compounds for Anti-ferroptotic Activity in Neuronal Cells and After Cerebral Ischemia-Reperfusion Injury

Qing-Zhang Tuo et al.

Summary: The emergence of ferroptosis as a cell death pathway associated with brain disorders highlights the importance of developing therapeutics targeting the brain and protecting neurons. Selenium compounds have shown to be effective in inhibiting ferroptosis, with organic selenium compounds like methylselenocysteine providing protection against neuronal damage in ischemia-reperfusion injury in vivo. This suggests the potential use of ferroptosis inhibitors and specific selenium compounds in preventing neuronal damage in ischemic stroke and other related brain diseases.

NEUROTHERAPEUTICS (2021)

Review Nutrition & Dietetics

Selenium, a Micronutrient That Modulates Cardiovascular Health via Redox Enzymology

Diane E. Handy et al.

Summary: Selenium is a trace nutrient that promotes human health through selenoproteins, with many of them playing essential roles in protecting against oxidative stress. Selenoproteins are crucial in regulating cellular reactive oxygen species and cardiovascular diseases.

NUTRIENTS (2021)

Article Nutrition & Dietetics

Selenium, Copper, Zinc Concentrations and Cu/Zn, Cu/Se Molar Ratios in the Serum of Patients with Acute Ischemic Stroke in Northeastern Poland-A New Insight into Stroke Pathophysiology

Anna Mironczuk et al.

Summary: The study showed that serum Se and Zn levels were significantly lower in patients with acute ischemic stroke, while Cu levels did not differ significantly. Patients with AIS had significantly higher Cu/Zn and Cu/Se ratios, indicating disturbed metal homeostasis as a significant contributor to the pathogenesis of AIS.

NUTRIENTS (2021)

Review Biochemistry & Molecular Biology

N-Acetylcysteine (NAC): Impacts on Human Health

Micaely Cristina dos Santos Tenorio et al.

Summary: NAC is a widely used medication for treating paracetamol overdose and inflammatory diseases, known for its safety and antioxidant/anti-inflammatory effects. Its mechanisms of action include increasing intracellular glutathione levels and suppressing inflammatory cytokines.

ANTIOXIDANTS (2021)

Article Biochemistry & Molecular Biology

An imbalanced ratio between PC(16:0/16:0) and LPC(16:0) revealed by lipidomics supports the role of the Lands cycle in ischemic brain injury

Lifeng Zheng et al.

Summary: The study used a high-sensitivity UPLC-MS method to semi-quantitatively measure lipid changes in the mouse cerebral cortex recovering from a stroke, revealing a strong relationship between phosphatidylcholine reduction and lysophosphatidylcholine increase during reperfusion. The data support the role of imbalanced lipid ratios in neuronal damage and inflammatory responses during stroke recovery.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Article Endocrinology & Metabolism

Metabolic endotoxemia promotes neuroinflammation after focal cerebral ischemia

Naohide Kurita et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2020)

Article Biochemistry & Molecular Biology

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

Nathalie Percie du Sert et al.

PLOS BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Serum levels of Trimethylamine-N-oxide in patients with ischemic stroke

Maimaiti Rexidamu et al.

BIOSCIENCE REPORTS (2019)

Article Biochemistry & Molecular Biology

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

Ishraq Alim et al.

Article Clinical Neurology

Pathogenesis of epileptic seizures and epilepsy after stroke

Huajun Yang et al.

NEUROLOGICAL RESEARCH (2018)

Article Engineering, Environmental

Effects of Dietary Selenium Supplementation on Intestinal Barrier and Immune Responses Associated with Its Modulation of Gut Microbiota

Qixiao Zhai et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS (2018)

Review Biochemistry & Molecular Biology

The effect of selenium supplementation on coronary heart disease: A systematic review and meta-analysis of randomized controlled trials

W. Ju et al.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2017)

Article Biochemistry & Molecular Biology

Phaseic Acid, an Endogenous and Reversible Inhibitor of Glutamate Receptors in Mouse Brain

Sheng Tao Hou et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Multidisciplinary Sciences

Memory retrieval by activating engram cells in mouse models of early Alzheimer's disease

Dheeraj S. Roy et al.

NATURE (2016)

Review Pharmacology & Pharmacy

Neuroprotection for ischaemic stroke: Current status and challenges

Antonio Moretti et al.

PHARMACOLOGY & THERAPEUTICS (2015)

Review Biochemistry & Molecular Biology

The chemistry and biological activities of N-acetylcysteine

Yuval Samuni et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2013)

Article Multidisciplinary Sciences

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

Zeneng Wang et al.

NATURE (2011)

Review Neurosciences

The Science of Stroke: Mechanisms in Search of Treatments

Michael A. Moskowitz et al.

NEURON (2010)

Article Biochemical Research Methods

TTC, Fluoro-Jade B and NeuN staining confirm evolving phases of infarction induced by middle cerebral artery occlusion

Fudong Liu et al.

JOURNAL OF NEUROSCIENCE METHODS (2009)

Article Clinical Neurology

Exciting, radical, suicidal - How brain cells die after stroke

EH Lo et al.

STROKE (2005)

Review Neurosciences

The thalamic reticular nucleus: structure, function and concept

D Pinault

BRAIN RESEARCH REVIEWS (2004)

Article Clinical Neurology

Serum ferritin levels and early prognosis of stroke

AK Erdemoglu et al.

EUROPEAN JOURNAL OF NEUROLOGY (2002)