☆ 4.7 Review

Ginsenosides from Panax ginseng as Key Modulators of NF-κB Signaling Are Powerful Anti-Inflammatory and Anticancer Agents

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Related references

Note: Only part of the references are listed.
Article Microbiology

Ginsenoside Rg3 treats acute radiation proctitis through the TLR4/MyD88/NF-κB pathway and regulation of intestinal flora

Xiaoyu Duan et al.

Frontiers in Cellular and Infection Microbiology (2023)

Add to Collection
Article Plant Sciences

Korean Red Ginseng modulates immune function by upregulating CD4+CD8+T cells and NK cell activities on porcine

Md Jahangir Alam et al.

Summary: In this study, the researchers investigated the potential of KRG treatment to improve immune activity parameters such as cytotoxicity, populations of CD4+ CD8+T cells, CD3-CD172-CD8+ NK cells, CD172+ monocytes, and natural cytotoxicity receptors like Nkp46, Nkp44, Nkp30. The results showed that KRG significantly increased these immune activities, indicating its distinct immune-enhancing effects on T cells and NK cells in pigs.

JOURNAL OF GINSENG RESEARCH (2023)

Add to Collection
Article Oncology

Cancer statistics, 2022

Rebecca L. Siegel et al.

Summary: Each year, the American Cancer Society compiles data on cancer occurrence and outcomes in the United States. The latest data shows that breast and prostate cancer progress has stagnated, while lung cancer has shown improvements in survival rates. Lung cancer incidence for advanced disease has declined while localized-stage rates have increased, resulting in higher survival rates. Mortality patterns align with incidence trends, with lung cancer deaths declining rapidly, breast cancer deaths slowing, and prostate cancer deaths stabilizing.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

Add to Collection
Article Plant Sciences

Ginsenoside Rg1 suppresses cancer cell proliferation through perturbing mitotic progression

Jihee Hong et al.

Summary: Ginsenoside Rg1 reduces cancer cell proliferation by inhibiting Haspin kinase activity and H3T3ph, leading to decreased levels of Aurora B at the centromere.

JOURNAL OF GINSENG RESEARCH (2022)

Add to Collection
Review Plant Sciences

Ginsenoside Rb2: A review of pharmacokinetics and pharmacological effects

Longxing Miao et al.

Summary: This paper provides an overview of the pharmacokinetics and pharmacological properties of Ginsenoside Rb2, as well as its mechanism of action in the prevention and treatment of various diseases. However, its clinical efficacy has not been evaluated and further research is needed.

JOURNAL OF GINSENG RESEARCH (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Rg1 exerts protective effect in CPZ-induced demyelination mouse model via inhibiting CXCL10-mediated glial response

Yi-xiao Dong et al.

Summary: This study demonstrates that Rg1 can alleviate motor impairments, improve motor coordination, reduce demyelination, and inhibit axonal injury in CPZ-induced demyelination mouse model. The neuroprotective effects of Rg1 are associated with its inhibition on CXCL10-mediated glial response.

ACTA PHARMACOLOGICA SINICA (2022)

Add to Collection
Article Plant Sciences

Syringaresinol derived from Panax ginseng berry attenuates oxidative stress-induced skin aging via autophagy

Wooram Choi et al.

Summary: Syringaresinol (SYR) has potential value as a cosmetic additive for preventing skin aging by reducing the expression of matrix metalloproteinases associated with skin aging and regulating antioxidant and autophagy activities.

JOURNAL OF GINSENG RESEARCH (2022)

Add to Collection
Article Multidisciplinary Sciences

Differential recognition of canonical NF-κB dimers by Importin α3

Tyler J. Florio et al.

Summary: The authors identify a bipartite Nuclear Localization Signal in the NF-kappa B p50/p65 heterodimer that is recognized with high affinity by importin alpha 3. This study reveals the specific structure and mechanism of this signal and highlights the important role of importin alpha 3 in NF-kappa B signaling.

NATURE COMMUNICATIONS (2022)

Add to Collection
Review Geriatrics & Gerontology

Microglia and Neuroinflammation: Crucial Pathological Mechanisms in Traumatic Brain Injury-Induced Neurodegeneration

Fangjie Shao et al.

Summary: Traumatic brain injury (TBI) is a common disease in the central nervous system with high mortality and morbidity. Patients with TBI often suffer from neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. The pathological mechanisms connecting these two processes are not fully understood. Further investigation of the pathophysiological mechanisms of TBI and TBI-induced neurodegeneration is crucial for developing accurate treatment options for these notorious consequences.

FRONTIERS IN AGING NEUROSCIENCE (2022)

Add to Collection
Article Plant Sciences

Korean Red Ginseng saponin fraction exerts anti-inflammatory effects by targeting the NF-κB and AP-1 pathways

Jeong-Oog Lee et al.

Summary: This study investigates the anti-inflammatory role of ginsenosides from Korea red ginseng (KRG) in macrophages and their potential mechanism. The results suggest that ginsenosides inhibit the NF-kappa B and AP-1 signaling pathways, reducing the generation of inflammatory molecules and exhibiting anti-inflammatory effects.

JOURNAL OF GINSENG RESEARCH (2022)

Add to Collection
Article Plant Sciences

The non-saponin fraction of Korean Red Ginseng ameliorates sarcopenia by regulating immune homeostasis in 22-26-month-old C57BL/6J mice

Hyun-Ji Oh et al.

Summary: This study investigated the effect of non-saponin fraction (NSF) of Korean Red Ginseng on age-associated sarcopenia in old mice. The results showed that NSF improved muscle strength and mass by regulating chronic inflammation and oxidative stress, and restored immune homeostasis in old mice.

JOURNAL OF GINSENG RESEARCH (2022)

Add to Collection
Article Plant Sciences

Evaluation of 20(S)-ginsenoside Rg3 loaded hydrogel for the treatment of perianal ulcer in a rat model

Longhai Jin et al.

Summary: This study developed a Rg3-loaded hydrogel for treating perianal ulcers, which showed significant efficacy in inhibiting inflammation, promoting ulcer healing, and could be a potential candidate for perianal ulcer treatment.

JOURNAL OF GINSENG RESEARCH (2022)

Add to Collection
Article Biology

Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness

Deborah Fanfone et al.

Summary: Breast cancer cells develop resistance to cell death triggered by loss of adhesion during metastasis, which is mediated by Inhibitory of Apoptosis Proteins. Mechanically stressed cancer cells with resistance to cell death display enhanced cell motility and evasion from immune surveillance, and have increased metastatic potential.

ELIFE (2022)

Add to Collection
Article Plant Sciences

Angiopteris cochinchinensis de Vriese Ameliorates LPS-Induced Acute Lung Injury via Src Inhibition

Won Young Jang et al.

