Environmental Air Pollutants Affecting Skin Functions with Systemic Implications

Review Dermatology

Climate change, the cutaneous microbiome and skin disease: implications for a warming world

Madeleine F. Isler et al.

Summary: Climate change has a significant impact on the cutaneous microbiome, which in turn affects the epidemiology and severity of skin diseases.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2023)

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Article Biochemistry & Molecular Biology

Blue light pollution causes retinal damage and degeneration by inducing ferroptosis

Xuan Li et al.

Summary: With the development of technology and electronic products, the problem of light pollution is getting worse. Blue light, as the most energetic light in visible light, is the main cause of vision problems in teenagers. The exact mechanism of how blue light-induced reactive oxygen species (ROS) cause retinal cell death is still unclear. This study reveals that blue light triggers ROS burst in retinal cells, leading to increased levels of intracellular Fe2+. Additionally, ferroptosis, a cell death pathway caused by excessive lipid peroxidation, is found to play a crucial role in blue light-induced retinal damage and degeneration.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2023)

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Article

Air Pollution and Atopic Dermatitis, from Molecular Mechanisms to Population-Level Evidence: A Review

Raj P. Fadadu et al.

International Journal of Environmental Research and Public Health (2023)

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Article Microbiology

Skin microbiome differentiates into distinct cutotypes with unique metabolic functions upon exposure to polycyclic aromatic hydrocarbons

Marcus H. Y. Leung et al.

Summary: This study explores the effect of polycyclic aromatic hydrocarbons (PAHs) on the skin microbiome in two Chinese cities with different levels of air pollution. The results show that high PAH exposure is linked to dry skin and a specific cutotype that has reduced correlation network structure integrity. The study also reveals the role of bacteria-produced arginine in moisturizing the skin and the limited hydration functions in cutotype 2, which explains the observed dry skin phenotype.

MICROBIOME (2023)

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Article Oncology

NRF2 and STAT3: friends or foes in carcinogenesis?

Andrea Arena et al.

Summary: NRF2 is a transcription factor that plays a critical role in carcinogenesis by interacting with pro-survival pathways. This perspective focuses on the intricate interplay between NRF2 and STAT3, both of which are transcription factors commonly activated in cancer and influence tumor formation and immune suppression. Regulation of NRF2 and STAT3 by ER stress/UPR activation, as well as their interaction with autophagy and cytokines, shape the microenvironment and control DNA damage response. Further investigations into their networking may lead to the discovery of novel strategies to combat cancer more effectively.

DISCOVER ONCOLOGY (2023)

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Review Allergy

Impact of Air Pollution on Atopic Dermatitis: A Comprehensive Review

Zhouxian Pan et al.

Summary: Air pollution is a global problem that contributes to various health issues, including increased morbidity and mortality. Growing evidence suggests that air pollution plays a role in the development of atopic dermatitis, a common allergic disease. Air pollutants, such as nitrogen dioxide, sulfur dioxide, carbon monoxide, particulate matter, and bioaerosols, can damage the skin barrier, trigger oxidative stress, and lead to immune dysregulation, enhancing sensitization to allergens. Although there are inconsistencies among studies, it is generally accepted that air pollution is a risk factor for atopic dermatitis. Future research should focus on understanding the mechanisms and implementing effective interventions.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2023)

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Article Environmental Sciences

The association between short-term ambient air pollution and acne vulgaris outpatient visits: a hospital-based time-series analysis in Xi'an

Xiang Li et al.

Summary: A hospital-based time-series analysis in Xi'an suggested that exposure to ambient air pollutants above WHO limits (PM10, SO2, or NO2) was associated with an increased risk of outpatient visits for acne. The study also found that the effects of air pollutants may vary with age.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2022)

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Review Dermatology

Aryl hydrocarbon receptor/nuclear factor E2-related factor 2 (AHR/NRF2) signalling: A novel therapeutic target for atopic dermatitis

Jonwei Hwang et al.

Summary: The AHR/NRF2 modulation pathway shows promise in the treatment of atopic dermatitis and other inflammatory skin disorders by impacting epidermal barrier function, immunomodulation, oxidative stress reduction, and cutaneous microbiome modulation.

EXPERIMENTAL DERMATOLOGY (2022)

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Review Biochemistry & Molecular Biology

Protective Role of Melatonin and Its Metabolites in Skin Aging

Georgeta Bocheva et al.

Summary: The skin, as the largest organ in the human body, is prone to aging due to both internal and external factors. Aging is characterized by clinical features and changes in cellular and extracellular components. Melatonin and its metabolites have the potential to counteract skin aging by regulating molecular mechanisms.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Medicine, General & Internal

Ambient air pollution and cardiovascular diseases: An umbrella review of systematic reviews and meta-analyses

Jeroen de Bont et al.

Summary: This umbrella review summarizes the current epidemiological evidence linking ambient air pollution and cardiovascular diseases (CVDs), with a focus on geographical differences and vulnerable subpopulations. The review found strong evidence that higher levels of ambient air pollution increase the risk of CVDs, especially all-cause CVD mortality, stroke, and ischemic heart diseases. The associations were stronger in Asian countries and among vulnerable subpopulations.

JOURNAL OF INTERNAL MEDICINE (2022)

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Article Dermatology

Particulate Matter Promotes Melanin Production through Endoplasmic Reticulum Stress-Mediated IRE1α signaling

Yuri Ahn et al.

Summary: Particulate matter (PM) is known to be associated with cardiovascular and respiratory diseases. This study found that PM exposure can increase melanin production and the IRE1a pathway is involved in PM-induced melanogenesis.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2022)

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Review Biochemistry & Molecular Biology

Molecular Mechanisms of Action of Selected Substances Involved in the Reduction of Benzo[a]pyrene-Induced Oxidative Stress

Bozena Bukowska et al.

Summary: BaP is a carcinogenic substance that induces oxidative stress through the production of reactive oxygen species and disturbance of antioxidant enzyme activity. Various chemicals, such as curcumin and vitamins, can reduce the oxidative stress induced by BaP by regulating gene expression and increasing the levels of antioxidants. These substances have the potential to protect against BaP activity.

MOLECULES (2022)

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Article Dermatology

Cigarettes, a skin killer! Cigarette smoke may cause ferroptosis in female skin

Qunxian Zhang et al.

Summary: Exposure to cigarette smoke can lead to ferroptosis in female skin, with ferroptosis-associated genes potentially regulated by miRNAs and transcription factors. This provides a theoretical basis for future research and anti-aging skin treatments.

JOURNAL OF COSMETIC DERMATOLOGY (2022)

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Article Oncology

Long-term Exposure to PM10 Increases Lung Cancer Risks: A Cohort Analysis

Hyun Woo Lee et al.

Summary: This study investigates the relationship between long-term exposure to PM10 and lung cancer incidence, and finds a significant association between PM10 exposure and lung cancer development, regardless of gender and smoking status.

