Related references
Note: Only part of the references are listed.Proteomics biomarker discovery for individualized prevention of familial pancreatic cancer using statistical learning
Chung Shing Rex Ha et al.
PLoS One (2023)
Elevated FSP1 protects KRAS-mutated cells from ferroptosis during tumor initiation
Fabienne Mueller et al.
CELL DEATH AND DIFFERENTIATION (2023)
Targeting glutamine metabolism as a therapeutic strategy for cancer
Jonghwa Jin et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2023)
A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers
Rongjie Cheng et al.
CELL RESEARCH (2023)
Docking Protein p130Cas Regulates Acinar to Ductal Metaplasia During Pancreatic Adenocarcinoma Development and Pancreatitis
Andrea Costamagna et al.
GASTROENTEROLOGY (2022)
miR-802 Suppresses Acinar-to-Ductal Reprogramming During Early Pancreatitis and Pancreatic Carcinogenesis
Wenjie Ge et al.
GASTROENTEROLOGY (2022)
Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARδ
Yi Liu et al.
NATURE COMMUNICATIONS (2022)
KRAS G12D targeted therapies for pancreatic cancer: Has the fortress been conquered?
Sahar F. Bannoura et al.
FRONTIERS IN ONCOLOGY (2022)
Targeting KRAS in PDAC: A New Way to Cure It?
Qianyu He et al.
CANCERS (2022)
Inhibitor of the Nuclear Transport Protein XPO1 Enhances the Anticancer Efficacy of KRAS G12C Inhibitors in Preclinical Models of KRAS G12C-Mutant Cancers
Husain Yar Khan et al.
CANCER RESEARCH COMMUNICATIONS (2022)
Deficient Rnf43 potentiates hyperactive Kras-mediated pancreatic preneoplasia initiation and malignant transformation
Xian Zhou et al.
ANIMAL MODELS AND EXPERIMENTAL MEDICINE (2022)
Post-translational modification of KRAS: potential targets for cancer therapy
Wei-hua Wang et al.
ACTA PHARMACOLOGICA SINICA (2021)
Combinations with Allosteric SHP2 Inhibitor TNO155 to Block Receptor Tyrosine Kinase Signaling
Chen Liu et al.
CLINICAL CANCER RESEARCH (2021)
SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling
Carmine Fedele et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2021)
Cancer Statistics, 2021
Rebecca L. Siegel et al.
CA-A CANCER JOURNAL FOR CLINICIANS (2021)
ANGPTL4 accelerates KRASG12D-Induced acinar to ductal metaplasia and pancreatic carcinogenesis
Hong Hua Yan et al.
CANCER LETTERS (2021)
Anticipating resistance to KRAS inhibition: a novel role for USP21 in macropinocytosis regulation
Howard C. Crawford
GENES & DEVELOPMENT (2021)
Loss of the wild-type KRAS allele promotes pancreatic cancer progression through functional activation of YAP1
Han Yan et al.
ONCOGENE (2021)
A gene-environment-induced epigenetic program initiates tumorigenesis
Direna Alonso-Curbelo et al.
NATURE (2021)
Important role of Nfkb2 in the KrasG12D-driven carcinogenesis in the pancreas
Zonera Hassan et al.
PANCREATOLOGY (2021)
Targeting KRAS in pancreatic cancer: new drugs on the horizon
Sahar F. Bannoura et al.
CANCER AND METASTASIS REVIEWS (2021)
Allosteric SHP2 inhibitors in cancer: Targeting the intersection of RAS, resistance, and the immune microenvironment
D. Lucas Kerr et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2021)
USP21 deubiquitinase elevates macropinocytosis to enable oncogenic KRAS bypass in pancreatic cancer
Pingping Hou et al.
GENES & DEVELOPMENT (2021)
Pancreatic Cancer: A Review
Wungki Park et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)
Acquired Resistance to KRASG12C Inhibition in Cancer
M. M. Awad et al.
NEW ENGLAND JOURNAL OF MEDICINE (2021)
Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis
Edoardo Del Poggetto et al.
SCIENCE (2021)
Intratumoral injection of TLR9 agonist promotes an immunopermissive microenvironment transition and causes cooperative antitumor activity in combination with anti-PD1 in pancreatic cancer
Carmine Carbone et al.
JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)
The KRAS(G12C) Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients
Jill Hallin et al.
CANCER DISCOVERY (2020)
Role of oncogenic KRAS in the diagnosis, prognosis and treatment of pancreatic cancer
Louis Buscail et al.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)
Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic Cancer Cells Utilizes Cytokines from the Tumor Microenvironment
Prasenjit Dey et al.
CANCER DISCOVERY (2020)
Carcinogenesis of Pancreatic Ductal Adenocarcinoma
Peter Storz et al.
