4.7 Editorial Material

Biocatalysis: An Eco-Friendly Scenario for the Manufacturing of APIs

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Comparative Analysis of Enzymatic Transglycosylation Using E. coli Nucleoside Phosphorylases: A Synthetic Concept for the Preparation of Purine Modified 2′-Deoxyribonucleosides from Ribonucleosides

Mikhail S. Drenichev et al.

Summary: A comparative analysis was conducted on the transglycosylation conditions catalyzed by E. coli nucleoside phosphorylases, leading to the formation of 2'-deoxynucleosides. The study demonstrated that maximal yields of modified 2'-deoxynucleosides can be achieved with a slight excess of carbohydrate residue donor nucleoside and a four-fold lack of phosphate.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Biochemistry & Molecular Biology

Industrially Relevant Enzyme Cascades for Drug Synthesis and Their Ecological Assessment

Regine Siedentop et al.

Summary: Biocatalytic synthesis routes with enzyme cascades have potential applications in environmentally friendly and sustainable production of active pharmaceutical ingredients. However, their use in the pharmaceutical industry is still limited. Ongoing research in the development of enzyme cascades holds promise for the pharmaceutical industry.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Biochemistry & Molecular Biology

Characteristics of Crosslinking Polymers Play Major Roles in Improving the Stability and Catalytic Properties of Immobilized Thermomyces lanuginosus Lipase

Yuhong Mao et al.

Summary: This study aimed to improve the stability and catalytic properties of Thermomyces lanuginosus lipase (TLL) adsorbed on a hydrophobic support. Bridging units, polyethylenimine (PEI) and chitosan (CS), were successfully applied to in situ crosslink the immobilized lipase molecules, resulting in improved lipase stability and catalytic efficiency.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Biochemistry & Molecular Biology

Magnetic Multi-Enzymatic System for Cladribine Manufacturing

Guillermo Cruz et al.

Summary: Enzyme-mediated processes provide a sustainable alternative to traditional chemical methods, and multi-enzymatic systems offer numerous advantages such as converting reversible reactions into irreversible processes and minimizing unwanted by-products. Immobilizing biocatalysts on magnetic supports allows for easy reusability and streamlining of downstream processes. This study developed a cascade system for cladribine synthesis using magnetic biocatalysts, which showed improved synthesis efficiency and transformation of by-products into high-value products.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Biochemistry & Molecular Biology

Immobilization of Lathyrus cicera Amine Oxidase on Magnetic Microparticles for Biocatalytic Applications

Elisa Di Fabio et al.

Summary: Amine oxidases, including the one from Lathyrus cicera, have shown potential in green synthesis of aldehydes. Immobilization on solid supports greatly improves the enzyme's performance and thermostability, allowing for multiple cycles of reuse.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Biochemistry & Molecular Biology

Microbial Lipases and Their Potential in the Production of Pharmaceutical Building Blocks

Cesar A. Godoy et al.

Summary: This article primarily introduces the importance of microbial lipases in the synthesis of active pharmaceutical ingredients and their advantages and influencing factors in industrial applications. It also summarizes the key reactions of microbial lipases in organic synthesis and the research directions for their future development.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Biochemistry & Molecular Biology

Rational Design of a Thermostable 2′-Deoxyribosyltransferase for Nelarabine Production by Prediction of Disulfide Bond Engineering Sites

Guillermo Cruz et al.

Summary: This study presents a structure-guided approach to develop novel and thermostable 2'-deoxyribosyltransferases (NDTs) using computational design of disulfide bonds. The most thermostable variant, LdNDT(S104C), showed enhanced stability at high temperatures and broad activity across different temperature and pH ranges. Furthermore, it demonstrated improved catalytic performance in the enzymatic synthesis of nelarabine.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Editorial Material Chemistry, Multidisciplinary

Efficient Industrial Organic Synthesis and the Principles of Green Chemistry

Thomas Schaub

Summary: The production of organic bulk chemicals in industry faces challenges in becoming greener while remaining efficient, requiring research and innovation. This article in Science Voices explores how industrial organic chemistry can align with the principles of green chemistry.

CHEMISTRY-A EUROPEAN JOURNAL (2021)

Review Biotechnology & Applied Microbiology

New trends in the biocatalytic production of nucleosidic active pharmaceutical ingredients using 2′-deoxyribosyltransferases

Jon Del Arco et al.

Summary: The pharmaceutical industry is demanding competitive and eco-friendly processes for active pharmaceutical ingredients (APIs) manufacturing, with enzymes and whole-cell mediated processes offering an efficient, sustainable, and cost-effective alternative to traditional chemical processes. 2'-deoxyribosyltransferases (NDTs) have emerged as a novel synthetic alternative, showcasing innovation and inventive steps in the industrial synthesis of nucleoside-based APIs.

BIOTECHNOLOGY ADVANCES (2021)

Review Biotechnology & Applied Microbiology

Accelerating the implementation of biocatalysis in industry

John M. Woodley

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2019)

Review Biochemistry & Molecular Biology

New developments in nucleoside analogues biosynthesis: A review

Maria J. Lapponi et al.

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC (2016)

Review Biotechnology & Applied Microbiology

New opportunities for biocatalysis: making pharmaceutical processes greener

John M. Woodley

TRENDS IN BIOTECHNOLOGY (2008)