CANCER RESEARCH AND TREATMENT (2022)

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Article Dermatology

Association Between Short-term Exposure to Environmental Air Pollution and Psoriasis Flare

Francesco Bellinato et al.

Summary: The findings of this study suggest that air pollution may be a trigger factor for psoriasis flare.

JAMA DERMATOLOGY (2022)

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Article Biochemistry & Molecular Biology

Chemical synthesis, biological activities and action on nuclear receptors of 20S(OH)D3, 20S,25(OH)2D3, 20S,23S(OH)2D3 and 20S,23R(OH)2D3

Pawel Brzeminski et al.

Summary: This study established new routes for the chemical synthesis of vitamin D-3 and its hydroxy metabolites. The compounds showed similar properties in inhibiting cell proliferation and inducing cell differentiation, as well as effects on T-cell immune activity. They also interacted with nuclear receptors in a similar manner. The findings have important implications for studying the role of these compounds in the immune system and inflammatory diseases.

BIOORGANIC CHEMISTRY (2022)

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Article Biochemistry & Molecular Biology

Host/microbiota interactions-derived tryptophan metabolites modulate oxidative stress and inflammation via aryl hydrocarbon receptor signaling

Yue-Qi Tan et al.

Summary: This review summarizes the endogenous ligands of AhR, especially host/gut microbiota-derived tryptophan metabolites, and investigates the role of AhR in regulating redox homeostasis and inflammation. It provides new insights for the diagnosis and treatment of refractory human diseases.

FREE RADICAL BIOLOGY AND MEDICINE (2022)

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Article Biochemistry & Molecular Biology

Molecular and structural basis of interactions of vitamin D3 hydroxyderivatives with aryl hydrocarbon receptor (AhR): An integrated experimental and computational study

Yuwei Song et al.

Summary: This study used molecular simulation to investigate the interaction between vitamin D3 hydroxyderivatives and AhR. It was found that these derivatives can stimulate downstream target genes of AhR. Molecular dynamics simulations showed favorable binding of the derivatives to AhR and revealed potential mechanisms underlying their binding affinities.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Dermatology

Exposure to air pollution and incidence of atopic dermatitis in the general population: A national population-based retrospective cohort study

Se Kwang Park et al.

Summary: This study, using a large-scale database, found a significant positive association between long-term exposure to air pollutants (including gases and particulate matter) and the incidence of atopic dermatitis (AD).

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2022)

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Review Oncology

Melanoma, Melanin, and Melanogenesis: The Yin and Yang Relationship

Radomir M. Slominski et al.

Summary: Melanin plays a vital role in protecting the skin from harmful UV radiation, but its presence may also contribute to the malignant transformation of melanocytes. The biosynthesis of melanin is regulated by sun exposure and hormonal factors, influencing melanoma development, progression, and treatment in diverse ways.

FRONTIERS IN ONCOLOGY (2022)

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Review Oncology

Ozone Layer Depletion and Emerging Public Health Concerns-An Update on Epidemiological Perspective of the Ambivalent Effects of Ultraviolet Radiation Exposure

Sheikh Ahmad Umar et al.

Summary: Solar UV radiation is the main cause of cutaneous malignancies, but optimal sun exposure is crucial for synthesizing vitamin D in the body. Climate change and UV radiation pose threats to human health, and sun protection measures may lead to vitamin D deficiency. Therefore, a balanced public health recommendation is needed for sun exposure and sun protection measures.

FRONTIERS IN ONCOLOGY (2022)

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Review Oncology

The Aryl Hydrocarbon Receptor in the Pathogenesis of Environmentally-Induced Squamous Cell Carcinomas of the Skin

Christian Vogeley et al.

Summary: This article summarizes the role of AHR in skin carcinogenesis, focusing on its impact on defense mechanisms such as DNA repair, apoptosis, and anti-tumor immune responses, as well as the possible consequences of simultaneous exposure to different AHR-stimulating environmental factors on the development of cutaneous SCC.

FRONTIERS IN ONCOLOGY (2022)

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Review Biochemistry & Molecular Biology

Aryl Hydrocarbon Receptors: Evidence of Therapeutic Targets in Chronic Inflammatory Skin Diseases

Han-Bi Kim et al.

Summary: The aryl hydrocarbon receptor (AhR) is crucial for the metabolism of xenobiotics and has been found to be associated with various diseases in different organs. Recent studies have shed light on its functions in chronic inflammatory skin diseases such as atopic dermatitis (AD) and psoriasis (PS), as well as its impact on the immune system of the skin. The therapeutic effects of AhR ligands have been demonstrated, but further research is needed to fully understand the roles of AhR in chronic inflammatory skin diseases.

BIOMEDICINES (2022)

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Review Biochemistry & Molecular Biology

Benzo[a]pyrene-Environmental Occurrence, Human Exposure, and Mechanisms of Toxicity

Bozena Bukowska et al.

Summary: Benzo[a]pyrene (B[a]P) is a representative polycyclic aromatic hydrocarbon (PAH) that is commonly found in the environment and human surroundings. It has been shown to have toxic effects on DNA, reproduction, neurology, and development. The metabolism of B[a]P is mediated by cytochrome P450 (CYP P450) and its polymorphism determines the sensitivity to B[a]P. Additionally, B[a]P may facilitate the replication of viruses.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biochemistry & Molecular Biology

Aryl Hydrocarbon Receptor in Oxidative Stress as a Double Agent and Its Biological and Therapeutic Significance

Alevtina Y. Grishanova et al.

Summary: This review examines the various mechanisms by which AhR participates in the oxidative stress response, including antioxidant and prooxidant enzymes and cytochrome P450. AhR, as a participant in the redox balance and as a modulator of redox signals, is being increasingly studied as a target for a new class of therapeutic compounds and as an explanation for the pathogenesis of some disorders.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biochemistry & Molecular Biology

The Damaging Effects of Long UVA (UVA1) Rays: A Major Challenge to Preserve Skin Health and Integrity

Francoise Bernerd et al.

Summary: UVA1 ultraviolet radiation has harmful effects on the skin, including oxidative stress, cell mutations, and skin diseases, highlighting the need for comprehensive photoprotection.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Oncology

CYP11A1-derived vitamin D hydroxyderivatives as candidates for therapy of basal and squamous cell carcinomas

Andrzej T. Slominski et al.

Summary: Hydroxyderivatives of vitamin D3 have anti-cancer activities by acting on vitamin D receptor and retinoid-related orphan receptors, inhibiting cell proliferation and tumor formation.

INTERNATIONAL JOURNAL OF ONCOLOGY (2022)

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Review Cell Biology

Effects of Air Pollution on Cellular Senescence and Skin Aging

Ines Martic et al.

Summary: This review summarizes the current knowledge about the effects of air pollution on the skin, including the relationship between air pollution components and cellular senescence, as well as the current therapeutic and cosmetic interventions.

CELLS (2022)

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Article Biochemistry & Molecular Biology

Liposomes Encapsulating Morin: Investigation of Physicochemical Properties, Dermal Absorption Improvement and Anti-Aging Activity in PM-Induced Keratinocytes

Hong-My Tran et al.

