Related references
Note: Only part of the references are listed.Drug discovery and amyotrophic lateral sclerosis: Emerging challenges and therapeutic opportunities
Pedro Soares et al.
AGEING RESEARCH REVIEWS (2023)
Metformin Repurposing for Parkinson Disease Therapy: Opportunities and Challenges
Francesco Agostini et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
Metabolic Alterations in a Drosophila Model of Parkinson's Disease Based on DJ-1 Deficiency
Cristina Solana-Manrique et al.
CELLS (2022)
The NRF2-Dependent Transcriptional Regulation of Antioxidant Defense Pathways: Relevance for Cell Type-Specific Vulnerability to Neurodegeneration and Therapeutic Intervention
Stephanie M. Boas et al.
ANTIOXIDANTS (2022)
Altered SOD1 maturation and post-translational modification in amyotrophic lateral sclerosis spinal cord
Benjamin G. Trist et al.
BRAIN (2022)
Activation of the Nrf2 Pathway as a Therapeutic Strategy for ALS Treatment
Liaisan Arslanbaeva et al.
MOLECULES (2022)
DJ-1 promotes energy balance by regulating both mitochondrial and autophagic homeostasis
Federica De Lazzari et al.
NEUROBIOLOGY OF DISEASE (2022)
Role of branched-chain amino acid metabolism in the pathogenesis of obesity and type 2 diabetes-related metabolic disturbances BCAA metabolism in type 2 diabetes
Froukje Vanweert et al.
NUTRITION & DIABETES (2022)
The Impact of Mitochondrial Dysfunction in Amyotrophic Lateral Sclerosis
Jiantao Zhao et al.
CELLS (2022)
DJ-1 and SOD1 Act Independently in the Protection against Anoxia in Drosophila melanogaster
Federica De Lazzari et al.
ANTIOXIDANTS (2022)
DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy
Dorien Imberechts et al.
BRAIN (2022)
DJ-1 Protein Inhibits Apoptosis in Cerebral Ischemia by Regulating the Notch1 and Nuclear Factor Erythroid2-Related Factor 2 Signaling Pathways
Tingting Wang et al.
NEUROSCIENCE (2022)
DJ-1 administration exerts cardioprotection in a mouse model of acute myocardial infarction
Alex Gallinat et al.
FRONTIERS IN PHARMACOLOGY (2022)
DJ-1 activates the AMPK/mTOR pathway by binding RACK1 to induce autophagy and protect the myocardium from ischemia/hypoxia injury
Xiao-Yan Zhao et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)
Superoxide Dismutase 1 in Health and Disease: How a Frontline Antioxidant Becomes Neurotoxic
Benjamin G. Trist et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)
Impaired antioxidant KEAP1-NRF2 system in amyotrophic lateral sclerosis: NRF2 activation as a potential therapeutic strategy
Silvia Bono et al.
MOLECULAR NEURODEGENERATION (2021)
Attenuation of Inflammation by DJ-1 May Be a Drug Target for Cerebral Ischemia-Reperfusion Injury
Na Zhao et al.
NEUROCHEMICAL RESEARCH (2021)
The Role of DJ-1 in Cellular Metabolism and Pathophysiological Implications for Parkinson's Disease
Pauline Mencke et al.
CELLS (2021)
Non-cell-autonomous pathogenic mechanisms in amyotrophic lateral sclerosis
Alexandra C. M. Van Harten et al.
TRENDS IN NEUROSCIENCES (2021)
DJ-1: A promising therapeutic candidate for ischemia-reperfusion injury
Federica De Lazzari et al.
REDOX BIOLOGY (2021)
Dysregulation of energy homeostasis in amyotrophic lateral sclerosis
Simon J. Guillot et al.
CURRENT OPINION IN NEUROLOGY (2021)
NRF2 as a therapeutic opportunity to impact in the molecular roadmap of ALS
J. Jimenez-Villegas et al.
FREE RADICAL BIOLOGY AND MEDICINE (2021)
Glucose Metabolic Dysfunction in Neurodegenerative Diseases-New Mechanistic Insights and the Potential of Hypoxia as a Prospective Therapy Targeting Metabolic Reprogramming
Rongrong Han et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
DJ-1 in neurodegenerative diseases: Pathogenesis and clinical application
Maoxin Huang et al.
