Pharmacological interventions for weight loss before conception-putative effects on subsequent gestational weight gain should be considered

Article Endocrinology & Metabolism

Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension

John P. H. Wilding et al.

Summary: One year after withdrawal of once-weekly subcutaneous semaglutide 2.4 mg and lifestyle intervention, participants regained two-thirds of their prior weight loss, with similar changes in cardiometabolic variables. Findings confirm the chronicity of obesity and suggest ongoing treatment is required to maintain improvements in weight and health.

DIABETES OBESITY & METABOLISM (2022)

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Review Medicine, General & Internal

Obesity in Pregnancy

Andreea A. Creanga et al.

Summary: This article reviews the numerous adverse effects of obesity on pregnancy, including various diseases and abnormalities.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Review Endocrinology & Metabolism

Fetal programming of obesity and type 2 diabetes

Sumudu Nimali Seneviratne et al.

Summary: The prevalence of obesity and type 2 diabetes mellitus has been rapidly increasing, and current prevention efforts are not successful. Fetal programming provides a new concept for lifelong prevention of obesity and type 2 diabetes mellitus. The World Health Organization now advocates a life-course approach to prevent/control obesity, starting with pre-conceptional and antenatal maternal health. This review summarizes current data on fetal programming of obesity and type 2 diabetes mellitus, including potential causative factors, mechanisms, and interventions to reduce its impact.

WORLD JOURNAL OF DIABETES (2022)

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Article Obstetrics & Gynecology

Effects of preconception weight loss after lifestyle intervention on fertility outcomes and pregnancy complications

Annemieke Hoek et al.

Summary: Obesity can negatively impact natural fertility in both men and women, as well as pregnancy chances. Lifestyle intervention is recommended as the first-line treatment for obesity, with or without medical treatments. Investigating the effects of lifestyle intervention on reproductive outcomes is crucial.

FERTILITY AND STERILITY (2022)

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Article Medicine, General & Internal

Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity The STEP 4 Randomized Clinical Trial

Domenica Rubino et al.

Summary: Continuing treatment with semaglutide resulted in greater weight loss maintenance and improvement in other physical indicators compared to switching to placebo over a 48-week period in adults with overweight or obesity. The study also found that gastrointestinal events were more common with continued semaglutide, but discontinuation rates were similar between the two groups.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Neurosciences

Long-term functional alterations following prenatal GLP-1R activation

Devon L. Graham et al.

Summary: The use of GLP-1R agonists during pregnancy has some effects on both dams and offspring, with the offspring primarily showing differences in weight and anxiety-like behaviors, which may be sex-specific.

NEUROTOXICOLOGY AND TERATOLOGY (2021)

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Article Cardiac & Cardiovascular Systems