Related references
Note: Only part of the references are listed.
Review
Dermatology
Jorg C. Prinz et al.
Summary: Generalized pustular psoriasis (GPP) is a rare auto-inflammatory skin disease with acute episodes of pustule formation. Understanding the epidemiology and clinical data of GPP is challenging due to its rarity. This review article provides an overview of GPP prevalence estimates in key demographics, genetic mutations associated with the disease, incidence of comorbidities, mortality rate, and causes of death.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
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Felix Lauffer et al.
Summary: Psoriasis is a common chronic inflammatory skin disease that causes systemic inflammation and severely impacts the patient's quality of life. Eczematized psoriasis, occurring in approximately 5-10% of patients with psoriasis, is a variant that is often overlooked. This review summarizes the clinical, histological, and immunological features of eczematized psoriasis, proposes diagnostic criteria, and evaluates therapeutic options.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2023)
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Dermatology
Benjamin Klein et al.
Summary: JAK inhibitors have shown promising results in treating various chronic inflammatory skin diseases through their ability to target proinflammatory cytokines released via the JAK-STAT pathway. Recent approvals of JAK inhibitors like Baricitinib, Upadacitinib, and Abrocitinib offer new systemic therapeutic options for moderate to severe atopic dermatitis patients. While these small molecules have demonstrated effectiveness, potential side effects and necessary laboratory examinations should be carefully considered.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
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Article
Dermatology
Stefan Haskamp et al.
Summary: Generalized pustular psoriasis is characterized by increased proportions of CD4+ cytotoxic T lymphocytes and other CD4+ effector cells, decreased frequencies of naive CD4+ T cells, and elevated expression of FGFBP2 in patients with disease-contributing variants. Differentially expressed genes in neutrophils are enriched in genes of the classical complement activation pathway.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
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Article
Dermatology
Lam C. Tsoi et al.
Summary: This study demonstrates that tape stripping with optimized high-resolution transcriptomic profiling can effectively assess and characterize inflammatory responses in the skin. By comparing different samples and sampling methods, the study shows that tape stripping can capture the transcriptome of the upper layers of the skin, providing insights into the molecular components of the immune amplification pathway in psoriasis. Additionally, the study suggests that nonlesional psoriatic skin exhibits activated, proinflammatory changes, which are not captured by full-thickness skin biopsy transcriptome profiling.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Roudin Sarama et al.
Summary: Psoriasis and Atopic Dermatitis are common inflammatory skin diseases with immune response dysregulation playing a crucial role in their pathogenesis. In vitro disease models have been widely used to study these conditions, but further development is needed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
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Allergy
Lam C. Tsoi et al.
Summary: This study evaluates the use of baseline molecular expression profiling to assess treatment outcome for patients with psoriasis. The results show a correlation between clinical response and molecular changes, particularly for genes responding to IL-17A/TNF in keratinocytes. Baseline gene expressions in nonlesional skin were found to be the best marker of treatment response, and cytokine gene signatures enriched in baseline nonlesional skin had strong correlations with treatment improvement.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
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Article
Biochemistry & Molecular Biology
Suphagan Boonpethkaew et al.
Summary: Exploring the transcriptome in the peripheral edge of lesional skin is crucial for understanding the molecules and signaling pathways that contribute to inflammation. The study identified differentially expressed genes in the lesional skin, which enhanced functions related to tissue growth, cell migration, and immune response. The findings suggest that inflammation in the lesional skin may be driven by specific signaling pathways, potentially leading to the discovery of new therapeutic targets for psoriasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Vidya S. Krishnan et al.
Summary: Transcriptome profiling techniques have greatly improved our understanding of the underlying mechanisms of psoriasis. The analysis of isoforms and alternative splicing is important for a comprehensive understanding of the disease. Blood transcriptome profiling provides immune status information, making it a less invasive platform for studying psoriasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Dermatology
Inga Hansen et al.
Summary: This article systematically collects epidemiological data on skin diseases in Germany and finds that data on many non-infectious diseases are not yet available. Among non-infectious skin diseases, psoriasis and atopic eczema are the most common, while acne has the highest lifetime prevalence.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2022)
Article
Dermatology
Amany Nassar et al.
