4.7 Article

Preparation of Apoptotic Extracellular Vesicles from Adipose Tissue and Their Efficacy in Promoting High-Quality Skin Wound Healing

Related references

Note: Only part of the references are listed.
Article Engineering, Biomedical

Apoptotic extracellular vesicles are metabolized regulators nurturing the skin and hair

Lan Ma et al.

Summary: Over 300 billion cells die every day, producing endogenous apoptotic extracellular vesicles (apoEVs). This study discovers that a portion of exogenous apoEVs is metabolized in the integumentary skin and hair follicles. The migration of apoEVs is influenced by treadmill exercise and tail suspension. Exogenous apoEVs promote wound healing and hair growth by activating the Wnt/beta-catenin pathway. This research reveals a new metabolic pathway of apoEVs and suggests their potential therapeutic applications in skin and hair disorders.

BIOACTIVE MATERIALS (2023)

Review Endocrinology & Metabolism

How to maximize the therapeutic effect of exosomes on skin wounds in diabetes mellitus: Review and discussion

Jia Dong et al.

Summary: Chronic skin wound healing, particularly in diabetes mellitus, remains unresolved despite numerous efforts. Exosomes have emerged as a promising approach for treating diabetic wounds, but their therapeutic potential requires further enhancement. This review highlights the areas that can be improved in utilizing exosomes, including sourcing, engineering, dosage, frequency, and delivery methods.

FRONTIERS IN ENDOCRINOLOGY (2023)

Article Dentistry, Oral Surgery & Medicine

BMSC-Derived ApoEVs Promote Craniofacial Bone Repair via ROS/JNK Signaling

M. Li et al.

Summary: This study found that transplanted bone marrow mesenchymal stem cells (BMSCs) undergo apoptosis shortly after transplantation, leading to the generation of apoptotic cell-derived extracellular vesicles (ApoEVs). ApoEVs can promote the proliferation, migration, and osteogenic differentiation of recipient BMSCs, with the most significant effects observed with ApoEVs released from cells in the middle stage of apoptosis. Additionally, local transplantation of ApoEVs was found to promote bone regeneration in a critical size bone defect model in rats by activating JNK signaling through increased intracellular reactive oxygen species.

JOURNAL OF DENTAL RESEARCH (2022)

Article Materials Science, Biomaterials

A multifunctional antibacterial and self-healing hydrogel laden with bone marrow mesenchymal stem cell-derived exosomes for accelerating diabetic wound healing

Xinrong Geng et al.

Summary: Chronic diabetic wound injury is a serious complication of diabetes, and effective treatment is crucial. In this study, a novel hydrogel loaded with bone marrow mesenchymal stem cell-derived exosomes was designed for chronic diabetic wound healing. The hydrogel promoted angiogenesis and adjusted the wound inflammation microenvironment to accelerate wound healing.

BIOMATERIALS ADVANCES (2022)

Article Dentistry, Oral Surgery & Medicine

Apoptotic extracellular vesicles alleviate Pg-LPS induced inflammation of macrophages via AMPK/SIRT1/NF-κB pathway and inhibit adjacent osteoclast formation

Qingyuan Ye et al.

Summary: The study discovered that apoptotic extracellular vesicles (ApoEVs) can inhibit macrophages from polarizing into proinflammatory phenotypes via the AMPK/SIRT1/NF-kappa B pathway, and also suppress nearby osteoclast formation by reducing the secretion of TNF-alpha. This provides a new approach for the treatment of periodontitis.

JOURNAL OF PERIODONTOLOGY (2022)

Article Biotechnology & Applied Microbiology

Apoptotic vesicles activate autophagy in recipient cells to induce angiogenesis and dental pulp regeneration

Zihan Li et al.

Summary: In this study, the researchers found that apoptotic cell-derived extracellular vesicles (apoVs) were ingested by endothelial cells (ECs) and elevated the expression of angiogenesis-related genes, leading to pulp revascularization and tissue regeneration.

MOLECULAR THERAPY (2022)

Article Chemistry, Multidisciplinary

Electrostatic Charge-Mediated Apoptotic Vesicle Biodistribution Attenuates Sepsis by Switching Neutrophil NETosis to Apoptosis

Qianmin Ou et al.

Summary: Mesenchymal stem cell (MSC)-derived apoptotic vesicles (apoVs) can alleviate organ damage and improve survival in septic mice. ApoVs mainly accumulate in the bone marrow of septic mice via electrostatic charge interactions with positively charged neutrophil extracellular traps (NETs). Additionally, apoVs switch neutrophils NETosis to apoptosis via the apoV-Fas ligand (FasL)-activated Fas pathway. These findings reveal a previously unknown role of apoVs in sepsis treatment and demonstrate an electrostatic charge-directed target therapeutic mechanism, suggesting the involvement of cell death in disease development and therapy.

