Primary hemostasis dysfunctions and bleeding risk in newly diagnosed acute myeloid leukemia

BackgroundAcute myeloid leukaemia carries the risk of complications associated with dysfunctions in haemostasis system. The purpose of this study was to investigate the factors associated with the risk of bleeding in patients with newly diagnosed acute myeloid leukaemia (AML).MethodsThis study involved the methods of immunoenzymatic analysis and classical coagulation studies. The number of biochemical parameters important for establishing coagulative dysfunction in acute myeloid leukaemia was determined, the main ones being the level of von Willebrand factor, the Ristocetin-cofactor activity of von Willebrand factor and factor VIII activity, prothrombin time, platelet count, and fibrinogen concentration.ResultsAccording to the results of the present study, the reduced activity of von Willebrand factor in patients with AML was associated with severe bleeding. The authors observed an increase in the number of platelets count in patients with AML who experienced haemorrhages compared to patients with no bleeding signs. The study also established an increase in the concentration of fibrinogen in cancer patients, compared to the control sample. Symptoms and quantitative indicators for diagnosing the severity of haemorrhagic syndrome were grouped. The authors considered the advantages and disadvantages of many therapeutic preparations and focussed on specific markers of activated haemorrhage-predicting platelets.ConclusionFurther studies concern the search for effective markers and therapeutic approaches to minimize haemorrhagic syndrome. The results were statistically processed using the functions ANOVA, t test, CORREL, determination of the value of reliability, and mean square deviation.

Automated summary

This study investigated the factors associated with the risk of bleeding in newly diagnosed acute myeloid leukaemia (AML) patients through immunoenzymatic analysis and classical coagulation studies. The results showed that reduced activity of von Willebrand factor was associated with severe bleeding in AML patients. In addition, patients with bleeding signs had increased platelet count and fibrinogen concentration. These findings contribute to the diagnosis and treatment of haemorrhagic syndrome.