Assessing the calculation of conductive and acinar ventilatory heterogeneity indices Scond and Sacin from multiple-breath washout data

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Nitrogen-based lung clearance index: a valid physiological biomarker for the clinic

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Summary: This study provides evidence that indirect measurement of N-2 can be safely used as a meaningful physiological measurement in N-2 multiple breath washout testing. The effects of N-2 indirect measurement accuracy and N-2 blood solubility are largely outweighed by the ease of use.

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The effect of oxygen and carbon dioxide cross-sensitivity sensor error in the Eco Medics Exhalyzer D device on measures of conductive and acinar airway function

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ERJ OPEN RESEARCH (2022)

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Mitigating increased variability of multiple breath washout indices due to tidal breathing

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Correction of sensor crosstalk error in Exhalyzer D multiple-breath washout device significantly impacts outcomes in children with cystic fibrosis

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Improved agreement between N2 and SF6 multiple-breath washout in healthy infants and toddlers with improved EXHALYZER D sensor performance

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Controlled versus free breathing for multiple breath nitrogen washout in healthy adults

Blake M. Handley et al.

Summary: Multiple breath nitrogen washout (MBNW) quantifies ventilation heterogeneity using two distinct protocols: controlled breathing and free breathing. While functional residual capacity (FRC) was comparable between the two protocols, indices of ventilation heterogeneity differed, with poor between-session repeatability for Scond and S-acin derived from free breathing. Differences in S-acin were related to differences in breathing patterns rather than FRC, indicating implications for the clinical implementation of MBNW.

ERJ OPEN RESEARCH (2021)

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Acinar and conductive ventilation heterogeneity in severe CF lung disease: Back to the model

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Assessing the calculation of conductive and acinar ventilatory heterogeneity indices Scond and Sacin from multiple-breath washout data

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