4.7 Article

Diversity of Cationic Antimicrobial Peptides in Black Cumin (Nigella sativa L.) Seeds

Journal

Publisher

MDPI
DOI: 10.3390/ijms24098066

Keywords

antimicrobial peptides; defensins; lipid-transfer proteins; Nigella sativa; proteomic analysis; fractionation; primary structure; 3D modeling; antimicrobial activity

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Black cumin contains antimicrobial peptides, including three novel peptides, that have been isolated and characterized. These peptides show a broad spectrum of antimicrobial activity against plant pathogens, making them potential candidates for the development of next-generation biopesticides for agricultural use.
Black cumin (Nigella sativa L.) is known to possess a wide variety of antimicrobial peptides belonging to different structural families. Three novel antimicrobial peptides have been isolated from black cumin seeds. Two of them were attributed as members of the non-specific lipid transfer proteins family, and one as a defensin. We have made an attempt of using the proteomic approach for novel antimicrobial peptides search in N. sativa seeds as well. The use of a well-established approach that includes extraction and fractionation stages remains relevant even in the case of novel peptides search because of the lacking N. sativa genome data. Novel peptides demonstrate a spectrum of antimicrobial activity against plant pathogenic organisms that may cause economically important crop diseases. These results obtained allow considering these molecules as candidates to be applied in next-generation biopesticides development for agricultural use.

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