4.6 Article

Diagnostic performance of RASSF1A and SHOX2 methylation combined with EGFR mutations for differentiation between small pulmonary nodules

Related references

Note: Only part of the references are listed.
Article Oncology

The Diagnostic Potential of SHOX2 and RASSF1A DNA Methylation in Early Lung Adenocarcinoma

Hong Gao et al.

Summary: The combined promoter methylation assay for SHOX2 and RASSF1A can be used for screening and diagnosis of early LUAD, with good sensitivity and specificity. The promoter methylation levels of SHOX2 and RASSF1A were associated with their abnormal mRNA expression, and affected DNA instability, cell proliferation, apoptosis, and tumor microenvironment in patients with LUAD.

FRONTIERS IN ONCOLOGY (2022)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Multidisciplinary Sciences

Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas

Xin Hu et al.

Summary: This study reveals that DNA methylation alterations accompany the evolution of pre-cancerous lesions in early carcinogenesis of lung adenocarcinomas, with global hypomethylation correlating with immune infiltration, mutational burden, and copy number alterations.

NATURE COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

Analysis of the Prognostic Value and Gene Expression Mechanism of SHOX2 in Lung Adenocarcinoma

Nanhong Li et al.

Summary: SHOX2 is highly expressed in various cancers, and its overexpression or hypomethylation in the gene body indicates poor differentiation and prognosis in LUAD. SHOX2 may be involved in important cancer-related signaling pathways, such as PI3K-Akt, to promote tumorigenesis.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

Review Oncology

Signaling pathways and clinical application of RASSF1A and SHOX2 in lung cancer

Nanhong Li et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2020)

Article Multidisciplinary Sciences

Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma

Xing Hua et al.

NATURE COMMUNICATIONS (2020)

Review Oncology

Early-Stage NSCLC: Advances in Thoracic Oncology 2018

Raymond U. Osarogiagbon et al.

JOURNAL OF THORACIC ONCOLOGY (2019)

Review Reproductive Biology

Biomarkers and algorithms for diagnosis of ovarian cancer: CA125, HE4, RMI and ROMA, a review

Vincent Dochez et al.

JOURNAL OF OVARIAN RESEARCH (2019)

Article Multidisciplinary Sciences

Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma

Xin Hu et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

Genomic and immune profiling of pre-invasive lung adenocarcinoma

Haiquan Chen et al.

NATURE COMMUNICATIONS (2019)

Article Oncology

Cancer Statistics, 2018

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2018)

Article Oncology

RASSF1A Deficiency Enhances RAS-Driven Lung Tumorigenesis

M. Lee Schmidt et al.

CANCER RESEARCH (2018)

Review Biotechnology & Applied Microbiology

Single-Cell DNA Methylation Profiling: Technologies and Biological Applications

Ino D. Karemaker et al.

TRENDS IN BIOTECHNOLOGY (2018)

Review Medical Laboratory Technology

Translating cancer epigenomics into the clinic: focus on lung cancer

Josep Mari-Alexandre et al.

TRANSLATIONAL RESEARCH (2017)

Review Biochemistry & Molecular Biology

Progress and prospects of early detection in lung cancer

Sean Blandin Knight et al.

OPEN BIOLOGY (2017)

Review Oncology

DNA Methylation in Cancer and Aging

Michael Klutstein et al.

CANCER RESEARCH (2016)

Article Oncology

Natural History of Pulmonary Subsolid Nodules: A Prospective Multicenter Study

Ryutaro Kakinuma et al.

JOURNAL OF THORACIC ONCOLOGY (2016)

Review Oncology

Clinical utility of RASSF1A methylation in human malignancies

A. M. Grawenda et al.

BRITISH JOURNAL OF CANCER (2015)

Review Biochemistry & Molecular Biology

Lineage factors and differentiation states in lung cancer progression

W. K. C. Cheung et al.

ONCOGENE (2015)

Article Biotechnology & Applied Microbiology

Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysis

Qing-Tao Zhao et al.

ONCOTARGETS AND THERAPY (2015)

Article Biochemistry & Molecular Biology

RASSF1A Inactivation Unleashes a Tumor Suppressor/Oncogene Cascade with Context-Dependent Consequences on Cell Cycle Progression

Rosalyn R. Ram et al.

MOLECULAR AND CELLULAR BIOLOGY (2014)

Article Medicine, General & Internal

Overdiagnosis in Low-Dose Computed Tomography Screening for Lung Cancer

Edward F. Patz et al.

JAMA INTERNAL MEDICINE (2014)

Review Pathology

Epigenetic biomarkers in laboratory diagnostics: emerging approaches and opportunities

Juan Sandoval et al.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2013)

Article Oncology

SHOX2 DNA Methylation Is a Biomarker for the Diagnosis of Lung Cancer in Plasma

Christoph Kneip et al.

JOURNAL OF THORACIC ONCOLOGY (2011)

Review Oncology

Do all lung adenocarcinomas follow a stepwise progression?

Yasushi Yatabe et al.

LUNG CANCER (2011)

Article Medicine, General & Internal

Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening

Denise R. Aberle et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Article Medicine, Research & Experimental

Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in lung cancer

Monica Castro et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2010)

Article Medicine, General & Internal

Erlotinib in lung cancer - Molecular and clinical predictors of outcome

MS Tsao et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

Article Oncology

Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers

H Shigematsu et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2005)

Article Multidisciplinary Sciences

EGF receptor gene mutations are common in lung cancers from never smokers and are associated with sensitivity of tumors to gefitinib and erlotinib

W Pao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Radiology, Nuclear Medicine & Medical Imaging

Longitudinal follow-up study of smoker's lung with thin-section CT in correlation with pulmonary function tests

M Remy-Jardin et al.

RADIOLOGY (2002)