☆ 4.7 Review

Liquid Biopsy in Lung Cancer: Biomarkers for the Management of Recurrence and Metastasis

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Correlation of exosomal microRNA clusters with bone metastasis in non-small cell lung cancer

Xiao-Rong Yang et al.

Summary: This study examined plasma-derived exosomal microRNAs in 30 non-small cell lung cancer patients and found significantly differential expression of miRNAs in BM+ patients, suggesting potential associations with preconditioning of the metastatic niche.

CLINICAL & EXPERIMENTAL METASTASIS (2021)

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Article Medical Laboratory Technology

Multiplex Detection of Clinically Relevant Mutations in Liquid Biopsies of Cancer Patients Using a Hybridization-Based Platform

Ana Gimenez-Capitan et al.

Summary: The study investigated the potential of using the nCounter platform for detecting clinically relevant alterations in fluid samples from cancer patients. It was found that the platform requires less DNA than NGS and can be employed for routine mutation testing in liquid biopsies. The results were validated through retrospective and prospective analyses, confirming the effectiveness of the nCounter SNV panel for detecting mutations in various genes.

CLINICAL CHEMISTRY (2021)

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Article Oncology

Circulating microbiome DNA: An emerging paradigm for cancer liquid biopsy

Haiming Chen et al.

Summary: Dysbiosis of the human microbiome has been linked to various cancers, with differential microbiome composition potentially serving as novel biomarkers for cancer detection and immunotherapy success. Furthermore, circulating microbiome DNA alterations have shown promise as noninvasive biomarkers for cancer detection, with distinct bacterial DNA able to differentiate cancer patients from healthy individuals.

CANCER LETTERS (2021)

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Review Biochemistry & Molecular Biology

Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment

Khiem C. Lam et al.

Summary: This study reveals how the microbiota influences the immune components of the TME to improve cancer therapy. Modulating the microbiota can trigger the IFN-I-NK cell-DC axis within tumors, enhancing the efficacy of immune checkpoint blockade (ICB).

CELL (2021)

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Review Oncology

Steps in metastasis: an updated review

Jamal Majidpoor et al.

Summary: Metastasis is a complex and deadly process involving various mechanisms and influencing factors. It can be targeted through strategies such as repressing pre-metastatic niche formation, suppressing environmental stressors, and targeting signaling pathways and cell types involved in the process.

MEDICAL ONCOLOGY (2021)

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Article Oncology

Liquid biopsy enters the clinic - implementation issues and future challenges

Michail Ignatiadis et al.

Summary: The approval of liquid biopsy assays for detecting genetic alterations in plasma cell-free DNA has marked a tipping point for the clinical use of this technology, especially in patients with advanced-stage cancer. The next frontier is likely to be the systemic treatment of patients with 'ctDNA relapse' and other potential future applications include cancer screening and diagnosis.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

VEGF-C mediates tumor growth and metastasis through promoting EMT-epithelial breast cancer cell crosstalk

Deguang Kong et al.

Summary: VEGF-C secreted by EMT breast cancer cells can promote proliferation, migration, and invasion of epithelial breast cancer cells through non-canonical activation of GLI signaling. Inhibiting VEGF-C in EMT cells or knocking down NRP2 in neighboring epithelial cancer cells disrupts the aggressive phenotypes induced by EMT cells, suggesting a novel therapeutic target for metastasis in breast cancer.

ONCOGENE (2021)

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Review Medicine, Research & Experimental

Progress of exosomes in the diagnosis and treatment of lung cancer

Kanghong Xu et al.

Summary: Lung cancer has the highest incidence and mortality rates worldwide, lacking early diagnostic biomarkers. Exosomes, as a mode of intercellular communication, play a role in regulating physiological processes in lung cancer by delivering various biomolecules. Studying the role of exosomes in diagnosing and treating lung cancer is crucial for improving treatment outcomes.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Review Biotechnology & Applied Microbiology

Nanopore sequencing technology, bioinformatics and applications

Yunhao Wang et al.

Summary: Advancements in nanopore technologies for sequencing long DNA and RNA molecules have greatly improved accuracy, read length, and throughput. The field of nanopore sequencing continues to offer opportunities for enhancing data quality and analytical approaches through the development of new technologies tailored to specific applications.

NATURE BIOTECHNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Nanopore sequencing from liquid biopsy: analysis of copy number variations from cell-free DNA of lung cancer patients

Filippo Martignano et al.

Summary: Liquid biopsy, particularly analyzing cell-free DNA, is crucial in precision oncology. Nanopore sequencing provides a cost-effective and rapid alternative for detecting copy number variations in plasma DNA, making it accessible for both research and clinical purposes.

MOLECULAR CANCER (2021)

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Review Biochemistry & Molecular Biology

Progress on pivotal role and application of exosome in lung cancer carcinogenesis, diagnosis, therapy and prognosis

Ming-Yue Li et al.

Summary: Lung cancer is often diagnosed late with poor prognosis, and conventional treatments are ineffective for metastatic lung cancer. Lung cancer cell-derived exosomes are receiving attention for their potential in carcinogenesis, diagnosis, therapy, and prognosis of lung cancer, with studies looking into their use as drug delivery vehicles and potential clinical applications.