Summary: Recently, there has been significant development in the global market for anti-aging skin care using botanicals. Morin, a polyphenol compound, has shown pharmacological properties such as antioxidant, anti-inflammatory, and photoprotection effects. However, its poor water solubility hinders its pharmaceutical applications. This study aimed to encapsulate morin into liposomal vesicles to improve its solubility and skin penetration and evaluate its ROS inhibition and anti-aging activity. The results demonstrated that morin exhibited strong DPPH radical scavenging activity and effectively protected keratinocytes from particulate matter-induced damage by downregulating MMP-1 expression through the suppression of p-ERK and p-p38 in the MAPK pathway. Additionally, the water solubility of liposomal morin was significantly improved compared to free morin, and deformable liposomal vesicles enhanced dermal absorption. In conclusion, liposomal morin shows potential as a promising candidate for various topical anti-aging and anti-pollution products.

ANTIOXIDANTS (2022)

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Review Biochemistry & Molecular Biology

Ultraviolet Light Protection: Is It Really Enough?

Patricia K. Farris et al.

Summary: Our current understanding of the mechanisms behind skin aging involves various environmental factors such as ultraviolet light, visible light, infrared, pollution, cigarette smoke, and others. These factors disrupt the cellular redox balance and lead to an oxidative stress condition by increasing the formation of reactive oxygen species. This disruption triggers downstream pathways that contribute to tissue inflammation and accelerate skin aging. Additionally, ultraviolet light and pollution increase intracellular free iron, which further promotes oxidative stress and contributes to extrinsic skin aging. Recent studies have shown that iron chelators can enhance the benefits of topically applied antioxidants. Therefore, a more comprehensive approach to protect against environmental aging should include sun protection, antioxidants, chelating agents, and DNA repair enzymes.

ANTIOXIDANTS (2022)

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Review Biochemistry & Molecular Biology

Focus on the Contribution of Oxidative Stress in Skin Aging

Federica Papaccio et al.

Summary: Skin aging is characterized by fine lines, wrinkling, loss of elasticity and volume, and rough-textured appearance. The alteration of oxidative balance plays a key role in driving senescence, with reactive oxygen species (ROS) being produced through cellular oxidative metabolism and environmental factors causing loss of redox equilibrium. In addition to the structural changes, aging skin also loses its natural functional characteristics and regenerative potential. The skin immune system undergoes functional senescence, resulting in reduced ability to counteract infections and increased frequency of autoimmune and neoplastic diseases.

ANTIOXIDANTS (2022)

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Review Cell Biology

Neuroendocrine signaling in the skin with a special focus on the epidermal neuropeptides

Andrzej T. Slominski et al.

Summary: The skin, as the largest organ in the human body, plays a crucial role in maintaining the body's homeostasis. It is regulated by local neuroendocrine and immune systems, with signaling molecules produced by resident and immune cells. Neurotransmitters, endocrine factors, neuropeptides, and cytokines released from nerve endings are involved in the skin's response to stress. The skin acts as a barrier against environmental stressors and communicates with other systems in the body to maintain overall homeostasis. Disturbances in these systems can lead to various skin pathologies.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2022)

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Article Public, Environmental & Occupational Health

Short-term exposure to ambient fine particulate matter and psoriasis: A time-series analysis in Beijing, China

Junhui Wu et al.

Summary: This study finds that short-term exposure to PM2.5 may be associated with exacerbations in psoriasis. Female and older patients appear to be more sensitive to the effects of PM2.5.

FRONTIERS IN PUBLIC HEALTH (2022)

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Review Allergy

The External Exposome and Allergies: From the Perspective of the Epithelial Barrier Hypothesis

Zeynep Celebi Sozener et al.

Summary: The external exposome has a significant impact on epithelial barriers and the development of allergic diseases. Factors such as pollution, microplastics, nanoparticles, climate change, altered dietary habits, and changes in microbial biodiversity can disrupt epithelial barriers and lead to increased vulnerability to allergens and microbes, resulting in chronic Th2 inflammation.

FRONTIERS IN ALLERGY (2022)

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Review Dermatology

The aryl hydrocarbon receptor pathway plays a central role in the cutaneous response to pollutants

Cecile Guillon et al.

Summary: This article highlights the significant health effects of atmospheric pollution, particularly on the skin. Research suggests that modulation of the AhR receptor may be an effective therapeutic approach to improve or prevent skin issues related to pollution.

EUROPEAN JOURNAL OF DERMATOLOGY (2022)

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Review Dermatology

Acne vulgaris: new evidence in pathogenesis and future modalities of treatment

Neirita Hazarika

Summary: Acne vulgaris, a common chronic disorder affecting up to 85% of adolescents and young adults, still has gaps in our understanding despite existing knowledge. This article reviews emerging evidence in the complex pathogenesis of acne and outlines potential future therapies in its management.

JOURNAL OF DERMATOLOGICAL TREATMENT (2021)

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Article Dermatology

Protective effects of a comprehensive topical antioxidant against ozone-induced damage in a reconstructed human skin model

Alessandra Pecorelli et al.

Summary: This study demonstrated that a topical antioxidant, WEL-DS, was effective in inhibiting oxidative damage caused by O-3 exposure in a human epidermal skin model. The pretreatment with WEL-DS significantly reduced the formation of reactive oxygen species, hydrogen peroxide, and 4-HNE protein adducts, while also decreasing the NF-kappa B p65 signal. Overall, WEL-DS showed protective effects against O-3-induced oxidative stress in the skin.

ARCHIVES OF DERMATOLOGICAL RESEARCH (2021)

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Article Dermatology

Efficacy and patient-reported outcomes from a phase 2b, randomized clinical trial of tapinarof cream for the treatment of adolescents and adults with atopic dermatitis

Amy S. Paller et al.

Summary: Tapinarof has shown significant efficacy in treating atopic dermatitis, improving severity of eczema and affected skin area. Patients' impressions of Tapinarof were generally positive. The results indicate that Tapinarof represents a potential important advancement in topical medicine development for atopic dermatitis.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2021)

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Article Dermatology

Implications of cigarette smoking on early-onset androgenetic alopecia: A cross-sectional Study

Ahmed S. Salem et al.

Summary: The study found that the prevalence of early-onset AGA was higher among smokers compared to nonsmokers, but the severity of AGA was not associated with the intensity of smoking.

JOURNAL OF COSMETIC DERMATOLOGY (2021)

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Letter Allergy

Association of prenatal Exposure to Fine Particulate matter Pollution with Childhood eczema

Tsung-Chieh Yao et al.

ALLERGY (2021)

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Review Biochemistry & Molecular Biology

A New Insight into the Potential Role of Tryptophan-Derived AhR Ligands in Skin Physiological and Pathological Processes

Monika Szelest et al.

