4.7 Review

An Overview of the Role of MicroRNAs on Carcinogenesis: A Focus on Cell Cycle, Angiogenesis and Metastasis

Related references

Note: Only part of the references are listed.
Review Cell Biology

Cell cycle control in cancer

Helen K. Matthews et al.

Summary: This review highlights the importance of cell cycle regulation in preventing genetic errors and cell proliferation, and how disruption of these mechanisms is associated with cancer development. Cancer arises from continuous cell division and evasion of cell cycle control mechanisms.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

Review Oncology

Clinical Applications of Classical and Novel Biological Markers of Pancreatic Cancer

Leonel Pekarek et al.

Summary: Pancreatic cancer is a highly heterogeneous and aggressive tumor with limited median survival. Developing new disease markers is necessary to improve the average survival of patients. The incidence and prevalence of pancreatic adenocarcinoma have increased in recent years, making it the seventh leading cause of cancer death. Most patients are diagnosed in advanced stages with low 5-year survival. Different tissue markers have provided insight into the underlying pathophysiology and risk stratification of pancreatic adenocarcinoma. New immunohistochemical and serological markers may serve as prognostic markers for recurrence and potential therapeutic targets.

CANCERS (2022)

Review Biochemistry & Molecular Biology

Towards the Search for Potential Biomarkers in Osteosarcoma: State-of-the-Art and Translational Expectations

Leonel Pekarek et al.

Summary: Osteosarcoma is a rare cancer that primarily affects children, adolescents, and young adults. It is also associated with rheumatic diseases and has a second incidence peak in people over 50 years old. Various environmental and genetic risk factors have been described, and diagnosis requires imaging tests to determine the local and distant spread of the disease. Treatment options, including chemotherapy, radiotherapy, and surgery, have shown improvements in prognosis and therapeutic approaches. However, the use of serological, genetic, or other biomarkers in clinical practice for osteosarcoma is limited compared to other cancers, highlighting the need for new diagnostic alternatives.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Biochemistry & Molecular Biology

Coordinating gene expression during the cell cycle

Martin Fischer et al.

Summary: Cell cycle-dependent gene transcription is tightly regulated by multiple complexes, controlling gene expression during G1/S and G2/M phases to fulfill different functions in processes such as DNA synthesis and mitosis.

TRENDS IN BIOCHEMICAL SCIENCES (2022)

Review Oncology

The role of miR-200 family in the regulation of hallmarks of cancer

Klaudia Klicka et al.

Summary: miR-200 family is a dysregulated miRNA family in cancer that has the potential to be used as diagnostic and prognostic biomarkers. They regulate various features of cancer and their levels correlate with clinical parameters such as patients' survival.

FRONTIERS IN ONCOLOGY (2022)

Review Health Care Sciences & Services

Clinical and Novel Biomarkers in Penile Carcinoma: A Prospective Review

Leonel Pekarek et al.

Summary: Penile carcinoma is a rare urological neoplasia that continues to affect a large number of patients worldwide, particularly in developing countries. Human papilloma virus is an important risk factor. The management of these patients is complex, with surgical interventions and aggressive chemotherapy. The study of serological and histological markers may help in selecting high-risk patients and improving targeted therapies for advanced disease.

JOURNAL OF PERSONALIZED MEDICINE (2022)

Review Multidisciplinary Sciences

Cell cycle associated miRNAs as target and therapeutics in lung cancer treatment

Atqiya Fariha et al.

Summary: Lung cancer is a major cause of cancer-related deaths worldwide. Limited treatment options and drug resistance have hindered progress in clinical success. Recent studies have highlighted the role of microRNA in regulating the cell cycle in lung cancer, making them potential tools for therapy and early diagnosis.

HELIYON (2022)

Review Biochemistry & Molecular Biology

Targeting metastatic cancer

Karuna Ganesh et al.

Summary: Improved understanding of metastases biology has led to advancements in targeting and treating both micro- and macrometastases. Recent studies have identified the unique biology of metastasis-initiating cells, providing new opportunities for developing more effective treatment strategies through cancer sequencing, mechanistic studies, and clinical trials. These insights offer potential for better outcomes in targeting metastatic relapse and improving patient survival.

