Sarcopenia and noncoding RNAs: A comprehensive review

Sarcopenia is an elderly disease and is related to frailty and loss of muscle mass (atrophy) of older adults. The exact molecular mechanisms contributing to the pathogenesis of disease are yet to be discovered. In recent years, the role of noncoding RNAs in the pathogenesis of almost every kind of malignant and nonmalignant conditions is pinpointed. Regarding their regulatory function, there have been an increased number of studies on the role of noncoding RNAs in the progress of sarcopenia. In this manuscript, we review the role of microRNAs and long noncoding RNAs in development and progression of disease. We also discuss their potential as therapeutic targets in this condition.

Automated summary

Sarcopenia is a disease characterized by muscle atrophy and frailty in older adults, with the underlying molecular mechanisms still unclear. Noncoding RNAs, particularly microRNAs and long noncoding RNAs, have been identified as playing a role in the development and progression of sarcopenia. This manuscript reviews the current understanding of their involvement and discusses their potential as therapeutic targets.