Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 370, Issue -, Pages 63-69Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2016.08.059
Keywords
Parkinson disease; Glucocerebrosidase; GBA1; Depression; Anxiety
Categories
Funding
- Bigglesworth Foundation
- NINDS [K02-NS073836, U01-094148]
- Empire Clinical Research Investigator Program (ECRIP) from the New York State Department of Health
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Mutations in GBA1 are a well-established risk factor for Parkinson disease (PD). GBA-associated PD (GBA-PD) may have a higher burden of nonmotor symptoms than idiopathic PD (IPD). We sought to characterize the relationship between GBA-PD and neuropsychiatric symptoms. Subjects were screened for common GBA1 mutations. GBA-PD (n = 31) and non-carrier (IPD; n = 55) scores were compared on the Unified Parkinson Disease Rating Scale (UPDRS), Montreal Cognitive Assessment (MoCA), Beck Depression Inventory (BDI), and the State-Trait Anxiety Index (STAI). In univariate comparisons, GBA-PD had a greater prevalence of depression (33.3%) versus IPD (132%) (p < 0.05). In regression models controlling for age, sex, disease duration, motor disability, and MoCA score, GBA-PD had an increased odds of depression (OR 3.66, 95% CI 1.13-11.8) (p = 0.03). Post-hoc analysis stratified by sex showed that, among men, GBA-PD had a higher burden of trait anxiety and depression than IPD; this finding was sustained in multivariate models. Among women, GBA-PD did not confer greater psychiatric morbidity than IPD. These results suggest that GBA1 mutations confer greater risk of neuropsychiatric morbidity in PD, and that sex may affect this association. (C) 2016 Elsevier B.V. All rights reserved.
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