Metabolic Profile Reflects Stages of Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease

Letter Gastroenterology & Hepatology

An elevated FIB-4 score predicts liver cancer development: A longitudinal analysis from 29,999 patients with NAFLD

Sven H. Loosen et al.

JOURNAL OF HEPATOLOGY (2022)

Article Gastroenterology & Hepatology

Progression to Cirrhosis Leads to Improvement in Atherogenic Milieu

Samarth Patel et al.

Summary: Patients with cirrhosis have a low risk of cardiovascular disease events, which may be potentially due to improvements in markers of atherogenic risk.

DIGESTIVE DISEASES AND SCIENCES (2021)

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Article Endocrinology & Metabolism

Untargeted metabolomics as a diagnostic tool in NAFLD: discrimination of steatosis, steatohepatitis and cirrhosis

Mario Masarone et al.

Summary: The study utilized metabolomics analysis to differentiate metabolic profiles of different stages in NAFLD patients, revealing key metabolites that could potentially serve as biomarkers for disease progression. Additionally, the use of an ensemble machine learning model demonstrated high accuracy in predicting clinical stages of NAFLD.

METABOLOMICS (2021)

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Article Gastroenterology & Hepatology

Long-term outcomes and predictive ability of non-invasive scoring systems in patients with non-alcoholic fatty liver disease

Ramy Younes et al.

Summary: This study compared various non-invasive scoring systems in identifying risk and predicting long-term outcomes for patients with non-alcoholic fatty liver disease. NFS, HFS, and FIB-4 outperformed APRI and BARD in both cross-sectional identification of fibrosis and prediction of long-term outcomes, making them useful tools for clinical management of NAFLD patients at increased risk of fibrosis and liver-related complications or death.

JOURNAL OF HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis-2021 update

Annalisa Berzigotti et al.

Summary: The article provides the latest update to the EASL Clinical Practice Guidelines on the use of non-invasive tests for assessing liver disease severity and prognosis, with a focus on topics with relevant evidence published in the last 5 years.

JOURNAL OF HEPATOLOGY (2021)

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Review Gastroenterology & Hepatology

Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests

Mojgan Masoodi et al.

Summary: Metabolomics and lipidomics approaches are utilized to identify biomarkers for NAFLD, with significant contributions in clinical studies; key metabolic pathway alterations in NAFLD and NASH have been identified, potentially serving as biomarkers for non-invasive diagnostic tests. Despite the discovery of potential biomarkers, few have been validated for clinical use.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

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Article Endocrinology & Metabolism