Summary: This study evaluated the anti-inflammatory effects of Angiopteris cochinchinensis de Vriese extract (Ac-EE) on acute lung injury (ALI) and demonstrated its potential as an effective botanical drug. Ac-EE reduced nitric oxide production and inhibited the production of proinflammatory mediators and cytokines. It also showed protective effects on lung tissue by reducing edema and lung injury.

PLANTS-BASEL (2022)

Add to Collection
Article Multidisciplinary Sciences

Author affiliations: aGene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037; bStorr Liver Centre, Westmead Institute for Medical Research and Sydney Medical School, University of Sydney, Westmead NSW 2145, Australia; and cImmunobiology and Microbial Pathogenesis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037

Ting Fu et al.

Summary: The activation of FXR selectively in the intestine has been shown to be protective in inflammation-driven models of IBD. FXR regulates innate lymphoid cells, blocking the increase of ILCs and the production of inflammatory cytokines. In addition, FXR is involved in the maturation/differentiation of ILC precursor cells.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Add to Collection
Article Multidisciplinary Sciences

Mannose ameliorates experimental colitis by protecting intestinal barrier integrity

Lijun Dong et al.

Summary: The study shows that mannose supplementation can alleviate symptoms of inflammatory bowel disease, including colitis. It improves intestinal barrier integrity, reduces the release of proteins, and prevents mitochondrial dysfunction. Mannose also synergizes with the conventional drug mesalamine in colitis treatment.

NATURE COMMUNICATIONS (2022)

Add to Collection
Article Chemistry, Medicinal

Ginsenoside Rb1 Alleviates Bleomycin-Induced Pulmonary Inflammation and Fibrosis by Suppressing Central Nucleotide-Binding Oligomerization-, Leucine-Rich Repeat-, and Pyrin Domains-Containing Protein Three Inflammasome Activation and the NF-KB Pathway

Jingjing Liu et al.

Summary: G-Rb1 exerts anti-inflammatory and anti-fibrotic effects by suppressing the activation of NLRP3 inflammasome and NF-KB pathway, which may provide a potential therapeutic approach for idiopathic pulmonary fibrosis.

DRUG DESIGN DEVELOPMENT AND THERAPY (2022)

Add to Collection
Article Immunology

Ginsenoside Rh2 Inhibits NLRP3 Inflammasome Activation and Improves Exosomes to Alleviate Hypoxia-Induced Myocardial Injury

Zhongwen Qi et al.

Summary: The study found that Ginsenoside Rh2 could improve the inflammatory microenvironment after acute myocardial infarction and enhance the protective effect of exosomes against myocardial injury, providing new insights into the modification of exosomes in MI treatment.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection
Review Cell Biology

NF-κB Regulation by Gut Microbiota Decides Homeostasis or Disease Outcome During Ageing

Shuning Zhang et al.

Summary: Human beings and their indigenous microbial communities have developed co-evolutionary mechanisms of communication and cooperation. The gastrointestinal tract plays a crucial role in regulating the interaction between the host and gut microbiota, with the transcription factor NF-kappa B playing a key role in host response to microbial cues.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

Add to Collection
Article Cell Biology

Ros-mediated mitochondrial oxidative stress is involved in the ameliorating effect of ginsenoside GSLS on chlorpyrifos induced hepatotoxicity in mice

Hongyan Pei et al.

Aging-US (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Black ginseng protects against Western diet-induced nonalcoholic steatohepatitis by modulating the TLR4/NF-κB signaling pathway in mice

Wei Wei et al.

Summary: This study investigated the protective effects of black ginseng (BG) against nonalcoholic steatohepatitis (NASH) and revealed its mechanism of action through the TLR4/NF-κ B pathway.

JOURNAL OF FOOD BIOCHEMISTRY (2022)

Add to Collection
Article Medicine, Research & Experimental

Ginsenoside Rh1 protects human endothelial cells against lipopolysaccharide-induced inflammatory injury through inhibiting TLR2/ 4-mediated STAT3, NF-?B, and ER stress signaling pathways

Yujin Jin et al.

Summary: This study demonstrates that ginsenoside Rh1 inhibits LPS-induced endothelial cell inflammation and apoptosis by suppressing STAT3/NF-kappa B and endoplasmic reticulum stress signaling pathways, mediated by blocking LPS binding to TLR2 and TLR4. Consistently, Rh1 effectively reduces endothelial cell dysfunction in an in vivo model.

LIFE SCIENCES (2022)

Add to Collection
Article Cell Biology

Hepatoprotective Mechanism of Ginsenoside Rg1 against Alcoholic Liver Damage Based on Gut Microbiota and Network Pharmacology

Ting Xia et al.

Summary: This study identified 11 potential targets of ginsenoside Rg1 (GRg1) against alcoholic liver disease (ALD) using network pharmacology. GRg1 was found to regulate Toll-like receptor (TLR) and nuclear factor-kappa B (NF-kappa B) signaling pathways, decrease oxidative stress, enhance intestinal barrier function, and reduce alcohol-induced inflammation. These findings suggest that GRg1 administration may be a promising strategy for protecting against alcohol-induced liver damage.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

Add to Collection
Article Pharmacology & Pharmacy

Ginsenoside Rc attenuates DSS-induced ulcerative colitis, intestinal inflammatory, and barrier function by activating the farnesoid X receptor

Kaijia Tang et al.

Summary: The study demonstrates that ginsenoside Rc can alleviate inflammation and barrier function deficiencies by activating FXR signaling, thereby protecting the intestines from damage induced by dextran sulfate sodium (DSS).

FRONTIERS IN PHARMACOLOGY (2022)

Add to Collection
Article Rheumatology

Macrophage polarization toward M1 phenotype through NE-κB signaling in patients with Behcet's disease

Xiuhua Wu et al.

Summary: This study investigated the effect of BD serum on the phenotypes and functions of macrophage polarization. The findings revealed that BD serum promoted macrophage polarization towards a proinflammatory M1-like phenotype through NF-kappa B signaling. This may contribute to inflammation in BD. The study suggests that M1 polarized macrophages could be a potential therapeutic target for BD.

ARTHRITIS RESEARCH & THERAPY (2022)

Add to Collection
Review Respiratory System

Type 2 inflammation in asthma and other airway diseases

Jorge Maspero et al.

Summary: Chronic inflammatory airway diseases, such as asthma and chronic rhinosinusitis, are a global health concern. Understanding the pathophysiology of type 2 inflammation, which involves both the innate and adaptive immune systems, is crucial for improving patient outcomes. Targeted therapies based on this understanding offer hope for better management of these diseases.