MOLECULAR CANCER (2021)

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Review Genetics & Heredity

Liquid Biopsies: Applications for Cancer Diagnosis and Monitoring

Ivana Martins et al.

Summary: Liquid biopsies are a revolutionary approach for cancer management as they can provide a more comprehensive characterization of tumor profiles through the detection of circulating tumor-derived components in biofluids. They have the potential to assist in diagnosis, prognosis, treatment selection, as well as monitoring disease evolution and treatment response in real-time. Despite their value in oncology, some limitations still need to be addressed for their routine clinical implementation.

GENES (2021)

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Article Multidisciplinary Sciences

The association between gut microbiome affecting concomitant medication and the effectiveness of immunotherapy in patients with stage IV NSCLC

M. V. Verschueren et al.

Summary: The study found that the use of antibiotics and opioids is associated with worse outcomes in both chemotherapy and immunotherapy treated NSCLC patients, suggesting that this association is likely due to confounding factors rather than affecting the composition of the microbiome.

SCIENTIFIC REPORTS (2021)

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Review Hematology

Lessons to learn from tumor-educated platelets

Harvey G. Roweth et al.

Summary: Platelets, beyond their traditional roles in hemostasis and thrombosis, are now recognized as mediators of malignant disease, particularly in cancer progression and metastasis. Platelets isolated from cancer patients, known as tumor-educated platelets, show distinct RNA and protein profiles, making them a potential liquid biopsy for early cancer detection. Mechanisms include direct uptake of tumor-derived factors, signal-dependent RNA processing changes, and differential platelet production by tumor-educated megakaryocytes.

BLOOD (2021)

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Review Oncology

Liquid Biopsy to Detect Minimal Residual Disease: Methodology and Impact

Natasha Honore et al.

Summary: Liquid biopsy is rapidly evolving as a tool for detecting minimal residual disease in cancer patients, but it still faces technical challenges and limitations that need to be addressed for its clinical applicability.

CANCERS (2021)

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Review Cell Biology

Emerging Role of Extracellular Vesicles and Cellular Communication in Metastasis

Aisling Forder et al.

Summary: Communication between cancer cells and stromal cells through extracellular vesicles plays a key role in promoting metastasis. Tumor-secreted EVs induce a pro-tumorigenic phenotype in non-malignant cells of the stroma, driving metastasis through various mechanisms. Targeting these EV-mediated signaling pathways may have therapeutic potential for developing biomarkers and novel treatment strategies.

CELLS (2021)

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Review Oncology

Circulating Tumor DNA and Minimal Residual Disease (MRD) in Solid Tumors: Current Horizons and Future Perspectives

Yan Peng et al.

Summary: ctDNA, as a non-invasive biomarker, has promising clinical applications for individualized cancer diagnosis and therapy in solid tumors. MRD detection aids in assessing treatment response, patient prognosis, and risk of recurrence.

FRONTIERS IN ONCOLOGY (2021)

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Review Multidisciplinary Sciences

Epigenetics, fragmentomics, and topology of cell-free DNA in liquid biopsies

Y. M. Dennis Lo et al.

Summary: Liquid biopsies, which analyze cell-free DNA in blood plasma, are utilized for noninvasive prenatal testing, oncology, and organ transplant monitoring. The physical and molecular features of cell-free DNA fragments, along with their distribution over the genome, contain information about their tissues of origin. These features, including DNA methylation patterns and nucleosomal organization, hold promise for noninvasive detection of tissue-specific pathologies with a variety of clinical applications.

SCIENCE (2021)

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Article Biotechnology & Applied Microbiology

Serum Exosomal miRNA Might Be a Novel Liquid Biopsy to Identify Leptomeningeal Metastasis in Non-Small Cell Lung Cancer

Qiuli Xu et al.

Summary: The study investigated the potential of serum exosomal miRNA in predicting leptomeningeal metastasis of lung cancer, with results showing that miRNA-483-5p and miRNA-342-5p had significant differences in LM patients, suggesting they could serve as predictive biomarkers for LM.

ONCOTARGETS AND THERAPY (2021)

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Article Oncology

Early plasma circulating tumor DNA (ctDNA) changes predict response to first-line pembrolizumab-based therapy in non-small cell lung cancer (NSCLC)

Biagio Ricciuti et al.

Summary: In patients with advanced NSCLC, changes in ctDNA levels after pembrolizumab treatment may predict treatment response before radiological assessment. Early decreases in ctDNA corresponded with clinical benefit, suggesting a potential role for ctDNA as an early pharmacodynamic biomarker of response or resistance to immunotherapies.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Review Oncology

The Role of Liquid Biopsy in Early Diagnosis of Lung Cancer

Claudia Freitas et al.

Summary: Liquid biopsy is an emerging technology that shows potential in the screening and early detection of lung cancer. Various liquid biopsy-derived biomarkers have been identified, but their diagnostic performance and clinical applicability are still limited. Combining different biomarkers and using them in conjunction with other diagnostic tools hold promise, but further research is needed to define and validate the role of liquid biopsies in clinical practice.

