4.6 Article

Uncovering Zn2+as a cofactor of FAD-dependent Pseudomonas aeruginosa PAO1 D-2-hydroxyglutarate dehydrogenase

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

The Pseudomonas aeruginosa PAO1 metallo flavoprotein D-2-hydroxyglutarate dehydrogenase requires Zn2+for substrate orientation and activation

Joanna A. Quaye et al.

Summary: Researchers have found that zinc ion (Zn2+) plays a crucial role in the catalytic process of Pseudomonas aeruginosa PAO1 D-2-hydroxyglutarate dehydrogenase (PaD2HGDH). It activates the water molecule coordinated to the metal, leading to the correct orientation and activation of the substrate in the enzyme's active site. This finding is important for understanding the catalytic mechanism of PaD2HGDH and other metalloflavoenzymes.

JOURNAL OF BIOLOGICAL CHEMISTRY (2023)

Review Biochemistry & Molecular Biology

Iron and manganese transport in mammalian systems

Qingli Liu et al.

Summary: Recent studies have expanded and refined our understanding of iron and manganese transport, focusing on the roles of membrane transporters and related proteins. These studies have looked at main organs, tissues, and cell types that actively regulate whole-body iron or manganese homeostasis, emphasizing direct measurement of metal transport or use of knockout mouse models. The reviews also provide overviews of whole-body and cellular iron and manganese homeostasis to contextualize the key transporters' participation in metal uptake, intracellular trafficking, and efflux.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

Article Biochemistry & Molecular Biology

Analytical and functional aspects of protein-ligand interactions: Beyond induced fit and conformational selection

Michelle Redhair et al.

Summary: The article discusses the importance of ligand-dependent changes in protein conformation in biology, introducing the induced fit and conformational selection mechanisms, and explaining their impact on protein substrate specificity, promiscuity, and regulatory properties. It also presents a new perspective based on interactions between protein ensembles and ligand ensembles, and describes how probing protein ensembles with multiple ligands can optimize mechanistic information.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2021)

Article Environmental Sciences

Heavy metal associated health hazards: An interplay of oxidative stress and signal transduction

Jagdish Gopal Paithankar et al.

Summary: The oxidative stress induced by heavy metals and its connection with different signaling pathways are complex, which may lead to a variety of health issues. Exposure to heavy metals/metalloids such as Arsenic, Chromium, Cadmium, and Lead can trigger oxidative stress and subsequently cellular and organismal responses, involving regulation of multiple signaling pathways.

CHEMOSPHERE (2021)

Article Cell Biology

Structure, substrate specificity, and catalytic mechanism of human D-2-HGDH and insights into pathogenicity of disease-associated mutations

Jun Yang et al.

Summary: The study presents the crystal structures of D-2-hydroxyglutarate dehydrogenase (D-2-HGDH) and analyzes its substrate specificity and catalytic reaction at a molecular level. Insights into the pathogenicity of disease-associated mutations are provided through structural and biochemical data.

CELL DISCOVERY (2021)

Article Biochemistry & Molecular Biology

Effects of free soluble iron on thermal aggregation of hemoglobin

Sushanta Debnath et al.

Summary: Iron ions, both in Fe2+ and Fe3+ forms, were found to inhibit hemoglobin aggregation, with a 60% inhibition in the presence of 100 mg/L FeCl3. Other metal ions such as Cu2+, Zn2+, and Ni2+ did not have significant effects on hemoglobin aggregation. These findings suggest a chaperone-like behavior of free iron that could have important consequences on the severity of hematological diseases.

BIOPHYSICAL CHEMISTRY (2021)

Article Chemistry, Physical

Ionic Atmosphere Effect on the Absorption Spectrum of a Flavoprotein: A Reminder to Consider Solution Ions

Benjamin D. Dratch et al.

Summary: This study found that deprotonating the active site significantly alters the flavin absorption spectrum, but accurate prediction can only be achieved by considering the influence of solution ions on the protein environment.

JOURNAL OF PHYSICAL CHEMISTRY LETTERS (2021)

Article Environmental Sciences

Simultaneous enhancement of heavy metal removal and electricity generation in soil microbial fuel cell

Jingran Zhang et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2020)

Article Clinical Neurology

Early life metal dysregulation in amyotrophic lateral sclerosis

Claudia Figueroa-Romero et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2020)

Review Biochemistry & Molecular Biology

The essential metals for humans: a brief overview

Maria Antonietta Zoroddu et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2019)

Article Biochemistry & Molecular Biology

Biochemical characterization of human D-2-hydroxyglutarate dehydrogenase and two disease related variants reveals the molecular cause of D-2-hydroxyglutaric aciduria

Marina Toplak et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2019)

Review Biology

Metalloproteins in the Biology of Heterocysts

Rafael Pernil et al.