ERJ OPEN RESEARCH (2022)

Add to Collection
Article Plant Sciences

Gypenoside XVII protects against myocardial ischemia and reperfusion injury by inhibiting ER stress-induced mitochondrial injury

Yingli Yu et al.

Summary: GP-17 provides cardioprotective effects by inhibiting myocardial apoptosis, reducing cardiac dysfunction, and improving contractile recovery. The study results demonstrate that GP-17 inhibits I/R-induced mitochondrial injury by delaying the onset of ER stress, which is controlled by the PI3K/AKT and P38 signaling pathways.

JOURNAL OF GINSENG RESEARCH (2021)

Add to Collection
Article Biochemistry & Molecular Biology

Protective effect of ginsenoside Rg1 on LPS-induced apoptosis of lung epithelial cells

Qijian Ji et al.

Summary: The study found that autophagy can counteract cell apoptosis in LPS-treated MLE-12 cells, while promoting autophagy effectively reduces cell apoptosis.

MOLECULAR IMMUNOLOGY (2021)

Add to Collection
Article Plant Sciences

Ginsenoside Rb1 inhibits monoiodoacetate-induced osteoarthritis in postmenopausal rats through prevention of cartilage degradation

Adithan Aravinthan et al.

Summary: The study demonstrates the anti-inflammatory effects of G-Rb1 on MIA-induced postmenopausal OA in rats, indicating a chondroprotective effect by inhibiting the expression of inflammatory cytokines.

JOURNAL OF GINSENG RESEARCH (2021)

Add to Collection
Review Plant Sciences

Pharmacological potential of ginseng and its major component ginsenosides

Zubair Ahmed Ratan et al.

Summary: Ginseng, as a traditional herb in Asian countries, has been used for thousands of years and contains a variety of active ingredients with numerous benefits, but further high-quality evidence is needed to prove its medicinal value.

JOURNAL OF GINSENG RESEARCH (2021)

Add to Collection
Article Plant Sciences

Ginsenosides Rk1 and Rg5 inhibit transforming growth factor-β1-induced epithelial-mesenchymal transition and suppress migration, invasion, anoikis resistance, and development of stem-like features in lung cancer

Hyunhee Kim et al.

Summary: The study found that Rk1 and Rg5 inhibited TGF-beta 1-induced EMT and the development of stem cell properties by regulating the Smad and NF-kB/ERK pathways.

JOURNAL OF GINSENG RESEARCH (2021)

Add to Collection
Article Plant Sciences

Ginseng gintonin alleviates neurological symptoms in the G93A-SOD1 transgenic mouse model of amyotrophic lateral sclerosis through lysophosphatidic acid 1 receptor

Sung Min Nam et al.

Summary: The active ingredient gintonin in ginseng has therapeutic effects on ALS, extending the survival time of mice and alleviating motor dysfunction, possibly by reducing neuronal loss and oxidative stress.

JOURNAL OF GINSENG RESEARCH (2021)

Add to Collection
Article Plant Sciences

Identification and quantification of oleanane triterpenoid saponins and potential analgesic and anti-inflammatory activities from the roots and rhizomes of Panax stipuleanatus

Pan-Pan Shu et al.

Summary: This study isolated and identified two triterpenoid saponins from Panax stipuleanatus, demonstrating their analgesic and anti-inflammatory activities. Furthermore, the optimal harvesting age of three to five-year-old plants was identified to obtain higher levels of triterpenoid saponins.

JOURNAL OF GINSENG RESEARCH (2021)

Add to Collection
Article Plant Sciences

20(S)-protopanaxadiol and oleanolic acid ameliorate cognitive deficits in APP/PS1 transgenic mice by enhancing hippocampal neurogenesis

Kaili Lin et al.

Summary: Alzheimer's disease (AD) is a prevalent neurodegenerative disorder. Enhancing hippocampal neurogenesis through compounds like 20(S)-protopanaxadiol (PPD) and oleanolic acid (OA) found in ginseng can alleviate cognitive deficits in animal models by activating the Wnt/GSK3 beta/beta-catenin pathway.

JOURNAL OF GINSENG RESEARCH (2021)

Add to Collection
Review Plant Sciences

Functional roles and mechanisms of ginsenosides from Panax ginseng in atherosclerosis

Qianqian Xue et al.

Summary: Atherosclerosis is a major cause of cardiovascular diseases and addressing it is crucial for reducing societal burden. Ginsenosides, natural compounds obtained from ginseng, have shown pharmacological activities against various diseases including atherosclerosis.

JOURNAL OF GINSENG RESEARCH (2021)

Add to Collection
Article Plant Sciences

Alleviative effects of 20(R)-Rg3 on HFD/STZ-induced diabetic nephropathy via MAPK/NF-κB signaling pathways in C57BL/6 mice

Ying Li et al.

Summary: In this study, treatment with 20(R)-Rg3 for 8 weeks in T2D mice not only decreased FBG and AGEs levels, but also improved insulin, blood lipids, oxidative stress, and renal function by regulating MAPKs and NF kappa B signal pathways, showing significant ameliorative effects on DN mice.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Add to Collection
Review Plant Sciences

The regulatory role of Korean ginseng in skin cells

Long You et al.

Summary: Skin, as the largest organ in our body, acts as a barrier against external stress and damages. Korean ginseng, processed into various products, has functional roles on different dermal cell types, including anti-photodamaging, anti-inflammatory, anti-oxidative, anti-melanogenic, and wound healing activities. This information may serve as the basis for future research on the effects of ginseng-derived components on skin health.

JOURNAL OF GINSENG RESEARCH (2021)

Add to Collection
Article Plant Sciences

Rg3-enriched Korean Red Ginseng extract inhibits blood-brain barrier disruption in an animal model of multiple sclerosis by modulating expression of NADPH oxidase 2 and 4

Min Jung Lee et al.

Summary: The study showed that Rg3-KRGE may alleviate symptoms and pathological features of EAE mice by improving BBB integrity. This includes reducing disease score and spinal demyelination, inhibiting vascular permeability, inflammation, and oxidative stress, as well as promoting anti-inflammatory response.

JOURNAL OF GINSENG RESEARCH (2021)

Add to Collection
Article Plant Sciences

Saponins from Panax japonicus ameliorate age-related renal fibrosis by inhibition of inflammation mediated by NF-κB and TGF-β1/Smad signaling and suppression of oxidative stress via activation of Nrf2-ARE signaling

Yan Gao et al.

Summary: The study found that total saponins from Panax japonicus (SPJs) can improve age-associated renal fibrosis by inhibiting TGF-beta 1/Smad, NF kappa B signaling pathways and activating Nrf2-ARE signaling pathways.

