Journal
JOURNAL OF CELL SCIENCE
Volume 136, Issue 11, Pages -Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.259440
Keywords
Peroxisome; Membrane contact site; Tether protein; Organelle; Yeast
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Membrane contact sites are regions of close proximity between two membranes, and their association is mediated by protein-protein and/or protein-lipid interactions. Peroxisomal membrane contact sites have received little attention compared to other organelles, but recent studies have greatly improved our understanding of their occurrence, composition, and function. Yeast studies have been particularly valuable in advancing our knowledge in this area.
Membrane contact sites are defined as regions of close proximity between two membranes; this association is mediated by protein- protein and/or protein-lipid interactions. Contact sites are often involved in lipid transport, but also can perform other functions. Peroxisomal membrane contact sites have obtained little attention compared to those of other cell organelles. However, recent studies resulted in a big leap in our knowledge of the occurrence, composition and function of peroxisomal contact sites. Studies in yeast strongly contributed to this progress. In this Review, we present an overview of our current knowledge on peroxisomal membrane contact sites in various yeast species, including Hansenula polymorpha, Saccharomyces cerevisiae, Pichia pastoris and Yarrowia lipolytica. Yeast peroxisomes form contacts with almost all other cellular organelles and with the plasma membrane. The absence of a component of a yeast peroxisomal contact site complex results in a range of peroxisomal phenotypes, including metabolic and biogenesis defects and alterations in organelle number, size or position.
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