LIFE-BASEL (2019)

Article Environmental Sciences

Acute Lethal Toxicity of Heavy Metals to the Seeds of Plants of High Importance to Humans

Kamila Pokorska-Niewiada et al.

BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY (2018)

Article Environmental Sciences

Heavy metals in the finest size fractions of road-deposited sediments

Christof Lanzerstorfer

ENVIRONMENTAL POLLUTION (2018)

Article Engineering, Environmental

Scenarios for Demand Growth of Metals in Electricity Generation Technologies, Cars, and Electronic Appliances

Sebastiaan Deetman et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2018)

Review Biochemistry & Molecular Biology

The Role of Heavy Metals in Plant Response to Biotic Stress

Iwona Morkunas et al.

MOLECULES (2018)

Review Biochemistry & Molecular Biology

Iron Chemistry at the Service of Life

Manu Sanchez et al.

IUBMB LIFE (2017)

Article Engineering, Environmental

Are scarce metals in cars functionally recycled?

Magnus Andersson et al.

WASTE MANAGEMENT (2017)

Review Environmental Sciences

Microbial and Plant-Assisted Bioremediation of Heavy Metal Polluted Environments: A Review

Omena Bernard Ojuederie et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2017)

Article Biochemistry & Molecular Biology

Saccharomyces cerevisiae Forms d-2-Hydroxyglutarate and Couples Its Degradation to d-Lactate Formation via a Cytosolic Transhydrogenase

Julia Becker-Kettern et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Review Environmental Sciences

Impact of heavy metals on the female reproductive system

Piotr Rzymski et al.

ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE (2015)

Review Physiology

MAGNESIUM IN MAN: IMPLICATIONS FOR HEALTH AND DISEASE

Jeroen H. F. de Baaij et al.

PHYSIOLOGICAL REVIEWS (2015)

Review Chemistry, Multidisciplinary

Metalloproteins Containing Cytochrome, Iron-Sulfur, or Copper Redox Centers

Jing Liu et al.

CHEMICAL REVIEWS (2014)

Article Multidisciplinary Sciences

Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases

Hanna Tarhonskaya et al.

NATURE COMMUNICATIONS (2014)

Article Agriculture, Multidisciplinary

Inhibition of Pseudomonas aeruginosa and Escherichia coli O157:H7 Biofilm Formation by Plant Metabolite ε-Viniferin

Hyun Seob Cho et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Reactive Cysteine in the Structural Zn2+ Site of the C1B Domain from PKCα

Mikaela D. Stewart et al.

BIOCHEMISTRY (2012)

Review Chemistry, Multidisciplinary

Application of Metal Coordination Chemistry To Explore and Manipulate Cell Biology

Kathryn L. Haas et al.

CHEMICAL REVIEWS (2009)

Article Biochemistry & Molecular Biology

A Novel Mammalian Flavin-dependent Histone Demethylase

Aristotele Karytinos et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Microbiology

A novel chromate reductase from Thermus scotoductus SA-01 related to old yellow enzyme

Diederik Johannes Opperman et al.

JOURNAL OF BACTERIOLOGY (2008)

Article Biochemistry & Molecular Biology

Structure of lactate dehydrogenase from Plasmodium vivax:: Complexes with NADH and APADH

A Chaikuad et al.

BIOCHEMISTRY (2005)

Review Multidisciplinary Sciences

Hydrogen storage methods

A Züttel

NATURWISSENSCHAFTEN (2004)

Article Biochemistry & Molecular Biology

Crystal structures of creatininase reveal the substrate binding site and provide an insight into the catalytic mechanism

T Yoshimoto et al.

JOURNAL OF MOLECULAR BIOLOGY (2004)

Review Chemistry, Multidisciplinary

Synthetic analogues relevant to the structure and function of zinc enzymes

G Parkin

CHEMICAL REVIEWS (2004)

Article Biochemistry & Molecular Biology

Identification of a dehydrogenase acting on D-2-hydroxyglutarate rate

Y Achouri et al.

BIOCHEMICAL JOURNAL (2004)

Article Chemistry, Multidisciplinary

UCSF chimera - A visualization system for exploratory research and analysis

EF Pettersen et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Proton transfer within the active-site cavity of carbonic anhydrase III

HQ An et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2002)

Article Public, Environmental & Occupational Health

National Nosocomial Infections Surveillance (NNIS) System report, data summary from January 1992-April 2000, issued June 2000

J Gerberding et al.

AMERICAN JOURNAL OF INFECTION CONTROL (2000)

Article Nutrition & Dietetics

Function and mechanism of zinc metalloenzymes

KA McCall et al.

JOURNAL OF NUTRITION (2000)