Summary: This study compared the efficacy of intralesional corticosteroid injection and topical application after fractional CO2 laser therapy in the treatment of nail psoriasis. The results showed no significant difference between the two methods in improving the nail matrix and bed psoriatic signs, while laser treatment was associated with lower pain scores and higher patient satisfaction.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2022)
Article
Dermatology
Galina Balakirski et al.
Summary: In the last decade, multiple systemic drugs have been approved for the treatment of psoriasis vulgaris and psoriasis arthritis (PsA). However, treatment decisions for women planning a pregnancy, as well as pregnant and lactating women, are challenging due to limited data. Topical corticosteroids have the strongest evidence for psoriasis therapy during pregnancy. Medically controlled use of UVB-therapy is also considered safe. TNF-alpha inhibitors have the best evidence for systemic therapy during pregnancy and lactation. Personalized therapeutic approaches should be based on the severity of psoriasis and patient's comorbidities.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2022)
Article
Genetics & Heredity
Charalabos Antonatos et al.
Summary: This study conducted a meta-analysis of publicly available gene expression datasets to examine the differential expression observed in response to anti-TNF alpha therapy in psoriasis, inflammatory bowel disease, and rheumatoid arthritis. The results identified distinct pro-inflammatory down-regulated genes for each disease and common inflammatory patterns involved in the pathogenesis of each disease. The analysis also revealed genes participating in anti-inflammatory pathways. These findings provide a framework for further transcriptomic research on the effects of anti-TNF alpha therapy in these diseases.
Article
Immunology
Xiu-ting Liu et al.
Summary: Microabscess of neutrophils in epidermis is a histological hallmark of psoriasis. This study found that blood neutrophils were increased in psoriasis patients, positively correlated with disease severity, and highly expressed CD66b. Keratinocytes expressed high levels of psoriasis-related inflammatory mediators through interaction with neutrophils, and this interaction was dependent on IL-17A produced by neutrophils. Neutrophils from psoriasis patients displayed more transcriptome changes related to integrin and increased migration capacity toward keratinocytes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jared Liu et al.
Summary: Early diagnosis of psoriatic arthritis (PSA) is important but challenging. In this study, single cell profiling was used to compare the immunocyte populations of individuals with PSA, individuals with cutaneous psoriasis (PSO) alone, and healthy individuals. Machine learning classification based on cell type-specific gene and protein expression differences achieved high accuracy in distinguishing PSA from PSO and healthy groups. These findings demonstrate the utility of machine learning-based diagnostics for PSA.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Bhupinder Kapoor et al.
Summary: This study explores the correlation between dysbiosis of gut and skin microbiota and psoriasis, and discusses the potential of bacteriotherapeutic approaches for psoriasis management.
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Marwa A. Amer et al.
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(2022)
Letter
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JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2022)
Article
Dermatology
Michael P. Schön
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(2022)
Article
Dermatology
Pinyadapat Vacharanukrauh et al.
Summary: Through RNA sequencing and pathway analysis, the study found that NB-UVB treatment may improve psoriasis by suppressing NF-κB, enhancing sirtuin signaling pathway, and decreasing the function of key upstream regulators associated with proinflammatory cytokines. The study also highlighted the gene expression changes associated with the modulation of autoinflammation after NB-UVB treatment.
JOURNAL OF DERMATOLOGICAL SCIENCE
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Review
Rheumatology
Sanjana Tarannum et al.
Summary: This narrative review focuses on the influence of sex and gender on psoriatic arthritis, covering disease progression and outcomes, underlying mechanisms, and response to therapies. It also discusses the disparities between male and female patients in terms of treatment response and differences in pathophysiological mechanisms including genetics, immune, and hormonal mechanisms. Furthermore, it outlines the association of psoriatic arthritis with fertility and pregnancy outcomes.
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Review
Immunology
Jin Bu et al.
Summary: Psoriasis is a chronic autoimmune inflammatory disease that affects not only the skin, but also other systems of the body and mental health. Recent studies have shown associations between psoriasis and various systemic diseases, including the skin system, reproductive system, and oral and ocular systems, as well as mental health diseases, due to a shared immune-inflammatory mechanism. This review summarizes epidemiological evidence from the past 5 years, supporting the association between psoriasis and important and/or newly reported systemic diseases, aiming to improve the management of people with psoriasis.
