A Comprehensive Investigation of Hydrazide and Its Derived Structures in the Agricultural Fungicidal Field

Hydrazidesare present in many bioactive molecules and exhibita variety of biological activities, such as insecticidal, herbicidal,antifungal, antitumor, and antiviral effects. In this Review, we reviewthe application of hydrazide and its derived structures in the agriculturalfungicidal field, including monohydrazides, diacylhydrazines, hydrazide-hydrazones,and sulfonyl hydrazides. In addition, the antifungal mechanism ofaction of the hydrazide derivatives was analyzed and summarized, mainlyinvolving succinate dehydrogenase inhibitors, laccase inhibitors,and targeting plasma membranes. Finally, based on the structural analysisof the novel fungicidal lead compounds, the structure-activityrelationship of the hydrazide derivatives was constructed and thedevelopment trend of hydrazide structures in fungicidal applicationswas prospected. It is hoped that this Review can provide some significantguidance for the development of new hydrazide fungicides in the future.

Automated summary

In this Review, the application of hydrazide and its derived structures in the agricultural fungicidal field was discussed. The antifungal mechanism of action of the hydrazide derivatives was analyzed and summarized. Furthermore, the structure-activity relationship of the hydrazide derivatives and the development trend of hydrazide structures in fungicidal applications were explored.