4.7 Editorial Material

The atlastin paralogs: The complexity in the tails

Related references

Note: Only part of the references are listed.
Article Cell Biology

Human atlastin-3 is a constitutive ER membrane fusion catalyst

Samantha Bryce et al.

Summary: Human ATL3 is a robust protein that can promote endoplasmic reticulum fusion and maintain its structure. Unlike ATL1/2, ATL3 does not have C-terminal autoinhibition, indicating that it is a constitutive fusion catalyst.

JOURNAL OF CELL BIOLOGY (2023)

Article Cell Biology

Human atlastins are sufficient to drive the fusion of liposomes with a physiological lipid composition

Eunhong Jang et al.

Summary: This study reveals that human atlastins are sufficient to induce membrane fusion when reconstituted into liposomes with a lipid composition mimicking that of the ER, including the weaker fusogenic activity of ATL1 predominantly expressed in neuronal cells. The addition of M1-spastin, a neuron-specific factor, significantly enhances ATL1-mediated liposome fusion. ATL2-1, an autoinhibited isoform of ATL2, is unable to support liposome fusion by itself, indicating the requirement of cellular factors for ATL2-1 to mediate ER fusion in vivo.

JOURNAL OF CELL BIOLOGY (2023)

Article Cell Biology

Reconstitution of human atlastin fusion activity reveals autoinhibition by the C terminus

Daniel Crosby et al.

Summary: ER network formation depends on membrane fusion by the atlastin (ATL) GTPase. Successful reconstitution of fusion activity by the human ATLs has been achieved. The major splice isoforms of ATL1 and ATL2 are found to be autoinhibited to different degrees. Autoinhibition can be relieved by charge reversal of residues in the inhibitory domain, leading to activation of fusion activity. Neurons express an ATL2 splice isoform with full fusion activity due to sequence differences in the inhibitory domain. These findings highlight the importance of autoinhibition and alternate splicing in regulating atlastin-mediated ER fusion.

JOURNAL OF CELL BIOLOGY (2022)

Article Cell Biology

Membrane fusion by Drosophila atlastin does not require GTP hydrolysis

Daniel Crosby et al.

Summary: Translation: Atlastin (ATL) GTPases play a crucial role in driving endoplasmic reticulum membrane fusion through trans dimerization and conformational rearrangement. The hydrolysis of GTP is found to be necessary for ATL dimerization and crossover, but dispensable for fusion. This study provides insights into the mechanism of ATL-mediated fusion and the role of GTP hydrolysis.

MOLECULAR BIOLOGY OF THE CELL (2022)

Article Cell Biology

The hypervariable region of atlastin-1 is a site for intrinsic and extrinsic regulation

Carolyn M. Kelly et al.

Summary: Research has identified the critical role of the N-terminal hypervariable region (HVR) in ATL proteins in membrane fusion, with regulation through phosphorylation-dependent modification. The structural features of HVR positively impact membrane tethering and cellular function of ATLs, laying the foundation for identifying cellular effectors of ATL-mediated membrane processes.

JOURNAL OF CELL BIOLOGY (2021)

Review Cell Biology

The Effects of Regulatory Lipids on Intracellular Membrane Fusion Mediated by Dynamin-Like GTPases

Yeojin Moon et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

A hereditary spastic paraplegia-associated atlastin variant exhibits defective allosteric coupling in the catalytic core

John P. O'Donnell et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

The Atlastin C-terminal Tail Is an Amphipathic Helix That Perturbs the Bilayer Structure during Endoplasmic Reticulum Homotypic Fusion

Joseph E. Faust et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Cell Biology

Comparison of human and Drosophila atlastin GTPases

Fuyun Wu et al.

PROTEIN & CELL (2015)

Article Biochemistry & Molecular Biology

Structural basis for conformational switching and GTP loading of the large G protein atlastin

Laura J. Byrnes et al.

EMBO JOURNAL (2013)

Article Multidisciplinary Sciences

Lipid interaction of the C terminus and association of the transmembrane segments facilitate atlastin-mediated homotypic endoplasmic reticulum fusion

Tina Y. Liu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes

Xin Bian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Multidisciplinary Sciences

Structural basis for the nucleotide-dependent dimerization of the large G protein atlastin-1/SPG3A

Laura J. Byrnes et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Medicine, Research & Experimental

Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network

Seong H. Park et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Article Multidisciplinary Sciences

Homotypic fusion of ER membranes requires the dynamin-like GTPase Atlastin

Genny Orso et al.

NATURE (2009)

Article Biochemistry & Molecular Biology

Atlastin GTPases are required for Golgi apparatus and ER morphogenesis

Neggy Rismanchi et al.

HUMAN MOLECULAR GENETICS (2008)

Article Biochemistry & Molecular Biology

A class of membrane proteins shaping the tubular endoplasmic reticulum

GK Voeltz et al.