PROGRESS IN NEUROBIOLOGY (2021)
Effect of High-Caloric Nutrition on Survival in Amyotrophic Lateral Sclerosis
Albert C. Ludolph et al.
ANNALS OF NEUROLOGY (2020)
DJ-1 is indispensable for the S-nitrosylation of Parkin, which maintains function of mitochondria
Kentaro Ozawa et al.
SCIENTIFIC REPORTS (2020)
Enhanced activity of glycolytic enzymes in Drosophila and human cell models of Parkinson's disease based on DJ-1 deficiency
Cristina Solana-Manrique et al.
FREE RADICAL BIOLOGY AND MEDICINE (2020)
Trial of Sodium Phenylbutyrate-Taurursodiol for Amyotrophic Lateral Sclerosis
Sabrina Paganoni et al.
NEW ENGLAND JOURNAL OF MEDICINE (2020)
Altered skeletal muscle glucose-fatty acid flux in amyotrophic lateral sclerosis
Frederik J. Steyn et al.
BRAIN COMMUNICATIONS (2020)
Effect of DJ-1 on the neuroprotection of astrocytes subjected to cerebral ischemia/reperfusion injury
Li Peng et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2019)
ALS Genetics, Mechanisms, and Therapeutics: Where Are We Now?
Rita Mejzini et al.
FRONTIERS IN NEUROSCIENCE (2019)
The biophysics of superoxide dismutase-1 and amyotrophic lateral sclerosis
Gareth S. A. Wright et al.
QUARTERLY REVIEWS OF BIOPHYSICS (2019)
Intracellular metal binding and redox behavior of human DJ-1
Letizia Barbieri et al.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2018)
DJ-1 based peptide, ND-13, promote functional recovery in mouse model of focal ischemic injury
Lior Molcho et al.
PLOS ONE (2018)
Metabolic Reprogramming in Amyotrophic Lateral Sclerosis
M. Szelechowski et al.
SCIENTIFIC REPORTS (2018)
Medium-Chain Fatty Acids, Beta-Hydroxybutyric Acid and Genetic Modulation of the Carnitine Shuttle Are Protective in a Drosophila Model of ALS Based on TDP-43
Ernesto Manzo et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)
DJ-1 Suppresses Cytoplasmic TDP-43 Aggregation in Oxidative Stress-Induced Cell Injury
Yang Lei et al.
JOURNAL OF ALZHEIMERS DISEASE (2018)
DJ-1 promotes survival of human colon cancer cells under hypoxia by modulating HIF-1α expression through the PI3K-AKT pathway
Hong Zheng et al.
CANCER MANAGEMENT AND RESEARCH (2018)
DJ-1 Deficiency Protects Hepatic Steatosis by Enhancing Fatty Acid Oxidation in Mice
Min Xu et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2018)
Hexokinases link DJ-1 to the PINK1/parkin pathway
David N. Hauser et al.
MOLECULAR NEURODEGENERATION (2017)
DJ-1 as a deglycating enzyme: a unique function to explain a multifaceted protein?
Federica De Lazzari et al.
NEURAL REGENERATION RESEARCH (2017)
Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease
Alice Biosa et al.
NEUROBIOLOGY OF DISEASE (2017)
The Role of Astrocyte Dysfunction in Parkinson's Disease Pathogenesis
Heather D. E. Booth et al.
TRENDS IN NEUROSCIENCES (2017)
Pretreatment with sodium Phenylbutyrate alleviates cerebral ischemia/reperfusion injury by Upregulating DJ-1 Protein
Rui-Xin Yang et al.
FRONTIERS IN NEUROLOGY (2017)
DJ-1 maintains energy and glucose homeostasis by regulating the function of brown adipose tissue
Rong Wu et al.
CELL DISCOVERY (2017)
CuII(atsm) improves the neurological phenotype and survival of SOD1G93A mice and selectively increases enzymatically active SOD1 in the spinal cord
James B. Hilton et al.
SCIENTIFIC REPORTS (2017)
The Effects of Variants in the Parkin, PINK1, and DJ-1 Genes along with Evidence for their Pathogenicity
David N. Hauser et al.
CURRENT PROTEIN & PEPTIDE SCIENCE (2017)
DJ-1 protects the heart against ischemia-reperfusion injury by regulating mitochondrial fission
Yuuki Shimizu et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2016)
Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia
Carolina Alquezar et al.
