Related references
Note: Only part of the references are listed.Safety and target engagement profile of two oxaloacetate doses in Alzheimer's patients
Eric D. Vidoni et al.
ALZHEIMERS & DEMENTIA (2021)
A ketogenic drink improves cognition in mild cognitive impairment: Results of a 6-month RCT
Melanie Fortier et al.
ALZHEIMERS & DEMENTIA (2021)
Mitonuclear interactions influence Alzheimer's disease risk
Shea J. Andrews et al.
NEUROBIOLOGY OF AGING (2020)
Modified ketogenic diet is associated with improved cerebrospinal fluid biomarker profile, cerebral perfusion, and cerebral ketone body uptake in older adults at risk for Alzheimer's disease: a pilot study
Bryan J. Neth et al.
NEUROBIOLOGY OF AGING (2020)
In vivo mitochondrial and glycolytic impairments in patients with Alzheimer disease
Tatsuhiro Terada et al.
NEUROLOGY (2020)
Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation
Erik C. B. Johnson et al.
NATURE MEDICINE (2020)
Exploratory analysis of mtDNA haplogroups in two Alzheimer's longitudinal cohorts
Russell H. Swerdlow et al.
ALZHEIMERS & DEMENTIA (2020)
Mitochondria in Alzheimer's disease and their potential role in Alzheimer's proteostasis
Ian W. Weidling et al.
EXPERIMENTAL NEUROLOGY (2020)
Detection of mitochondria-pertinent components in exosomes
Xiaowan Wang et al.
MITOCHONDRION (2020)
Mitochondrial DNA Manipulations Affect Tau Oligomerization
Ian W. Weidling et al.
JOURNAL OF ALZHEIMERS DISEASE (2020)
Inflammation and mitochondrial dysfunction: A vicious circle in neurodegenerative disorders?
Jack van Horssen et al.
NEUROSCIENCE LETTERS (2019)
Preliminary Report on the Feasibility and Efficacy of the Modified Atkins Diet for Treatment of Mild Cognitive Impairment and Early Alzheimer's Disease
Jason Brandt et al.
JOURNAL OF ALZHEIMERS DISEASE (2019)
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Brian W. Kunkle et al.
NATURE GENETICS (2019)
Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease
Evandro F. Fang et al.
NATURE NEUROSCIENCE (2019)
PTCD1 Is Required for Mitochondrial Oxidative-Phosphorylation: Possible Genetic Association with Alzheimer's Disease
Daniel Fleck et al.
JOURNAL OF NEUROSCIENCE (2019)
TOMM40 '523 Associations with Baseline and Longitudinal Cognition in APOE ε3 Homozygotes
Amber Watts et al.
JOURNAL OF ALZHEIMERS DISEASE (2019)
Mitochondria and Alzheimer's: Is PTCD1 the Smoking Gun?
Judy Pa et al.
TRENDS IN NEUROSCIENCES (2019)
Brain clusterin protein isoforms and mitochondrial localization
Sarah K. Herring et al.
ELIFE (2019)
Assembly of 809 whole mitochondrial genomes with clinical, imaging, and fluid biomarker phenotyping
Perry G. Ridge et al.
ALZHEIMERS & DEMENTIA (2018)
Evidence for brain glucose dysregulation in Alzheimer's disease
Yang An et al.
ALZHEIMERS & DEMENTIA (2018)
NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease
Clifford R. Jack et al.
ALZHEIMERS & DEMENTIA (2018)
Mitochondria and Mitochondrial Cascades in Alzheimer's Disease
Russell H. Swerdlow
JOURNAL OF ALZHEIMERS DISEASE (2018)
Sex differences in Alzheimer disease - the gateway to precision medicine
Maria Teresa Ferretti et al.
NATURE REVIEWS NEUROLOGY (2018)
Mitochondria and Alzheimer's Disease: the Role of Mitochondrial Genetic Variation
Perry G. Ridge et al.
CURRENT GENETIC MEDICINE REPORTS (2018)
A Mitochondrial Biomarker-Based Study of S-Equol in Alzheimer's Disease Subjects: Results of a Single-Arm, Pilot Trial
Heather M. Wilkins et al.
JOURNAL OF ALZHEIMERS DISEASE (2017)
Cytosolic proteostasis through importing of misfolded proteins into mitochondria
Linhao Ruan et al.