Summary: The aryl hydrocarbon receptor (AhR) plays a crucial role in skin physiology and pathological processes, including melanogenesis, inflammation, and cancer. Tryptophan metabolites are distinct among natural and synthetic AhR ligands, affecting various signaling pathways and expanding interest in their influence on skin physiological and pathological processes. Further investigation is needed to understand the mechanisms by which AhR regulates skin function.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Fine Particulate Matter-Induced Oxidative Stress Mediated by UVA-Visible Light Leads to Keratinocyte Damage

Krystian Mokrzynski et al.

Summary: To protect the skin, it is essential to provide proper care and nutrition for efficient metabolism. Particulate matter like PM2.5 in the air can cause skin issues, while exposure to light can affect the health of skin cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Allergy

Association between ambient air pollution and development and persistence of atopic and non-atopic eczema in a cohort of adults

Diego J. Lopez et al.

Summary: The study found that increased exposure to residential ambient air pollutants was associated with an increased odds of eczema in males, but not in females. Additionally, there was a significant interaction between gender and ambient air pollution exposure and aeroallergen sensitization.

ALLERGY (2021)

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Review Dermatology

The impact of air pollution on skin and related disorders: A comprehensive review

Ruhollah Abolhasani et al.

Summary: Air pollutants may disrupt the normal barrier function of the skin, leading to various skin conditions and an increased risk of skin cancer. The mechanisms of action of different pollutants may vary, but most are related to oxidative stress and inflammation.

DERMATOLOGIC THERAPY (2021)

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Article Dermatology

Vitamin C prevents epidermal damage induced by PM-associated pollutants and UVA1 combined exposure

Ariane Dimitrov et al.

Summary: The study suggests that polycyclic aromatic hydrocarbons found in ultrafine particles may have a negative impact on skin health, affecting the survival and structure of epidermal cells. Additionally, the use of vitamin C provides significant protection against these harmful effects.

EXPERIMENTAL DERMATOLOGY (2021)

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Article Dermatology

A comprehensive topical antioxidant inhibits oxidative stress induced by blue light exposure and cigarette smoke in human skin tissue

Mitchell Wortzman et al.

Summary: The study found that the topical antioxidant WEL-DS significantly reduced ROS production induced by blue light and blue light combined with cigarette smoke (CS) in human skin. Untreated skin exposed to blue light and CS showed at least a tenfold increase in ROS, while pretreatment with WEL-DS led to a significant decrease in ROS production in both scenarios.

JOURNAL OF COSMETIC DERMATOLOGY (2021)

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Article Dermatology

Anti-pollution skincare: Research on effective ways to protect skin from particulate matter

Jongeun Lee et al.

Summary: The study evaluated the efficacy of different skincare products in protecting skin from particulate matter pollution. It found that maintaining skin barrier function with barrier cream is sufficient for individuals sensitive to PM, as there were no significant differences in skin measurements before and after application, indicating no worsening of skin condition during high-PM periods.

DERMATOLOGIC THERAPY (2021)

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Review Dermatology

Atopic dermatitis: Role of the skin barrier, environment, microbiome, and therapeutic agents

Thomas Luger et al.

Summary: AD is a chronic inflammatory skin disorder characterized by eczematous and pruritic skin lesions, with increasing prevalence worldwide in recent decades. Studies have shown that genetic defects affecting structural proteins of the skin barrier, as well as exposure to environmental allergens and pollutants, contribute to the development of AD. Research on epidermal barrier function, inflammation, lipid metabolism, and bacterial communities is crucial for understanding the complex etiology of AD and developing new therapies.

JOURNAL OF DERMATOLOGICAL SCIENCE (2021)

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Review Dermatology

Tapinarof in the treatment of psoriasis: A review of the unique mechanism of action of a novel therapeutic aryl hydrocarbon receptor-modulating agent

Robert Bissonnette et al.

Summary: Tapinarof is a novel topical therapeutic agent for psoriasis and atopic dermatitis, which works by specifically binding and activating the AhR to downregulate proinflammatory cytokines and regulate skin barrier proteins. Its efficacy and tolerability in early clinical trials are attributed to AhR signaling-mediated effects on immune and skin cells.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2021)

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Review Medicine, General & Internal

Atopic Dermatitis

Sonja Staender

Summary: Atopic dermatitis is a chronic condition that typically begins in childhood and can persist into adulthood, with treatment options including both topical and systemic approaches targeting the underlying immune condition.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Review Dermatology

Daily photoprotection to prevent photoaging

Jean Krutmann et al.

Summary: Research indicates that broad protection against the entire solar range of UVB, UVA, UVA1, visible light, and short infrared (IRA) is required to prevent extrinsic skin aging. In addition, daily broad-spectrum sunscreen containing antioxidant and anti-aging active ingredients can effectively reduce extrinsic aging.

PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE (2021)

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Article Dermatology

Association of Wildfire Air Pollution and Health Care Use for Atopic Dermatitis and Itch

Raj P. Fadadu et al.

Summary: This study found that short-term exposure to air pollution from wildfires was associated with increased healthcare use for patients with AD and itch, providing a better understanding of the association between poor air quality and skin health and guiding healthcare professionals in counseling patients with skin diseases and public health practices.

JAMA DERMATOLOGY (2021)

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Review Cell Biology

Sirtuin 1 and Skin: Implications in Intrinsic and Extrinsic Aging-A Systematic Review

Angelika Bielach-Bazyluk et al.

Summary: Skin aging is influenced by both intrinsic and extrinsic factors, with UV radiation being a major extrinsic factor. Sirtuin 1 plays a key role in regulating protein, histone, and chromatin expression, demonstrating beneficial effects on skin aging but with controversial role in carcinogenesis.

CELLS (2021)

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Review Medicine, Research & Experimental

Natural compounds protect the skin from airborne particulate matter by attenuating oxidative stress

Ping Diao et al.

Summary: The review highlights the mechanisms of skin damage caused by particulate matter (PM), emphasizing the effects of reactive oxygen species accumulation and autophagy, while suggesting that extracts with high antioxidant capacity from plants and natural compounds may have potential protective effects against air pollution-related skin damage.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Public, Environmental & Occupational Health

Association between exposure to ambient air pollution and occurrence of inflammatory acne in the adult population

Claudia El Haddad et al.

Summary: This study found that inflammatory acne in Lebanese adults was associated with high levels of NO2 exposure and employment near a power plant emitting CO2, CO, SO2, NO2, and PM. These findings can be the first step towards implementing appropriate skin care routines in highly polluted areas.

BMC PUBLIC HEALTH (2021)

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Article Microbiology

Commensal microbiota regulates skin barrier function and repair via signaling through the aryl hydrocarbon receptor

Aayushi Uberoi et al.

Summary: This research demonstrates the essential role of the skin microbiome in regulating skin barrier formation and repair, mediated by microbiota signaling through the aryl hydrocarbon receptor (AHR) in keratinocytes. These findings reveal a fundamental mechanism whereby the microbiota influences the integrity of the skin barrier.

