Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 24, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/ijms24087382
Keywords
microplastics; liver; oxidative stress; SIRT3; SOD2
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Microplastics have emerged as a new type of environmental pollutant that can accumulate in various tissues and organs of the body, leading to chronic damage. This study investigated the impact of polystyrene microplastics (PS-MPs) with different particle sizes (5 μm and 0.5 μm) on oxidative stress in the liver using mouse models. The results demonstrated that PS-MPs exposure resulted in decreased body weight and liver-to-body weight ratio. Histological and electron microscopy analysis revealed disorganized cellular structure, nuclear crinkling, and mitochondrial vacuolation in the liver tissue exposed to PS-MPs. Moreover, PS-MPs exposure exacerbated oxidative stress in hepatocytes, with the 5 μm PS-MPs group showing more severe damage compared to the 0.5 μm PS-MPs group.
Microplastics have become a new type of environmental pollutant that can accumulate in various tissues and organs of the body and cause chronic damage. In this study, two different size polystyrene microplastics (PS-MPs, 5 mu m and 0.5 mu m) exposure models were established in mice to investigate the effects of PS-MPs with different particle sizes on oxidative stress in the liver. The results showed that PS-MPs exposure caused a decrease in body weight and liver-to-body weight. The hematoxylin and eosin staining and transmission electron microscopy results showed that exposure to PS-MPs led to the disorganized cellular structure of liver tissue, nuclear crinkling, and mitochondrial vacuolation. The extent of damage in the 5 mu m PS-MP exposure group was more extensive when compared with the other group. The evaluation of oxidative-stress-related indicators showed that PS-MPs exposure exacerbated oxidative stress in hepatocytes, especially in the 5 mu m PS-MPs group. The expression of oxidative-stress-related proteins sirtuin 3(SIRT3) and superoxide dismutase (SOD2) was significantly reduced, and the reduction was more pronounced in the 5 mu m PS-MPs group. In conclusion, PS-MPs exposure led to oxidative stress in mouse hepatocytes and caused more severe damage in the 5 mu m PS-MPs group when compared with the 0.5 mu m PS-MPs group.
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