NATURE (2017)
TOMM40′523 variant and cognitive decline in older persons with APOE ε3/3 genotype
Lei Yu et al.
NEUROLOGY (2017)
ATP as a biological hydrotrope
Avinash Patel et al.
SCIENCE (2017)
Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms
Jesse S. Kerr et al.
TRENDS IN NEUROSCIENCES (2017)
Platelet cytochrome oxidase and citrate synthase activities in APOE ε4 carrier and non-carrier Alzheimer's disease patients
Heather M. Wilkins et al.
REDOX BIOLOGY (2017)
Neuropathologic features of TOMM40 ′523 variant on late-life cognitive decline
Lei Yu et al.
ALZHEIMERS & DEMENTIA (2017)
PINK1 signalling rescues amyloid pathology and mitochondrial dysfunction in Alzheimer's disease
Fang Du et al.
BRAIN (2017)
TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease
Tyler K. Ulland et al.
CELL (2017)
Antioxidants Rescue Mitochondrial Transport in Differentiated Alzheimer's Disease Trans-Mitochondrial Cybrid Cells
Qing Yu et al.
JOURNAL OF ALZHEIMERS DISEASE (2016)
Chronic consumption of Annona muricata juice triggers and aggravates cerebral tau phosphorylation in wild-type and MAPT transgenic mice
Robert Rottscholl et al.
JOURNAL OF NEUROCHEMISTRY (2016)
Extracellular Mitochondria and Mitochondrial Components Act as Damage-Associated Molecular Pattern Molecules in the Mouse Brain
Heather M. Wilkins et al.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2016)
Tau and Aβ imaging, CSF measures, and cognition in Alzheimer's disease
Matthew R. Brier et al.
SCIENCE TRANSLATIONAL MEDICINE (2016)
Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate
Sama F. Sleiman et al.
ELIFE (2016)
Alzheimer's Disease Risk Genes and Mechanisms of Disease Pathogenesis
Celeste M. Karch et al.
BIOLOGICAL PSYCHIATRY (2015)
Dose-specific effect of simvastatin on hypoxia-induced HIF-1α and BACE expression in Alzheimer's disease cybrid cells
Jin-Heon Jeong et al.
BMC NEUROLOGY (2015)
Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia A Meta-analysis
Willemijn J. Jansen et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2015)
Chronic Optogenetic Activation Augments Aβ Pathology in a Mouse Model of Alzheimer Disease
Kaoru Yamamoto et al.
CELL REPORTS (2015)
Role of diffuse low-level heteroplasmy of mitochondria! DNA in Alzheimer's disease neurodegeneration
Tiziana Casoli et al.
FRONTIERS IN AGING NEUROSCIENCE (2015)
Hypoxia-Inducible Factor-1 in Physiological and Pathophysiological Angiogenesis: Applications and Therapies
Agnieszka Zimna et al.
BIOMED RESEARCH INTERNATIONAL (2015)
White Matter Lipids as a Ketogenic Fuel Supply in Aging Female Brain: Implications for Alzheimer's Disease
Lauren P. Klosinski et al.
EBIOMEDICINE (2015)
Mitochondrial Lysates Induce Inflammation and Alzheimer's Disease-Relevant Changes in Microglial and Neuronal Cells
Heather M. Wilkins et al.
JOURNAL OF ALZHEIMERS DISEASE (2015)
Is Alzheimer's disease a systemic disease?
Jill K. Morris et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)
The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives
Russell H. Swerdlow et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)
Inhibition of ERK-DLP1 signaling and mitochondrial division alleviates mitochondrial dysfunction in Alzheimer's disease cybrid cell
Xueqi Gan et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)
Bioenergetic medicine
Russell H. Swerdlow
BRITISH JOURNAL OF PHARMACOLOGY (2014)
Cerebral Blood Flow is Diminished in Asymptomatic Middle-Aged Adults with Maternal History of Alzheimer's Disease
Ozioma C. Okonkwo et al.
CEREBRAL CORTEX (2014)
Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of EDP-17 transgenic mice
Elizabeth S. Yamada et al.
