Palmitoylation in apoptosis

Palmitoylation, a critical lipid modification of proteins, is involved in various physiological processes such as altering protein localization, transport, and stability, which perform essential roles in protein function. Palmitoyltransferases are specific enzymes involved in the palmitoylation modification of substrates. S-palmitoylation, as the only reversible palmitoylation modification, is able to be deacylated by deacyltransferases. As an important mode of programmed cell death, apoptosis functions in the maintenance of organismal homeostasis as well as being associated with inflammatory and immune diseases. Recently, studies have found that palmitoylation and apoptosis have been demonstrated to be related in many human diseases. In this review, we will focus on the role of palmitoylation modifications in apoptosis.

Automated summary

Palmitoylation, a crucial lipid modification, plays a vital role in various physiological processes by altering protein localization, transport, and stability. Palmitoyltransferases are specific enzymes responsible for this modification. S-palmitoylation, the only reversible form of palmitoylation, can be deacylated by deacyltransferases. Recent studies have revealed the association between palmitoylation and apoptosis in numerous human diseases. This review focuses on the involvement of palmitoylation modifications in apoptosis.