Journal
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
Volume 149, Issue 11, Pages 9435-9450Publisher
SPRINGER
DOI: 10.1007/s00432-023-04805-z
Keywords
mRNA vaccination; Breast cancer; Cancer vaccine
Categories
Ask authors/readers for more resources
Messenger RNA (mRNA) vaccination is highly successful against COVID-19 and has sparked tremendous interest. It is also viewed as a promising treatment strategy for cancer immunotherapy. However, breast cancer patients have limited access to immunotherapy benefits. This review discusses the potential of mRNA vaccination to convert cold breast cancer into hot and improve efficacy by combining appropriate vaccination platforms or other immunotherapies.
Messenger RNA (mRNA) vaccination has proven to be highly successful in combating Coronavirus disease 2019 (COVID-19) and has recently sparked tremendous interest. This technology has been a popular topic of research over the past decade and is viewed as a promising treatment strategy for cancer immunotherapy. However, despite being the most prevalent malignant disease for women worldwide, breast cancer patients have limited access to immunotherapy benefits. mRNA vaccination has the potential to convert cold breast cancer into hot and expand the responders. Effective mRNA vaccine design for in vivo function requires consideration of vaccine targets, mRNA structures, transport vectors, and injection routes. This review provides an overview of pre-clinical and clinical data on various mRNA vaccination platforms used for breast cancer treatment and discusses potential approaches to combine appropriate vaccination platforms or other immunotherapies to improve mRNA vaccine therapy efficacy for breast cancer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available