FRONTIERS IN ONCOLOGY (2021)

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Article Medical Laboratory Technology

What do we need to obtain high quality circulating tumor DNA (ctDNA) for routine diagnostic test in oncology?-Considerations on pre-analytical aspects by the IFCC workgroup cfDNA

R. Danesi et al.

Summary: The analysis of circulating cell free DNA is crucial for studying tumor resistance, heterogeneity, detecting minimal residual disease, and allograft rejection in transplant patients. Proper use of this technique begins with pre-analytic considerations. This paper discusses important technical considerations to ensure the appropriate and coordinated use of cfDNA techniques.

CLINICA CHIMICA ACTA (2021)

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Article Oncology

EpiPanGI Dx: A Cell-free DNA Methylation Fingerprint for the Early Detection of Gastrointestinal Cancers

Raju Kandimalla et al.

Summary: This study successfully developed a diagnostic approach for multiple gastrointestinal cancers through genome-wide DNA methylation analysis and machine learning algorithms, including three distinct DMR panels: cancer-specific biomarker panels, a pan-GI panel, and a multi-cancer prediction panel based on tissue of origin, demonstrating robust diagnostic accuracy for GI cancers.

CLINICAL CANCER RESEARCH (2021)

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Article Medical Laboratory Technology

Liquid Biopsy Hotspot Variant Assays: Analytical Validation for Application in Residual Disease Detection and Treatment Monitoring

Ariane Hallermayr et al.

Summary: The study evaluated the suitability of 5 droplet digital PCR (ddPCR) assays for analyzing ctDNA in clinical use targeting KRAS, BRAF, and EGFR variants. The results showed significant differences in the detection and quantification of low mutant variant allele frequencies (VAFs) between the tested assays, highlighting the need for assay-specific analytical validation. In addition to in-depth evaluation, a guide for clinical interpretation of obtained VAFs in plasma was developed based on the limits of blank and limits of quantification values, allowing comprehensive clinical reports on actionable variants.

CLINICAL CHEMISTRY (2021)

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Review Biochemistry & Molecular Biology

Tumor-associated exosomes promote lung cancer metastasis through multiple mechanisms

Chunyang Jiang et al.

Summary: Exosomes play a crucial role in the communication between tumor cells and their microenvironment, especially in the development of lung cancer metastasis. Studies have shown that tumor-derived exosomes promote lung cancer via processes such as inducing epithelial-mesenchymal transition. Understanding these mechanisms provides researchers with new ideas to explore clinical applications for the diagnosis and treatment of lung cancer metastasis.

MOLECULAR CANCER (2021)

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Article Oncology

Monitoring HOTTIP levels on extracellular vesicles for predicting recurrence in surgical non-small cell lung cancer patients

Han Bing et al.

Summary: The study showed that EV HOTTIP could serve as a potential biomarker for monitoring disease recurrence in NSCLC patients after surgery, allowing for early detection and improved patient outcomes.

TRANSLATIONAL ONCOLOGY (2021)

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Review Medicine, Research & Experimental

Exosomes and organ-specific metastasis

Lei Zhao et al.

Summary: Communication via exosomes between tumor cells and the microenvironment is crucial for tumor metastasis, with integrins playing a key role in regulating these interactions. Understanding the functions of exosomal integrins may have significant implications for future clinical applications. Continued research using updated purification techniques and identification methods is essential, as exosomes also offer new avenues for precision medicine.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2021)

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Review Oncology

The Liquid Biopsy for Lung Cancer: State of the Art, Limitations and Future Developments

Daniel Di Capua et al.

Summary: Liquid biopsies involve isolating and studying tumor cells or cellular components shed into bodily fluids during the development and progression of lung tumors. They have the potential to play a role in lung cancer screening, diagnosis, and providing prognostic information, but also have limitations.

CANCERS (2021)

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Article Oncology

Clinical Application of Next-Generation Sequencing of Plasma Cell-Free DNA for Genotyping Untreated Advanced Non-Small Cell Lung Cancer

Maria Gabriela O. Fernandes et al.

Summary: Plasma ctDNA testing showed high accuracy and clinical relevance in newly diagnosed advanced NSCLC patients, highlighting its potential as a valuable tool for mutation detection in clinical practice.

CANCERS (2021)

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Review Oncology

Urine as a Source of Liquid Biopsy for Cancer

Masanori Oshi et al.

Summary: Liquid biopsy, including urine analysis, has become a popular and less invasive method for detecting circulating tumor cells and nucleic acids in cancer patients. It allows for longitudinal repeat sampling and can provide real-time information on tumor evolution, making it a powerful tool for diagnosis and treatment monitoring in both urological and non-urological cancers. Advances in extraction methods of urinary substances have shown close relationships with carcinogenesis, metastasis, and therapeutic response in various types of cancers.

CANCERS (2021)

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Review Oncology

Exosomes in Lung Cancer: Actors and Heralds of Tumor Development

Amaia Sandua et al.

Summary: Lung cancer is a major cause of cancer-related deaths globally, with late detection and frequent treatment resistance being common issues. Exosomes, as microvesicles secreted by cells, especially tumor cells, play a crucial role in lung cancer development and can be utilized for diagnosis, prognosis, and follow-up. However, the isolation and analysis of exosomes can be challenging, yet their cargo proteins, RNA, and DNA provide valuable insights into lung cancer progression and management.

CANCERS (2021)

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Article Cell Biology

Liquid Biopsy for Disease Monitoring in Non-Small Cell Lung Cancer: The Link between Biology and the Clinic

Maria Gabriela O. Fernandes et al.