NATURE MEDICINE (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Multidisciplinary Sciences

Combined analysis of miR-200 family and its significance for breast cancer

Andrea Fontana et al.

Summary: The miR-200 family members show differential expression in breast cancer molecular subtypes, indicating their potential as biomarkers for breast cancer.

SCIENTIFIC REPORTS (2021)

Review Cell Biology

Regulation of Cell Cycle Progression by Growth Factor-Induced Cell Signaling

Zhixiang Wang

Summary: The cell cycle is a series of events driving cell division and production of two new daughter cells, involving phases G1, S, G2, and M. Progression is mediated by Cdks and their cyclin subunits, but growth factor signaling pathways are the driving force. Role of growth factor signaling in phases other than G1 is still poorly understood, with research focusing on regulation of cell cycle progression through different phases.

CELLS (2021)

Review Biochemistry & Molecular Biology

MicroRNAs as Critical Biomarkers of Major Depressive Disorder: A Comprehensive Perspective

Miguel A. Ortega et al.

Summary: miRNAs play a key role in the pathophysiology of Major Depressive Disorder and could serve as potential biomarkers. Lifestyle interventions such as physical activity, mindfulness, and diet are also important considerations.

BIOMEDICINES (2021)

Review Biochemistry & Molecular Biology

MicroRNA-375: potential cancer suppressor and therapeutic drug

Jiahui Wei et al.

Summary: MiR-375, a conserved noncoding RNA, plays a crucial role in tumor cell proliferation, migration, and drug resistance. Studies have shown that it affects the epithelial-mesenchymal transition of tumor cells through key transcription factors and signaling pathways, making it vital for cancer development. Recent research has also identified microRNA delivery systems for enhanced in vivo transportation of miR-375.

BIOSCIENCE REPORTS (2021)

Review Biochemistry & Molecular Biology

Angiogenesis and Anti-Angiogenic Treatment in Prostate Cancer: Mechanisms of Action and Molecular Targets

Evangelia Ioannidou et al.

Summary: Prostate cancer is the most common cancer in men and despite therapeutic advances, many patients still cannot be cured. Antiagiogenic therapies have shown limited benefits for prostate cancer compared to other types of cancer. Clinical trials and treatments for refractory castration-resistant prostate cancer face challenges and further research is needed to better understand mechanisms of resistance.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Oncology

Regulation of angiogenesis by microRNAs in cancer

Qi Zheng et al.

Summary: MicroRNAs (miRs) are small non-coding RNA molecules that play key roles in regulating gene expression and cellular functions, particularly in angiogenesis related to tumor development and progression. Investigating the roles of miRs in angiogenesis may lead to novel strategies for treating tumors, and their potential as biomarkers for diagnosing and monitoring therapy response is also being explored.

MOLECULAR MEDICINE REPORTS (2021)

Review Genetics & Heredity

Association of Exosomal miR-210 with Signaling Pathways Implicated in Lung Cancer

Qiaoyi Chen et al.

Summary: MicroRNA is a class of non-coding RNA involved in post-transcriptional gene regulation, with miR-210 playing a significant role in the progression of various cancers, particularly lung cancer. Exosomes have been shown to facilitate cell-cell communication by packaging and transporting active biomolecules like miRNAs, thereby modifying the cellular microenvironment favorable for lung cancers, with exosomal miR-210 playing a crucial role in regulating lung cancer-related signaling molecules and pathways.

GENES (2021)

Review Medicine, General & Internal

Unraveling the Wide Spectrum of Melanoma Biomarkers

Antonios Revythis et al.

Summary: The use of biomarkers in medicine is crucial for diagnosis, prognostication, and prediction of treatment response. With advancements in understanding DNA mutational profiles, new gene targets and proteins are being identified. Currently, only a small number of available biomarkers are being utilized, but this could change with more research being published.

DIAGNOSTICS (2021)

Review Biochemistry & Molecular Biology

MicroRNA-9 as a paradoxical but critical regulator of cancer metastasis: Implications in personalized medicine

Yichen Liu et al.

Summary: Metastasis refers to secondary tumor growth at a distant site from the primary tumor, which is closely linked to poor prognosis and mortality. miR-9 plays a dual role as a promoter or suppressor in cancer metastasis and is involved in coordinating multiple steps of the metastatic process. Studying the various mechanisms of miR-9 in regulating metastasis can facilitate further research and potentially inform clinical applications in the future.