FRONTIERS IN IMMUNOLOGY
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Article
Immunology
Jingwen Deng et al.
Summary: This study used a machine learning approach to explore the gene regulatory networks of psoriasis and identified key regulators. Interferon signaling was found to play a crucial role in psoriatic inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Francesco Bellinato et al.
Summary: Chronic plaque psoriasis is an immune-mediated skin disease affecting approximately 2-3% of the global adult population. The IL-23/Th17 pathway plays a crucial role in its pathogenesis. New targeted pharmacotherapies have shown significant improvements in skin lesions, prevention of arthritis, and enhancement of the patient's quality of life.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
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Medicine, General & Internal
Mark G. Lebwohl et al.
Summary: Treatment with 0.3% roflumilast cream once daily for 8 weeks showed better clinical outcomes compared to vehicle cream in patients with chronic plaque psoriasis. Further research is required to compare efficacy with other active treatments and assess long-term efficacy and safety.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Letter
Dermatology
Philipp Bentz et al.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2022)
Review
Dermatology
I-Hsin Huang et al.
Summary: This study compared the efficacy and safety of biologic treatments for pediatric psoriasis approved by the FDA and EMA. The results showed that biologic treatments were effective in improving PASI scores and had a low risk of adverse events. SEC-L showed the best response in terms of PASI improvement.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2022)
Letter
Dermatology
Sarah Heyer et al.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2022)
Article
Dermatology
Suphagan Boonpethkaew et al.
Summary: This study compared the gene profiles in the peripheral edge (PE) and center (CE) of plaques to elucidate the chronological molecular events in plaque formation. Inflammation is likely initiated in the PE, characterized by the presence of specific molecules such as IL-36 alpha, S100A7, and S100A15. The inflammatory state progresses towards a more stable state in the CE, where growth factor activities are increased, potentially leading to the regression of inflammation. These findings contribute to the development of novel therapies for psoriasis.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
John Kee et al.
Summary: Research reveals that the ORF8 protein of SARS-CoV-2 functions as a mimic of histone H3, disrupting the epigenetic regulation of host cells. This finding provides insight into how SARS-CoV-2 controls host cell epigenome and sheds light on the association between the absence of ORF8 and decreased severity of COVID-19.
Review
Immunology
Melissa Simard et al.
Summary: The skin's barrier function is crucial for maintaining skin homeostasis. Bioactive lipid mediators derived from n-3 and n-6 PUFAs play complex roles in skin diseases, including psoriasis. High intake of n-3 PUFAs has been shown to reduce the severity and frequency of psoriatic plaques.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Eric Toussirot et al.
Summary: Psoriasis and psoriatic arthritis are immune-mediated diseases that affect the skin, joints or both. They involve complex pathophysiological mechanisms and increased inflammation. These conditions are also associated with a higher risk of cardiometabolic diseases, which are linked to systemic inflammation and can impact disease severity and treatment outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Michael P. Schoen et al.
Summary: Research into the pathophysiology of psoriasis is challenging as the disease does not occur naturally in laboratory animals. Various animal models have been developed to study its immune-pathology, but they have not been systematically validated. Despite this, these models provide valuable insights into inflammatory mediators and immune system communication.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Dermatology
Richard G. Langley et al.
Summary: Biologic therapy was found to be associated with reduced mortality risk in patients with moderate to severe psoriasis, regardless of treatment duration. Methotrexate only reduced mortality risk after at least 1 year of exposure.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Editorial Material
Cell & Tissue Engineering
Tram Mai Nguyen et al.
Summary: This study reveals the molecular machinery behind epidermal stem cell memory, including the roles of STAT3 and AP1 family in establishing memory, and the importance of JUN and FOS in the memory process.
Article
Dermatology
Madison E. Jones et al.
DERMATOLOGIC CLINICS
(2021)
Review
Pharmacology & Pharmacy
Egidio Freitas et al.
Summary: Psoriasis is a chronic, immune-mediated disease with skin and joint manifestations. Bimekizumab, a selective IL-17A and IL-17F inhibitor, has shown high efficacy in phase 3 trials compared to other biologic treatments, with a similar safety profile. Dual inhibition of IL-17A and IL-17F is an effective therapeutic option for both naive and resistant psoriasis patients.
Review
Immunology
Azin Aghamajidi et al.