SMALL (2022)

Article Engineering, Biomedical

In situ delivery of apoptotic bodies derived from mesenchymal stem cells via a hyaluronic acid hydrogel: A therapy for intrauterine adhesions

Liaobing Xin et al.

Summary: Stem cell-derived apoptotic bodies (ABs) have been shown to promote endometrial regeneration through immunomodulation, cell proliferation, and angiogenesis. Incorporating ABs into hyaluronic acid hydrogel can effectively reduce fibrosis and promote endometrial regeneration in mouse and rat models, leading to fertility restoration.

BIOACTIVE MATERIALS (2022)

Article Cell Biology

Adipose tissue-derived small extracellular vesicles modulate macrophages to improve the homing of adipocyte precursors and endothelial cells in adipose tissue regeneration

Jia Dong et al.

Summary: This study reveals that small extracellular vesicles derived from adipose tissue (sEV-AT) can increase macrophage infiltration and directly promote macrophage migration, leading to improved migration of adipocyte precursors and endothelial cells and ultimately facilitating adipose tissue regeneration.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

Article Engineering, Biomedical

ADSC-exo@MMP-PEG smart hydrogel promotes diabetic wound healing by optimizing cellular functions and relieving oxidative stress

Tao Jiang et al.

Summary: The smart hydrogel loaded with ADSC-exo showed promising results in enhancing cell function and accelerating wound healing in diabetic patients.

MATERIALS TODAY BIO (2022)

Article Cell & Tissue Engineering

Human adipose-derived mesenchymal stem cells-derived exosomes encapsulated in pluronic F127 hydrogel promote wound healing and regeneration

Yang Zhou et al.

Summary: This study explores the potential clinical application of hADSCs-Exos encapsulated in PF-127 hydrogel for wound healing. The results showed that PF-127/hADSCs-Exos complexes enhanced skin wound healing, promoted re-epithelialization, increased collagen synthesis and expression of skin barrier proteins, and reduced inflammation. Using PF-127/hADSCs-Exos complexes allows for lower doses and frequency of exosome administration while maintaining therapeutic effects.

STEM CELL RESEARCH & THERAPY (2022)

Article Cell Biology

Proteomic analysis of MSC-derived apoptotic vesicles identifies Fas inheritance to ameliorate haemophilia a via activating platelet functions

Xiao Zhang et al.

Summary: This study compared the characteristics and functions of apoptotic vesicles (apoVs) and exosomes derived from different sources of mesenchymal stem cells (MSCs). The results revealed unique protein compositions and specific enrichment of proteins in apoVs, which can serve as biomarkers. Additionally, apoVs exhibited therapeutic effects in treating haemophilia A through a specific Fas/FasL linkage mechanism.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

Article Engineering, Biomedical

Apoptotic vesicles inherit SOX2 from pluripotent stem cells to accelerate wound healing by energizing mesenchymal stem cells

Yan Qu et al.

Summary: This study revealed that pluripotent stem cell-derived apoptotic vesicles (PSC-apoVs) can inherit pluripotent molecules and promote the activation of adult stem cells and skin wound healing. These findings provide a potential cell-free strategy for clinical applications using PSC-apoVs.

ACTA BIOMATERIALIA (2022)

Review Biochemistry & Molecular Biology

Cationic, anionic and neutral polysaccharides for skin tissue engineering and wound healing applications

Hamed Nosrati et al.

Summary: The limitations of current approaches for wound healing have led to the development of more efficient alternative approaches, such as polysaccharide-based scaffolds. These scaffolds have distinctive properties that make them ideal for wound healing applications, including biocompatibility, biodegradability, high water retention capacity, and nontoxicity.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Review Biotechnology & Applied Microbiology

Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis

Hamed Nosrati et al.

Summary: The skin serves as the body's primary barrier against external pathogens and maintaining homeostasis. Damage to the skin can have significant impacts on health and quality of life. Tissue engineering aims to enhance tissue regeneration, with improving angiogenesis being one of the most effective treatments for skin tissue regeneration.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

Article Cell & Tissue Engineering

Exosomes derived from human adipose mesenchymal stem cells attenuate hypertrophic scar fibrosis by miR-192-5p/IL-17RA/Smad axis

Yan Li et al.

Summary: ADSC-Exo has shown to effectively inhibit the proliferation and migration of HSFs, decrease the expression of related proteins, promote wound healing in mice, and reduce collagen deposition. miR-192-5p plays a positive role in fibrosis by targeting IL-17RA and regulating the Smad pathway.