GASTROENTEROLOGY (2020)
Adoptive Cell Therapy Targeting Neoantigens: A Frontier for Cancer Research
Zhidong Wang et al.
FRONTIERS IN IMMUNOLOGY (2020)
Generation of KS-58 as the first K-Ras(G12D)-inhibitory peptide presenting anti-cancer activity in vivo
Kotaro Sakamoto et al.
SCIENTIFIC REPORTS (2020)
USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathway activation
Pingping Hou et al.
GENES & DEVELOPMENT (2019)
Development of targeted protein degradation therapeutics
Philip P. Chamberlain et al.
NATURE CHEMICAL BIOLOGY (2019)
The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity
Jude Canon et al.
NATURE (2019)
Emerging cancer trends among young adults in the USA: analysis of a population-based cancer registry
Hyuna Sung et al.
LANCET PUBLIC HEALTH (2019)
KRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer
Andrew M. Waters et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2018)
Zeb1 in Stromal Myofibroblasts Promotes Kras-Driven Development of Pancreatic Cancer
Irene Sangrador et al.
CANCER RESEARCH (2018)
RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1-and RAS-driven cancers
Robert J. Nichols et al.
NATURE CELL BIOLOGY (2018)
SHP2 Inhibition Prevents Adaptive Resistance to MEK Inhibitors in Multiple Cancer Models
Carmine Fedele et al.
CANCER DISCOVERY (2018)
Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer
Giannicola Genovese et al.
NATURE (2017)
Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer
Prasenjit Dey et al.
NATURE (2017)
Overexpression of Yes Associated Protein 1, an Independent Prognostic Marker in Patients With Pancreatic Ductal Adenocarcinoma, Correlated With Liver Metastasis and Poor Prognosis
Maria Teresa Salcedo Allende et al.
PANCREAS (2017)
Identification of T-cell Receptors Targeting KRAS-Mutated Human Tumors
Qiong J. Wang et al.
CANCER IMMUNOLOGY RESEARCH (2016)
Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, phase 3 trial
Andrea Wang-Gillam et al.
LANCET (2016)
Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases
Ying-Nan P. Chen et al.
NATURE (2016)
Genomic analyses identify molecular subtypes of pancreatic cancer
Peter Bailey et al.
NATURE (2016)
Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism
Piro Lito et al.
SCIENCE (2016)
Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism
Hongyun Zhao et al.
ELIFE (2016)
Ras activation revisited: role of GEF and GAP systems
Anne Hennig et al.
BIOLOGICAL CHEMISTRY (2015)
Genetic Events That Limit the Efficacy of MEK and RTK Inhibitor Therapies in a Mouse Model of KRAS-Driven Pancreatic Cancer
Piergiorgio Pettazzoni et al.
CANCER RESEARCH (2015)
Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
Andrea Viale et al.
NATURE (2014)
Selective Induction of Apoptosis: Promising Therapy in Pancreatic Cancer
Zuojia Liu et al.
CURRENT PHARMACEUTICAL DESIGN (2013)
Rational Drug Design: The Search for Ras Protein Hydrolysis Intermediate Conformation Inhibitors with Both Affinity and Specificity
Xiliang Zheng et al.
CURRENT PHARMACEUTICAL DESIGN (2013)
A small-molecule induces apoptosis and suppresses metastasis in pancreatic cancer cells
Dan Li et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2013)
p53 status determines the role of autophagy in pancreatic tumour development
Mathias T. Rosenfeldt et al.
NATURE (2013)
Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine
Daniel D. Von Hoff et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Maintenance of acinar cell organization is critical to preventing Kras-induced acinar-ductal metaplasia
G. Shi et al.
ONCOGENE (2013)
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Scott J. Dixon et al.
CELL (2012)
Regulating the regulator: post-translational modification of RAS
Ian M. Ahearn et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence
Carmen Guerra et al.
CANCER CELL (2011)
The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells
Michelangelo Cordenonsi et al.
CELL (2011)
FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer
Thierry Conroy et al.
NEW ENGLAND JOURNAL OF MEDICINE (2011)
Dose and context dependent effects of Myc on epidermal stem cell proliferation and differentiation
Melanie A. Berta et al.
EMBO MOLECULAR MEDICINE (2010)
Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic K-Ras
Sharon Y. Gidekel Friedlander et al.
CANCER CELL (2009)
Basic-liver, pancreas, and biliary tract
Oliver Strobel et al.
GASTROENTEROLOGY (2007)
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinorna by k-Ras Oncogenes in adult mice
Carmen Guerra et al.
CANCER CELL (2007)
Comparison of novel delivery systems for antisense peptide nucleic acids
L Chiarantini et al.
JOURNAL OF CONTROLLED RELEASE (2005)