CELL HOST & MICROBE (2021)

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Article Environmental Sciences

Particulate matter promotes hyperpigmentation via AhR/MAPK signaling activation and by increasing a-MSH paracrine levels in keratinocytes

Yaqian Shi et al.

Summary: PM2.5 has become a global concern for public health and the environment, with the ability to induce skin aging and hyperpigmentation. By activating specific signaling pathways, PM2.5 can induce melanogenesis and promote hyperpigmentation.

ENVIRONMENTAL POLLUTION (2021)

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Review Environmental Sciences

Epigenetic related changes on air quality

Alvaro del Real et al.

Summary: The review focuses on the relationship between epigenetic marks, exposure to air pollution, and human health, highlighting how air contaminants lead to changes in the epigenome, increasing susceptibility to diseases. Further analyses derived from particulate matter (PM) exposure are necessary to identify new targets and disease biomarkers, as some epigenetic change mechanisms remain unclear.

ENVIRONMENTAL RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Immunological Aspects of Skin Aging in Atopic Dermatitis

Georgeta St Bocheva et al.

Summary: The aging skin undergoes immunosenescence and immunological alterations, which together with environmental stressors and genetic factors can lead to immune dysregulation and epidermal barrier abnormalities, facilitating the late onset of atopic dermatitis (AD) in the elderly. While healthy aged skin shows overproduction of cytokines, older AD patients have decreased levels of Th2/Th22 related cytokines and increased expression of terminal differentiation markers, reflecting the persistence of AD in an aged skin environment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

The Impact of Vitamin D on Skin Aging

Georgeta Bocheva et al.

Summary: The active metabolites of vitamin D-3 and lumisterol have antiaging and photoprotective effects on the skin through immunomodulation, antioxidative responses, and DNA repair mechanisms. They interact with multiple nuclear receptors and have potential for preventing, attenuating, or treating premature skin aging. Further clinical evaluation of topically applied derivatives is needed for future trials.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Melatonin, Its Metabolites and Their Interference with Reactive Nitrogen Compounds

Rudiger Hardeland

Summary: Melatonin and its metabolites interfere with reactive nitrogen, with metabolites mainly found in tissues rather than in the circulation. They possess antioxidant properties, downregulate NO synthases, scavenge NO, and play protective roles in oxidative processes.

MOLECULES (2021)

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Article Dermatology

Traffic-derived air pollution compromises skin barrier function and stratum corneum redox status: A population study

Nan Huang et al.

JOURNAL OF COSMETIC DERMATOLOGY (2020)

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Article Oncology

Relevance of Vitamin D in Melanoma Development, Progression and Therapy

Anna A. Brozyna et al.

ANTICANCER RESEARCH (2020)

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Article Medicine, General & Internal

Aryl hydrocarbon receptor expression in serum, peripheral blood mononuclear cells, and skin lesions of patients with atopic dermatitis and its correlation with disease severity

Yu-Qing Hu et al.

CHINESE MEDICAL JOURNAL (2020)

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Article Endocrinology & Metabolism

Characterization of serotonin and N-acetylserotonin systems in the human epidermis and skin cells

Andrzej T. Slominski et al.

JOURNAL OF PINEAL RESEARCH (2020)

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Review Endocrinology & Metabolism

New aspects of vitamin D metabolism and action - addressing the skin as source and target

Daniel Bikle et al.

NATURE REVIEWS ENDOCRINOLOGY (2020)

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Toxicity and DNA repair in normal human keratinocytes co-exposed to benzo[α]pyrene and sunlight

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Ultrafine particles: unique physicochemical properties relevant to health and disease

Hyouk-Soo Kwon et al.

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Ambient particulate matter oxidative potential: Chemical determinants, associated health effects, and strategies for risk management

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CYP11A1-derived vitamin D 3 products protect against UVB-induced inflammation and promote keratinocytes differentiation

Anyamanee Chaiprasongsuk et al.

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Role of Aryl Hydrocarbon Receptor Activation and Autophagy in Psoriasis-Related Inflammation

Hye Ran Kim et al.

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Air Particulate Matter Induces Skin Barrier Dysfunction and Water Transport Alteration on a Reconstructed Human Epidermis Model

Daniele Seo Hieda et al.

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Pigmentation effects of blue light irradiation on skin and how to protect against them

R. Campiche et al.

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NRF2, a Transcription Factor for Stress Response and Beyond

Feng He et al.

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Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic Dermatitis

Masutaka Furue

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Clinical and biological impact of the exposome on the skin

T. Passeron et al.

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Mechanisms of blue light-induced eye hazard and protective measures: a review

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Effects of air pollution on the nervous system and its possible role in neurodevelopmental and neurodegenerative disorders

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Exposing human primary dermal fibroblasts to particulate matter induces changes associated with skin aging

Wil J. Reynolds et al.

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Immunologic Effects of Vitamin D on Human Health and Disease

Nipith Charoenngam et al.

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Air Pollution and Atopic Dermatitis (AD): The Impact of Particulate Matter (PM10) on an AD Mouse-Model

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Night Cream Containing Melatonin, Carnosine andHelichrysum italicumExtract Helps Reduce Skin Reactivity and Signs of Photodamage: Ex Vivo and Clinical Studies

Corinne Granger et al.

DERMATOLOGY AND THERAPY (2020)

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IL-24 Negatively Regulates Keratinocyte Differentiation Induced by Tapinarof, an Aryl Hydrocarbon Receptor Modulator: Implication in the Treatment of Atopic Dermatitis

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Hydroxylumisterols, Photoproducts of Pre-Vitamin D3, Protect Human Keratinocytes against UVB-Induced Damage

Anyamanee Chaiprasongsuk et al.

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Air Pollution and Central Nervous System Disease: A Review of the Impact of Fine Particulate Matter on Neurological Disorders

Hyunyoung Kim et al.

FRONTIERS IN PUBLIC HEALTH (2020)

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Short-term effects of exposure to air pollution on biophysical parameters of skin in a panel of healthy adults

Mansour Shamsipour et al.

DERMATOLOGIC THERAPY (2020)

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Particulate Matters Induce Apoptosis in Human Hair Follicular Keratinocytes

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ANNALS OF DERMATOLOGY (2020)

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Revival of AHR Agonist for the Treatment of Atopic Dermatitis: Tapinarof

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CURRENT TREATMENT OPTIONS IN ALLERGY (2020)

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Photoprotective Properties of Vitamin D and Lumisterol Hydroxyderivatives

Andrzej T. Slominski et al.

CELL BIOCHEMISTRY AND BIOPHYSICS (2020)

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A phase 2, randomized dose-finding study of tapinarof (GSK2894512 cream) for the treatment of atopic dermatitis

Johnny Peppers et al.

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The serum vitamin D metabolome: What we know and what is still to discover

Robert C. Tuckey et al.

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Tropospheric ozone and skin aging: Results from two German cohort studies

Kateryna B. Fuks et al.

