4.5 Article

Biological impact of sequential exposures to allergens and ultrafine particle-rich combustion aerosol on human bronchial epithelial BEAS-2B cells at the air liquid interface

Related references

Note: Only part of the references are listed.
Article Toxicology

An alternative in vitro model considering cell-cell interactions in fiber-induced pulmonary fibrosis

Jana Pantzke et al.

Summary: This study develops an advanced in vitro cell model that closely resembles the physiological structure of the alveoli, and compares it with simpler models to predict fibrotic changes. Through analyzing the cytotoxic effects of fiber-like multi-walled carbon nanotubes on different cell culture systems, it is found that the triple culture system can more accurately detect fibrotic phenotype, as well as inflammatory and genotoxic changes.

TOXICOLOGY MECHANISMS AND METHODS (2023)

Article Allergy

House dust mite sensitization and exposure affects bronchial epithelial anti-microbial response to viral stimuli in patients with asthma

Samuel Cerps et al.

Summary: This study found that exposure to house dust mite (HDM) affected the anti-viral and anti-bacterial responses in airway epithelial cells of allergic asthma patients, potentially leading to asthma exacerbations. However, HDM exposure did not affect the release of TSLP, a driver of T2 inflammation.

ALLERGY (2022)

Article Environmental Sciences

Effect of Atmospheric Aging on Soot Particle Toxicity in Lung Cell Models at the Air-Liquid Interface: Differential Toxicological Impacts of Biogenic and Anthropogenic Secondary Organic Aerosols (SOAs)

Svenja Offer et al.

Summary: This study investigated the toxicological effects of aerosols generated by atmospheric aging on combustion soot particles (SPs) of gaseous biogenic or anthropogenic precursors in lung cell models. The researchers found that secondary organic aerosols (SOAs) had greater toxicity than primary SPs. Moreover, anthropogenic SOAs showed stronger toxic effects compared to biogenic SOAs.

ENVIRONMENTAL HEALTH PERSPECTIVES (2022)

Article Geosciences, Multidisciplinary

Sources, characteristics, toxicity, and control of ultrafine particles: An overview

Andrea L. Moreno-Rios et al.

Summary: Air pollution caused by particulate matter is a major threat to human health, especially in large cities. The size, composition, and toxicity of these particles vary. Ultrafine particles have a greater impact on human health as they can enter the lungs and vital organs, leading to diseases. In addition, particulate matter pollution is associated with respiratory conditions, genotoxicity, mutagenicity, and carcinogenicity.

GEOSCIENCE FRONTIERS (2022)

Article Biotechnology & Applied Microbiology

A comparative study of persistent DNA oxidation and chromosomal instability induced in vitro by oxidizers and reference airborne particles

Xin Cao et al.

Summary: This study compared the genotoxic effects of two oxidizing agents and three different reference PM samples on cells, and found that all PM samples caused similar oxidative DNA damage as the oxidizers, but with different persistency. Diesel PM was more effective in inducing chromosomal instability compared to fine and urban dust. The study revealed an interplay between DNA oxidation persistence and chromosomal damage in driving particulate matter-induced genome instability.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2022)

Article Toxicology

Toxicological impact of organic ultrafine particles (UFPs) in human bronchial epithelial BEAS-2B cells at air-liquid interface

A. T. Juarez Facio et al.

Summary: This study investigated the toxicological effects of ultrafine particles (UFPs) with high organic content on BEAS-2B cells at low doses. The results showed an increase in oxidative stress and induction of genes related to xenobiotic metabolism, while inflammatory gene expression decreased. These findings highlight the mechanisms by which organic UFPs induce toxic effects.

TOXICOLOGY IN VITRO (2022)

Article Water Resources

Impact of Volatile and Semi-volatile Organic Compounds from Farming Environments on Allergy-Related Cellular Processes

Nadine Gawlitta et al.

Summary: Studies indicate that small-sized semi-volatile organic compounds in farming environments play a crucial role in regulating inflammatory and allergy-related genes, thus contributing to a protective effect against allergic asthma.

EXPOSURE AND HEALTH (2022)

Article Allergy

NLRP6 negatively regulates type 2 immune responses in mice

Pauline Chenuet et al.

Summary: This study identifies NLRP6 as a negative regulator of type 2 immune responses, highlighting its importance in preventing lung inflammation.