EXPERIMENTAL NEUROLOGY (2014)
PGC-1α overexpression exacerbates β-amyloid and tau deposition in a transgenic mouse model of Alzheimer's disease
Magali Dumont et al.
FASEB JOURNAL (2014)
Oxidative stress-mediated activation of extracellular signal-regulated kinase contributes to mild cognitive impairitent-related mitochondrial dysfunction
Xueqi Gan et al.
FREE RADICAL BIOLOGY AND MEDICINE (2014)
Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer's disease
Jee Hoon Roh et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2014)
Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease
Lokesh Kukreja et al.
MOLECULAR NEURODEGENERATION (2014)
Effect of high-intensity exercise on aged mouse brain mitochondria, neurogenesis, and inflammation
E. Lezi et al.
NEUROBIOLOGY OF AGING (2014)
Piericidin A Aggravates Tau Pathology in P301S Transgenic Mice
Matthias Hoellerhage et al.
PLOS ONE (2014)
Contribution of non-reference alleles in mtDNA of Alzheimer's disease patients
Tiziana Casoli et al.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2014)
TOMM40 intron 6 poly-T length, age at onset, and neuropathology of AD in individuals with APOE ε3/ε3
Ge Li et al.
ALZHEIMERS & DEMENTIA (2013)
Glycolysis-respiration relationships in a neuroblastoma cell line
Russell H. Swerdlow et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2013)
Prodromal Metabolic Phenotype in MCI Cybrids: Implications for Alzheimer’s Disease
D. F. Silva et al.
Current Alzheimer Research (2013)
Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines
Diana F. Silva et al.
HUMAN MOLECULAR GENETICS (2013)
Effect of Cholinergic Signaling on Neuronal Cell Bioenergetics
Jianghua Lu et al.
JOURNAL OF ALZHEIMERS DISEASE (2013)
Lactate administration reproduces specific brain and liver exercise-related changes
Lezi E et al.
JOURNAL OF NEUROCHEMISTRY (2013)
Mitochondria-associated ER membranes in Alzheimer disease
Eric A. Schon et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2013)
Mitochondrial DNA damage in a mouse model of Alzheimer's disease decreases amyloid beta plaque formation
Milena Pinto et al.
NEUROBIOLOGY OF AGING (2013)
Mitochondrial DNA polymorphisms specifically modify cerebral β-amyloid proteostasis
Katja Scheffler et al.
ACTA NEUROPATHOLOGICA (2012)
Longitudinal modeling of cognitive aging and the TOMM40 effect
Richard J. Caselli et al.
ALZHEIMERS & DEMENTIA (2012)
National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease
Bradley T. Hyman et al.
ALZHEIMERS & DEMENTIA (2012)
A homopolymer polymorphism in the TOMM40 gene contributes to cognitive performance in aging
Kathleen M. Hayden et al.
ALZHEIMERS & DEMENTIA (2012)
Mitochondria and Cell Bioenergetics: Increasingly Recognized Components and a Possible Etiologic Cause of Alzheimer's Disease
Russell H. Swerdlow
ANTIOXIDANTS & REDOX SIGNALING (2012)
Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease
Baiyang Sheng et al.
JOURNAL OF NEUROCHEMISTRY (2012)
A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
Thorlakur Jonsson et al.
NATURE (2012)
Effects of ApoE4 and maternal history of dementia on hippocampal atrophy
John P. Andrawis et al.
NEUROBIOLOGY OF AGING (2012)
Amyloid β-induced ER stress is enhanced under mitochondrial dysfunction conditions
Rui O. Costa et al.
NEUROBIOLOGY OF AGING (2012)
Dietary ketosis enhances memory in mild cognitive impairment
Robert Krikorian et al.
NEUROBIOLOGY OF AGING (2012)
Mitochondrial DNA deletions cause the biochemical defect observed in Alzheimer's disease
Kim J. Krishnan et al.
NEUROBIOLOGY OF AGING (2012)
Cognitively normal individuals with AD parents may be at risk for developing aging-related cortical thinning patterns characteristic of AD
Katherine Reiter et al.
NEUROIMAGE (2012)
From system to organ to cell: oxygenation and perfusion measurement in anesthesia and critical care
Patrick Schober et al.
JOURNAL OF CLINICAL MONITORING AND COMPUTING (2012)
Defects in amphiphysin 2 (BIN1) and triads in several forms of centronuclear myopathies
Anne Toussaint et al.
