Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume -, Issue -, Pages -Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2023.2209564
Keywords
Ranunculaceae; Delphinium; Delphinium trichophorum; diterpenoid alkaloids; anti-inflammatory
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Three new hetisine type C-20-diterpenoid alkaloids, trichophorines A-C (1-3), were isolated from Delphinium trichophorum, along with nine known alkaloids (4-12). Their structures were determined using spectroscopic methods. None of the compounds showed significant inhibitory activity against LPS-induced NO production in RAW 264.7 macrophage cells.
Three new hetisine type C-20-diterpenoid alkaloids, named as trichophorines A-C (1-3), were isolated from Delphinium trichophorum, together with nine known alkaloids (4-12). Their structures were elucidated on the basis of spectroscopic data (1D, 2D NMR, single-crystal X-ray, and HR-ESI-MS). All compounds were evaluated for the inhibitory activities against LPS induced NO production in RAW 264.7 macrophage cells, and none of them showed considerable inhibitory activity.
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