MOLECULAR NEURODEGENERATION (2016)
Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SODG93A mice co-expressing the Copper-Chaperone-for-SOD
Jared R. Williams et al.
NEUROBIOLOGY OF DISEASE (2016)
A novel homozygous DJ1 mutation causes parkinsonism and ALS in a Turkish family
Hasmet A. Hanagasi et al.
PARKINSONISM & RELATED DISORDERS (2016)
Hypoxia as a therapy for mitochondrial disease
Isha H. Jain et al.
SCIENCE (2016)
DJ1 represses glycolysis and cell proliferation by transcriptionally up-regulating pink1
Raquel Requejo-Aguilar et al.
BIOCHEMICAL JOURNAL (2015)
DJ-1 Mediates the Delayed Cardioprotection of Hypoxic Preconditioning Through Activation of Nrf2 and Subsequent Upregulation of Antioxidative Enzymes
Yu-Feng Yan et al.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2015)
DJ-1 upregulates anti-oxidant enzymes and attenuates hypoxia/re-oxygenation-induced oxidative stress by activation of the nuclear factor erythroid 2-like 2 signaling pathway
Yu-Feng Yan et al.
MOLECULAR MEDICINE REPORTS (2015)
Gene expression signatures in motor neurone disease fibroblasts reveal dysregulation of metabolism, hypoxia-response and RNA processing functions
R. Raman et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2015)
DJ-1 Knockout Augments Disease Severity and Shortens Survival in a Mouse Model of ALS
Nirit Lev et al.
PLOS ONE (2015)
A new split-GFP-based probe reveals DJ-1 translocation into the mitochondrial matrix to sustain ATP synthesis upon nutrient deprivation
Tito Cali et al.
HUMAN MOLECULAR GENETICS (2015)
The Parkinson's Disease-Related Protein DJ-1 Protects Dopaminergic Neurons in vivo and Cultured Cells from Alpha-Synuclein and 6-Hydroxydopamine Toxicity
Sara Batelli et al.
NEURODEGENERATIVE DISEASES (2015)
Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model of inherited amyotrophic lateral sclerosis
Ernesto Miquel et al.
FREE RADICAL BIOLOGY AND MEDICINE (2014)
DJ-1 Is a Copper Chaperone Acting on SOD1 Activation
Stefania Girotto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Regulation of the VHL/HIF-1 Pathway by DJ-1
Mohammad Parsanejad et al.
JOURNAL OF NEUROSCIENCE (2014)
Oral Treatment with CuII(atsm) Increases Mutant SOD1 In Vivo but Protects Motor Neurons and Improves the Phenotype of a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
Blaine R. Roberts et al.
JOURNAL OF NEUROSCIENCE (2014)
Hypercaloric enteral nutrition in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled phase 2 trial
Anne-Marie Wills et al.
LANCET (2014)
DJ-1 protects against cell death following acute cardiac ischemia-reperfusion injury
R. K. Dongworth et al.
CELL DEATH & DISEASE (2014)
DJ-1 contributes to adipogenesis and obesity-induced inflammation
Jung-Min Kim et al.
SCIENTIFIC REPORTS (2014)
Genetic Susceptibility Model of Parkinson's Disease Resulting from Exposure of DJ-1 Deficient Mice to MPTP: Evaluation of Neuroprotection by Ubisol-Q10
Krithika Muthukumaran et al.
JOURNAL OF PARKINSONS DISEASE (2014)
Stable overexpression of DJ-1 protects H9c2 cells against oxidative stress under a hypoxia condition
Hai-Hong Yu et al.
CELL BIOCHEMISTRY AND FUNCTION (2013)
The Parkinson disease-related protein DJ-1 counteracts mitochondrial impairment induced by the tumour suppressor protein p53 by enhancing endoplasmic reticulum-mitochondria tethering
Denis Ottolini et al.
HUMAN MOLECULAR GENETICS (2013)
Parkinson Disease Protein DJ-1 Binds Metals and Protects against Metal-induced Cytotoxicity
Benny Bjorkblom et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Altered Expression of DJ-1 and PINK1 in Sporadic ALS and in the SOD1G93A ALS Mouse Model
Sarah Knippenberg et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2013)
Structure of Cu(I)-Bound DJ-1 Reveals a Biscysteinate Metal Binding Site at the Homodimer Interface: Insights into Mutational Inactivation of DJ-1 in Parkinsonism
M. Rhyan Puno et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
DJ-1 Null Dopaminergic Neuronal Cells Exhibit Defects in Mitochondrial Function and Structure: Involvement of Mitochondrial Complex I Assembly
Jun Young Heo et al.