ACTA NEUROPATHOLOGICA (2011)
The effect of TOMM40 poly-T length on gray matter volume and cognition in middle-aged persons with APOE ε3/ε3 genotype
Sterling C. Johnson et al.
ALZHEIMERS & DEMENTIA (2011)
Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
Reisa A. Sperling et al.
ALZHEIMERS & DEMENTIA (2011)
The Mitochondrial Cascade Hypothesis for Parkinsons Disease
Sandra M. Cardoso
CURRENT PHARMACEUTICAL DESIGN (2011)
Puerarin protects Alzheimer's disease neuronal cybrids from oxidant-stress induced apoptosis by inhibiting pro-death signaling pathways
Haiying Zhang et al.
EXPERIMENTAL GERONTOLOGY (2011)
Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage
Maria Manczak et al.
HUMAN MOLECULAR GENETICS (2011)
Long-term Effects of Galantamine Treatment on Brain Functional Activities as Measured by PET in Alzheimer's Disease Patients
Connor Keller et al.
JOURNAL OF ALZHEIMERS DISEASE (2011)
Reduced Mitochondria Cytochrome Oxidase Activity in Adult Children of Mothers with Alzheimer's Disease
Lisa Mosconi et al.
JOURNAL OF ALZHEIMERS DISEASE (2011)
Apolipoprotein E4 Domain Interaction Mediates Detrimental Effects on Mitochondria and Is a Potential Therapeutic Target for Alzheimer Disease
Hung-Kai Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Lipid metabolism in myelinating glial cells: lessons from human inherited disorders and mouse models
Roman Chrast et al.
JOURNAL OF LIPID RESEARCH (2011)
Tissue-specific differences in mitochondrial activity and biogenesis
Erika Fernandez-Vizarra et al.
MITOCHONDRION (2011)
Neuronal activity regulates the regional vulnerability to amyloid-β deposition
Adam W. Bero et al.
NATURE NEUROSCIENCE (2011)
Structural brain changes in normal individuals with a maternal history of Alzheimer's
Valentina Berti et al.
NEUROBIOLOGY OF AGING (2011)
Progressive regional atrophy in normal adults with a maternal history of Alzheimer disease
Robyn A. Honea et al.
NEUROLOGY (2011)
Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging
Douglas R. Green et al.
SCIENCE (2011)
An Inherited Variable Poly-T Repeat Genotype in TOMM40 in Alzheimer Disease
Allen D. Roses
ARCHIVES OF NEUROLOGY (2010)
Oxidative Stress and Amyloid-Beta Pathology in Normal Individuals with A Maternal History of Alzheimer's
Lisa Mosconi et al.
BIOLOGICAL PSYCHIATRY (2010)
The Role of Mitochondria in the Pathogenesis of Type 2 Diabetes
Mary-Elizabeth Patti et al.
ENDOCRINE REVIEWS (2010)
The Alzheimer's Disease Mitochondrial Cascade Hypothesis
Russell H. Swerdlow et al.
JOURNAL OF ALZHEIMERS DISEASE (2010)
Systemic Mitochondrial Dysfunction and the Etiology of Alzheimer's Disease and Down Syndrome Dementia
Pinar E. Coskun et al.
JOURNAL OF ALZHEIMERS DISEASE (2010)
Reduced Posterior Cingulate Mitochondrial Activity in Expired Young Adult Carriers of the APOE epsilon 4 Allele, the Major Late-Onset Alzheimer's Susceptibility Gene
Jon Valla et al.
JOURNAL OF ALZHEIMERS DISEASE (2010)
Nerve growth factor attenuates oxidant-induced β-amyloid neurotoxicity in sporadic Alzheimer's disease cybrids
Isaac G. Onyango et al.
JOURNAL OF NEUROCHEMISTRY (2010)
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
Clifford R. Jack et al.
LANCET NEUROLOGY (2010)
Reduced gray matter volume in normal adults with a maternal family history of Alzheimer disease
R. A. Honea et al.
NEUROLOGY (2010)
A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease
A. D. Roses et al.
PHARMACOGENOMICS JOURNAL (2010)
Increased fibrillar amyloid-β burden in normal individuals with a family history of late-onset Alzheimer's
Lisa Mosconi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Donepezil- and scopolamine-induced rCMRglu changes assessed by PET in conscious rhesus monkeys
Makoto Asai et al.