ALLERGY (2022)

Article Environmental Sciences

Genotoxic and inflammatory effects of spruce and brown coal briquettes combustion aerosols on lung cells at the air-liquid interface

Tuukka Ihantola et al.

Summary: The study compared the toxicological responses of spruce and brown coal combustion aerosols on human alveolar epithelial cells, showing both aerosols causing cytotoxic and genotoxic effects on the cells.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

Article Environmental Sciences

Exposure to naphthalene and β-pinene-derived secondary organic aerosol induced divergent changes in transcript levels of BEAS-2B cells

Michal Pardo et al.

Summary: This study investigates the toxicities of secondary organic aerosols (SOAs) derived from different precursor compounds. It shows that SOAs derived from a typical anthropogenic precursor have higher toxicological potency and activate different cellular mechanisms compared to those derived from a typical biogenic precursor.

ENVIRONMENT INTERNATIONAL (2022)

Article Environmental Sciences

The priming effect of diesel exhaust on native pollen exposure at the air-liquid interface

Joana Candeias et al.

Summary: Pollen related allergic diseases have been increasing, and diesel exhaust may play a role. This study explored the priming effects of diesel exhaust on native pollen exposure for the first time. The results showed that diesel exhaust can make cells react more rapidly to pollen exposure, especially inflammation-related genes. These findings provide guidance for investigating the impact of modern diesel exhaust exposure on the development of allergic diseases.

ENVIRONMENTAL RESEARCH (2022)

Article Environmental Sciences

In vitro genotoxicity of dibutyl phthalate on A549 lung cells at air-liquid interface in exposure concentrations relevant at workplaces

Stephanie Binder et al.

Summary: The widespread use of phthalates in various materials and their potential adverse effects on human health are of great concern. This study demonstrates that exposure of A549 alveolar epithelial cells at the air-liquid interface can induce genotoxicity under sub-cytotoxic conditions, suggesting that oxidative stress may play a significant role in phthalate-induced genotoxicity.

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2021)

Article Multidisciplinary Sciences

Dosing intact birch pollen grains at the air-liquid interface (ALI) to the immortalized human bronchial epithelial cell line BEAS-2B

Joana Candeias et al.

Summary: A system for in vitro dosing of whole pollen grains at the air-liquid interface was developed to study their effect on immortalized human bronchial epithelial cells. The dosing process involved resuspending single pollen particles and delivering them to cells with limited loss. The system allowed for gentle and reliable dosing of cells with whole pollen exposure.

PLOS ONE (2021)

Article Immunology

Benzo(a)pyrene Enhanced Dermatophagoides Group 1 (Der f 1)-Induced TGFβ1 Signaling Activation Through the Aryl Hydrocarbon Receptor-RhoA Axis in Asthma

Eryi Wang et al.

Summary: The study demonstrates that co-exposure to benzo(a)pyrene (BaP) and dermatophagoides group 1 allergen (Der f 1) enhances airway inflammation in asthma by activating the AhR-RhoA axis, which regulates the expression and signaling activation of TGF beta 1. This suggests a potential therapeutic target for allergic asthma.

FRONTIERS IN IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

Diesel exhaust particles increase nasal symptoms and IL-17A in house dust mite-induced allergic mice

Hahn Jin Jung et al.

Summary: This study investigated the effect of DEP exposure on allergic rhinitis using a mouse model sensitized to house dust mite. The results showed that mice co-exposed to HDM and DEP exhibited increased allergic symptom scores compared to mice exposed to HDM alone. This suggests that DEP may exacerbate allergic rhinitis by increasing levels of interleukin-17A in the nasal mucosa.

SCIENTIFIC REPORTS (2021)

Article Chemistry, Multidisciplinary

Evaluating Particle Emissions and Toxicity of 3D Pen Printed Filaments with Metal Nanoparticles As Additives: In Vitro and in Silico Discriminant Function Analysis

Ajay Vikram Singh et al.

Summary: The study examined the safety concerns surrounding low-cost 3D printing, particularly with 3D pens, in home and school environments by analyzing filament washing and particle emission during printing. Results showed that additives in PLA filaments, such as carbon nanotubes and steel, had minimal toxicity effects, except for copper which caused significant cellular stress, death, and metabolic disturbances. Therefore, caution should be exercised when using 3D printing pens with redox active metal additives in a home setting.

