Osteohematology: To be or Notch to be

Osteohematology is an emerging research field that studies the crosstalk between hematopoietic and bone stromal cells, to elucidate the mechanisms of hematological and skeletal malignancies and diseases. The Notch is an evolutionary conserved developmental signaling pathway, with critical roles in embryonic development by controlling cell proliferation and differentiation. However, the Notch pathway is also critically involved in cancer initiation and progression, such as osteosarcoma, leukemia, and multiple myeloma. The Notch-mediated malignant cells dysregulate bone and bone marrow cells in the tumour microenvironment, resulting in disorders ranging from osteoporosis to bone marrow dysfunction. To date, the complex interplay of Notch signaling molecules in hematopoietic and bone stromal cells is still poorly understood. In this mini-review, we summarize the crosstalk between cells in bone and bone marrow and their influence under the Notch signaling pathway in physiological conditions and in tumour microenvironment.

Automated summary

Osteohematology is an emerging field studying the interaction between hematopoietic and bone stromal cells to understand hematological and skeletal malignancies and diseases. The Notch signaling pathway plays critical roles in embryonic development and cancer progression, including osteosarcoma, leukemia, and multiple myeloma. Dysregulation of Notch-mediated malignant cells disrupts normal bone and bone marrow function, leading to disorders such as osteoporosis and bone marrow dysfunction. This mini-review summarizes the interplay between cells in bone and bone marrow under the Notch signaling pathway in both physiological and tumor microenvironments.