4.7 Article

Reversal of Tau-Dependent Cognitive Decay by Blocking Adenosine A1 Receptors: Comparison of Transgenic Mouse Models with Different Levels of Tauopathy

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration

Tara E. Tracy et al.

Summary: In this study, the researchers used APEX approach and AP-MS technique to characterize the Tau interactomes modified by neuronal activity and FTD mutations. They found that Tau interacts with presynaptic vesicle proteins and identified the binding sites. They also discovered that FTD mutations impair Tau's interaction with mitochondria proteins, which has important implications for the pathogenesis of AD.
Article Neurosciences

Olfactory Bulb Integrity in Frontotemporal Dementia and Alzheimer's Disease

Sarah E. Carnemolla et al.

Summary: This study used MRI to measure OB volume in FTD and AD patients. The results showed that at the first visit to the clinic, OB volumes were similar to controls, but volumes of olfactory network regions were significantly reduced in all patient groups. Longitudinal data revealed that OB volume became significantly reduced with disease progression in all dementia groups.

JOURNAL OF ALZHEIMERS DISEASE (2022)

Review Biochemistry & Molecular Biology

Adenosine receptor signalling in Alzheimer's disease

Phuc N. H. Trinh et al.

Summary: Alzheimer's disease is the most common form of dementia in the elderly, and current treatments are unable to modify its underlying causes or effectively address cognitive and memory deficits. Recent research suggests that targeting adenosine receptors may hold promise for treating Alzheimer's disease, as preclinical studies have shown that such targeting can reduce pathological proteins and improve cognitive function. While there are currently no approved medicines targeting these receptors for dementia treatment, novel strategies such as allosterism and oligomer targeting may enhance drug discovery success and therapeutic response.

PURINERGIC SIGNALLING (2022)

Review Biochemistry & Molecular Biology

Role of phosphodiesterases in the pathophysiology of neurodevelopmental disorders

Sebastien Delhaye et al.

Summary: Phosphodiesterases (PDEs) are enzymes that regulate the homeostasis of cAMP and cGMP, with potential therapeutic implications for neurodevelopmental disorders.

MOLECULAR PSYCHIATRY (2021)

Editorial Material Multidisciplinary Sciences

Brain's immune cells put the brakes on neurons

Thomas Pfeiffer et al.

NATURE (2020)

Article Multidisciplinary Sciences

Negative feedback control of neuronal activity by microglia

Ana Badimon et al.

NATURE (2020)

Article Geriatrics & Gerontology

Screening of a neuronal cell model of tau pathology for therapeutic compounds

Marcus Pickhardt et al.

NEUROBIOLOGY OF AGING (2019)

Article Multidisciplinary Sciences

Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice

Julia Gamache et al.

NATURE COMMUNICATIONS (2019)

Review Clinical Neurology

Olfactory and other sensory impairments in Alzheimer disease

Claire Murphy

NATURE REVIEWS NEUROLOGY (2019)

Review Medicine, General & Internal

18F-FDG-PET in Mouse Models of Alzheimer's Disease

Caroline Bouter et al.

FRONTIERS IN MEDICINE (2019)

Review Clinical Neurology

Tau-targeting therapies for Alzheimer disease

Erin E. Congdon et al.

NATURE REVIEWS NEUROLOGY (2018)

Article Neurosciences

Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau

Joseph McInnes et al.

NEURON (2018)

Editorial Material Medicine, General & Internal

Why do so many clinical trials of therapies for Alzheimer's disease fail?

Roy M. Anderson et al.

LANCET (2017)

Article Neurosciences

Anti-aggregant tau mutant promotes neurogenesis

Maria Joseph et al.

MOLECULAR NEURODEGENERATION (2017)

Review Biochemistry & Molecular Biology

Adenosine A1 and A2A Receptors in the Brain: Current Research and Their Role in Neurodegeneration

Jocelyn Stockwell et al.

MOLECULES (2017)

Article Clinical Neurology

Tracking progressive pathological and functional decline in the rTg4510 mouse model of tauopathy

Thomas Blackmore et al.

ALZHEIMERS RESEARCH & THERAPY (2017)

Article Multidisciplinary Sciences

Adenosine A1 receptor antagonist rolofylline alleviates axonopathy caused by human Tau ΔK280

Frank J. A. Dennissen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Biochemistry & Molecular Biology

A(2A) adenosine receptor deletion is protective in a mouse model of Tauopathy

C. Laurent et al.

MOLECULAR PSYCHIATRY (2016)

Article Neurosciences

Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca++ dysregulation

Jochen Martin Decker et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2015)

Article Neurosciences

Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau

Katja Hochgraefe et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2015)

Review Clinical Neurology

Olfactory bulb involvement in neurodegenerative diseases

Johannes Attems et al.