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The impact of airborne pollution on skin

E. Araviiskaia et al.

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Particulate matter induces pro-inflammatory cytokines via phosphorylation of p38 MAPK possibly leading to dermal inflammaging

MinJeong Kim et al.

EXPERIMENTAL DERMATOLOGY (2019)

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Climate change and skin cancer

M. J. Lin et al.

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An in vitro model to evaluate the impact of environmental fine particles (PM0.3-2.5) on skin damage

Anthony Verdin et al.

TOXICOLOGY LETTERS (2019)

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Associations of gestational and the first year of life exposure to ambient air pollution with childhood eczema in Hubei, China

Shumin Deng et al.

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AhR regulates the expression of human cytochrome P450 1A1 (CYP1A1) by recruiting Sp1

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Neuroendocrine Aspects of Skin Aging

Georgeta Bocheva et al.

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The interactive effects between air pollution and meteorological factors on the hospital outpatient visits for atopic dermatitis in Beijing, China: a time-series analysis

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Environmental Stressors on Skin Aging. Mechanistic Insights

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Protective effects of novel derivatives of vitamin D3 and lumisterol against UVB-induced damage in human keratinocytes involve activation of Nrf2 and p53 defense mechanisms

Anyamanee Chaiprasongsuk et al.

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Propionibacterium acnes and Acne Vulgaris: New Insights from the Integration of Population Genetic, Multi-Omic, Biochemical and Host-Microbe Studies

Joseph McLaughlin et al.

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Blue light disrupts the circadian rhythm and create damage in skin cells

K. Dong et al.

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Aryl Hydrocarbon Receptor in Atopic Dermatitis and Psoriasis

Masutaka Furue et al.

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Particulate Matter 2.5 Mediates Cutaneous Cellular Injury by Inducing Mitochondria-Associated Endoplasmic Reticulum Stress: Protective Effects of Ginsenoside Rb1

Mei Jing Piao et al.

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Air pollution, environmental chemicals, and smoking may trigger vitamin D deficiency: Evidence and potential mechanisms

Sayed Esmaeil Mousavi et al.

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Ultraviolet radiation, both UVA and UVB, influences the composition of the skin microbiome

Erin M. Burns et al.

EXPERIMENTAL DERMATOLOGY (2019)

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Relative impact of meteorological factors and air pollutants on childhood allergic diseases in Shanghai, China

Yabin Hu et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2019)

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Chloracne and Hyperpigmentation Caused by Exposure to Hazardous Aryl Hydrocarbon Receptor Ligands

Masutaka Furue et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2019)

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Establishment of an Anti-acne Vulgaris Evaluation Method Based on TLR2 and TLR4-mediated Interleukin-8 Production

Pichit Suvanprakorn et al.

IN VIVO (2019)

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Acne prevalence and associations with lifestyle: a cross-sectional online survey of adolescents/young adults in 7 European countries

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JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2018)

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Particulate matter 2.5 damages skin cells by inducing oxidative stress, subcellular organelle dysfunction, and apoptosis

Mei Jing Piao et al.

ARCHIVES OF TOXICOLOGY (2018)

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Outdoor air pollution, green space, and cancer incidence in Saxony: a semi-individual cohort study

Thomas Datzmann et al.

BMC PUBLIC HEALTH (2018)

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The impact of air pollutants, UV exposure and geographic location on vitamin D deficiency

Edris Hoseinzadeh et al.

FOOD AND CHEMICAL TOXICOLOGY (2018)

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Urban particulate matter in air pollution penetrates into the barrier-disrupted skin and produces ROS-dependent cutaneous inflammatory response in vivo

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Microbiome analysis of forehead skin in patients with atopic dermatitis and healthy subjects: Implication of Staphylococcus and Corynebacterium

Masutaka Furue et al.

JOURNAL OF DERMATOLOGY (2018)

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Vitamin D Receptor Is Required for Proliferation, Migration, and Differentiation of Epidermal Stem Cells and Progeny during Cutaneous Wound Repair

Yuko Oda et al.

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Ferulic acid photoprotective properties in association with UV filters: multifunctional sunscreen with improved SPF and UVA-PF

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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2018)

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On the role of classical and novel forms of vitamin D in melanoma progression and management

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JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2018)

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The influence of exposome on acne

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JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2018)

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Keratinocytes oxidative damage mechanisms related to airbone particle matter exposure

Arianna Romani et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2018)

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A Time-Series Study of the Effect of Air Pollution on Outpatient Visits for Acne Vulgaris in Beijing

Wei Liu et al.

SKIN PHARMACOLOGY AND PHYSIOLOGY (2018)

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Polycyclic aromatic hydrocarbons (PAHs) skin permeation rates change with simultaneous exposures to solar ultraviolet radiation (UV-S)

Nancy B. Hopf et al.

TOXICOLOGY LETTERS (2018)

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Preventive Effect of Residential Green Space on Infantile Atopic Dermatitis Associated with Prenatal Air Pollution Exposure

Ji-Young Lee et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2018)

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Air pollution exposure during pregnancy and spontaneous abortion and stillbirth

Alexandra Grippo et al.

REVIEWS ON ENVIRONMENTAL HEALTH (2018)

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Air Pollution, Autophagy, and Skin Aging: Impact of Particulate Matter (PM10) on Human Dermal Fibroblasts

Seo-Yeon Park et al.

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Pollution and Sun Exposure: A Dele serious Synergy Mechanisms and Opportunities for Skin Protection

Laurent Marrot

CURRENT MEDICINAL CHEMISTRY (2018)

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Differential and Overlapping Effects of 20,23(OH)2D3 and 1,25(OH)2D3 on Gene Expression in Human Epidermal Keratinocytes: Identification of AhR as an Alternative Receptor for 20,23(OH)2D3

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Old Receptor, New TricksThe Ever-Expanding Universe of Aryl Hydrocarbon Receptor Functions. Report from the 4th AHR Meeting, 29-31 August 2018 in Paris, France

Charlotte Esser et al.

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Melatonin and Its Metabolites Ameliorate UVR-Induced Mitochondrial Oxidative Stress in Human MNT-1 Melanoma Cells

Konrad Kleszczynski et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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How UV Light Touches the Brain and Endocrine System Through Skin, and Why

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ENDOCRINOLOGY (2018)

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Multi-year Study of PAHs in Mainstream Cigarette Smoke

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Exposure to fine particulate matter associated with senile lentigo in Chinese women: a cross-sectional study

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The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin

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NATURE IMMUNOLOGY (2017)

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Bad air gets under your skin

Roxanna Koohgoli et al.

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Metabolism of melatonin in the skin: Why is it important?

Andrzej T. Slominski et al.

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Blue light-induced oxidative stress in live skin

Yuya Nakashima et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

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The interplay between genetic and environmental factors in the pathogenesis of atopic dermatitis

Atsushi Otsuka et al.