GENES & DISEASES (2021)

Review Biochemistry & Molecular Biology

MicroRNA-375: potential cancer suppressor and therapeutic drug

Jiahui Wei et al.

Summary: MiR-375 plays a crucial role in tumor cell proliferation, migration, and drug resistance by affecting key transcription factors and signaling pathways. Recent studies have shown the potential of miR-375 as a molecular biomarker and therapeutic target for improving the efficiency of clinical cancer diagnosis.

BIOSCIENCE REPORTS (2021)

Review Biochemistry & Molecular Biology

Regulatory Mechanism of MicroRNA Expression in Cancer

Zainab Ali Syeda et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Medicine, Research & Experimental

MiR-199a-3p/5p participated in TGF-β and EGF induced EMT by targeting DUSP5/MAP3K11 in pterygium

Siying He et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

Review Oncology

microRNAs Biogenesis, Functions and Role in Tumor Angiogenesis

Tiziana Annese et al.

FRONTIERS IN ONCOLOGY (2020)

Review Biochemistry & Molecular Biology

Molecular principles of metastasis: a hallmark of cancer revisited

Jawad Fares et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Article Oncology

MiR-9 promotes tumorigenesis and angiogenesis and is activated by MYC and OCT4 in human glioma

Xu Chen et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

Review Oncology

Defining the Hallmarks of Metastasis

Danny R. Welch et al.

CANCER RESEARCH (2019)

Review Genetics & Heredity

MicroRNA in Pancreatic Cancer: From Biology to Therapeutic Potential

Manmeet Rawat et al.

GENES (2019)

Article Medicine, Research & Experimental

MiR-143-3p suppresses tumorigenesis in pancreatic ductal adenocarcinoma by targeting KRAS

Fei Xie et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Review Biochemistry & Molecular Biology

The Regulatory Role of MicroRNAs in Breast Cancer

Hui-Yi Loh et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Cell Biology

The Non-Canonical Aspects of MicroRNAs: Many Roads to Gene Regulation

Christiaan J. Stavast et al.

CELLS (2019)

Review Oncology

Overview of microRNA-199a Regulation in Cancer

Qiwen Wang et al.

CANCER MANAGEMENT AND RESEARCH (2019)

Review Health Care Sciences & Services

The Developing Story of Predictive Biomarkers in Colorectal Cancer

Stergios Boussios et al.

JOURNAL OF PERSONALIZED MEDICINE (2019)

Article Allergy

MicroRNA

Thomas X. Lu et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

Review Pathology

The promising role of miR-296 in human cancer

Lingling Zhu et al.

PATHOLOGY RESEARCH AND PRACTICE (2018)

Review Endocrinology & Metabolism

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

Jacob O'Brien et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Review Oncology

MicroRNAs and metastasis: small RNAs play big roles

Jongchan Kim et al.

CANCER AND METASTASIS REVIEWS (2018)

Review Genetics & Heredity

MicroRNA in pancreatic cancer

Keiichi Yonemori et al.

JOURNAL OF HUMAN GENETICS (2017)

Review Oncology

Microenvironmental regulation of tumour angiogenesis

Michele de Palma et al.

NATURE REVIEWS CANCER (2017)

Review Biochemistry & Molecular Biology

The sweet side of the cell cycle

Ee Phie Tan et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2017)

Review Oncology

OncomiR or Tumor Suppressor? The Duplicity of MicroRNAs in Cancer

Alexander A. Svoronos et al.

CANCER RESEARCH (2016)

Review Biochemistry & Molecular Biology

MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions

Caterina Catalanotto et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Review Biochemistry & Molecular Biology

The role of MicroRNAs in human cancer

Yong Peng et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2016)

Article Medicine, Research & Experimental

Emerging role of microRNA-21 in cancer

Yin-Hsun Feng et al.

BIOMEDICAL REPORTS (2016)

Review Oncology

Tumorigenesis: it takes a village

Doris P. Tabassum et al.

NATURE REVIEWS CANCER (2015)

Review Cell Biology

Regulation of cancer metastasis by microRNAs

Shih-Hsuan Chan et al.