JOURNAL OF GINSENG RESEARCH (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Ginsenoside Rg1 exerts neuroprotective effects in 3-nitropronpionic acid-induced mouse model of Huntington's disease via suppressing MAPKs and NF-κB pathways in the striatum

Xiong Yang et al.

Summary: Ginsenoside Rg1 shows potential neuroprotective effects in a mouse model of Huntington's disease, alleviating weight loss, behavioral defects, and neuronal loss, possibly through inhibiting the activation of MAPKs and NF-kappa Beta signaling pathways. It may serve as a novel therapeutic option for Huntington's disease.

ACTA PHARMACOLOGICA SINICA (2021)

Add to Collection
Article Biochemistry & Molecular Biology

Ginsenoside Rh1 Prevents Migration and Invasion through Mitochondrial ROS-Mediated Inhibition of STAT3/NF-κB Signaling in MDA-MB-231 Cells

Yujin Jin et al.

Summary: The study demonstrated the potent anticancer effect of Rh1 on TNBC migration and invasion by inhibiting STAT3 and NF-kappa B signaling through mtROS generation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection
Article Multidisciplinary Sciences

Thermal transformation of polar into less-polar ginsenosides through demalonylation and deglycosylation in extracts from ginseng pulp

Fan Yao et al.

Summary: The study investigated the dynamic changes of ginsenosides in ginseng pulp steamed at different temperatures and durations, revealing that polar ginsenosides decreased while less-polar ginsenosides increased with higher steaming temperature and longer duration. Optimal conditions for the highest total ginsenosides were found to be 100°C for 1 hour. Additionally, the transformation of polar into less-polar ginsenosides increased the variety of ginsenoside species in the pulp.

SCIENTIFIC REPORTS (2021)

Add to Collection
Article Plant Sciences

Enhancement of skin barrier and hydration-related molecules by protopanaxatriol in human keratinocytes

Jeong-Oog Lee et al.

Summary: PPT enhances skin barrier function and hydration by promoting the expression of filaggrin, transglutaminase, claudin, hyaluronic acid synthase, and activating Src/AKT/NF-kappa B and MAPK signaling pathways.

JOURNAL OF GINSENG RESEARCH (2021)

Add to Collection
Article Plant Sciences

Red ginseng oil promotes hair growth and protects skin against UVC radiation

Van-Long Truong et al.

Summary: The study found that red ginseng oil can promote hair growth in mice, with specific compounds playing an important role in promoting hair growth. In addition, red ginseng oil also has a protective effect on skin damage caused by UV radiation.

JOURNAL OF GINSENG RESEARCH (2021)

Add to Collection
Article Nanoscience & Nanotechnology

Protective Effect of Ginsenoside Rb1 Nanoparticles Against Contrast-Induced Nephropathy by Inhibiting High Mobility Group Box 1 Gene/Toll-Like Receptor 4/NF-κB Signaling Pathway

Shuai Zhou et al.

Summary: With the increasing application of interventional radiology procedures, concerns about acute kidney injury caused by iodine contrast medium have risen. Targeting renal inflammatory response and cytokine release may offer a solution to mitigate this issue. Ginsenoside Rb1 shows potential in protecting against various diseases through antioxidant and anti-inflammatory effects, and it could protect against contrast-induced nephropathy by inhibiting inflammatory response via the HMGB1/TLR4/NF-kappa B pathway.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2021)

Add to Collection
Review Pharmacology & Pharmacy

Ginsenosides in Panax genus and their biosynthesis

Maoqi Hou et al.

Summary: This review summarizes the structures, distributions, and contents of representative saponins in ginseng plants, updates the biosynthetic pathways of ginsenosides, emphasizes the roles of enzymes, transcription factors, and non-coding RNAs, and highlights the major biotechnological applications for ginsenosides production.

ACTA PHARMACEUTICA SINICA B (2021)

Add to Collection
Article Biochemistry & Molecular Biology

Ginsenoside Rb3 Alleviates CSE-induced TROP2 Upregulation through p38 MAPK and NF-κB Pathways in Basal Cells

Haijun Li et al.

Summary: Smoking-induced changes in airway basal cells may lead to disruption of airway homeostasis and COPD-associated airway remodeling. TROP2 is upregulated in the airway epithelia of smokers, with ginsenoside Rb3 identified as a potential therapeutic molecule to prevent epithelial disruption in COPD.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2021)

Add to Collection
Article Clinical Neurology

Global Epidemiology of Stroke and Access to Acute Ischemic Stroke Interventions

Vasu Saini et al.

Summary: This review provides an up-to-date overview of stroke and large vessel occlusion (LVO) globally, as well as the eligibility and access to IV thrombolysis (IVT) and mechanical thrombectomy (MT) worldwide. Despite advances in treatment eligibility in the past 5 years, access to acute stroke care and utilization of MT or IVT remains low, highlighting a significant gap among eligible patients. Multiple global initiatives are currently in progress to improve systems of care and bridge this gap.

NEUROLOGY (2021)

Add to Collection
Article Agriculture, Multidisciplinary

Ginsenoside Rk3 Ameliorates Obesity-Induced Colitis by Regulating of Intestinal Flora and the TLR4/NF-κB Signaling Pathway in C57BL/6 Mice

Hongwei Chen et al.

Summary: The study showed that ginsenoside Rk3 intervention improved intestinal barrier dysfunction, reduced inflammatory cytokine levels and oxidative stress, suppressed macrophage infiltration, regulated gut microbiota and inhibited the inflammatory cascade in high-fat diet-induced obese mice, suggesting it can be potentially used as a natural anti-inflammatory agent to alleviate chronic obesity-induced colitis.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

Add to Collection
Article Pharmacology & Pharmacy

Urolithin A suppresses RANKL-induced osteoclastogenesis and postmenopausal osteoporosis by, suppresses inflammation and downstream NF-κB activated pyroptosis pathways

Huaqiang Tao et al.

Summary: UA administration reduced systemic bone loss in ovariectomized animals by suppressing osteoclast formation through modulation of the inflammatory signal-dependent pyroptosis pathway, indicating its potential as a safe and promising therapeutic strategy for osteoclast-related bone diseases like OP.

PHARMACOLOGICAL RESEARCH (2021)

Add to Collection
Review Plant Sciences

Panax ginseng and its ginsenosides: potential candidates for the prevention and treatment of chemotherapy-induced side effects

Yan Wan et al.

Summary: Panax ginseng and its ginsenosides are effective options for treating chemotherapy-induced side effects, with mechanisms including antioxidation, anti-inflammation, anti-apoptosis, and modulation of various signaling pathways.