Summary: T cell-mediated autoimmune skin diseases arise from aberrant immune response to skin cells, with immunomodulating agents proving successful in their management thanks to improved understanding of pathophysiology. This study discusses immunopathogenic mechanisms and the role of T lymphocytes in these diseases, offering new insights into targeted therapeutic pathways and biological therapies.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Dermatology
Marina Otten et al.
Summary: Patient data documentation in psoriasis clinical practice is important for improving care, and a standardized data set with 69 variables has been developed through the consensus of 27 psoriasis experts. The data set includes standard, optimal, and optional variables covering patient demographics, medical history, psoriasis status, diagnostics, comorbidities, therapies, and patient-reported outcomes.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2021)
Article
Dermatology
Felicitas Bardehle et al.
Summary: This study systematically examined capillary pathologies in psoriasis patients by digital video nailfold capillaroscopy and found marked microvascular abnormalities in psoriasis patients, accompanied by increased markers of systemic inflammation and atherosclerosis. Prospective cohort studies are needed to assess the role of nailfold capillaroscopy for predicting the cardiovascular risk of psoriasis patients.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2021)
Article
Dermatology
Norman Langer et al.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2021)
Article
Dermatology
Matthias Augustin et al.
Summary: In Germany, skin diseases are mainly treated in dermatological hospitals, with a high number of inpatient treatment cases in 2018. The most common cases include epithelial skin cancer and melanoma. The average length of stay is 5.69 days, and there is expected to be continued high demand for inpatient care for skin diseases in the future.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2021)
Review
Dermatology
Ugur Uslu
Summary: This study investigates the feasibility of combining two different transfection methods to equip T lymphocytes with two different tumor antigen-specific receptors, aiming to improve the potential use of CAR T cell therapy in dermatologic oncology.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2021)
Article
Medicine, General & Internal
H. Bachelez et al.
Summary: In a phase 2 randomized trial, spesolimab, an interleukin-36 receptor inhibitor, showed a higher rate of lesion clearance in GPP patients compared to placebo, but was associated with risks of infections and systemic drug reactions. Further longer and larger trials are needed to assess the efficacy and safety of spesolimab in patients with pustular psoriasis.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
Mark G. Lebwohl et al.
Summary: Tapinarof cream used once daily was more effective in reducing the severity of plaque psoriasis over 12 weeks compared to vehicle control, but was associated with local adverse events and headache. Larger and longer trials are needed to evaluate the efficacy and safety of tapinarof cream.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Medicine, General & Internal
Kamran Ghoreschi et al.
Summary: Psoriasis is a chronic inflammatory disease affecting 2-3% of the global population, characterized by sharply demarcated erythematous and scaly skin lesions. The disease results from hyperproliferation and disturbed differentiation of epidermal keratinocytes provoked by immune mediators of the IL-23 and IL-17 pathway. Therapeutics targeting IL-23, IL-17, and IL-17RA have shown excellent efficacy in treating psoriasis.
Article
Multidisciplinary Sciences
David Froelicher et al.
Summary: The authors propose a federated analytics system based on multiparty homomorphic encryption to protect patient privacy and ensure accurate results in biomedical research. They demonstrate the system's effectiveness in various essential biomedical analysis tasks. This work represents a key step towards enabling multi-centric scientific collaborations and overcoming privacy obstacles.
NATURE COMMUNICATIONS
(2021)
Review
Dermatology
Akshitha Thatiparthi et al.
Summary: The emergence of biologics has increased therapeutic possibilities for psoriasis treatment, with data from clinical trials and studies providing essential information for personalized care. Treatment recommendations should consider comorbid conditions and special populations.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2021)
Review
Immunology
Lilla Landeck et al.
Summary: In the past two decades, significant progress has been made in treating psoriasis by targeting the human cytokine network with 11 biologicals. These substances can be classified into four classes based on their targets, posing a challenge in selecting the right drug for individual patients. This article provides an overview of the available biologicals for psoriasis treatment, highlighting their advantages, limitations, and criteria for therapy selection.
Review
Biochemistry & Molecular Biology
Helena Iznardo et al.
Summary: Unmet needs in the treatment of psoriasis require novel therapeutic strategies. Focus on IL-36 cytokines as a critical driver of autoinflammatory responses in pustular psoriasis has led to promising results in clinical trials of two IL-36R blocking antibodies, imsidolimab and spesolimab.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Robert Girones Petit et al.
