Synthesis and antimicrobial activity of new 3,5-diarylidene-4-piperidone derivatives

Three series of heteroaromatic analogues (twenty seven compounds) with monoketone linkers were synthesized and evaluated for their antimicrobial activity against six microbial strains. Among them, 3,5-dibenzylidene-1-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]piperidin-4-one (5e) showed the best antifungal activity against Aspergillus niger and A. fumigatus. Structural elucidation of the synthesized compounds was realised based on various spectroscopic methods.