JOURNAL OF GINSENG RESEARCH (2021)

Add to Collection
Article Plant Sciences

Korean Red Ginseng attenuates ultraviolet-mediated inflammasome activation in keratinocytes

Huijeong Ahn et al.

Summary: The study found that RGE and its saponins can inhibit the secretion of IL-1 beta in response to UV exposure in skin keratinocytes and macrophages, with RGE primarily interrupting the priming step in keratinocytes.

JOURNAL OF GINSENG RESEARCH (2021)

Add to Collection
Review Biochemistry & Molecular Biology

Mechanisms of Non-Alcoholic Fatty Liver Disease in the Metabolic Syndrome. A Narrative Review

Luca Rinaldi et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS) share similar features, with insulin resistance being a key factor. Lifestyle changes can improve symptoms, and there is a correlation between diabetes and multiorgan damage.

ANTIOXIDANTS (2021)

Add to Collection
Article Pathology

The epithelial-mesenchymal transition regulators Twist, Slug, and Snail are associated with aggressive tumour features and poor outcome in prostate cancer patients

Astrid Borretzen et al.

Summary: This study reveals a strong relationship between EMT, hypoxia, and angiogenesis, as well as a significant link between EMT regulators and aggressive tumor features and poor patient outcomes in prostate cancer. Co-expression of factors has an enhanced influence on outcome, especially in E-cadherin(low) carcinomas where Slug overexpression is associated with shorter time to all endpoints and is an independent predictor of time to multiple endpoints, including cancer-specific death.

JOURNAL OF PATHOLOGY CLINICAL RESEARCH (2021)

Add to Collection
Article Plant Sciences

Korean Red Ginseng exerts anti-inflammatory and autophagy-promoting activities in aged mice

Jin Kyeong Kim et al.

Summary: The study revealed that Korean Red Ginseng water extract has anti-inflammatory effects and can promote autophagy in aged mice by reducing the expression of inflammation-related genes and increasing the expression of autophagy-related genes.

JOURNAL OF GINSENG RESEARCH (2021)

Add to Collection
Article Biochemistry & Molecular Biology

Nuclear factor-kappa B and its role in inflammatory lung disease

Khalid Saad Alharbi et al.

Summary: NF-xB is a crucial transcription factor involved in inflammation, immune response, and various physiological processes, playing a key role in many respiratory disorders.

CHEMICO-BIOLOGICAL INTERACTIONS (2021)

Add to Collection
Article Immunology

Ginsenoside Rg3 attenuates angiotensin II-induced myocardial hypertrophy through repressing NLRP3 inflammasome and oxidative stress via modulating SIRT1/NF-κB pathway

Bei Ren et al.

Summary: The study demonstrated that Rg3 can attenuate myocardial hypertrophy and fibrosis by inhibiting the NLRP3 inflammasome and oxidative stress, and promoting SIRT1/NF-kappa B pathway.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Add to Collection
Article Oncology

Ginsenoside Re exhibits neuroprotective effects by inhibiting neuroinflammation via CAMK/MAPK/NF-κB signaling in microglia

Iskander Madhi et al.

Summary: Ginsenoside Re (G-Re) inhibits the production of inflammatory mediators in microglial cells and protects hippocampal cells from inflammatory and neurotoxic factors. This suggests G-Re may be a potential treatment option for neuroinflammatory disorders and various neurodegenerative diseases.

MOLECULAR MEDICINE REPORTS (2021)

Add to Collection
Article Plant Sciences

Gintonin-enriched fraction improves sarcopenia by maintaining immune homeostasis in 20-to 24-month-old C57BL/6J mice

Hyun-Ji Oh et al.

Summary: The study showed that Gintonin-enriched fraction (GEF) can improve muscle strength, mass, and fiber size in old mice, restore immune homeostasis, and reduce inflammation, thus slowing muscle loss.

JOURNAL OF GINSENG RESEARCH (2021)

Add to Collection
Review Biotechnology & Applied Microbiology

Diabetic Nephropathy: Challenges in Pathogenesis, Diagnosis, and Treatment

Nur Samsu

Summary: Diabetic nephropathy is the leading cause of end-stage renal disease worldwide and diagnosis and treatment pose challenges, requiring additional therapeutic interventions. In addition to standard therapy, vitamin D receptor activators, incretin-related drugs, and therapies targeting inflammation may also be promising for preventing the progression of DN.

BIOMED RESEARCH INTERNATIONAL (2021)

Add to Collection
Review Cell Biology

RelB and Neuroinflammation

Karli Mockenhaupt et al.

Summary: Neuroinflammation involves multiple cell types in the central nervous system, which coordinate their responses by secreting and responding to inflammatory mediators. Critical activation of NF-kappa B pathways is observed during neuroinflammation, with specific mechanisms and roles of RelB activation in different cell types being less understood. This review summarizes the mechanisms of RelB activation in specific cell types within the CNS and its specialized effects during neuroinflammation.

CELLS (2021)

Add to Collection
Article Biochemistry & Molecular Biology

Ginsenoside Rg1 attenuates cardiomyocyte apoptosis and inflammation via the TLR4/NF-kB/NLRP3 pathway

Man Luo et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2020)

Add to Collection
Article Medicine, Research & Experimental

HMGB1 upregulates NF-kB by inhibiting IKB-α and associates with diabetic retinopathy

Wen-Jing Liang et al.

LIFE SCIENCES (2020)

Add to Collection
Article Pharmacology & Pharmacy

Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice

Yanyan Zhu et al.

PHARMACOLOGICAL RESEARCH (2020)

Add to Collection
Review Medicine, General & Internal

Osteoarthritis and inflammation: a serious disease with overlapping phenotypic patterns

Francis Berenbaum et al.

POSTGRADUATE MEDICINE (2020)

Add to Collection
Review Cell Biology

Impact of HMGB1, RAGE, and TLR4 in Alzheimer's Disease (AD): From Risk Factors to Therapeutic Targeting

Yam Nath Paudel et al.

CELLS (2020)

Add to Collection
Article Behavioral Sciences

Ginsenoside 20(S)-protopanaxadiol attenuates depressive-like behaviour and neuroinflammation in chronic unpredictable mild stress-induced depressive rats

Ning Jiang et al.

BEHAVIOURAL BRAIN RESEARCH (2020)

Add to Collection
Review Immunology

Targeting Inflammation Driven by HMGB1

Huan Yang et al.

FRONTIERS IN IMMUNOLOGY (2020)

Add to Collection
Article Neurosciences

Ginsenoside Rd attenuates blood-brain barrier damage by suppressing proteasome-mediated signaling after transient forebrain ischemia

Xiao Zhang et al.