ANNALS OF NUCLEAR MEDICINE (2009)
PGC-1α Expression Decreases in the Alzheimer Disease Brain as a Function of Dementia
Weiping Qin et al.
ARCHIVES OF NEUROLOGY (2009)
The Alzheimer's disease mitochondrial cascade hypothesis: An update
Russell H. Swerdlow et al.
EXPERIMENTAL NEUROLOGY (2009)
Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease
Xinglong Wang et al.
JOURNAL OF NEUROSCIENCE (2009)
Age, Neuropathology, and Dementia
George M. Savva et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle
Jae-Eun Kang et al.
SCIENCE (2009)
Influence of mitochondrial DNA level on cellular energy metabolism: implications for mitochondrial diseases
Christophe Rocher et al.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2008)
Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease
Heng Du et al.
NATURE MEDICINE (2008)
Prevalence of dementia after age 90 - Results from The 90+Study
M. M. Corrada et al.
NEUROLOGY (2008)
Amyloid-β dynamics correlate with neurological status in the injured human brain
David L. Brody et al.
SCIENCE (2008)
Amyloid precursor protein and mitochondrial dysfunction in Alzheimer's disease
Hindupur K. Anandatheerthavarada et al.
NEUROSCIENTIST (2007)
Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism
Lisa Mosconi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Mitochondria in cybrids containing mtDNA from persons with mitochondriopathies
Russell H. Swerdlow
JOURNAL OF NEUROSCIENCE RESEARCH (2007)
Lessons that can be learned from patients with diabetogenic mutations in mitochondrial DNA: Implications for common type 2 diabetes
Johannes A. Maassen et al.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2007)
Is aging part of Alzheimer's disease, or is Alzheimer's disease part of aging?
Russell H. Swerdlow
NEUROBIOLOGY OF AGING (2007)
Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a mouse model of Alzheimer's disease
Hirokazu Fukui et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Annonacin, a natural mitochondrial complex I inhibitor, causes tau pathology in cultured neurons
Myriam Escobar-Khondiker et al.
JOURNAL OF NEUROSCIENCE (2007)
Insulin resistance and Alzheimer's disease pathogenesis: Potential mechanisms and implications for treatment
Suzanne Craft
CURRENT ALZHEIMER RESEARCH (2007)
Tissue heterogeneity of the mammalian mitochondrial proteome
D. Thor Johnson et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)
Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction
Katsutaro Morino et al.
DIABETES (2006)
Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction
Latha Devi et al.
JOURNAL OF NEUROSCIENCE (2006)
Treatment monitoring and response prediction with proton MR spectroscopy in AD
F. Jessen et al.
NEUROLOGY (2006)
Mitochondria are a direct site of Aβ accumulation in Alzheimer's disease neurons:: implications for free radical generation and oxidative damage in disease progression
M Manczak et al.
HUMAN MOLECULAR GENETICS (2006)
Therapy Insight: type 2 diabetes mellitus and the risk of late-onset Alzheimer's disease
MN Haan
NATURE CLINICAL PRACTICE NEUROLOGY (2006)
The effect of drugs for Alzheimer disease assessed by means of neuroradiological techniques
Pedro J. Modrego
CURRENT MEDICINAL CHEMISTRY (2006)
Synaptic activity regulates interstitial fluid amyloid-β levels in vivo
JR Cirrito et al.
NEURON (2005)
Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity
SJ Chang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy
GU Höglinger et al.
JOURNAL OF NEUROCHEMISTRY (2005)
Differentiated Alzheimer's disease transmitochondrial cybrid cell lines exhibit reduced organelle movement
PA Trimmer et al.
ANTIOXIDANTS & REDOX SIGNALING (2005)
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
GC Kujoth et al.
SCIENCE (2005)
Altered intracellular signaling and reduced viability of Alzheimer's disease neuronal cybrids is reproduced by β-amyloid peptide acting through receptor for advanced glycation end products (RAGE)
IG Onyango et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2005)
Endogenous oxidative stress in sporadic Alzheimer's disease neuronal cybrids reduces viability by increasing apoptosis through pro-death signaling pathways and is mimicked by oxidant exposure of control cybrids
IG Onyango et al.
