Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 24, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/ijms24076085
Keywords
sugar transporters; transmembrane communication; transport-derived diseases; therapeutics
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Sugar transport through the plasma membrane is a critical event in cellular nutrient transport. Complex systems and diverse protein systems are involved in this process, making it highly regulated and modulated to meet the needs of different types of cells. The deregulation of these systems can lead to diseases, so it is important to study and correct the alterations to promote health. This review highlights the mechanisms of importing valuable sugars for cellular homeostasis and survival.
Sugar transport through the plasma membrane is one of the most critical events in the cellular transport of nutrients; for example, glucose has a central role in cellular metabolism and homeostasis. The way sugars enter the cell involves complex systems. Diverse protein systems participate in the membrane traffic of the sugars from the extracellular side to the cytoplasmic side. This diversity makes the phenomenon highly regulated and modulated to satisfy the different needs of each cell line. The beautiful thing about this process is how evolutionary processes have diversified a single function: to move glucose into the cell. The deregulation of these entrance systems causes some diseases. Hence, it is necessary to study them and search for a way to correct the alterations and utilize these mechanisms to promote health. This review will highlight the various mechanisms for importing the valuable sugars needed to create cellular homeostasis and survival in all kinds of cells.
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