Molecular Mechanism of Chronic Viral and Non-Viral Liver Diseases

Article Virology

Drug Screening for Hepatitis A Virus (HAV): Nicotinamide Inhibits c-Jun Expression and HAV Replication

Reina Sasaki-Tanaka et al.

Summary: This study identified nicotinamide as a potential therapeutic drug for HAV infection by inhibiting HAV replication through suppressing AP-1 activity and HAV IRES-mediated translation.

JOURNAL OF VIROLOGY (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Autoantibodies to PAX5, PTCH1, and GNA11 as Serological Biomarkers in the Detection of Hepatocellular Carcinoma in Hispanic Americans

Cuipeng Qiu et al.

Summary: This study analyzed the presence of autoantibodies to PAX5, PTCH1, and GNA11 in the sera of Hispanic Americans, including HCC patients, LC patients, CH patients, and normal controls, using an ELISA. The results showed that these autoantibodies could serve as biomarkers for the early detection of HCC and they may monitor the transition of high-risk patients to HCC.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Add to Collection

Letter Gastroenterology & Hepatology

Alcohol-Associated Liver Disease Mortality Increased From 2017 to 2020 and Accelerated During the COVID-19 Pandemic

Sasha Deutsch-Link et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Evaluation of Potential Anti-Hepatitis A Virus 3C Protease Inhibitors Using Molecular Docking

Reina Sasaki-Tanaka et al.

Summary: Hepatitis A virus (HAV) infection is a major cause of acute hepatitis worldwide, and the prevalence of HAV vaccination is not adequate in some countries. The development of new anti-HAV therapeutic options has been motivated, and in silico and in vitro studies have identified potential inhibitors for HAV replication.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Genotype-Phenotype Association in ABCC2 Exon 18 Missense Mutation Leading to Dubin-Johnson Syndrome: A Case Report

Ji-Hoon Kim et al.

Summary: This case report describes a patient with Dubin-Johnson syndrome confirmed through genetic study. The patient presented with symptoms of calculous cholecystitis and during a cholecystectomy, a black-colored liver was noted. Liver biopsy results and genetic study confirmed the diagnosis of Dubin-Johnson syndrome. Conservative treatment was given and the patient showed stable liver function after one month of follow-up.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Article Public, Environmental & Occupational Health

Alcohol consumption and mental health conditions: Insights from a South Australian population survey to inform policy and practice

Tara Guckel et al.

Summary: Among individuals with mental health conditions, risky alcohol consumption is prevalent, with gender differences observed. This study investigates the prevalence of lifetime risky drinking and single occasion risky drinking in individuals with different severities of mental health conditions.

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Molecular Changes in Relation to Alcohol Consumption and Hepatocellular Carcinoma

Reina Sasaki-Tanaka et al.

Summary: Alcohol is a major cause of liver diseases, such as liver cirrhosis and hepatocellular carcinoma. This is due to the conversion of alcohol to acetaldehyde in hepatocytes, leading to various liver damage, as well as the production of toxins from intestinal bacteria aggravating inflammation. Genetic factors also play a role in this process.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Article Gastroenterology & Hepatology

Impact of the COVID-19 pandemic on liver disease-related mortality rates in the United States

Xu Gao et al.

JOURNAL OF HEPATOLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

LIGHTHOUSE illuminates therapeutics for a variety of diseases including COVID-19

Hideyuki Shimizu et al.

Summary: In this study, a graph-based deep learning approach called LIGHTHOUSE was developed to discover the hidden principles underlying the association of small-molecule compounds with target proteins. LIGHTHOUSE estimated protein-compound scores without relying on 3D structural information, incorporating known evolutionary relations and available experimental data. It successfully identified therapeutics for various diseases and predicted ethoxzolamide as a therapeutic for COVID-19, which was proven effective against different variants of SARS-CoV-2.

ISCIENCE (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Antiviral Compounds Screening Targeting HBx Protein of the Hepatitis B Virus

Yaojia Ma et al.

Summary: In this study, antiviral compounds targeting HBx protein were identified by analyzing HBx binding activity. Tranilast, one of the identified compounds, was found to inhibit HBV replication and infection without affecting cell viability. These findings provide new insights into the development of drugs for the treatment of HBV infection.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Article Multidisciplinary Sciences

The impact of the COVID-19 epidemic on hospital admissions for alcohol-related liver disease and pancreatitis in Japan

Hisashi Itoshima et al.

Summary: This study found an increase in hospital admissions for alcohol-related liver disease and pancreatitis during the COVID-19 epidemic in Japan, with higher rates for females. This suggests that alcohol consumption during the pandemic may have negative health impacts.

SCIENTIFIC REPORTS (2021)

Add to Collection

Article Gastroenterology & Hepatology