Summary: The study found that changes in variant allelic frequency (VAF) can predict treatment response and disease progression, as well as anticipate radiographic changes in most cases. The conclusion suggests that targeted NGS of circulating tumor DNA (ctDNA) can be used to monitor treatment response in patients with advanced lung adenocarcinoma.

CELLS (2021)

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Article Oncology

ctDNA Predicts Overall Survival in Patients With NSCLC Treated With PD-L1 Blockade or With Chemotherapy

Wei Zou et al.

Summary: In this study, the association between ctDNA MMPM levels at 6 weeks post-treatment and OS in advanced non-small-cell lung cancer patients treated with atezolizumab or docetaxel was investigated. The results suggest that ctDNA has the potential to serve as a noninvasive early liquid biopsy predictor for OS, highlighting the need for further studies to demonstrate its clinical utility.

JCO PRECISION ONCOLOGY (2021)

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Review Oncology

Exosomal microRNAs in non-small cell lung cancer

Elena Durendez-Saez et al.

Summary: Despite recent insights into lung cancer pathobiology and the development of novel therapies, late diagnosis and limited treatments remain major challenges. Exosomal miRNAs play a critical role in NSCLC pathobiogenesis and hold potential clinical utility as biomarkers for diagnosis, prognosis, drug resistance and therapeutic strategies.

TRANSLATIONAL CANCER RESEARCH (2021)

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Article Oncology

Plasma ctDNA Response Is an Early Marker of Treatment Effect in Advanced NSCLC

Michael L. Cheng et al.

Summary: Plasma ctDNA response is an early phenomenon, with the majority of change detectable within the first cycle of therapy. These findings suggest that early insight into treatment effect may be obtained through monitoring ctDNA levels before treatment initiation.

JCO PRECISION ONCOLOGY (2021)

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Review Oncology

Genetic and non-genetic clonal diversity in cancer evolution

James R. M. Black et al.

Summary: This article discusses the importance of functional and non-functional intra-tumour heterogeneity (ITH) in cancer evolution. It emphasizes the need to consider genetic and non-genetic factors in tumor evolution, and highlights the role of systems-biology analytical approaches in understanding the functional ITH. Ultimately, deepening our understanding of tumour evolution through functional ITH will lead to the development of novel therapies and improved outcomes for patients.

NATURE REVIEWS CANCER (2021)

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Editorial Material Biochemical Research Methods

MS-Based Biomarker Discovery in Bronchoalveolar Lavage Fluid for Lung Cancer

Rune Matthiesen

PROTEOMICS CLINICAL APPLICATIONS (2020)

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Article Respiratory System

Lung Cancer 2020 Epidemiology, Etiology, and Prevention

Brett C. Bade et al.

CLINICS IN CHEST MEDICINE (2020)

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Review Oncology

Tumor-educated platelet as liquid biopsy in lung cancer patients

Lian Liu et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2020)

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Article Immunology

Current status and development of anti-PD-1/PD-L1 immunotherapy for lung cancer

Luyao Wang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Article Medicine, General & Internal

Combined use of circulating tumor cells and salivary mRNA to detect non-small-cell lung cancer

Xianwen Gu et al.

MEDICINE (2020)

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Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

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Review Oncology

Extracellular Vesicles in Non-Small-Cell Lung Cancer: Functional Role and Involvement in Resistance to Targeted Treatment and Immunotherapy

Luigi Pasini et al.

CANCERS (2020)

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Review Respiratory System

Current and future applications of liquid biopsy in nonsmall cell lung cancer from early to advanced stages

Nicolas Guibert et al.

EUROPEAN RESPIRATORY REVIEW (2020)

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Review Cell Biology

Interaction between microbiota and immunity in health and disease

Danping Zheng et al.

CELL RESEARCH (2020)

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Article Oncology

Plasma Long Non-Coding RNA RP11-438N5.3 as a Novel Biomarker for Non-Small Cell Lung Cancer

Qingjuan Chen et al.

CANCER MANAGEMENT AND RESEARCH (2020)

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Article Oncology

Sputum supernatant as an alternative source for liquid biopsy in patients with advanced lung cancer.

Ting Guo et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

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Article Oncology

EGFR mutation tracking predicts survival in advanced EGFR-mutated non-small cell lung cancer patients treated with osimertinib

Anna Buder et al.

TRANSLATIONAL LUNG CANCER RESEARCH (2020)

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Article Oncology

Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA

M. C. Liu et al.

ANNALS OF ONCOLOGY (2020)

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Review Oncology

The Metastatic Cascade as the Basis for Liquid Biopsy Development

Zahra Eslami-S et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Oncology

Development and validation of a preoperative noninvasive predictive model based on circular tumor DNA for lymph node metastasis in resectable non-small cell lung cancer

Rusi Zhang et al.

TRANSLATIONAL LUNG CANCER RESEARCH (2020)

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Review Medicine, General & Internal

Next Generation Sequencing for Gene Fusion Analysis in Lung Cancer: A Literature Review

Rossella Bruno et al.

DIAGNOSTICS (2020)

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Article Pathology

Genomic Analysis of Circulating Tumor Cells at the Single-Cell Level

Shan Lu et al.