Summary: Research on the pathogenesis of inflammatory skin diseases has seen some significant breakthroughs in recent years, with a focus on understanding the impact of age, gender, and genetics on disease development. Molecular mechanisms behind the pathological features of psoriasis have been discussed, along with the exploration of innovative treatments and drug delivery systems using nanotechnological approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dermatology
Michael P. Schön
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2021)
Letter
Dermatology
Clemens Painsi et al.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2021)
Review
Dermatology
Johanna Heitmann et al.
Summary: Psoriasis and non-alcoholic fatty liver disease (NAFLD) share common inflammatory pathways, such as cytokines TNFα, IL-6, and IL-17. Pharmacological blockade of IL-17 may be a promising strategy for treating both psoriasis and NAFLD.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2021)
Article
Dermatology
Anna Caroline Pilz et al.
Summary: The study investigated the utilization of the healthcare system among psoriasis patients in Germany and found that many individuals are dissatisfied with the current treatment options. Main reasons for dissatisfaction included lack of treatment efficacy and medication side effects. Additionally, some patients cited lack of time on the part of physicians as a main barrier to seeking medical help.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2021)
Article
Medicine, General & Internal
Christopher E M Griffiths et al.
Article
Medicine, General & Internal
Kim A Papp et al.
Review
Biochemistry & Molecular Biology
Claudia De Pasquale et al.
Summary: Innate Lymphoid Cells (ILC) have emerged as important effector cells playing multiple roles in maintaining tissue homeostasis and responding to tissue insults. Dysregulations of their function and distribution have been observed in a variety of immune-mediated diseases, suggesting a specific role for ILC in the pathophysiology of several disorders.
MOLECULAR ASPECTS OF MEDICINE
(2021)
Review
Rheumatology
Filippo Fagni et al.
Summary: Patients with immune-mediated inflammatory diseases do not have an increased risk of SARS-CoV-2 infection or severe COVID-19, and certain medications like cytokine inhibitors may even lower the risk of severe illness. However, glucocorticoids might worsen COVID-19 outcomes, and the immune response to vaccination in these patients could be somewhat reduced.
LANCET RHEUMATOLOGY
(2021)
Article
Pediatrics
Miguel Nogueira et al.
Summary: Psoriasis is an inflammatory immune-mediated skin disease affecting both adults and children. Advances in understanding its pathogenesis have led to the development of effective biological drugs for severe cases in adults. Although the use of adult-approved drugs in pediatric populations has been limited for years, recent developments have seen increased understanding of their efficacy and safety in children. Multiple clinical trials are ongoing to further enhance our armamentarium for targeting psoriasis in pediatric populations.
Review
Pharmacology & Pharmacy
Rebecca Fischer-Betz et al.
Summary: TNF inhibitors (TNFi) have been extensively studied in relation to reproduction with no contraindications found in pregnancy, lactation, and paternal exposure. However, more prospective controlled studies are needed for other biologics and small molecules, especially regarding outcomes in early and late pregnancy. Data on potential effects of all biologics on immune function, infection rates, and vaccine responses in prenatally exposed children need further expansion. Until more data become available, small molecules should be avoided during pregnancy and breastfeeding with more reproduction-related data expected from national and international registries in the future.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Emmanuel Mahe et al.
Summary: Current management of pediatric psoriasis has a wide range of treatment options available including new topical and systemic therapies. The future holds promise with new topical combinations, oral therapies, and biologics being developed, as well as genetically targeted therapies for specific types of psoriasis.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2021)
Review
Immunology
Grace E. Ryan et al.
Summary: Tissue resident memory T cells (TRM) play a crucial role in the immune system by providing immediate and specific responses against pathogens re-infecting peripheral tissues. However, they have also been found to contribute to autoimmune diseases, where self-antigens continuously activate self-reactive TRM T cells, leading to destructive outcomes. This article focuses on how TRMs mediate disease in autoimmune skin conditions, such as vitiligo, psoriasis, cutaneous lupus erythematosus, alopecia areata, and frontal fibrosing alopecia.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Koji Kamiya et al.
