4.7 Article

Polystyrene Microplastics Induce Oxidative Stress in Mouse Hepatocytes in Relation to Their Size

Related references

Note: Only part of the references are listed.
Article Environmental Sciences

Effects of nano- and microplastics on kidney: Physicochemical properties, bioaccumulation, oxidative stress and immunoreaction

Xuemei Meng et al.

Summary: The study revealed that nanoplastics and microplastics had toxic effects on the kidneys of mice, causing aggregation and biotoxicity, leading to weight loss, increased death rate, altered biomarkers, and kidney tissue damage. Additionally, exposure to these particles induced oxidative stress and inflammation in the mice.

CHEMOSPHERE (2022)

Article Pharmacology & Pharmacy

The role of DRP1-PINK1-Parkin-mediated mitophagy in early cadmium-induced liver damage

Jian Sun et al.

Summary: Cadmium is an important environmental pollutant that causes damage to multiple systems of the body. This study found that cadmium damages liver cells, disrupts the structure and function of mitochondria, and increases the production of superoxide anions. It was also discovered that cadmium increases mitochondrial division and induces mitophagy through the PINK1-Parkin pathway. Mitophagy plays a protective role in early cadmium-induced liver damage.

TOXICOLOGY (2022)

Article Environmental Sciences

Activation of pyroptosis and ferroptosis is involved in the hepatotoxicity induced by polystyrene microplastics in mice

Yingwen Mu et al.

Summary: The study shows that microplastics can damage the liver structure and function in mice, leading to inflammation and oxidative damage, and triggering processes of pyroptosis and ferroptosis.

CHEMOSPHERE (2022)

Article Environmental Sciences

Enrichment of polystyrene microplastics induces histological damage, oxidative stress, Keap1-Nrf2 signaling pathway-related gene expression in loach juveniles (Paramisgurnus dabryanus)

Xianqing Wang et al.

Summary: Polystyrene microplastics (PS-MPs) have harmful effects on aquatic organisms, but their precise effects are not completely understood. This study investigated the enrichment of PS-MPs in loach juveniles and its effects on their growth, liver histomorphology, antioxidant enzymes, and Keap1-Nrf2 signaling pathway-related gene expression. The results showed that PS-MPs were enriched in the liver, intestine, and gill of loach, and their enrichment amount was higher in the liver than in the gill and intestine. PS-MPs also caused liver damage and decreased the activities of antioxidant enzymes.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

Review Biochemistry & Molecular Biology

Oxidative Stress, Genomic Integrity, and Liver Diseases

Nanthini Sadasivam et al.

Summary: Excessive production of reactive oxygen species and free radicals can cause oxidative stress, damaging cells and leading to various diseases. Antioxidants play a crucial role in maintaining cellular homeostasis and protecting organs from oxidative damage, especially the liver which is more susceptible to oxidative conditions.

MOLECULES (2022)

Article Environmental Sciences

Polystyrene microplastics induce hepatotoxicity and disrupt lipid metabolism in the liver organoids

Wei Cheng et al.

Summary: This study investigated the adverse biological effects of microplastic particles on human liver using a novel in vitro 3D model, revealing potential hepatotoxicity and disruption of lipid metabolism. The findings provide insights into the risks associated with microplastics on human health.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

Article Oncology

SIRT3-mediated deacetylation protects inner hair cell synapses in a H2O2-induced oxidative stress model in vitro

Chunli Zhao et al.

Summary: The overexpression of SIRT3 may be a potential therapeutic approach for damaged inner hair cell synapses induced by oxidative stress.

EXPERIMENTAL CELL RESEARCH (2022)

Review Environmental Sciences

Are Ingested or Inhaled Microplastics Involved in Nonalcoholic Fatty Liver Disease?

Teresa Auguet et al.

Summary: Nonalcoholic fatty liver disease (NAFLD) is influenced by dietary and environmental factors, and plastic pollution may contribute to its development and progression. Laboratory studies have shown that plastic particles can cause inflammation, immune responses, and metabolic disorders, as well as potentially alter gut microbiota composition. Mitigation of plastic pollution and reducing human exposure levels may help reduce the risk of NAFLD.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

Article Chemistry, Multidisciplinary

Effects of Polystyrene Microplastics on Human Kidney and Liver Cell Morphology, Cellular Proliferation, and Metabolism

Kerestin E. Goodman et al.