ACTA NEUROPATHOLOGICA (2014)

Review Pharmacology & Pharmacy

Tau-aggregation inhibitor therapy for Alzheimer's disease

Claude M. Wischik et al.

BIOCHEMICAL PHARMACOLOGY (2014)

Review Neurosciences

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer's Disease

Tara L. Spires-Jones et al.

NEURON (2014)

Review Neurosciences

Tauopathies and Tau Oligomers

Akihiko Takashima

JOURNAL OF ALZHEIMERS DISEASE (2013)

Article Biochemistry & Molecular Biology

Structural Determinants of Tau Aggregation Inhibitor Potency

Kelsey N. Schafer et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Geriatrics & Gerontology

Cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors

Lars Messing et al.

NEUROBIOLOGY OF AGING (2013)

Article Clinical Neurology

Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau

Ann Van der Jeugd et al.

ACTA NEUROPATHOLOGICA (2012)

Article Medicine, Research & Experimental

Deciphering Alzheimer Disease

Dennis Selkoe et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)

Article Medicine, Research & Experimental

Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration

Eva-Maria Mandelkow et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)

Review Neurosciences

PSD-95-like membrane associated guanylate kinases (PSD-MAGUKs) and synaptic plasticity

Weifeng Xu

CURRENT OPINION IN NEUROBIOLOGY (2011)

Article Biochemistry & Molecular Biology

Reversibility of Tau-Related Cognitive Defects in a Regulatable FTD Mouse Model

Astrid Sydow et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2011)

Review Biotechnology & Applied Microbiology

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

Eric Karran et al.

NATURE REVIEWS DRUG DISCOVERY (2011)

Review Urology & Nephrology

Adenosine A1 receptor antagonists in clinical research and development

Berthold Hocher

KIDNEY INTERNATIONAL (2010)

Article Medicine, General & Internal

Rolofylline, an Adenosine A(sub 1)-Receptor Antagonist, in Acute Heart Failure.

Barry M. Massie et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Review Neurosciences

Hypometabolism as a therapeutic target in Alzheimer's disease

Lauren C. Costantini et al.

BMC NEUROSCIENCE (2008)

Review Physiology

Metabolic control of proteasome function

Fengxue Zhang et al.

PHYSIOLOGY (2007)

Article Biochemistry & Molecular Biology

The β-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy

Katrin Eckermann et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Geriatrics & Gerontology

Early detection of Alzheimer's disease using neuroimaging

Lisa Mosconi et al.

EXPERIMENTAL GERONTOLOGY (2007)

Article Multidisciplinary Sciences

Tau suppression in a neurodegenerative mouse model improves memory function

K SantaCruz et al.

SCIENCE (2005)

Article Clinical Neurology

Brain metabolic decreases related to the dose of the ApoE e4 allele in Alzheimer's disease

L Mosconi et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2004)

Review Psychology

The neurobiology of consolidations, or, how stable is the engram?

Y Dudai

ANNUAL REVIEW OF PSYCHOLOGY (2004)

Article Cell Biology

Dendrite and dendritic spine alterations in Alzheimer models

DL Moolman et al.

JOURNAL OF NEUROCYTOLOGY (2004)

Article Biochemistry & Molecular Biology

The relationship between amyloid and tau

J Hardy

JOURNAL OF MOLECULAR NEUROSCIENCE (2003)

Article Geriatrics & Gerontology

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease

S Oddo et al.

NEUROBIOLOGY OF AGING (2003)

Article Behavioral Sciences

Food intake, water intake, and drinking spout side preference of 28 mouse strains

AA Bachmanov et al.

BEHAVIOR GENETICS (2002)

Review Neurosciences

The role and regulation of adenosine in the central nervous system

TV Dunwiddie et al.

ANNUAL REVIEW OF NEUROSCIENCE (2001)

Review Neurosciences

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders

L Buée et al.

BRAIN RESEARCH REVIEWS (2000)

Article Multidisciplinary Sciences

Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease

GW Small et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

Article Multidisciplinary Sciences

Assembly of τ protein into Alzheimer paired helical filaments depends on a local sequence motif (306VQIVYK311) forming β structure

M von Bergen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)