Summary: Psoriasis is a chronic inflammatory disease that mainly affects the skin and joints, but recent therapeutic advancements, particularly biologics, have significantly improved treatment outcomes. During the COVID-19 pandemic, the use of biologics for psoriasis treatment appears to have some benefits against COVID-19 infection, emphasizing the importance of shared decision-making based on updated information.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dermatology
April W. Armstrong et al.
Summary: This study evaluated the efficacy of biologic and oral treatments for moderate-to-severe psoriasis, finding that ixekizumab, risankizumab, and brodalumab had the highest short-term efficacy, while risankizumab demonstrated the highest long-term efficacy.
DERMATOLOGY AND THERAPY
(2021)
Review
Engineering, Biomedical
Nadim Ahamad et al.
Summary: Inflammatory diseases encompass various illnesses with chronic inflammation as the central manifestation, posing a significant burden on healthcare systems and global socio-economic balance. Current standard therapies are limited in providing relief, whereas immunomodulatory nanosystems present new opportunities for treating inflammatory diseases.
Review
Dermatology
S. M. Lwin et al.
Summary: Biological therapies have transformed the management of moderate-to-severe psoriasis, but for patients who do not respond, cell therapy may be a new option. Well-designed trials and mechanistic studies are needed for the development and delivery of advanced cell therapies for severe psoriasis.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Cell & Tissue Engineering
Samantha B. Larsen et al.
Summary: The research explains how cells establish, maintain, and recall inflammatory memory, revealing the collaboration between factors like FOS and JUN, and their crucial role in re-recruiting and activating genes under diverse secondary challenges.
Review
Biochemistry & Molecular Biology
Pio Conti et al.
Summary: Psoriasis is a skin disease characterized by autoimmune features and inflammatory symptoms, often accompanied by various comorbidities. Immune cells like MCs and cytokines such as IL-36 play significant roles in the inflammation process of psoriasis, while IL-38 and IL-37 may serve as potential therapeutic tools for inhibiting inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dermatology
Babak Monshi et al.
Summary: The study in Austrian cohort found that psoriasis is associated with fissured tongue but not with geographic tongue. The point-prevalence of tongue lesions was low, and geographic tongue was associated with smoking.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2021)
Article
Dermatology
Alexander Nast et al.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2021)
Article
Dermatology
Alexander Nast et al.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2021)
Article
Dermatology
Petra Staubach et al.
Summary: The study evaluated the prevalence of genital symptoms in patients with psoriasis and chronic urticaria, as well as their impact on quality of life, physician-patient relations, and disease management. The results showed that the majority of patients suffered from genital involvement and impaired quality of life.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2021)
Article
Dermatology
Christian Kromer et al.
Summary: Screening for depressive symptoms in psoriasis patients at risk led to increased utilization of mental health care and improvement in disease activity, depressive symptoms, and quality of life. Implementing such screening in routine care is recommended to optimize patient management.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2021)
Review
Allergy
George E. Fragoulis et al.
Summary: JAK inhibitors are a new class of targeted therapy that can block the signaling activity of proinflammatory cytokines, showing potential therapeutic benefits for immune-mediated rheumatic conditions. While they offer efficacy in certain diseases, there are unresolved safety concerns, particularly regarding an increased risk of venous thromboembolism.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Dermatology
Sarah Wack et al.
Summary: This review explores the safety and efficacy of COVID-19 vaccines in patients with immune-mediated inflammatory diseases (IMID), indicating that these patients are not at a greater risk of harm from vaccination compared to healthy controls. Most patients with IMID will benefit from vaccination to prevent severe COVID-19, although it remains to be seen if patients on biologics will generate a sufficient immune response to the vaccine.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ying Luo et al.
Summary: Psoriasis is a chronic inflammatory skin disease with genetic, immune, and environmental factors playing a role in its onset. DNA methylation, as an epigenetic modification, is involved in the pathogenesis of psoriasis, regulating target genes that have been validated indirectly or directly. Understanding the role of DNA methylation in psoriasis comprehensively will aid in diagnostic and therapeutic strategies for psoriatic patients.
MOLECULAR GENETICS AND GENOMICS
(2021)
Review
Medicine, General & Internal
Sylwia Sluczanowska-Glabowska et al.
Summary: Janus kinase inhibitors target JAK/STAT pathway to reduce inflammation in inflammatory and autoimmune diseases. Divided into first and second generations, with second generation being more specific. Oral JAK inhibitors show promise in psoriasis treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Masaru Honma et al.