JOURNAL OF MOLECULAR DIAGNOSTICS (2020)

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Review Cell Biology

Extracellular Vesicles Are Key Regulators of Tumor Neovasculature

Naoya Kuriyama et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Meeting Abstract Oncology

Analytical development of the RaDaR™ assay, a highly sensitive and specific assay for the monitoring of minimal residual disease

Giovanni Marsico et al.

CANCER RESEARCH (2020)

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Article Oncology

Turnaround Time of Plasma Next-Generation Sequencing in Thoracic Oncology Patients: A Quality Improvement Analysis

Yi Lee et al.

JCO PRECISION ONCOLOGY (2020)

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Article Medicine, General & Internal

Prospective Evaluation of Single Nucleotide Variants by Two Different Technologies in Paraffin Samples of Advanced Non-Small Cell Lung Cancer Patients

Elba Marin et al.

DIAGNOSTICS (2020)

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Review Oncology

Liquid Biopsies to Evaluate Immunogenicity of Gynecological/Breast Tumors: On the Way to Blood-Based Biomarkers for Immunotherapies

Corinna Keup et al.

BREAST CARE (2020)

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Article Oncology

Personalized circulating tumor DNA analysis as a predictive biomarker in solid tumor patients treated with pembrolizumab

Scott V. Bratman et al.

NATURE CANCER (2020)

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Article Cell Biology

Clonal Evolution and Heterogeneity of Osimertinib Acquired Resistance Mechanisms in EGFR Mutant Lung Cancer

Nitin Roper et al.

CELL REPORTS MEDICINE (2020)

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Review Biochemistry & Molecular Biology

Molecular principles of metastasis: a hallmark of cancer revisited

Jawad Fares et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Article Biochemistry & Molecular Biology

Hypoxic BMSC-derived exosomal miRNAs promote metastasis of lung cancer cells via STAT3-induced EMT

Xina Zhang et al.

MOLECULAR CANCER (2019)

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Article Multidisciplinary Sciences

Neutrophils escort circulating tumour cells to enable cell cycle progression

Barbara Maria Szczerba et al.

NATURE (2019)

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Article Biochemical Research Methods

RNA sequencing and swarm intelligence-enhanced classification algorithm development for blood-based disease diagnostics using spliced blood platelet RNA

Myron G. Best et al.

NATURE PROTOCOLS (2019)

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Review Oncology

Defining the Hallmarks of Metastasis

Danny R. Welch et al.

CANCER RESEARCH (2019)

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Article Oncology

Inferring the Evolution and Progression of Small-Cell Lung Cancer by Single-Cell Sequencing of Circulating Tumor Cells

Zhe Su et al.

CLINICAL CANCER RESEARCH (2019)

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Review Oncology

Matrix metalloproteinases participation in the metastatic process and their diagnostic and therapeutic applications in cancer

Georgina Gonzalez-Avila et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2019)

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Article Multidisciplinary Sciences

Genome-wide cell-free DNA fragmentation in patients with cancer

Stephen Cristiano et al.

NATURE (2019)

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Article Oncology

Safety and Success of Repeat Lung Needle Biopsies in Patients with Epidermal Growth Factor Receptor-Mutant Lung Cancer

Florian J. Fintelmann et al.

ONCOLOGIST (2019)

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Review Biotechnology & Applied Microbiology

Potential Role of Exosomes in Cancer Metastasis

Wenjuan Tian et al.

BIOMED RESEARCH INTERNATIONAL (2019)

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Review Cell Biology

Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis

Laura M. Doyle et al.

CELLS (2019)

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Article Cell Biology

MicroRNA-330-3p promotes brain metastasis and epithelial-mesenchymal transition via GRIA3 in non-small cell lung cancer

Chunhua Wei et al.

AGING-US (2019)

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Article Oncology

A panel of DNA methylated markers predicts metastasis of pN0M0 gastric carcinoma: a prospective cohort study

Zhaojun Liu et al.

BRITISH JOURNAL OF CANCER (2019)

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Article Multidisciplinary Sciences

Early change in circulating tumor DNA as a potential predictor of response to chemotherapy in patients with metastatic colorectal cancer

Hiroki Osumi et al.

SCIENTIFIC REPORTS (2019)

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Review Genetics & Heredity

DNA Methylation Cancer Biomarkers: Translation to the Clinic

Warwick J. Locke et al.

FRONTIERS IN GENETICS (2019)

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Review Oncology

Liquid biopsies

Evi Lianidou et al.

GENES CHROMOSOMES & CANCER (2019)

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Article Endocrinology & Metabolism

Blood mRNA Measurement (NETest) for Neuroendocrine Tumor Diagnosis of Image-Negative Liver Metastatic Disease

Anna Malczewska et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2019)

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Article Oncology

Clinical Implications of Plasma-Based Genotyping With the Delivery of Personalized Therapy in Metastatic Non-Small Cell Lung Cancer

Charu Aggarwal et al.

JAMA ONCOLOGY (2019)

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Article Oncology

Transfer of Extracellular Vesicle-Associated-RNAs Induces Drug Resistance in ALK-Translocated Lung Adenocarcinoma

Hoi-Hin Kwok et al.

CANCERS (2019)

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Review Oncology

Role of Matrix Metalloproteinases in Angiogenesis and Cancer

Saray Quintero-Fabian et al.