PLOS ONE (2012)
DJ-1 Modulates the Expression of Cu/Zn-Superoxide Dismutase-1 through the Erk1/2-Elk1 Pathway in Neuroprotection
Zhiquan Wang et al.
ANNALS OF NEUROLOGY (2011)
The Role of Cysteine Oxidation in DJ-1 Function and Dysfunction
Mark A. Wilson
ANTIOXIDANTS & REDOX SIGNALING (2011)
Induction of the Mitochondrial NDUFA4L2 Protein by HIF-1α Decreases Oxygen Consumption by Inhibiting Complex I Activity
Daniel Tello et al.
CELL METABOLISM (2011)
DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy
Kelly Jean Thomas et al.
HUMAN MOLECULAR GENETICS (2011)
Phenylbutyrate Up-regulates the DJ-1 Protein and Protects Neurons in Cell Culture and in Animal Models of Parkinson Disease
Wenbo Zhou et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
DEREGULATION OF THE HYPOXIA INDUCIBLE FACTOR-1α PATHWAY IN MONOCYTES FROM SPORADIC AMYOTROPHIC LATERAL SCLEROSIS PATIENTS
C. Moreau et al.
NEUROSCIENCE (2011)
Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics
I. Irrcher et al.
HUMAN MOLECULAR GENETICS (2010)
The Arabidopsis DJ-1a protein confers stress protection through cytosolic SOD activation
Xiang Ming Xu et al.
JOURNAL OF CELL SCIENCE (2010)
DJ-1 forms complexes with mutant SOD1 and ameliorates its toxicity
Satoshi Yamashita et al.
JOURNAL OF NEUROCHEMISTRY (2010)
Reduced Basal Autophagy and Impaired Mitochondrial Dynamics Due to Loss of Parkinson's Disease-Associated Protein DJ-1
Guido Krebiehl et al.
PLOS ONE (2010)
DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function
Ling-Yang Hao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Mitochondrial Localization of DJ-1 Leads to Enhanced Neuroprotection
Eunsung Junn et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2009)
DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses
Sophie Vasseur et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology:: a genetic and histopathological analysis
Vivianna M. Van Deerlin et al.
LANCET NEUROLOGY (2008)
TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
Edor Kabashi et al.
NATURE GENETICS (2008)
TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis
Jemeen Sreedharan et al.
SCIENCE (2008)
DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats
Daijiro Yanagisawa et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2008)
The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage
Hossein Aleyasin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
High erythropoletin and low vascular endothelial growth factor levels in cerebrospinal fluid from hypoxemic ALS patients suggest an abnormal response to hypoxia
N. Just et al.
NEUROMUSCULAR DISORDERS (2007)
Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis
Carsten W. Lederer et al.
BMC GENOMICS (2007)
DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2
Casey M. Clements et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis
Zhong Zhao et al.
BMC NEUROSCIENCE (2006)
Paradoxical response of VEGF expression to hypoxia in CSF of patients with ALS
C Moreau et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2006)
DJ-1 mutations and parkinsonism-dementia-amyotrophic lateral sclerosis complex
G Annesi et al.
ANNALS OF NEUROLOGY (2005)
Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease
M Meulener et al.
CURRENT BIOLOGY (2005)
Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress
RH Kim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
DJ-1 has a role in antioxidative stress to prevent cell death
T Taira et al.
EMBO REPORTS (2004)
Evidence for defective energy homeostasis in amyotrophic lateral sclerosis:: benefit of a high-energy diet in a transgenic mouse
L Dupuis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization
RM Canet-Avilés et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Low levels of the vascular endothelial growth factor in CSF from early ALS patients
D Devos et al.
NEUROLOGY (2004)
Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: An ES-derived cell model of primary Parkinsonism
C Martinat et al.
PLOS BIOLOGY (2004)
Selective targeting of a redox-active ubiquinone to mitochondria within cells - Antioxidant and antiapoptotic properties
GF Kelso et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Share Paper
