4.7 Article

Electrophysiological Properties of Tetraploid Cardiomyocytes Derived from Murine Pluripotent Stem Cells Generated by Fusion of Adult Somatic Cells with Embryonic Stem Cells

Related references

Note: Only part of the references are listed.
Article Cell Biology

Accelerated Growth, Differentiation, and Ploidy with Reduced Proliferation of Right Ventricular Cardiomyocytes in Children with Congenital Heart Defect Tetralogy of Fallot

Tatyana V. Sukhacheva et al.

Summary: Children with tetralogy of Fallot (TF) experience hemodynamic overload and hypoxemia after birth. Comparative analysis showed significant increase in ploidy and morphology of right ventricular cardiomyocytes in these children. Connexin43-containing gap junctions were predominantly distributed diffusely over the cardiomyocytes sarcolemma and redistributed into intercalated discs during cardiomyocyte differentiation. The number of Ki67-positive cardiomyocytes varied greatly and decreased with increased myocytes differentiation. Ultrastructural signs of immaturity and proliferative activity were observed in cardiomyocytes of children with TF. The proportion of interstitial tissue did not differ significantly from the control group. Myocardium in children with TF under six months of age was most sensitive to hypoxemia, resulting in delayed intercalated discs and myofibril assembly, and dystrophic changes in cardiomyocytes. The adaptation to hemodynamic overload and hypoxemia in immature myocardium of TF children involved the acceleration of ontogenetic growth and differentiation of cardiomyocytes, rather than reactivation of their proliferation.

CELLS (2022)

Review Cardiac & Cardiovascular Systems

Changes in Cardiomyocyte Cell Cycle and Hypertrophic Growth During Fetal to Adult in Mammals

Sanford P. Bishop et al.

Summary: The inability of adult cardiomyocytes to repair injuries leads to severe cardiac disability and even death, while fetal cardiomyocytes can continuously replicate. Recent studies showing complete repair of severe injuries in early neonatal mice and pigs have prompted further research into regulating the cardiomyocyte cell cycle.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

Article Cardiac & Cardiovascular Systems

Proximity to injury, but neither number of nuclei nor ploidy define pathological adaptation and plasticity in cardiomyocytes

Michael Hesse et al.

Summary: Researchers investigated transcriptomes and cellular features of mononuclear and binuclear cardiomyocytes in adult mouse hearts, finding that mononuclear cardiomyocytes generally had a higher ploidy level. However, gene expression profiles and injury responses in cardiomyocytes were independent of the number of nuclei or ploidy levels.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2021)

Article Cell Biology

Mitochondrial-cell cycle cross-talk drives endoreplication in heart disease

Corinne Bischof et al.

Summary: Endoreplication, a type of growth mechanism in disease, is still poorly understood in terms of its metabolic basis and connection to morphologic growth. Studies have shown a direct coupling between endoreplication and hypertrophy in heart disease, revealing a new mechanism for pathologic overgrowth in failing myocardium.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Review Developmental Biology

Polyploid cardiomyocytes: implications for heart regeneration

Anna Kirillova et al.

Summary: Terminally differentiated cardiomyocytes are usually polyploid, limiting cell proliferation and cardiac regeneration. Mechanisms generating bi- and multi-nucleated cardiomyocytes, as well as polyploid nuclei, have been studied.

DEVELOPMENT (2021)

Review Physiology

Cardiomyocyte Polyploidy and Implications for Heart Regeneration

Peiheng Gan et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 82 (2020)

Review Cardiac & Cardiovascular Systems

Polyploidy in Cardiomyocytes Roadblock to Heart Regeneration?

Wouter Derks et al.

CIRCULATION RESEARCH (2020)

Article Biochemistry & Molecular Biology

Abcg2-expressing side population cells contribute to cardiomyocyte renewal through fusion

Amritha Yellamilli et al.

FASEB JOURNAL (2020)

Review Cardiac & Cardiovascular Systems

Role of Mononuclear Cardiomyocytes in Cardiac Turnover and Regeneration

Cora Becker et al.

CURRENT CARDIOLOGY REPORTS (2020)

Review Gastroenterology & Hepatology

Polyploidy in liver development, homeostasis and disease

Romain Donne et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

Article Cell & Tissue Engineering

Naive Pluripotent Stem Cells Exhibit Phenotypic Variability that Is Driven by Genetic Variation

Daniel Ortmann et al.

CELL STEM CELL (2020)

Article Cardiac & Cardiovascular Systems

Mono- and multi-nucleated ventricular cardiomyocytes constitute a transcriptionally homogenous cell population

Michail Yekelchyk et al.

BASIC RESEARCH IN CARDIOLOGY (2019)

Article Cell Biology

Myocardial Polyploidization Creates a Barrier to Heart Regeneration in Zebrafish

Juan Manuel Gonzalez-Rosa et al.

DEVELOPMENTAL CELL (2018)

Article Genetics & Heredity

Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration

Michaela Patterson et al.

NATURE GENETICS (2017)

Article Biochemistry & Molecular Biology

No Evidence for Cardiomyocyte Number Expansion in Preadolescent Mice

Kanar Alkass et al.

Article Biochemistry & Molecular Biology

Dynamics of Cell Generation and Turnover in the Human Heart

Olaf Bergmann et al.

