Journal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Volume 151, Issue 5, Pages 1191-+Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2023.02.005
Keywords
Airway diseases; cystatin SN; type 2 immunity
Categories
Ask authors/readers for more resources
Cystatin SN, a member of the cystatin protein superfamily, is associated with inflammatory airway diseases. It plays a protective role against destructive proteolysis and also initiates T2 immunity, leading to disease. Understanding the role of cystatin SN can assist in the management of airway diseases.
Cystatin SN, encoded by CST1, belongs to the type 2 (T2) cystatin protein superfamily. In the past decade, several publications have highlighted the association between cystatin SN and inflammatory airway diseases including chronic rhinosinusitis, rhinitis, asthma, chronic obstructive pulmonary disease, and chronic hypersensitivity pneumonitis. It is, therefore, crucial to understand the role of cystatin SN in the wider context of T2 inflammatory diseases. Here, we review the expression of cystatin SN in airwayrelated diseases with different endotypes. We also emphasize the physiological and pathological roles of cystatin SN. Physiologically, cystatin SN protects host tissues from destructive proteolysis by cysteine proteases present in the external environment or produced via internal dysregulated expression. Pathologically, the secretion of cystatin SN from airway epithelial cells initiates and amplifies T2 immunity and subsequently leads to disease. We further discuss the development of cystatin SN as a T2 immunity marker that can be monitored noninvasively and assist in airway disease management. The discovery, biology, and inhibition capability are also introduced to better understand the role of cystatin SN in airway diseases. (J Allergy Clin Immunol 2023;151:1191-203.)
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available