NEUROBIOLOGY OF DISEASE (2005)
Cyclical mitochondrial ΔΨM fluctuations linked to electron transport, F0F1 ATP-synthase and mitochondrial Na+/Ca+2 exchange are reduced in Alzheimer's disease cybrids
C Thiffault et al.
MITOCHONDRION (2005)
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease - is this type 3 diabetes?
E Steen et al.
JOURNAL OF ALZHEIMERS DISEASE (2005)
ABAD directly links Aβ to mitochondrial toxicity in Alzheimer's disease
JW Lustbader et al.
SCIENCE (2004)
Mitochondrial abnormalities in cybrid cell models of sporadic Alzheimer's disease worsen with passage in culture
PA Trimmer et al.
NEUROBIOLOGY OF DISEASE (2004)
Worker functions and traits associated with occupations and the development of AD
KA Smyth et al.
NEUROLOGY (2004)
Nicastrin, presenilin, APH-1, and PEN-2 form active γ-secretase complexes in mitochondria
CA Hansson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication
PE Coskun et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
A mitochondrial cascade hypthesis for sporadic Alzheimer's disease
RH Swerdlow et al.
MEDICAL HYPOTHESES (2004)
Mitochondria-derived oxidative stress induces a heat shock protein response
MJ Barrett et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2004)
Mitochondria dysfunction of Alzheimer's disease cybrids enhances Aβ toxicity
SM Cardoso et al.
JOURNAL OF NEUROCHEMISTRY (2004)
Premature ageing in mice expressing defective mitochondrial DNA polymerase
A Trifunovic et al.
NATURE (2004)
Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells
HK Anandatheerthavarada et al.
JOURNAL OF CELL BIOLOGY (2003)
Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases?
G Perry et al.
FREE RADICAL BIOLOGY AND MEDICINE (2002)
Medicine - The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
J Hardy et al.
SCIENCE (2002)
Does insulin dysfunction play a role in Alzheimer's disease?
L Gasparini et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2002)
Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease
F Bosetti et al.
NEUROBIOLOGY OF AGING (2002)
High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain
MT Lin et al.
HUMAN MOLECULAR GENETICS (2002)
beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities
CS Casley et al.
JOURNAL OF NEUROCHEMISTRY (2002)
Current concepts in mild cognitive impairment
RC Petersen et al.
ARCHIVES OF NEUROLOGY (2001)
Prevalence of Alzheimer's disease in very elderly people -: A prospective neuropathological study
T Polvikoski et al.
NEUROLOGY (2001)
Mitochondrial abnormalities in Alzheimer's disease
K Hirai et al.
JOURNAL OF NEUROSCIENCE (2001)
Functional mitochondria are required for amyloid β-mediated neurotoxicity
SM Cardoso et al.
FASEB JOURNAL (2001)
Is mitochondrial DNA depletion involved in Alzheimer's disease?
B Rodríguez-Santiago et al.
EUROPEAN JOURNAL OF HUMAN GENETICS (2001)
Mitochondrial DNA haplogroups and APOE4 allele are non-independent variables in sporadic Alzheimer's disease
G Carrieri et al.
HUMAN GENETICS (2001)
Correlation of the clinical severity of Alzheimer's disease with an aberration in mitochondrial DNA (antDNA)
AM Brown et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2001)
Quantification of mitochondrial DNA in human blood cells using an automated detection system
C Meissner et al.
FORENSIC SCIENCE INTERNATIONAL (2000)
Mitochondrial DNA damage as a mechanism of cell loss in Alzheimer's disease
SM de la Monte et al.
LABORATORY INVESTIGATION (2000)
The frequency of point mutations in mitochondrial DNA is elevated in the Alzheimer's brain
SW Chang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
Abnormal mitochondrial morphology in sporadic Parkinson's and Alzheimer's disease cybrid cell lines
PA Trimmer et al.
EXPERIMENTAL NEUROLOGY (2000)
Alterations in muscarinic receptor-coupled phosphoinositide hydrolysis and AP-1 activation in Alzheimer's disease cybrid cells
P De Sarno et al.
NEUROBIOLOGY OF AGING (2000)