FRONTIERS IN ONCOLOGY (2019)

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Article Oncology

Extracellular vesicle-based EGFR genotyping in bronchoalveolar lavage fluid from treatment-naive non-small cell lung cancer patients

Jae Young Hur et al.

TRANSLATIONAL LUNG CANCER RESEARCH (2019)

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Review Oncology

Liquid biopsy: one cell at a time

Su Bin Lim et al.

NPJ PRECISION ONCOLOGY (2019)

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Review Genetics & Heredity

Next-generation sequencing in liquid biopsy: cancer screening and early detection

Ming Chen et al.

HUMAN GENOMICS (2019)

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Review Oncology

Tumour heterogeneity and resistance to cancer therapies

Ibiayi Dagogo-Jack et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

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Article Oncology

Targeted methylation sequencing of plasma cell-free DNA for cancer detection and classification

L. Liu et al.

ANNALS OF ONCOLOGY (2018)

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Article Oncology

Unique genetic profiles from cerebrospinal fluid cell-free DNA in leptomeningeal metastases of EGFR-mutant non-small-cell lung cancer: a new medium of liquid biopsy

Y. S. Li et al.

ANNALS OF ONCOLOGY (2018)

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Article Biochemistry & Molecular Biology

Frequencies and expression levels of programmed death ligand 1 (PD-L1) in circulating tumor RNA (ctRNA) in various cancer types

Toshiyuki Ishiba et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

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Article Oncology

The potential predictive value of circulating immune cell ratio and tumor marker in atezolizumab treated advanced non-small cell lung cancer patients

Minglei Zhuo et al.

CANCER BIOMARKERS (2018)

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Review Biochemistry & Molecular Biology

Circulating cell-free nucleic acids: characteristics and applications

Ondrej Pos et al.

EUROPEAN JOURNAL OF HUMAN GENETICS (2018)

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Review Oncology

Leptomeningeal metastases in non-small-cell lung cancer

Haiying Cheng et al.

LANCET ONCOLOGY (2018)

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Article Cell Biology

Platelets Promote Metastasis via Binding Tumor CD97 Leading to Bidirectional Signaling that Coordinates Transendothelial Migration

Yvona Ward et al.

CELL REPORTS (2018)

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Article Respiratory System

The role of liquid biopsy in predicting post-operative recurrence of non-small cell lung cancer

Hengrui Liang et al.

JOURNAL OF THORACIC DISEASE (2018)

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Meeting Abstract Oncology

Analytical validation of the Signatera™ RUO assay, a highly sensitive patient-specific multiplex PCR NGS-based noninvasive cancer recurrence detection and therapy monitoring assay

Himanshu Sethi et al.

CANCER RESEARCH (2018)

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Article Oncology

Liquid biopsy using the supernatant of a pleural effusion for EGFR genotyping in pulmonary adenocarcinoma patients: a comparison between cell-free DNA and extracellular vesicle-derived DNA

Jong Sik Lee et al.

BMC CANCER (2018)

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Article Biotechnology & Applied Microbiology

Identification of tumor-educated platelet biomarkers of non-small-cell lung cancer

Meiling Sheng et al.

ONCOTARGETS AND THERAPY (2018)

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Review Biochemistry & Molecular Biology

Techniques of using circulating tumor DNA as a liquid biopsy component in cancer management

Maha Elazezy et al.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2018)

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Article Oncology

Circulating exosomal microRNAs as prognostic biomarkers for non-small-cell lung cancer

Qingyun Liu et al.

ONCOTARGET (2017)

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Review Biochemistry & Molecular Biology

Platelet-derived Extracellular Vesicles: An Emerging Therapeutic Approach

Shi-Cong Tao et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2017)

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Article Biochemical Research Methods

Microfluidic isolation of platelet-covered circulating tumor cells

Xiaocheng Jiang et al.

LAB ON A CHIP (2017)

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Review Oncology

Integrating liquid biopsies into the management of cancer

Giulia Siravegna et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

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Article Oncology

Recurrence and Risk Factors for Relapse in Patients with Non-Small Cell Lung Cancer Treated by Surgery with Curative Intent

Cristiana Cruz et al.

ONCOLOGY (2017)

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Article Oncology

Prolactin as a Potential Early Predictive Factor in Metastatic Non-Small Cell Lung Cancer Patients Treated with Nivolumab

Salvatore Caponnetto et al.

ONCOLOGY (2017)

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Article Oncology

Circulating microRNA-422a is associated with lymphatic metastasis in lung cancer

Lina Wu et al.

ONCOTARGET (2017)

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Review Oncology

Liquid biopsy genotyping in lung cancer: ready for clinical utility?

Wei-Lun Huang et al.

ONCOTARGET (2017)

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Article Multidisciplinary Sciences

Exosomes from metastatic cancer cells transfer amoeboid phenotype to non-metastatic cells and increase endothelial permeability: their emerging role in tumor heterogeneity

Odessa Schillaci et al.

SCIENTIFIC REPORTS (2017)

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Article Biochemistry & Molecular Biology

Serum long non coding RNA MALAT-1 protected by exosomes is up-regulated and promotes cell proliferation and migration in non-small cell lung cancer

Rui Zhang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

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Review Cardiac & Cardiovascular Systems

Extracellular Vesicles in Angiogenesis

Dilyana Todorova et al.