IMMUNOLOGICAL REVIEWS (2017)

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Photo-pollution stress in skin: Traces of pollutants (PAH and particulate matter) impair redox homeostasis in keratinocytes exposed to UVA1

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Inhibition of aryl hydrocarbon receptor signaling and induction of NRF2-mediated antioxidant activity by cinnamaldehyde in human keratinocytes

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Classification, Source, and Effect of Environmental Pollutants and Their Biodegradation

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JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY (2017)

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Protective Effects of Topical Vitamin C Compound Mixtures against Ozone-Induced Damage in Human Skin

Giuseppe Valacchi et al.

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Oral Vitamin D Rapidly Attenuates Inflammation from Sunburn: An Interventional Study

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Cigarette Smoking and the Risks of Basal Cell Carcinoma and Squamous Cell Carcinoma

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Tapinarof Is a Natural AhR Agonist that Resolves Skin Inflammation in Mice and Humans

Susan H. Smith et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2017)

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Challenge and perspective: the relevance of ultraviolet (UV) radiation and the vitamin D endocrine system (VDES) for psoriasis and other inflammatory skin diseases

Joerg Reichrath et al.

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES (2017)

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Atopic dermatitis is associated with active and passive cigarette smoking in adolescents

So Young Kim et al.

PLOS ONE (2017)

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Antioxidants for Healthy Skin: The Emerging Role of Aryl Hydrocarbon Receptors and Nuclear Factor-Erythroid 2-Related Factor-2

Masutaka Furue et al.

NUTRIENTS (2017)

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Melatonin reverses the enhanced oxidative damage to membrane lipids and improves skin biophysical characteristics in former-smokers - A study in postmenopausal women

Dorota Sagan et al.

ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE (2017)

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Independent impacts of aging on mitochondrial DNA quantity and quality in humans

Ruoyu Zhang et al.

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Melatonin as a mitochondria-targeted antioxidant: one of evolution's best ideas

Russel J. Reiter et al.

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Cutaneous squamous cell carcinoma: an epidemiological review

A. C. Green et al.

BRITISH JOURNAL OF DERMATOLOGY (2017)

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Airborne polycyclic aromatic hydrocarbons trigger human skin cells aging through aryl hydrocarbon receptor

Yuan Qiao et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

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Pollution and acne: is there a link?

Jean Krutmann et al.

CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY (2017)

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Skin Damage Mechanisms Related to Airborne Particulate Matter Exposure

Natalia D. Magnani et al.

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Consequences of urban pollution upon skin status. A controlled study in Shanghai area

M-A. Lefebvre et al.

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Mitochondrial oxidative DNA damage and exposure to particulate air pollution in mother-newborn pairs

Lotte Grevendonk et al.

ENVIRONMENTAL HEALTH (2016)

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Benzo(a)pyrene in Europe: Ambient air concentrations, population exposure and health effects

C. B. B. Guerreiro et al.

ENVIRONMENTAL POLLUTION (2016)

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Classical and non-classical metabolic transformation of vitamin D in dermal fibroblasts

Andrzej T. Slominski et al.

EXPERIMENTAL DERMATOLOGY (2016)

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Benzopyrene, a major polyaromatic hydrocarbon in smoke fume, mobilizes Langerhans cells and polarizes Th2/17 responses in epicutaneous protein sensitization through the aryl hydrocarbon receptor

Chien-Hui Hong et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2016)

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Relationships Between Urinary Phthalate Metabolite and Bisphenol A Concentrations and Vitamin D Levels in US Adults: National Health and Nutrition Examination Survey (NHANES), 2005-2010

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JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2016)

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Aryl Hydrocarbon Receptor in Keratinocytes Is Essential for Murine Skin Barrier Integrity

Katharina Haas et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2016)

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Association of atopic dermatitis with smoking: A systematic review and meta-analysis

Robert Kantor et al.

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Targeting the vitamin D endocrine system (VDES) for the management of inflammatory and malignant skin diseases: An historical view and outlook

Joerg Reichrath et al.

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS (2016)

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In vitro model adapted to the study of skin ageing induced by air pollution

Sarah Lecas et al.

TOXICOLOGY LETTERS (2016)

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Urban particulate matter down-regulates filaggrin via COX2 expression/PGE2 production leading to skin barrier dysfunction

Chiang-Wen Lee et al.

SCIENTIFIC REPORTS (2016)

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Oxidation events and skin aging

A. Kammeyer et al.

AGEING RESEARCH REVIEWS (2015)

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Secondhand smoke exposure-induced nucleocytoplasmic shuttling of HMGB1 in a rat premature skin aging model

Sirintip Chaichalotornkul et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

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Nrf2-A regulator of keratinocyte redox signaling

Matthias Schaefer et al.

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The impact of urban particulate pollution on skin barrier function and the subsequent drug absorption

Tai-Long Pan et al.

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The Janus-Faced Role of Aryl Hydrocarbon Receptor Signaling in the Skin: Consequences for Prevention and Treatment of Skin Disorders

Thomas Haarmann-Stemmann et al.

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Melatonin: an ancient molecule that makes oxygen metabolically tolerable

Lucien C. Manchester et al.

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CYP11A1 in skin: An alternative route to photoprotection by vitamin D compounds

Wannit Tongkao-on et al.

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Recognizing the impact of ambient air pollution on skin health

S. E. Mancebo et al.

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The contribution of outdoor air pollution sources to premature mortality on a global scale

J. Lelieveld et al.

NATURE (2015)

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Vitamin C Compound Mixtures Prevent Ozone-Induced Oxidative Damage in Human Keratinocytes as Initial Assessment of Pollution Protection

Giuseppe Valacchi et al.

PLOS ONE (2015)

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Nanoparticles skin absorption: New aspects for a safety profile evaluation

Francesca Larese Filon et al.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2015)

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Evaluation of the impact of urban pollution on the quality of skin: a multicentre study in Mexico

M. -A. Lefebvre et al.

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Oxidization of squalene, a human skin lipid: a new and reliable marker of environmental pollution studies

D. -M. Pham et al.

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Winter 25-hydroxyvitamin D levels in young urban adults are affected by smoking, body mass index and educational level

A. Shinkov et al.

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2015)

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Exposure to Non-Extreme Solar UV Daylight: Spectral Characterization, Effects on Skin and Photoprotection

Claire Marionnet et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

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Effective Photoprotection of Human Skin against Infrared A Radiation by Topically Applied Antioxidants: Results from a Vehicle Controlled, Double-Blind, Randomized Study

Susanne Grether-Beck et al.

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2015)

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The relationship between UV exposure and incidence of skin cancer

Johan Moan et al.

PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE (2015)

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Cigarette Smoke-Induced Interleukin-1 Alpha May Be Involved in the Pathogenesis of Adult Acne

Yun Seok Yang et al.

ANNALS OF DERMATOLOGY (2014)

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Role of AhR/ARNT system in skin homeostasis

Masutaka Furue et al.

