4.7 Review

The Cellular Response to Complex DNA Damage Induced by Ionising Radiation

Related references

Note: Only part of the references are listed.
Review Oncology

Review of the Geant4-DNA Simulation Toolkit for Radiobiological Applications at the Cellular and DNA Level

Ioanna Kyriakou et al.

Summary: This article presents a brief description of the methodologies and tools, specifically Geant4-DNA, for simulating ionizing radiation transport in biologically relevant matter. Geant4-DNA allows for mechanistic radiobiological modeling at the cellular and DNA level, enabling improvements in cancer radiotherapeutic modalities. The article highlights the physical, chemical, and biological models implemented in Geant4-DNA, with a focus on the latest developments, including the ability to predict early DNA damage. The Geant4-DNA toolkit offers unique capabilities for studying the relative biological effectiveness of different ionizing radiations, which is crucial for various radiotherapeutic modalities.

CANCERS (2022)

Article Multidisciplinary Sciences

Formation of clustered DNA damage in vivo upon irradiation with ionizing radiation: Visualization and analysis with atomic force microscopy

Toshiaki Nakano et al.

Summary: This study established a method to evaluate the yield and complexity of clustered DNA damage in irradiated cells using atomic force microscopy. It was found that clustered DNA damage is a signature of ionizing radiation, and Fe ion beams produce clustered DNA damage with high complexity.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Article Multidisciplinary Sciences

Characterization of γ-H2AX foci formation under alpha particle and X-ray exposures for dose estimation

Ui-Seob Lee et al.

Summary: This study investigates the feasibility of utilizing the focus size distribution and dephosphorylation rate of gamma-H2AX to identify the type of causative radiation and dose. The results show a linear relationship between the average number of foci and the dose, and the focus size distribution can identify the type of causative radiation. The dose can be estimated with a small difference from the actual value using these methods.

SCIENTIFIC REPORTS (2022)

Article Oncology

Effectiveness of PARP inhibition in enhancing the radiosensitivity of 3D spheroids of head and neck squamous cell carcinoma

Chumin Zhou et al.

Summary: The study explored the impact of HPV infection on head and neck squamous cell carcinoma (HNSCC) response to radiotherapy, highlighting the increased radiosensitivity of HPV-positive cells compared to HPV-negative cells. PARP inhibitors were found to enhance the radiosensitivity of HPV-negative HNSCC spheroids to photons and protons, resulting in significant growth suppression.

FRONTIERS IN ONCOLOGY (2022)

Article Oncology

Factors affecting the radiation response in glioblastoma

Radhika Aiyappa-Maudsley et al.

Summary: Glioblastoma is a highly invasive brain tumor with poor survival rates. Conventional radiotherapy has shown limited improvement in outcomes, but precision radiotherapy techniques like proton beam therapy and carbon ion radiotherapy provide new options for treatment.

NEURO-ONCOLOGY ADVANCES (2022)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Oncology

Inhibition of ATM Induces Hypersensitivity to Proton Irradiation by Upregulating Toxic End Joining

Qin Zhou et al.

Summary: This study investigated whether targeting the DNA damage response could enhance vulnerability to the distinct damage induced by proton Bragg peak irradiation, and found that ATM inhibitor could sensitize cells to more densely ionizing proton Bragg peak irradiation.

CANCER RESEARCH (2021)

Article Biochemistry & Molecular Biology

Focused Ion Microbeam Irradiation Induces Clustering of DNA Double-Strand Breaks in Heterochromatin Visualized by Nanoscale-Resolution Electron Microscopy

Yvonne Lorat et al.

Summary: Increasing numbers of carbon ions per beam spot enhanced spatial clustering of DNA lesions, especially in heterochromatin. Euchromatic DSBs were efficiently processed and repaired, while clustered DSBs in heterochromatin continued to increase in numbers over time, posing a challenge for appropriate processing by the cell.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Oncology

Evaluation of Histone Deacetylase Inhibitors as Radiosensitizers for Proton and Light Ion Radiotherapy

Alicia M. Johnson et al.

Summary: This study investigated the radiosensitization effects of HDACi on different types of tumor and normal cells, showing that the radiosensitization effects of HDACi are dependent on cell type and ion species.

FRONTIERS IN ONCOLOGY (2021)

Article Biochemical Research Methods

The Enzyme-Modified Neutral Comet (EMNC) Assay for Complex DNA Damage Detection

Maria Rita Fabbrizi et al.

Summary: The comet assay is a sensitive method for detecting DNA damage, particularly single and double DNA strand breaks, in individual cells. By detecting specific DNA lesions and studying the repair of these lesions, the assay can provide important insights into the complexity of DNA damage induced by ionizing radiation and other genotoxic agents.

METHODS AND PROTOCOLS (2021)

Article Otorhinolaryngology

Proton and photon radiosensitization effects of niraparib, a PARP-1/-2 inhibitor, on human head and neck cancer cells

Li Wang et al.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2020)

Review Biochemistry & Molecular Biology

Base excision repair and its implications to cancer therapy

Gabrielle J. Grundy et al.

