Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 24, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/ijms241210167
Keywords
diabetic choroidopathy; diabetes mellitus; diabetic retinopathy; choriocapillaris; choroid; optical coherence tomography
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Diabetic choroidopathy refers to the accumulation of PAS-positive material in the tissue of diabetic eyes. Inflammation and activation of neutrophils are crucial factors in the impairment of choriocapillaris. The presence of diabetic choroidopathy in vivo has been confirmed with multimodal imaging, which provides important qualitative and quantitative features to characterize the involvement of choroid.
Diabetic choroidopathy was first described on histopathological specimens of diabetic eyes. This alteration was characterized by the accumulation of PAS-positive material within the intracapillary stroma. Inflammation and polymorphonuclear neutrophils (PMNs) activation are crucial elements in choriocapillaris impairment. The evidence of diabetic choroidopathy in vivo was confirmed with multimodal imaging, which provides key quantitative and qualitative features to characterize the choroidal involvement. The choroid can be virtually affected in each vascular layer, from Haller's layer to the choriocapillaris. However, the damage on the outer retina and photoreceptor cells is essentially driven by a choriocapillaris deficiency, which can be assessed through optical coherence tomography angiography (OCTA). The identification of characteristic features of diabetic choroidopathy can be significant for understanding the potential pathogenic and prognostic implications in diabetic retinopathy.
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