NEUROREPORT (2020)

Add to Collection
Article Biochemistry & Molecular Biology

(20S)G-Rh2 Inhibits NF-κB Regulated Epithelial-Mesenchymal Transition by Targeting Annexin A2

Yu-Shi Wang et al.

BIOMOLECULES (2020)

Add to Collection
Article Plant Sciences

Ginsenoside Rb1 exerts anti-inflammatory effects in vitro and in vivo by modulating toll-like receptor 4 dimerization and NF-kB/MAPKs signaling pathways

Hongwei Gao et al.

PHYTOMEDICINE (2020)

Add to Collection
Article Biochemistry & Molecular Biology

Ginsenoside Rh2 impedes proliferation and migration and induces apoptosis by regulating NF-κB, MAPK, and PI3K/Akt/mTOR signaling pathways in osteosarcoma cells

Chenchen Li et al.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2020)

Add to Collection
Article Immunology

Interplay between RAGE and TLR4 Regulates HMGB1-Induced Inflammation by Promoting Cell Surface Expression of RAGE and TLR4

Hanhui Zhong et al.

JOURNAL OF IMMUNOLOGY (2020)

Add to Collection
Review Biochemistry & Molecular Biology

Insights into predicting diabetic nephropathy using urinary biomarkers

Naseer Ullah Khan et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2020)

Add to Collection
Article Pharmacology & Pharmacy

NF-κB inhibitors in treatment and prevention of lung cancer

Rajan Radha Rasmi et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Add to Collection
Article Chemistry, Medicinal

Design, synthesis and anti-inflammatory activity of 3-amino acid derivatives of ocotillol-type sapogenins

Gangqiang Yang et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

Add to Collection
Review Chemistry, Medicinal

Anticancer property of ginsenoside Rh2 from ginseng

Xun Li et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

Add to Collection
Article Biochemistry & Molecular Biology

Ginsenoside Rb3 Inhibits Pro-Inflammatory Cytokines via MAPK/AKT/NF-κB Pathways and Attenuates Rat Alveolar Bone Resorption in Response to Porphyromonas gingivalis LPS

Minmin Sun et al.

MOLECULES (2020)

Add to Collection
Article Medicine, Research & Experimental

Ginsenoside Rg3 alleviates inflammation in a rat model of myocardial infarction via the SIRT1/NF-κB pathway

Chenchen Tu et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2020)

Add to Collection
Review Cardiac & Cardiovascular Systems

What Is the Role of the Inflammation in the Pathogenesis of Heart Failure?

Elena C. Castillo et al.

CURRENT CARDIOLOGY REPORTS (2020)

Add to Collection
Article Plant Sciences

Effects of a dammarane-type saponin, ginsenoside Rd, in nicotine-induced vascular endothelial injury

Baobao Zhang et al.

PHYTOMEDICINE (2020)

Add to Collection
Review Immunology

Regulation of PD-L1 Expression by NF-κB in Cancer

Fabrizio Antonangeli et al.

FRONTIERS IN IMMUNOLOGY (2020)

Add to Collection
Review Biochemistry & Molecular Biology

Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study

Hui Yu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Add to Collection
Article Pharmacology & Pharmacy

PLGA microsphere-based composite hydrogel for dual delivery of ciprofloxacin and ginsenoside Rh2 to treat Staphylococcus aureus-induced skin infections

Minghao Sun et al.

DRUG DELIVERY (2020)

Add to Collection
Article Endocrinology & Metabolism

Ginsenoside Rb2 improves insulin resistance by inhibiting adipocyte pyroptosis

Yi Lin et al.

ADIPOCYTE (2020)

Add to Collection
Review Biochemistry & Molecular Biology

Molecular principles of metastasis: a hallmark of cancer revisited

Jawad Fares et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Add to Collection
Review Biochemistry & Molecular Biology

Kupffer Cells in Non-alcoholic Fatty Liver Disease: Friend or Foe?

Jiajia Chen et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2020)

Add to Collection
Review Plant Sciences

Non-clinical pharmacokinetic behavior of ginsenosides

Hyo-Joong Won et al.

JOURNAL OF GINSENG RESEARCH (2019)

Add to Collection
Review Biochemistry & Molecular Biology

Insulin and Insulin Receptors in Adipose Tissue Development

Angelo Cignarelli et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Crosstalk between the Akt/mTORC1 and NF-κB signaling pathways promotes hypoxia-induced pulmonary hypertension by increasing DPP4 expression in PASMCs

Ying Li et al.

ACTA PHARMACOLOGICA SINICA (2019)

Add to Collection
Review Biochemistry & Molecular Biology

Chemical Structures and Pharmacological Profiles of Ginseng Saponins

Ze-Yu Shi et al.

MOLECULES (2019)

Add to Collection
Review Immunology

NF-κB Signaling in Macrophages: Dynamics, Crosstalk, and Signal Integration

Michael G. Dorrington et al.

FRONTIERS IN IMMUNOLOGY (2019)

Add to Collection
Article Gastroenterology & Hepatology

Lactobacillus fermentum species ameliorate dextran sulfate sodium-induced colitis by regulating the immune response and altering gut microbiota

You Jin Jang et al.

GUT MICROBES (2019)

Add to Collection
Article Immunology

L-Fucose ameliorates DSS-induced acute colitis via inhibiting macrophage M1 polarization and inhibiting NLRP3 inflammasome and NF-kB activation

Ruohang He et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

Add to Collection
Review Plant Sciences

Ginsenosides: the need to move forward from bench to clinical trials

Seung Eun Yu et al.

JOURNAL OF GINSENG RESEARCH (2019)

Add to Collection
Article Biochemistry & Molecular Biology

Preparation of Polyethylene Glycol-Ginsenoside Rh1 and Rh2 Conjugates and Their Efficacy against Lung Cancer and Inflammation

Ramya Mathiyalagan et al.

MOLECULES (2019)

Add to Collection
Article Behavioral Sciences

Ginsenoside Rh2 reverses sleep deprivation-induced cognitive deficit in mice

Cong Lu et al.

BEHAVIOURAL BRAIN RESEARCH (2018)

Add to Collection
Article Biochemistry & Molecular Biology

Isoliquiritigenin protects against sepsis-induced lung and liver injury by reducing inflammatory responses

Xiong Chen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Add to Collection
Article Cell Biology

NFKB1 mediates Th1/Th17 activation in the pathogenesis of psoriasis

Fusheng Zhou et al.

CELLULAR IMMUNOLOGY (2018)

Add to Collection
Article Oncology

Exosome-mediated miR-222 transferring: An insight into NF-κ-mediated breast cancer metastasis

Jiaji Ding et al.