Article Cell Biology

Electrophysiological Characteristics of Embryonic Stem Cell-Derived Cardiomyocytes are Cell Line-Dependent

Tobias Hannes et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2015)

Article Cardiac & Cardiovascular Systems

Cardiac Stem Cell Hybrids Enhance Myocardial Repair

Pearl Quijada et al.

CIRCULATION RESEARCH (2015)

Article Medicine, Research & Experimental

Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease

Geraldine Gentric et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Review Genetics & Heredity

When bigger is better: the role of polyploidy in organogenesis

Terry L. Orr-Weaver

TRENDS IN GENETICS (2015)

Review Pharmacology & Pharmacy

Binucleation of cardiomyocytes: the transition from a proliferative to a terminally differentiated state

Alexandra N. Paradis et al.

DRUG DISCOVERY TODAY (2014)

Article Cardiac & Cardiovascular Systems

Effect of Human Donor Cell Source on Differentiation and Function of Cardiac Induced Pluripotent Stem Cells

Veronica Sanchez-Freire et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2014)

Article Multidisciplinary Sciences

Chromosome Instability in mouse Embryonic Stem Cells

Nerea Gaztelumendi et al.

SCIENTIFIC REPORTS (2014)

Review Cell Biology

The incredible journey: From megakaryocyte development to platelet formation

Kellie R. Machlus et al.

JOURNAL OF CELL BIOLOGY (2013)

Article Multidisciplinary Sciences

Mammalian heart renewal by pre-existing cardiomyocytes

Samuel E. Senyo et al.

NATURE (2013)

Article Multidisciplinary Sciences

Cardiomyocyte proliferation contributes to heart growth in young humans

Mariya Mollova et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Cell Biology

Physiological significance of polyploidization in mammalian cells

Shusil K. Pandit et al.

TRENDS IN CELL BIOLOGY (2013)

Review Biochemistry & Molecular Biology

Mononucleated and binucleated cardiomyocytes in left atrium and pulmonary vein have different electrical activity and calcium dynamics

Chun-Feng Huang et al.

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2012)

Article Multidisciplinary Sciences

Myogenic Reprogramming of Bone Marrow Derived Cells in a W41Dmdmdx Deficient Mouse Model

Stuart Walsh et al.

PLOS ONE (2011)

Article Biochemistry & Molecular Biology

Functional characterization of cardiomyocytes derived from murine induced pluripotent stem cells in vitro

Alexey Kuzmenkin et al.

FASEB JOURNAL (2009)

Article Cardiac & Cardiovascular Systems

Generation of functional murine cardiac myocytes from induced pluripotent stem cells

Christina Mauritz et al.

CIRCULATION (2008)

Article Neurosciences

Bone marrow stromal cells protect and repair damaged neurons through multiple mechanisms

Masaaki Hokari et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2008)

Article Biotechnology & Applied Microbiology

Marked differences in differentiation propensity among human embryonic stem cell lines

Kenji Osafune et al.

NATURE BIOTECHNOLOGY (2008)

Article Biochemistry & Molecular Biology

Dominant manifestation of pluripotency in embryonic stem cell hybrids with various numbers of somatic chromosomes

Anna A. Vasilkova et al.

MOLECULAR REPRODUCTION AND DEVELOPMENT (2007)

Article Immunology

Serpin-6 expression protects embryonic stem cells from lysis by antigen-specific CTL

Zeinab Abdullah et al.

JOURNAL OF IMMUNOLOGY (2007)

Article Cell & Tissue Engineering

Genome-wide reprogramming in hybrids of somatic cells and embryonic stem cells

Dominic J. Ambrosi et al.

STEM CELLS (2007)

Article Cardiac & Cardiovascular Systems

Anillin localization defect in cardiomyocyte binucleation

Felix B. Engel et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2006)

Article Cardiac & Cardiovascular Systems

Endomitosis and polyploidization of myocardial cells in the periphery of human acute myocardial infarction

PC Meckert et al.

CARDIOVASCULAR RESEARCH (2005)

Article Biochemistry & Molecular Biology

Unequal segregation of parental chromosomes in embryonic stem cell hybrids

NM Matveeva et al.

MOLECULAR REPRODUCTION AND DEVELOPMENT (2005)

Article Cell Biology

Cardiomyocytes fuse with surrounding noncardiomyocytes and reenter the cell cycle

K Matsuura et al.

JOURNAL OF CELL BIOLOGY (2004)

Article Cell & Tissue Engineering

Nuclei of embryonic stem cells reprogram somatic cells

JT Do et al.

STEM CELLS (2004)

Article Biochemistry & Molecular Biology

Liver cell polyploidization:: A pivotal role for binuclear hepatocytes

JE Guidotti et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Multidisciplinary Sciences

Contribution of transplanted bone marrow cells to Purkinje neurons in human adult brains

JM Weimann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Multidisciplinary Sciences

Changing potency by spontaneous fusion

QL Ying et al.

NATURE (2002)

Article Biochemistry & Molecular Biology

Differentiation of mouse embryonic stem cells and their hybrids during embryoid body formation

J Mittmann et al.

GENETICS AND MOLECULAR BIOLOGY (2002)

Article Biochemistry & Molecular Biology

Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells

M Tada et al.

CURRENT BIOLOGY (2001)

Article Biochemistry & Molecular Biology

Expression of distinct ERG proteins in rat, mouse, and human heart -: Relation to functional IKr channels

AL Pond et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)