The Human Virome and Its Crosslink with Glomerulonephritis and IgA Nephropathy

The prokaryotic, viral, fungal, and parasitic microbiome exists in a highly intricate connection with the human host. In addition to eukaryotic viruses, due to the existence of various host bacteria, phages are widely spread throughout the human body. However, it is now evident that some viral community states, as opposed to others, are indicative of health and might be linked to undesirable outcomes for the human host. Members of the virome may collaborate with the human host to retain mutualistic functions in preserving human health. Evolutionary theories contend that a particular microbe's ubiquitous existence may signify a successful partnership with the host. In this Review, we present a survey of the field's work on the human virome and highlight the role of viruses in health and disease and the relationship of the virobiota with immune system control. Moreover, we will analyze virus involvement in glomerulonephritis and in IgA nephropathy, theorizing the molecular mechanisms that may be responsible for the crosslink with these renal diseases.

Automated summary

The human virome, consisting of prokaryotes, viruses, fungi, and parasites, is intricately connected with the human host. Different viral community states have been identified as indicators of health or undesirable outcomes for the host. The virome can collaborate with the human host in maintaining mutualistic functions and preserving human health. This Review explores the role of viruses in health and disease, the relationship between the virobiota and immune system control, and the potential molecular mechanisms linking viruses to glomerulonephritis and IgA nephropathy.