EXPERIMENTAL CELL RESEARCH (2018)

Add to Collection
Article Multidisciplinary Sciences

Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment

Claudia M. Wunderlich et al.

NATURE COMMUNICATIONS (2018)

Add to Collection
Review Plant Sciences

Functional role of ginseng-derived compounds in cancer

Akash Ahuja et al.

JOURNAL OF GINSENG RESEARCH (2018)

Add to Collection
Article Immunology

Inflammatory cytokines IL-17 and TNF-α up-regulate PD-L1 expression in human prostate and colon cancer cells

Xun Wang et al.

IMMUNOLOGY LETTERS (2017)

Add to Collection
Review Medicine, Research & Experimental

Anticancer effects of ginsenoside Rg3 (Review)

Mengyao Sun et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2017)

Add to Collection
Article Clinical Neurology

Hemorrhagic transformation and cerebral edema in acute ischemic stroke: Link to cerebral autoregulation

Pedro Castro et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2017)

Add to Collection
Review Biochemistry & Molecular Biology

State of Panax ginseng Research: A Global Analysis

Wanqi Xu et al.

MOLECULES (2017)

Add to Collection
Article Anesthesiology

Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis

Holly T. Philpott et al.

PAIN (2017)

Add to Collection
Article Pathology

Bone and the Immune System

M. Neale Weitzmann

TOXICOLOGIC PATHOLOGY (2017)

Add to Collection
Review Nutrition & Dietetics

Nonalcoholic Fatty Liver Disease and Insulin Resistance: New Insights and Potential New Treatments

Hironori Kitade et al.

NUTRIENTS (2017)

Add to Collection
Review Plant Sciences

Effects of ginseng on stress-related depression, anxiety, and the hypothalamic-pituitary-adrenal axis

Seungyeop Lee et al.

JOURNAL OF GINSENG RESEARCH (2017)

Add to Collection
Review Plant Sciences

Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases

Ji Hye Kim et al.

JOURNAL OF GINSENG RESEARCH (2017)

Add to Collection
Article Multidisciplinary Sciences

NF-kappaB Is Involved in the Regulation of EMT Genes in Breast Cancer Cells

Bruno R. B. Pires et al.

PLOS ONE (2017)

Add to Collection
Review Biochemistry & Molecular Biology

NF-kappa B signaling in inflammation

Ting Liu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2017)

Add to Collection
Review Immunology

The non-canonical NF-κB pathway in immunity and inflammation

Shao-Cong Sun

NATURE REVIEWS IMMUNOLOGY (2017)

Add to Collection
Article Oncology

Inhibition of MMP-2 and MMP-9 decreases cellular migration, and angiogenesis in in vitro models of retinoblastoma

Anderson H. Webb et al.

BMC CANCER (2017)

Add to Collection
Review Pharmacology & Pharmacy

JAK-STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects

Shubhasree Banerjee et al.

DRUGS (2017)

Add to Collection
Article Biochemistry & Molecular Biology

Dexamethasone-induced muscular atrophy is mediated by functional expression of connexin-based hemichannels

Luis A. Cea et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2016)

Add to Collection
Editorial Material Gastroenterology & Hepatology

Inflammation in Alcoholic and Nonalcoholic Fatty Liver Disease: Friend or Foe?

Bin Gao et al.

GASTROENTEROLOGY (2016)

Add to Collection
Review Immunology

The immune system's role in sepsis progression, resolution, and long-term outcome

Matthew J. Delano et al.

IMMUNOLOGICAL REVIEWS (2016)

Add to Collection
Article Neurosciences

A NOVEL NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 2 (Nrf2) ACTIVATOR RS9 ATTENUATES BRAIN INJURY AFTER ISCHEMIA REPERFUSION IN MICE

Keita Yamauchi et al.

NEUROSCIENCE (2016)

Add to Collection
Article Multidisciplinary Sciences

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells

Giuseppina Arbore et al.

SCIENCE (2016)

Add to Collection
Review Medicine, General & Internal

Role of EMT in Metastasis and Therapy Resistance

Bethany N. Smith et al.

JOURNAL OF CLINICAL MEDICINE (2016)

Add to Collection
Review Cell Biology

Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches

Mi Hee Park et al.

CELLS (2016)

Add to Collection
Article Rehabilitation

Risk factors and burden of osteoarthritis

Clemence Palazzo et al.

ANNALS OF PHYSICAL AND REHABILITATION MEDICINE (2016)

Add to Collection
Article Biochemistry & Molecular Biology

Migration and invasion of drug-resistant lung adenocarcinoma cells are dependent on mitochondrial activity

Ji Hoon Jeon et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2016)

Add to Collection
Article Biochemistry & Molecular Biology

NLRP3 inflammasome expression is driven by NF-κB in cultured hepatocytes

Sorina Georgiana Boaru et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Add to Collection
Article Biochemistry & Molecular Biology

Dissecting molecular cross-talk between Nrf2 and NF-kappa B response pathways

Joanna D. Wardyn et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2015)

Add to Collection
Article Oncology

EGF-stimulated AKT activation is mediated by EGFR recycling via an early endocytic pathway in a gefitinib-resistant human lung cancer cell line

Yukio Nishimura et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2015)

Add to Collection
Article Plant Sciences

Characterization of Korean Red Ginseng (Panax ginseng Meyer): History, preparation method, and chemical composition

Sang Myung Lee et al.

JOURNAL OF GINSENG RESEARCH (2015)

Add to Collection
Article Endocrinology & Metabolism

Metformin and Inflammation: Its Potential Beyond Glucose-lowering Effect

Yoshifumi Saisho

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS (2015)

Add to Collection
Review Rheumatology

Fatigue in chronic inflammation - a link to pain pathways

Karine Louati et al.

ARTHRITIS RESEARCH & THERAPY (2015)

Add to Collection
Review Biochemistry & Molecular Biology

NF-kappaB Signaling in Chronic Inflammatory Airway Disease

Michael Schuliga

BIOMOLECULES (2015)

Add to Collection
Review Biochemistry & Molecular Biology

Stress, Inflammation, and Defense of Homeostasis

Raj Chovatiya et al.

MOLECULAR CELL (2014)

Add to Collection
Review Cardiac & Cardiovascular Systems

The inflammatory response in myocardial injury, repair, and remodelling

Nikolaos G. Frangogiannis

NATURE REVIEWS CARDIOLOGY (2014)

Add to Collection
Article Neurosciences

Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis

Ashley E. Frakes et al.

NEURON (2014)

Add to Collection
Editorial Material Immunology

Beyonc MyD88 and TRIF pathways in Toll-like receptor signaling

Vincent Piras et al.