STEM CELL RESEARCH & THERAPY (2021)

Article Chemistry, Multidisciplinary

Apoptotic Extracellular Vesicles Ameliorate Multiple Myeloma by Restoring Fas-Mediated Apoptosis

Juan Wang et al.

Summary: The study demonstrates that apoEVs can induce multiple myeloma cell apoptosis and inhibit tumor growth, suggesting a potential therapeutic use of apoEVs for MM treatment.

ACS NANO (2021)

Article Medicine, Research & Experimental

Adipose mesenchymal stem cell-derived exosomes accelerate skin wound healing via the lncRNA H19/miR-19b/SOX9 axis

Li Qian et al.

Summary: This study demonstrates that the high expression of H19 in exosomes derived from adipose mesenchymal stem cells accelerates skin tissue wound healing by upregulating SOX9 via miR-19b.

LABORATORY INVESTIGATION (2021)

Review Cell Biology

Emerging understanding of apoptosis in mediating mesenchymal stem cell therapy

Yu Fu et al.

Summary: Research has shown that mesenchymal stem cell transplantation plays a critical role in therapy, with apoptotic extracellular vesicles being key for intercellular communication and therapeutic efficacy.

CELL DEATH & DISEASE (2021)

Article Cell Biology

Apoptotic vesicles restore liver macrophage homeostasis to counteract type 2 diabetes

Chenxi Zheng et al.

Summary: The study revealed that apoptotic vesicles (apoVs) derived from MSCs can modulate liver macrophage homeostasis and counteract type 2 diabetes (T2D) by inducing macrophage reprogramming. Through efferocytosis, apoVs inhibit macrophage accumulation and promote their transformation towards an anti-inflammatory phenotype in the liver to ameliorate T2D phenotypes.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

Article Cell & Tissue Engineering

Ex vivo Induction of Apoptotic Mesenchymal Stem Cell by High Hydrostatic Pressure

Tien Minh Le et al.

Summary: MSCs have become a focus of attention in tissue repair and wound healing. Recent studies have shown the importance of apoptosis in MSC-mediated immunomodulation. High hydrostatic pressure treatment induced complete apoptosis in MSCs, offering potential for manipulated products in cell-based therapies.

STEM CELL REVIEWS AND REPORTS (2021)

Editorial Material Cell & Tissue Engineering

Skinny Fat Cells Stimulate Wound Healing

David Merrick et al.

CELL STEM CELL (2020)

Article Nanoscience & Nanotechnology

Comparison of the Therapeutic Effect of Allogeneic and Xenogeneic Small Extracellular Vesicles in Soft Tissue Repair

Jia Dong et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

Article Multidisciplinary Sciences

Stem cell proliferation is induced by apoptotic bodies from dying cells during epithelial tissue maintenance

Courtney K. Brock et al.

NATURE COMMUNICATIONS (2019)

Article Medicine, Research & Experimental

Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice

Zhuzhen Zhang et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Article Surgery

Unfiltered Nanofat Injections Rejuvenate Postburn Scars of Face

Saadia Nosheen Jan et al.

ANNALS OF PLASTIC SURGERY (2019)

Article Cell & Tissue Engineering

Promising effects of exosomes isolated from menstrual blood-derived mesenchymal stem cell on wound-healing process in diabetic mouse model

Razieh Dalirfardouei et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2019)

Review Physiology

WOUND HEALING: A CELLULAR PERSPECTIVE

Melanie Rodrigues et al.

PHYSIOLOGICAL REVIEWS (2019)

Article Critical Care Medicine

Use of the Stromal Vascular Fraction in Intermediate-Deep Acute Burns: A Case With Its Own Control

Giuseppe Giudice et al.

JOURNAL OF BURN CARE & RESEARCH (2018)

Review Endocrinology & Metabolism

Emerging nonmetabolic functions of skin fat

Christian F. Guerrero-Juarez et al.

NATURE REVIEWS ENDOCRINOLOGY (2018)

Article Multidisciplinary Sciences

Regeneration of fat cells from myofibroblasts during wound healing

Maksim V. Plikus et al.

SCIENCE (2017)

Article Cell Biology

Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation

Antonio Galleu et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

Article Surgery

Fat Grafting for Burn, Traumatic, and Surgical Scars

Rafi Fredman et al.

CLINICS IN PLASTIC SURGERY (2017)

Article Multidisciplinary Sciences

A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure

Georgia K. Atkin-Smith et al.

NATURE COMMUNICATIONS (2015)

Article Multidisciplinary Sciences

Distinct fibroblast lineages determine dermal architecture in skin development and repair

Ryan R. Driskell et al.

NATURE (2013)

Article Multidisciplinary Sciences

Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPARγ

Fenfen Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Pathology

Apoptosis: A review of programmed cell death

Susan Elmore

TOXICOLOGIC PATHOLOGY (2007)