ACS SUSTAINABLE CHEMISTRY & ENGINEERING (2021)

Article Immunology

Progranulin Protects Against Airway Remodeling Through the Modulation of Autophagy via HMGB1 Suppression in House Dust Mite-Induced Chronic Asthma

Meixuan Liu et al.

Summary: The study demonstrates that PGRN protects against asthmatic airway remodeling by negatively regulating autophagy via HMGB1 suppression. This finding provides new insights into therapeutic options for HDM-induced chronic asthma.

JOURNAL OF INFLAMMATION RESEARCH (2021)

Review Public, Environmental & Occupational Health

Environmental and Health Impacts of Air Pollution: A Review

Ioannis Manisalidis et al.

FRONTIERS IN PUBLIC HEALTH (2020)

Review Biochemistry & Molecular Biology

Ultrafine particles: unique physicochemical properties relevant to health and disease

Hyouk-Soo Kwon et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

Review Biochemistry & Molecular Biology

The health effects of ultrafine particles

Dean E. Schraufnagel

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

Article Allergy

The Role of Dust Mites in Allergy

Jeffrey D. Miller

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2019)

Article Cell Biology

Chinese Birch Pollen Allergy and Immunotherapy in Mice

Zhijuan Xie et al.

INFLAMMATION (2019)

Article Thermodynamics

Aircraft and MiniCAST soot at the nanoscale

Iman Marhaba et al.

COMBUSTION AND FLAME (2019)

Review Biochemistry & Molecular Biology

Ultrafine Particles from Residential Biomass Combustion: A Review on Experimental Data and Toxicological Response

Emanuela Corsini et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Allergy

Birch pollen allergy in Europe

T. Biedermann et al.

ALLERGY (2019)

Article Respiratory System

Ethyl pyruvate reduces organic dust-induced airway inflammation by targeting HMGB1-RAGE signaling

Sanjana Mahadev Bhat et al.

RESPIRATORY RESEARCH (2019)

Article Allergy

Histamine and T helper cytokine-driven epithelial barrier dysfunction in allergic rhinitis

Brecht Steelant et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

Review Cell Biology

Emerging role of HMGB1 in lung diseases: friend or foe

Junying Ding et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2017)

Review Respiratory System

Applications and mechanisms of immunotherapy in allergic rhinitis and asthma

Jasper H. Kappen et al.

THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE (2017)

Review Engineering, Environmental

Air Pollution and Climate Change Effects on Allergies in the Anthropocene: Abundance, Interaction, and Modification of Allergens and Adjuvants

Kathrin Reinmuth-Selzle et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2017)

Review Biochemistry & Molecular Biology

Oxidative Stress: Promoter of Allergic Sensitization to Protease Allergens?

Leonie S. van Rijt et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Physiology

Pollen-induced oxidative DNA damage response regulates miRNAs controlling allergic inflammation

Leopoldo Aguilera-Aguirre et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2017)

Article Environmental Sciences

Characteristics of Organic Carbon and Elemental Carbon in the Ambient Air of Coking Plant

Xiaofeng Liu et al.

AEROSOL AND AIR QUALITY RESEARCH (2015)

Article Biochemistry & Molecular Biology

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Biochemistry & Molecular Biology

Efficient Bioactive Delivery of Aerosolized Drugs to Human Pulmonary Epithelial Cells Cultured in Air-Liquid Interface Conditions

Anke-Gabriele Lenz et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2014)

Article Cell Biology

Gene expression profiling of replicative and induced senescence

Maggie Purcell et al.

CELL CYCLE (2014)

Article Allergy

The biodiversity hypothesis and allergic disease: world allergy organization position statement

Tari Haahtela et al.

WORLD ALLERGY ORGANIZATION JOURNAL (2013)

Article Immunology

Pollen-Derived E1-Phytoprostanes Signal via PPAR-γ and NF-κB-Dependent Mechanisms

Stefanie Gilles et al.

JOURNAL OF IMMUNOLOGY (2009)

Review Allergy

Effects of climate change on environmental factors in respiratory allergic diseases

G. D'Amato et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2008)

Article Engineering, Environmental

The IMPROVE-A temperature protocol for thermal/optical carbon analysis: maintaining consistency with a long-term database

Judith C. Chow et al.

JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION (2007)