FRONTIERS IN IMMUNOLOGY (2014)

Add to Collection
Article Ophthalmology

NF-κB-Mediated Nitric Oxide Production and Activation of Caspase-3 Cause Retinal Ganglion Cell Death in the Hypoxic Neonatal Retina

Gurugirijha Rathnasamy et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2014)

Add to Collection
Article Cardiac & Cardiovascular Systems

Forecasting the Impact of Heart Failure in the United States A Policy Statement From the American Heart Association

Paul A. Heidenreich et al.

CIRCULATION-HEART FAILURE (2013)

Add to Collection
Article Integrative & Complementary Medicine

The Efficacy of Red Ginseng in Type 1 and Type 2 Diabetes in Animals

Bin Na Hong et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013)

Add to Collection
Review Immunology

The inflammatory response in sepsis

Markus Bosmann et al.

TRENDS IN IMMUNOLOGY (2013)

Add to Collection
Article Physiology

Kupffer Cells in the Liver

Laura J. Dixon et al.

COMPREHENSIVE PHYSIOLOGY (2013)

Add to Collection
Review Immunology

Pathogen Recognition by the Innate Immune System

Himanshu Kumar et al.

INTERNATIONAL REVIEWS OF IMMUNOLOGY (2011)

Add to Collection
Article Immunology

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

Laura Codarri et al.

NATURE IMMUNOLOGY (2011)

Add to Collection
Article Immunology

The encephalitogenicity of TH17 cells is dependent on IL-1-and IL-23-induced production of the cytokine GM-CSF

Mohamed El-Behi et al.

NATURE IMMUNOLOGY (2011)

Add to Collection
Article Integrative & Complementary Medicine

Neuroprotective effects of ginsenosides Rh-1 and Rg(2) on neuronal cells

Xiao-Fan Li et al.

CHINESE MEDICINE (2011)

Add to Collection
Review Oncology

TNF-α/NF-κB/Snail pathway in cancer cell migration and invasion

Y. Wu et al.

BRITISH JOURNAL OF CANCER (2010)

Add to Collection
Review Cardiac & Cardiovascular Systems

The nuclear factor-kappa B-interleukin-6 signalling pathway mediating vascular inflammation

Allan R. Brasier

CARDIOVASCULAR RESEARCH (2010)

Add to Collection
Review Biochemistry & Molecular Biology

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

Kai Kessenbrock et al.

CELL (2010)

Add to Collection
Article Immunology

Nonsteroidal Anti-Inflammatory Drugs Increase TNF Production in Rheumatoid Synovial Membrane Cultures and Whole Blood

Theresa H. Page et al.

JOURNAL OF IMMUNOLOGY (2010)

Add to Collection
Article Biochemistry & Molecular Biology

The role of hepatic fat accumulation in pathogenesis of non-alcoholic fatty liver disease (NAFLD)

Qing Liu et al.

LIPIDS IN HEALTH AND DISEASE (2010)

Add to Collection
Review Biotechnology & Applied Microbiology

Targeting Toll-like receptors: emerging therapeutics?

Elizabeth J. Hennessy et al.

NATURE REVIEWS DRUG DISCOVERY (2010)

Add to Collection
Review Cell Biology

MAPK signaling in inflammation-associated cancer development

Pengyu Huang et al.

PROTEIN & CELL (2010)

Add to Collection
Article Immunology

The immune system and the gut microbiota: friends or foes?

Nadine Cerf-Bensussan et al.

NATURE REVIEWS IMMUNOLOGY (2010)

Add to Collection
Article Oncology

Akt-mediated regulation of NFκB and the essentialness of NFκB for the oncogenicity of PI3K and Akt

Dong Bai et al.

INTERNATIONAL JOURNAL OF CANCER (2009)

Add to Collection
Article Biochemistry & Molecular Biology

The NF-κB Factor RelB and Histone H3 Lysine Methyltransferase G9a Directly Interact to Generate Epigenetic Silencing in Endotoxin Tolerance

Xiaoping Chen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Add to Collection
Article Cell Biology

The glycosaminoglycan-binding domain of PRELP acts as a cell type-specific NF-κB inhibitor that impairs osteoclastogenesis

Nadia Rucci et al.

JOURNAL OF CELL BIOLOGY (2009)

Add to Collection
Article Cell Biology

The NF-κB Family of Transcription Factors and Its Regulation

Andrea Oeckinghaus et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2009)

Add to Collection
Article Pharmacology & Pharmacy

20(S)-ginsenoside Rg3 enhances glucose-stimulated insulin secretion and activates AMPK

Min Woo Park et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2008)

Add to Collection
Article Integrative & Complementary Medicine

Effect and mechanism of ginsenoside Rg3 on postoperative life span of patients with non-small cell lung cancer

Ping Lu et al.

Chinese Journal of Integrative Medicine (2008)

Add to Collection
Review Peripheral Vascular Disease

Angiogenesis in cancer

Naoyo Nishida et al.

VASCULAR HEALTH AND RISK MANAGEMENT (2006)

Add to Collection
Article Multidisciplinary Sciences

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

M Yamamoto et al.

SCIENCE (2003)

Add to Collection
Article Biochemistry & Molecular Biology

Modulation of NF-κB activity by exchange of dimers

S Saccani et al.

MOLECULAR CELL (2003)

Add to Collection
Article Medicine, General & Internal

Molecular mechanisms underlying anti-tumor promoting activities of heat-processed Panax ginseng CA Meyer

YJ Surh et al.

JOURNAL OF KOREAN MEDICAL SCIENCE (2001)

Add to Collection
Article Medicine, General & Internal

Chemistry and cancer preventing activities of ginseng saponins and some related triterpenoid compounds

S Shibata

JOURNAL OF KOREAN MEDICAL SCIENCE (2001)

Add to Collection
Review Gastroenterology & Hepatology

COX-1 and COX-2 inhibitors

CJ Hawkey

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY (2001)

Add to Collection
Article Medicine, Research & Experimental

Therapeutic potential of inhibition of the NF-kappa B pathway in the treatment of inflammation and cancer

Y Yamamoto et al.

JOURNAL OF CLINICAL INVESTIGATION (2001)

Add to Collection
Article Medicine, Research & Experimental

NF-kappa B: a key role in inflammatory diseases

PP Tak et al.

JOURNAL OF CLINICAL INVESTIGATION (2001)

Add to Collection
Webinars Posters Questions Hubs Funding Journals Papers Connect Collections Reviewers About Us FAQs Mobile App Privacy Policy Terms of Use
© Peeref 2019-2024. All rights reserved.