Summary: Psoriasis is a chronic inflammatory skin disease with bothersome symptoms, but recent advances in molecular-targeted therapies have shown promising clinical effects in treating severe symptoms and related skin diseases. Biomarkers such as cytokines, chemokines play a crucial role in defining therapeutic strategies, and blood protein markers show great potential in daily clinical practice.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Jen-Chih Tseng et al.
Summary: Psoriasis is a complex inflammatory autoimmune skin disorder affecting 2-3% of the global population, mainly influenced by genetic and environmental factors, with current treatments focusing on immune responses. While biologics have shown better efficacy and safety in alleviating symptoms, psoriasis remains incurable.
Review
Medicine, General & Internal
Sandeep Arora et al.
Summary: Combining different therapies for psoriasis, including newer and conventional agents, based on evidence from literature can improve efficacy and reduce toxicity of higher dosages, providing therapeutic guidelines for better management of the disease.
FRONTIERS IN MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Hye One Kim et al.
Summary: Psoriasis is a chronic inflammatory systemic disease that primarily affects the skin, with one-third of cases starting in childhood. Pediatric psoriasis has unique clinical characteristics, but treatment usually involves methods similar to adults. Research on pediatric psoriasis is lacking, and targeted therapies using newly developed biologics are increasingly being applied.
Review
Rheumatology
Conor Magee et al.
Summary: The current study indicates that some biomarkers may be associated with treatment response in psoriatic disease, however, due to the diversity in research methods and outcomes, firm conclusions cannot be drawn and further validation is needed.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2021)
Review
Medicine, General & Internal
Trung T. Vu et al.
Summary: Tissue-resident memory T cells (T-RM) remain in peripheral tissues for long periods, providing the first line of adaptive immune response. Skin T-RM play a significant role in chronic inflammatory skin diseases, such as psoriasis, where IL-17A-producing CD8(+) T-RM are considered pathogenic. Targeting skin T-RM could be a potential strategy in treating psoriasis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Dermatology
Marissa T. Ayasse et al.
EXPERIMENTAL DERMATOLOGY
(2020)
Review
Endocrinology & Metabolism
Ana Karen Sandoval-Talamantes et al.
Review
Immunology
Barbara Polese et al.
FRONTIERS IN IMMUNOLOGY
(2020)
Review
Dermatology
Timo Buhl et al.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2020)
Article
Allergy
Johann E. Gudjonsson et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Review
Dermatology
Michael P. Schoen et al.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2020)
Review
Immunology
Xuan Zhang et al.
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Allergy
Sophie Twelves et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2019)
Review
Biochemistry & Molecular Biology
Dayasagar Das et al.
CYTOKINE & GROWTH FACTOR REVIEWS
(2019)
Review
Dermatology
E. Christophers et al.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2019)
Review
Immunology
Michael P. Schoen
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Dermatology
Lisa Eisert et al.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2019)
Article
Dermatology
Lisa Eisert et al.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2019)
Review
Dermatology
K. Eyerich et al.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2018)
Review
Immunology
Michael P. Schoen et al.
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Medicine, General & Internal
Kim Papp et al.
NEW ENGLAND JOURNAL OF MEDICINE
(2018)
Article
Allergy
Andrew Johnston et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2017)
Review
Biotechnology & Applied Microbiology
Daniella M. Schwartz et al.
NATURE REVIEWS DRUG DISCOVERY
(2017)
Letter
Allergy
Paola Di Meglio et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2016)
Article
Medicine, General & Internal
Wolf-Henning Boehncke et al.
Article
Immunology
Stanley Cheuk et al.
JOURNAL OF IMMUNOLOGY
(2014)
Article
Cell Biology
Maria Quaranta et al.
SCIENCE TRANSLATIONAL MEDICINE
(2014)
Review
Immunology
Leeyen Hsu et al.
JOURNAL OF IMMUNOLOGY RESEARCH
(2014)
Article
Medicine, General & Internal
Kim Papp et al.
Article
Medicine, General & Internal
Christopher E. M. Griffiths et al.
Article
Immunology
O Boyman et al.
JOURNAL OF EXPERIMENTAL MEDICINE
(2004)