ARCHIVES OF DERMATOLOGICAL RESEARCH (2014)

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Psoriasis and smoking: a systematic review and meta-analysis

A. W. Armstrong et al.

BRITISH JOURNAL OF DERMATOLOGY (2014)

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Increased expression of the aryl hydrocarbon receptor in patients with chronic inflammatory skin diseases

Hye One Kim et al.

EXPERIMENTAL DERMATOLOGY (2014)

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Cutaneous glucocorticosteroidogenesis: securing local homeostasis and the skin integrity

Andrzej T. Slominski et al.

EXPERIMENTAL DERMATOLOGY (2014)

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New insights in photoaging, UVA induced damage and skin types

Claire Battie et al.

EXPERIMENTAL DERMATOLOGY (2014)

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Effects of climate changes on skin diseases

Nicola Balato et al.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2014)

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Local Melatoninergic System as the Protector of Skin Integrity

Andrzej T. Slominski et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)

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The role of CYP11A1 in the production of vitamin D metabolites and their role in the regulation of epidermal functions

Andrzej T. Slominski et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2014)

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Modulation of sebum oxidation and interleukin-1α levels associates with clinical improvement of mild comedonal acne

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Article Pharmacology & Pharmacy

Keratinocyte-derived IL-24 plays a role in the positive feedback regulation of epidermal inflammation in response to environmental and endogenous toxic stressors

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TOXICOLOGY AND APPLIED PHARMACOLOGY (2014)

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The dioxin receptor has tumor suppressor activity in melanoma growth and metastasis

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ENDOCRINE REVIEWS (2013)

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Role of the aryl hydrocarbon receptor in tobacco smoke extractinduced matrix metalloproteinase-1 expression

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EXPERIMENTAL DERMATOLOGY (2013)

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Letter Allergy

Symptoms of atopic dermatitis are influenced by outdoor air pollution

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JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)

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Article Endocrinology & Metabolism

Melatonin enhances antioxidative enzyme gene expression (CAT, GPx, SOD), prevents their UVR-induced depletion, and protects against the formation of DNA damage (8-hydroxy-2′-deoxyguanosine) in ex vivo human skin

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JOURNAL OF PINEAL RESEARCH (2013)

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On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK

Annia Galano et al.

JOURNAL OF PINEAL RESEARCH (2013)

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Review Biochemistry & Molecular Biology

Steroidogenesis in the skin: Implications for local immune functions

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JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2013)

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Article Multidisciplinary Sciences

Exposure to Atmospheric Particulate Matter Enhances Th17 Polarization through the Aryl Hydrocarbon Receptor

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PLOS ONE (2013)

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Review Immunology

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SEMINARS IN IMMUNOPATHOLOGY (2013)

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Article Toxicology

2,3,7,8-Tetrachlorodibenzo-p-dioxin-Mediated Production of Reactive Oxygen Species Is An Essential Step in the Mechanism of Action to Accelerate Human Keratinocyte Differentiation

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Review Dermatology

Novel vitamin D photoproducts and their precursors in the skin

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DERMATO-ENDOCRINOLOGY (2013)

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Article Biochemistry & Molecular Biology

In vivo evidence for a novel pathway of vitamin D3 metabolism initiated by P450scc and modified by CYP27B1

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FASEB JOURNAL (2012)

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Article Endocrinology & Metabolism

Gestational Exposure to Urban Air Pollution Related to a Decrease in Cord Blood Vitamin D Levels

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JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2012)

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Identification of Ketoconazole as an AhR-Nrf2 Activator in Cultured Human Keratinocytes: The Basis of Its Anti-Inflammatory Effect

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JOURNAL OF INVESTIGATIVE DERMATOLOGY (2012)

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Article Multidisciplinary Sciences

Langerhans Cells Facilitate Epithelial DNA Damage and Squamous Cell Carcinoma

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SCIENCE (2012)

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Article Pharmacology & Pharmacy

Polycyclic aromatic hydrocarbons as skin carcinogens: Comparison of benzo [a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse

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TOXICOLOGY AND APPLIED PHARMACOLOGY (2012)

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Article Toxicology

Simultaneous determination of nicotine and PAH metabolites in human hair specimen: A potential methodology to assess tobacco smoke contribution in PAH exposure

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TOXICOLOGY LETTERS (2012)

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Environmental influences on skin aging and ethnic-specific manifestations

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1α,25(OH)2-Vitamin D and a Nongenomic Vitamin D Analogue Inhibit Ultraviolet Radiation-Induced Skin Carcinogenesis

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CANCER PREVENTION RESEARCH (2011)

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Article Dermatology

The Aryl Hydrocarbon Receptor Mediates UVB Radiation-Induced Skin Tanning

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JOURNAL OF INVESTIGATIVE DERMATOLOGY (2011)

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Article Biotechnology & Applied Microbiology

Activation of the aryl hydrocarbon receptor is the major toxic mode of action of an organic extract of a reference urban dust particulate matter mixture: The role of polycyclic aromatic hydrocarbons

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Airborne Particle Exposure and Extrinsic Skin Aging

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Aryl Hydrocarbon Receptor Is an Ozone Sensor in Human Skin

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Molecular Basis of Tobacco Smoke-Induced Premature Skin Aging

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Article Medicine, General & Internal

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) poisoning in Victor Yushchenko: identification and measurement of TCDD metabolites

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EGF receptor signaling blocks aryl hydrocarbon receptor-mediated transcription and cell differentiation in human epidermal keratinocytes

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Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair

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EXPERIMENTAL DERMATOLOGY (2008)

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IL-8 as antibody therapeutic target in inflammatory diseases: Reduction of clinical activity in palmoplantar pustulosis

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Intrinsic and extrinsic factors in skin ageing: a review

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Temporal changes in sebum excretion and propionibacterial colonization in preadolescent children with and without acne

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BRITISH JOURNAL OF DERMATOLOGY (2007)

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Endogenous UVA-photosensitizers: mediators of skin photodamage and novel targets for skin photoprotection

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Review Biochemistry & Molecular Biology

The cutaneous serotoninergic/melatoninergic system: securing a place under the sun

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Ultraviolet a induces generation of squalene monohydroperoxide isomers in human sebum and skin surface lipids in vitro and in vivo

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Article Dermatology

Effect of smoking and sun on the aging skin

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Article Biochemical Research Methods

Quantification of polycyclic aromatic hydrocarbons (PAHs) in human hair by HPLC with fluorescence detection: a biological monitoring method to evaluate the exposure to PAHs

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Tobacco smoke extract induces age-related changes due to modulation of TGF-beta

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Expression of hypothalamic-pituitary-thyroid axis related genes in the human skin

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Serotoninergic and melatoninergic systems are fully expressed in human skin

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FASEB JOURNAL (2002)

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Review Biochemistry & Molecular Biology

Cutaneous expression of corticotropin-releasing hormone (CRH), urocortin, and CRH receptors

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Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress

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Induction of alopecia in mice exposed to cigarette smoke

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Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

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Tanning as part of the eukaryotic SOS response

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Environmental Air Pollutants Affecting Skin Functions with Systemic Implications

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