Research Progress on the Construction and Application of a Diabetic Zebrafish Model

Diabetes is a metabolic disease characterized by high blood glucose levels. With economic development and lifestyle changes, the prevalence of diabetes is increasing yearly. Thus, it has become an increasingly serious public health problem in countries around the world. The etiology of diabetes is complex, and its pathogenic mechanisms are not completely clear. The use of diabetic animal models is helpful in the study of the pathogenesis of diabetes and the development of drugs. The emerging vertebrate model of zebrafish has many advantages, such as its small size, large number of eggs, short growth cycle, simple cultivation of adult fish, and effective improvement of experimental efficiency. Thus, this model is highly suitable for research as an animal model of diabetes. This review not only summarizes the advantages of zebrafish as a diabetes model, but also summarizes the construction methods and challenges of zebrafish models of type 1 diabetes, type 2 diabetes, and diabetes complications. This study provides valuable reference information for further study of the pathological mechanisms of diabetes and the research and development of new related therapeutic drugs.

Automated summary

Diabetes is a metabolic disease with high blood glucose levels, and its prevalence has been increasing due to economic development and lifestyle changes. The use of diabetic animal models, such as zebrafish, has proven helpful for studying the pathogenesis of diabetes and drug development. This review summarizes the advantages of zebrafish as a diabetes model and the construction methods and challenges of zebrafish models for type 1 diabetes, type 2 diabetes, and diabetes complications. The study provides valuable reference information for further research on the pathological mechanisms of diabetes and the development of new therapeutic drugs.