Journal
INTERNATIONAL JOURNAL OF NEURAL SYSTEMS
Volume 33, Issue 8, Pages -Publisher
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S0129065723500417
Keywords
Ensemble learning; neuroimaging; Parkinson's disease; MRI; SPECT; computer-aided-diagnosis; machine learning; image processing
Categories
Ask authors/readers for more resources
Parkinson's Disease (PD) is the second most prevalent neurodegenerative disorder among adults. We proposed a Computer-Aided Diagnosis (CAD) system that combines structural and functional imaging data to detect PD with 96.48% accuracy. The system utilizes Ensemble Learning methodology, image preprocessing techniques, dimensionality reduction methods, and a bagging classification schema for unbalanced data.
Parkinson's Disease (PD) is the second most prevalent neurodegenerative disorder among adults. Although its triggers are still not clear, they may be due to a combination of different types of biomarkers measured through medical imaging, metabolomics, proteomics or genetics, among others. In this context, we have proposed a Computer-Aided Diagnosis (CAD) system that combines structural and functional imaging data from subjects in Parkinson's Progression Markers Initiative dataset by means of an Ensemble Learning methodology trained to identify and penalize input sources with low classification rates and/or high-variability. This proposal improves results published in recent years and provides an accurate solution not only from the point of view of image preprocessing (including a comparison between different intensity preservation techniques), but also in terms of dimensionality reduction methods (Isomap). In addition, we have also introduced a bagging classification schema for scenarios with unbalanced data.As shown by our results, the CAD proposal is able to detect PD with 96.48% of balanced accuracy, and opens up the possibility of combining any number of input data sources relevant for PD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available