GUARDIANS OF THE GENOME: DNA DAMAGE AND REPAIR (2020)

Review Biochemistry & Molecular Biology

The radiobiology of HPV-positive and HPV-negative head and neck squamous cell carcinoma

Chumin Zhou et al.

EXPERT REVIEWS IN MOLECULAR MEDICINE (2020)

Article Oncology

Characterisation of Deubiquitylating Enzymes in the Cellular Response to High-LET Ionizing Radiation and Complex DNA Damage

Rachel J. Carter et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2019)

Article Oncology

DNA damage response of clinical carbon ion versus photon radiation in human glioblastoma cells

Ramon Lopez Perez et al.

RADIOTHERAPY AND ONCOLOGY (2019)

Article Oncology

Development of a high-throughput γ-H2AX assay based on imaging flow cytometry

Younghyun Lee et al.

RADIATION ONCOLOGY (2019)

Article Biochemistry & Molecular Biology

Histone Deacetylase Inhibitor Induced Radiation Sensitization Effects on Human Cancer Cells after Photon and Hadron Radiation Exposure

Ariungerel Gerelchuluun et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Oncology

Complex DNA Damage Induced by High Linear Energy Transfer Alpha-Particles and Protons Triggers a Specific Cellular DNA Damage Response

Rachel J. Carter et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2018)

Review Biochemistry & Molecular Biology

Radiation-induced clustered DNA lesions: Repair and mutagenesis

Evelyne Sage et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Review Cell Biology

Non-homologous DNA end joining and alternative pathways to double-strand break repair

Howard H. Y. Chang et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

Article Multidisciplinary Sciences

Chromatin organization revealed by nanostructure of irradiation induced γH2AX, 53BP1 and Rad51 foci

Judith Reindl et al.

SCIENTIFIC REPORTS (2017)

Article Pharmacology & Pharmacy

Histone Deacetylase Inhibitors Sensitize Murine B16F10 Melanoma Cells to Carbon Ion Irradiation by Inducing G1 Phase Arrest

Katsuyo Saito et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2017)

Article Oncology

The In Vitro Response of Tissue Stem Cells to Irradiation With Different Linear Energy Transfers

Peter W. Nagle et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2016)

Review Biochemistry & Molecular Biology

Base Excision Repair, a Pathway Regulated by Posttranslational Modifications

Rachel J. Carter et al.

MOLECULAR AND CELLULAR BIOLOGY (2016)

Article Oncology

Differential DNA repair pathway choice in cancer cells after proton- and photon-irradiation

Andrea O. Fontana et al.

RADIOTHERAPY AND ONCOLOGY (2015)

Review Biology

Induction and Repair of Clustered DNA Lesions: What Do We Know So Far?

Alexandros G. Georgakilas et al.

RADIATION RESEARCH (2013)

Article Oncology

Biological Considerations When Comparing Proton Therapy. With Photon Therapy

Harald Paganetti et al.

SEMINARS IN RADIATION ONCOLOGY (2013)

Review Biotechnology & Applied Microbiology

Delayed repair of radiation induced clustered DNA damage: Friend or foe?

Laura J. Eccles et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2011)

Review Biotechnology & Applied Microbiology

Clustered DNA lesion repair in eukaryotes: Relevance to mutagenesis and cell survival

Evelyne Sage et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2011)

Article Multidisciplinary Sciences

Unrepaired clustered DNA lesions induce chromosome breakage in human cells

Aroumougame Asaithamby et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Oncology

Charged particles in radiation oncology

Marco Durante et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2010)

Review Biochemistry & Molecular Biology

gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

Andrea Kinner et al.

NUCLEIC ACIDS RESEARCH (2008)

Article Environmental Sciences

Energy deposition stochastics and track structure: What about the target?

Dudley T. Goodhead

RADIATION PROTECTION DOSIMETRY (2006)

Article Multidisciplinary Sciences

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

H Farmer et al.

NATURE (2005)

Review Oncology

Role of cell cycle in mediating sensitivity to radiotherapy

TM Pawlik et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2004)

Article Biochemistry & Molecular Biology

Processing of bistranded abasic DNA clusters in gamma-irradiated human hematopoietic cells

AG Georgakilas et al.

NUCLEIC ACIDS RESEARCH (2004)

Article Biotechnology & Applied Microbiology

Quantifying clustered DNA damage induction and repair by gel electrophoresis, electronic imaging and number average length analysis

BM Sutherland et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2003)

Article Multidisciplinary Sciences

M-FISH analysis shows that complex chromosome aberrations induced by α-particle tracks are cumulative products of localized rearrangements

RM Anderson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Environmental Sciences

Modelling of DNA damage induced by energetic electrons (100 eV to 100 keV)

H Nikjoo et al.

RADIATION PROTECTION DOSIMETRY (2002)

Article Multidisciplinary Sciences

Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation

BM Sutherland et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)