CIRCULATION RESEARCH (2017)

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Article Oncology

The role of circulating tumor cells in evaluation of prognosis and treatment response in advanced non-small-cell lung cancer

Jia Zhou et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2017)

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Review Oncology

Liquid biopsies come of age: towards implementation of circulating tumour DNA

Jonathan C. M. Wan et al.

NATURE REVIEWS CANCER (2017)

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Review Biochemistry & Molecular Biology

Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future

Nicholas McGranahan et al.

CELL (2017)

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Review Oncology

Progression and metastasis of lung cancer

Helmut H. Popper

CANCER AND METASTASIS REVIEWS (2016)

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Article Medical Laboratory Technology

Cell-free DNA in maternal plasma and serum: A comparison of quantity, quality and tissue origin using genomic and epigenomic approaches

Felix C. K. Wong et al.

CLINICAL BIOCHEMISTRY (2016)

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Review Medicine, Research & Experimental

Exosomes and tumor-mediated immune suppression

Theresa L. Whiteside

JOURNAL OF CLINICAL INVESTIGATION (2016)

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Article Medicine, General & Internal

Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial

Roy S. Herbst et al.

LANCET (2016)

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Article Medicine, General & Internal

Identifying Thoracic Malignancies Through Pleural Fluid Biomarkers A Predictive Multivariate Model

Jose M. Porcel et al.

MEDICINE (2016)

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Article Biotechnology & Applied Microbiology

Haplotyping germline and cancer genomes with high-throughput linked-read sequencing

Grace X. Y. Zheng et al.

NATURE BIOTECHNOLOGY (2016)

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Article Oncology

Molecular Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in ALK-Rearranged Lung Cancer

Justin F. Gainor et al.

CANCER DISCOVERY (2016)

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Meeting Abstract Oncology

Follow up analysis by exosomal miRNAs in EGFR mutated non-small cell lung cancer (NSCLC) patients during osimertinib (AZD9291) treatment: A potential prognostic biomarker tool.

Marco Giallombardo et al.

JOURNAL OF CLINICAL ONCOLOGY (2016)

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Article Biotechnology & Applied Microbiology

The Oxford Nanopore MinION: delivery of nanopore sequencing to the genomics community

Miten Jain et al.

GENOME BIOLOGY (2016)

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Article Biology

Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study

Mikolaj P. Zaborowski et al.

BIOSCIENCE (2015)

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Article Biotechnology & Applied Microbiology

Non-random fragmentation patterns in circulating cell-free DNA reflect epigenetic regulation

Maxim Ivanov et al.

BMC GENOMICS (2015)

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Article Oncology

RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics

Myron G. Best et al.

CANCER CELL (2015)

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Article Multidisciplinary Sciences

Tumour exosome integrins determine organotropic metastasis

Ayuko Hoshino et al.

NATURE (2015)

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Article Cell Biology

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

Bruno Costa-Silva et al.

NATURE CELL BIOLOGY (2015)

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Article Biochemistry & Molecular Biology

Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M

Kenneth S. Thress et al.

NATURE MEDICINE (2015)

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Article Multidisciplinary Sciences

Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma

Leticia De Mattos-Arruda et al.

NATURE COMMUNICATIONS (2015)

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Article Oncology

Highly sensitive and quantitative evaluation of the EGFR T790M mutation by nanofluidic digital PCR

Eiji Iwama et al.

ONCOTARGET (2015)

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Article Oncology

Long noncoding RNA MALAT1 promotes brain metastasis by inducing epithelial-mesenchymal transition in lung cancer

Liqin Shen et al.

JOURNAL OF NEURO-ONCOLOGY (2015)

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Review Cell Biology

Biological properties of extracellular vesicles and their physiological functions

Maria Yanez-Mo et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

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Article Oncology

Specific organ metastases and survival in metastatic non-small-cell lung cancer

Tomohiro Tamura et al.

MOLECULAR AND CLINICAL ONCOLOGY (2015)

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Article Biochemical Research Methods

Towards standardisation of cell-free DNA measurement in plasma: controls for extraction efficiency, fragment size bias and quantification

Alison S. Devonshire et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2014)

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Article Cardiac & Cardiovascular Systems

Differences in Patterns of Recurrence in Early-Stage Versus Locally Advanced Non-Small Cell Lung Cancer

Feiran Lou et al.

ANNALS OF THORACIC SURGERY (2014)

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Article Oncology

Serum biomarkers for assessing histology and outcomes in patients with metastatic lung cancer

Emil Lou et al.

CANCER BIOMARKERS (2014)

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Review Oncology

The role of the tumor-microenvironment in lung cancer-metastasis and its relationship to potential therapeutic targets

Steven L. Wood et al.

CANCER TREATMENT REVIEWS (2014)

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Article Oncology

Noninvasive Diagnosis of Actionable Mutations by Deep Sequencing of Circulating Free DNA in Lung Cancer from Never-Smokers: A Proof-of-Concept Study from BioCAST/IFCT-1002

Sebastien Couraud et al.