Summary: Microplastics have gained attention due to their prevalence in our daily lives. This study found that ingestion of microplastics could have adverse effects on human kidney and liver cells, potentially leading to problems with cell metabolism and cell-cell interactions.

ACS OMEGA (2022)

Article Engineering, Environmental

Reproductive toxicity of polystyrene microplastics: In vivo experimental study on testicular toxicity in mice

Baolian Hou et al.

Summary: This study evaluated the impact of microplastics on spermatogenesis in mice, showing a significant reduction in sperm count and an increase in deformity rate. Exposure to microplastics caused atrophy, shedding, and apoptosis of sperm cells in the testis, and disrupted the balance of Nrf2/HO-1/NF-κB pathway, leading to abnormal sperm quality in ICR mice.

JOURNAL OF HAZARDOUS MATERIALS (2021)

Article Environmental Sciences

Exposure to polystyrene microplastics impairs gonads of zebrafish (Danio rerio)

Liyuan Qiang et al.

Summary: This study found that exposure to polystyrene microplastics can induce molecular responses and histological alterations in fish gonads, potentially causing adverse effects on fish reproductive organs.

CHEMOSPHERE (2021)

Review Toxicology

Distribution and translocation of micro- and nanoplastics in fish

Cuizhu Ma et al.

Summary: The study summarizes the distribution of microplastics and nanoplastics in fish, discusses their translocation ability and pathways into cells. Understanding the presence and translocation mechanisms of these plastic particles in aquatic organisms is crucial for assessing pollution impacts and environmental protection.

CRITICAL REVIEWS IN TOXICOLOGY (2021)

Article Engineering, Environmental

Dietary polystyrene nanoplastics exposure alters liver lipid metabolism and muscle nutritional quality in carnivorous marine fish large yellow croaker (Larimichthys crocea)

Wencong Lai et al.

Summary: The study revealed that PS NPs adversely affected the survival and growth of carnivorous marine fish, inducing excessive liver lipid accumulation and altering the fatty acid composition and texture of fish muscle.

JOURNAL OF HAZARDOUS MATERIALS (2021)

Article Environmental Sciences

Effects of microplastics and glyphosate on growth rate, morphological plasticity, photosynthesis, and oxidative stress in the aquatic species Salvinia cucullata

Hongwei Yu et al.

Summary: Glyphosate and microplastics have specific ecotoxicity effects on aquatic plants, with glyphosate reducing growth rate, photosynthetic capacity, and root activity of S. cucullata, while microplastics mainly affect growth rate and root activity. Both pollutants activate antioxidant defense systems in plants. Synergistic effects of glyphosate and microplastics were observed in leaf yellowing under high concentrations. Overall, the study highlights the potential impact of pervasive microplastics and herbicide contamination on the growth of aquatic plants in freshwater ecosystems.

ENVIRONMENTAL POLLUTION (2021)

Article Nutrition & Dietetics

Protective Effects of Sesamol against Liver Oxidative Stress and Inflammation in High-Fat Diet-Induced Hepatic Steatosis

Wenya Zheng et al.

Summary: The study demonstrated that sesamol (SEM) has inhibitory effects on oxidative stress induced by chronic high-fat diet (HFD) in the liver, reversing inflammation and enhancing antioxidant defenses through the Nrf2 pathway, ultimately protecting liver health.

NUTRIENTS (2021)

Article Environmental Sciences

The Kidney-Related Effects of Polystyrene Microplastics on Human Kidney Proximal Tubular Epithelial Cells HK-2 and Male C57BL/6 Mice

Yung-Li Wang et al.

Summary: The study aimed to investigate the effects of PS-MPs on kidney cells in vitro and in vivo. The results showed that PS-MPs caused mitochondrial dysfunction, ER stress, inflammation, and autophagy in kidney cells, and accumulated in both cells and mouse kidneys.