JOURNAL OF BIOMEDICAL SCIENCE (2015)

Review Oncology

The Emerging Role of miR-375 in Cancer

Jun-Wei Yan et al.

INTERNATIONAL JOURNAL OF CANCER (2014)

Review Cell Biology

MicroRNA-145: a potent tumour suppressor that regulates multiple cellular pathways

Shi-Yun Cui et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2014)

Review Oncology

Multiple functions of hypoxia-regulated miR-210 in cancer

Qin Qin et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2014)

Article Medicine, Research & Experimental

miR-10b is overexpressed in hepatocellular carcinoma and promotes cell proliferation, migration and invasion through RhoC, uPAR and MMPs

Cheng-gong Liao et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2014)

Review Cell Biology

Regulation of microRNA biogenesis

Minju Ha et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Article Oncology

MiR-29c inhibits glioma cell proliferation, migration, invasion and angiogenesis

Yue-chao Fan et al.

JOURNAL OF NEURO-ONCOLOGY (2013)

Article Cell Biology

MiR-145 inhibits tumor angiogenesis and growth by N-RAS and VEGF

Chao Zou et al.

CELL CYCLE (2012)

Review Oncology

The cell cycle and cancer

Gareth H. Williams et al.

JOURNAL OF PATHOLOGY (2012)

Article Multidisciplinary Sciences

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

Muller Fabbri et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Chemistry, Multidisciplinary

Macro-management of microRNAs in cell cycle progression of tumor cells and its implications in anti-cancer therapy

Lin-hui Liang et al.

ACTA PHARMACOLOGICA SINICA (2011)

Review Biochemistry & Molecular Biology

MicroRNAs and the cell cycle

Maria Jose Bueno et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2011)

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Article Oncology

Perspectives on Lymphangiogenesis and Angiogenesis in Cancer

Tanja Holopainen et al.

JOURNAL OF SURGICAL ONCOLOGY (2011)

Article Multidisciplinary Sciences

MiR-21 Induced Angiogenesis through AKT and ERK Activation and HIF-1α Expression

Ling-Zhi Liu et al.

PLOS ONE (2011)

Review Pathology

microRNA, Cell Cycle, and Human Breast Cancer

Zuoren Yu et al.

AMERICAN JOURNAL OF PATHOLOGY (2010)

Article Oncology

EP300-a miRNA-regulated metastasis suppressor gene in ductal adenocarcinomas of the pancreas

Soeren Torge Mees et al.

INTERNATIONAL JOURNAL OF CANCER (2010)

Article Biotechnology & Applied Microbiology

Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model

Li Ma et al.

NATURE BIOTECHNOLOGY (2010)

Review Immunology

MicroRNAs: Small RNAs With Big Effects

Dany Anglicheau et al.

TRANSPLANTATION (2010)

Review Oncology

Role of miR-10b in breast cancer metastasis

Li Ma

BREAST CANCER RESEARCH (2010)

Review Oncology

Metastamir: The Field of Metastasis-Regulatory microRNA Is Spreading

Douglas R. Hurst et al.

CANCER RESEARCH (2009)

Article Biochemistry & Molecular Biology

Repression of the miR-17-92 cluster by p53 has an important function in hypoxia-induced apoptosis

Hong-li Yan et al.

EMBO JOURNAL (2009)

Article Multidisciplinary Sciences

p53 represses c-Myc through induction of the tumor suppressor miR-145

Mohit Sachdeva et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

MiR-15a and miR-16-1 cluster functions in human leukemia

George A. Calin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

Regulation of the p27Kip1 tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation

Carlos le Sage et al.

EMBO JOURNAL (2007)

Article Biochemistry & Molecular Biology

RNA polymerase III transcribes human microRNAs

Glen M. Borchert et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)

Review Peripheral Vascular Disease

Angiogenesis in cancer

Naoyo Nishida et al.

VASCULAR HEALTH AND RISK MANAGEMENT (2006)

Article Multidisciplinary Sciences

The Microprocessor complex mediates the genesis of microRNAs

RI Gregory et al.

NATURE (2004)

Article Biochemistry & Molecular Biology

MicroRNA genes are transcribed by RNA polymerase II

Y Lee et al.

EMBO JOURNAL (2004)