CLINICAL CANCER RESEARCH (2014)

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Article Oncology

Feasibility and clinical impact of re-biopsy in advanced non small-cell lung cancer: A prospective multicenter study in a real-world setting (GFPC study 12-01)

Christos Chouaid et al.

LUNG CANCER (2014)

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Article Oncology

Metastatic sites and survival in lung cancer

M. Riihimaeki et al.

LUNG CANCER (2014)

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Article Multidisciplinary Sciences

Time-Varying Pattern of Postoperative Recurrence Risk of Early-Stage (T1a-T2bN0M0) Non-Small Cell Lung Cancer (NSCLC): Results of a Single-Center Study of 994 Chinese Patients

Jian-fei Zhu et al.

PLOS ONE (2014)

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Article Oncology

Updated overall survival results from a randomized phase III trial comparing gefitinib with carboplatin-paclitaxel for chemo-naive non-small cell lung cancer with sensitive EGFR gene mutations (NEJ002)

A. Inoue et al.

ANNALS OF ONCOLOGY (2013)

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Article Oncology

Analysis of Tumor Specimens at the Time of Acquired Resistance to EGFR-TKI Therapy in 155 Patients with EGFR-Mutant Lung Cancers

Helena A. Yu et al.

CLINICAL CANCER RESEARCH (2013)

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Review Oncology

Liquid biopsy: monitoring cancer-genetics in the blood

Emily Crowley et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2013)

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Article Medicine, General & Internal

Crizotinib versus Chemotherapy in Advanced ALK-Positive Lung Cancer

Alice T. Shaw et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

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Article Multidisciplinary Sciences

Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients

Xiaohui Ni et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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Article Oncology

Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial

Rafael Rosell et al.

LANCET ONCOLOGY (2012)

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Article Biochemistry & Molecular Biology

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

Hector Peinado et al.

NATURE MEDICINE (2012)

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Article Oncology

Specific organ metastases and survival in small cell lung cancer

Kensuke Nakazawa et al.

ONCOLOGY LETTERS (2012)

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Review Oncology

The Initial Hours of Metastasis: The Importance of Cooperative Host-Tumor Cell Interactions during Hematogenous Dissemination

Myriam Labelle et al.

CANCER DISCOVERY (2012)

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Article Oncology

Lung Cancer Signatures in Plasma Based on Proteome Profiling of Mouse Tumor Models

Ayumu Taguchi et al.

CANCER CELL (2011)

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Article Oncology

Recovering circulating extracellular or cell-free RNA from bodily fluids

Georgios Tzimagiorgis et al.

CANCER EPIDEMIOLOGY (2011)

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Article Oncology

A metabolomic approach to lung cancer

Suya Hori et al.

LUNG CANCER (2011)

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Review Multidisciplinary Sciences

A Perspective on Cancer Cell Metastasis

Christine L. Chaffer et al.

SCIENCE (2011)

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Article Cell Biology

Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors

Lecia V. Sequist et al.

SCIENCE TRANSLATIONAL MEDICINE (2011)

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Article Oncology

The Detection of Chromosomal Aneusomy by Fluorescence In situ Hybridization in Sputum Predicts Lung Cancer Incidence

Marileila Varella-Garcia et al.

CANCER PREVENTION RESEARCH (2010)

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Article Medicine, Research & Experimental

Significant Downregulation of Platelet Gene Expression in Metastatic Lung Cancer

David C. Calverley et al.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2010)

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Article Oncology

Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial

Tetsuya Mitsudomi et al.

LANCET ONCOLOGY (2010)

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Article Multidisciplinary Sciences

Real-Time DNA Sequencing from Single Polymerase Molecules

John Eid et al.

SCIENCE (2009)

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Article Oncology

Pooled analysis of the effect of age on adjuvant cisplatin-based chemotherapy for completely resected non-small-cell lung cancer

Martin Frueh et al.

JOURNAL OF CLINICAL ONCOLOGY (2008)

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Article Oncology

National survey of non-small cell lung cancer in the United States: Epidemiology, pathology and patterns of care

Alex G. Little et al.

LUNG CANCER (2007)

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Review Oncology

Tumor-released microvesicles as vehicles of immunosuppression

Roberta Valenti et al.

CANCER RESEARCH (2007)

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Review Biochemistry & Molecular Biology

Cancer metastasis:: Building a framework

Gaorav P. Gupta et al.

CELL (2006)

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Review Oncology

Matrix metalloproteinases and tumor metastasis

EI Deryugina et al.

CANCER AND METASTASIS REVIEWS (2006)

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Article Biochemical Research Methods

Determination of allele frequency in pooled DNA:: comparison of three PCR-based methods

S Wilkening et al.

BIOTECHNIQUES (2005)

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Review Oncology

Molecular biology of breast cancer metastasis - Clinical implications of experimental studies on metastatic inefficiency

AF Chambers et al.

BREAST CANCER RESEARCH (2000)

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Review Oncology

Role of ctDNA for the detection of minimal residual disease in resected non-small cell lung cancer: a systematic review

Michela Verze et al.

Summary: Liquid biopsy plays a crucial role in assessing post-surgical MRD in resected NSCLC. The detection of MRD post-operatively can help predict recurrence and guide the decision on adjuvant treatment, with MRD-positive patients benefiting more from adjuvant therapy.

TRANSLATIONAL LUNG CANCER RESEARCH

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