ENVIRONMENTAL HEALTH PERSPECTIVES (2021)

Article Environmental Sciences

Transgenerational neurotoxicity of polystyrene microplastics induced by oxidative stress in Caenorhabditis elegans

Haibo Chen et al.

Summary: This study found that maternal exposure to PS-MPs can result in the transgenerational neurotoxicity in C. elegans, with oxidative stress playing a key role in this process. Furthermore, the upregulation of oxidative stress-related genes across generations may be involved in regulating neurotoxicity in C. elegans.

CHEMOSPHERE (2021)

Article Engineering, Environmental

Polystyrene microplastics-induced ROS overproduction disrupts the skeletal muscle regeneration by converting myoblasts into adipocytes

Wang Shengchen et al.

Summary: The environmental problem of Microplastics pollution has caused a significant threat to human and animal health globally. The exposure to different sizes of polystyrene microplastics affects the growth and repair of skeletal muscles in mice, with delayed regeneration and negative correlation with particle size. Mechanistic research revealed that ROS overproduction caused by microplastics disturbed muscle regeneration and directed the fate of satellite cells.

JOURNAL OF HAZARDOUS MATERIALS (2021)

Article Toxicology

Underestimated health risks: polystyrene micro- and nanoplastics jointly induce intestinal barrier dysfunction by ROS-mediated epithelial cell apoptosis

Boxuan Liang et al.

Summary: The study found that the combination of PS50 and PS500 in the mouse intestines could lead to dysfunction of the intestinal barrier, primarily through ROS-mediated epithelial cell apoptosis. It suggests that the health risks of exposure to PS micro- and nanoplastics on organisms may be underestimated due to previous studies focusing on single particle sizes.

PARTICLE AND FIBRE TOXICOLOGY (2021)

Review Environmental Sciences

Environmental exposure to microplastics: An overview on possible human health effects

Joana Correia Prata et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2020)

Review Chemistry, Analytical

Ecotoxicological effects of microplastics: Examination of biomarkers, current state and future perspectives

Marko D. Prokic et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2019)

Review Environmental Sciences

Inhibition of copper-zinc superoxide dismutase activity by selected environmental xenobiotics

Lukasz Lewandowski et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2018)

Review Urology & Nephrology

Sirtuins in Renal Health and Disease

Marina Morigi et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)

Article Environmental Sciences

Polystyrene microplastics induce gut microbiota dysbiosis and hepatic lipid metabolism disorder in mice

Liang Lu et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2018)

Article Biochemistry & Molecular Biology

SIRT3/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress

Jing Gao et al.

CELL DEATH AND DIFFERENTIATION (2018)

Article Biochemistry & Molecular Biology

Protective Role of Tetrahydrocurcumin: an Active Polyphenolic Curcuminoid on Cadmium-InducedOxidative Damage in Rats

Ramalingam Ramakrishnan et al.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2017)

Article Cardiac & Cardiovascular Systems

Sirt3 Impairment and SOD2 Hyperacetylation in Vascular Oxidative Stress and Hypertension

Anna E. Dikalova et al.

CIRCULATION RESEARCH (2017)

Article Engineering, Environmental

Uptake and Accumulation of Polystyrene Microplastics in Zebrafish (Danio rerio) and Toxic Effects in Liver

Yifeng Lu et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2016)

Review Cardiac & Cardiovascular Systems

Protective effects of sirtuins in cardiovascular diseases: from bench to bedside

Stephan Winnik et al.

EUROPEAN HEART JOURNAL (2015)

Article Environmental Sciences

Microplastics in freshwater ecosystems: what we know and what we need to know

Martin Wagner et al.

Environmental Sciences Europe (2014)

Review Biochemistry & Molecular Biology

Manganese superoxide dismutase: beyond life and death

Aaron K. Holley et al.

AMINO ACIDS (2012)

Review Environmental Sciences

Microplastics as contaminants in the marine environment: A review

Matthew Cole et al.

MARINE POLLUTION BULLETIN (2011)

Review Gastroenterology & Hepatology

AGA technical review on the evaluation of liver chemistry tests

RM Green et al.

GASTROENTEROLOGY (2002)