☆ 4.7 Article

ERR alpha Up-Regulates Invadopodia Formation by Targeting HMGCS1 to Promote Endometrial Cancer Invasion and Metastasis

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Related references

Note: Only part of the references are listed.

Article Oncology

Lipid reprogramming induced by the TFEB-ERRα axis enhanced membrane fluidity to promote EC progression

Xiaodan Mao et al.

Summary: This study reveals that lipid reprogramming induced by the TFEB-ERRα axis enhances the progression of endometrial cancer through EMT signaling. The TFEB-ERRα axis increases membrane fluidity, promotes pseudopod formation, and enhances cell invasion. TFEB and ERRα are highly expressed in EC patients and correlated with EC progression. Furthermore, the TFEB-ERRα axis affects lipid metabolism by altering mitochondrial function.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

Add to Collection

Editorial Material Medicine, General & Internal

New Insights into Immunotherapy for Gynecological Cancer

Takuro Kobori

JOURNAL OF CLINICAL MEDICINE (2022)

Add to Collection

Article Medicine, General & Internal

Immune Checkpoint Inhibitors and Mismatch Repair Status in Advanced Endometrial Cancer: Elective Affinities

Alessandro Rizzo

Summary: This paper provides an overview of the clinical development of immunotherapy in advanced or recurrent EC, discussing the role of MMR and the relationship between ICIs and this predictive biomarker in this setting.

JOURNAL OF CLINICAL MEDICINE (2022)

Add to Collection

Review Oncology

Role of HIF-1α/ERRα in Enhancing Cancer Cell Metabolism and Promoting Resistance of Endometrial Cancer Cells to Pyroptosis

Pingping Su et al.

Summary: Oxygen is crucial for energy metabolism in tumors, which often occur in a hypoxic microenvironment. The interaction between HIF-1 alpha and ERR alpha plays a key role in regulating the metabolic and functional changes in cancer cells. This review gives an overview of the tumor metabolic reprogramming involving HIF-1 alpha/ERR alpha and explores their role in promoting tumor growth adaptation and pyroptosis resistance.

FRONTIERS IN ONCOLOGY (2022)

Add to Collection

Article Oncology

Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer

Pik-Fang Kho et al.

Summary: This study used Mendelian randomization analysis to investigate the relationship between blood lipids and endometrial cancer risk. Genetically elevated LDL cholesterol levels were associated with reduced risk of endometrial cancer, while higher predicted HDL cholesterol levels were linked to increased risk of non-endometrioid endometrial cancer. Obesity may influence these associations, but triglycerides showed no evidence of involvement in endometrial cancer development.

INTERNATIONAL JOURNAL OF CANCER (2021)

Add to Collection

Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Cholesterol and Sphingolipid Enriched Lipid Rafts as Therapeutic Targets in Cancer

Michela Codini et al.

Summary: Lipid rafts are critical cell membrane platforms enriched in sphingolipids and cholesterol, playing roles in various cellular processes, including cancer. Recent findings on cholesterol, sphingolipids, and lipid rafts in cellular and nuclear membranes provide insights into using lipid rafts as biomolecular targets for developing innovative therapeutic strategies in cancer.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Integrated Multi-Omics Investigations of Metalloproteinases in Colon Cancer: Focus on MMP2 and MMP9

Miriam Buttacavoli et al.

Summary: This study conducted a multi-omics analysis to investigate the expression and potential roles of matrix metalloproteinases in colorectal cancer. The findings suggest that MMPs could be targeted in colon cancer treatment and serve as novel biomarkers, especially for their involvement in the immune response. Further research is needed to explore the detailed biological functions and molecular mechanisms of MMPs in CRC, considering their expression and regulation in different tissues.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Orphan nuclear receptors as regulators of intratumoral androgen biosynthesis in castration-resistant prostate cancer

Jianfu Zhou et al.

Summary: CRPC typically occurs after ADT, driven by AR reactivation and upregulation of steroidogenic enzymes. ONRs play crucial roles in the transcriptional regulation and promotion of intratumoral androgen synthesis, potentially serving as therapeutic targets for CRPC.

ONCOGENE (2021)

Add to Collection

Article Oncology

Influence of cholesterol on cancer progression and therapy

Shyamananda Singh Mayengbam et al.

Summary: Cholesterol plays a crucial role in maintaining cell structure and normal biological function, but is also linked to lifestyle-related diseases. Research has shown alterations in blood cholesterol levels in cancer patients compared to healthy individuals, highlighting its significance in cancer progression and therapy.

TRANSLATIONAL ONCOLOGY (2021)

Add to Collection

Review Genetics & Heredity

Cholesterol-Lowering Drugs on Akt Signaling for Prevention of Tumorigenesis

Navneet Kumar et al.

Summary: Cholesterol accumulation in cancer cells is associated with tumor development, while cholesterol-lowering drugs have been found to play a role in the prevention and treatment of various cancers. Dysregulation of Akt in cancer is common and targeting Akt is considered an effective approach for cancer therapy. Cholesterol-lowering drugs affect Akt expression and activation in cancer cells, showing anticancer activity in different types of cancers.

FRONTIERS IN GENETICS (2021)

Add to Collection

Article Oncology

Cholesterol-Induced Metabolic Reprogramming in Breast Cancer Cells Is Mediated via the ERRα Pathway

Faegheh Ghanbari et al.

Summary: This study demonstrates that obesity and high blood cholesterol levels are associated with an increased risk of recurrence and higher mortality in breast cancer patients by altering metabolic programming in breast cancer cells. Cholesterol acts as an endogenous agonist of ERR alpha, regulating cellular metabolism. The findings provide mechanistic insights into the link between cholesterol/obesity and metabolic reprogramming in breast cancer, potentially identifying therapeutic targets.

CANCERS (2021)

Add to Collection

Review Oncology

Epithelial-to-mesenchymal transition and invadopodia markers in breast cancer: Lumican a key regulator

Konstantina Karamanou et al.

SEMINARS IN CANCER BIOLOGY (2020)

Add to Collection

Article Oncology

MiR-612 regulates invadopodia of hepatocellular carcinoma by HADHA-mediated lipid reprogramming

Yang Liu et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

Add to Collection

Review Nutrition & Dietetics

Effects of obesity on cholesterol metabolism and its implications for healthy ageing

Mark Tomas Mc Auley

NUTRITION RESEARCH REVIEWS (2020)

Add to Collection

Article Obstetrics & Gynecology

A novel non-invasive molecular biomarker in ovarian endometriosis: estrogen-related receptor α

Chen Liu et al.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS (2020)

Add to Collection

Article Oncology

Annual report to the nation on the status of cancer, part I: National cancer statistics

S. Jane Henley et al.

CANCER (2020)

Add to Collection

Article Oncology

Mevalonate Pathway Enzyme HMGCS1 Contributes to Gastric Cancer Progression

I-Han Wang et al.

CANCERS (2020)

Add to Collection

Review Oncology

Invadopodia: clearing the way for cancer cell invasion

Katarzyna Augoff et al.

ANNALS OF TRANSLATIONAL MEDICINE (2020)

Add to Collection

Article Cell Biology

PGC-1α and ERRα in patients with endometrial cancer: a translational study for predicting myometrial invasion

LiLi Chen et al.

Aging-US (2020)

Add to Collection

Article Multidisciplinary Sciences

The mevalonate precursor enzyme HMGCS1 is a novel marker and key mediator of cancer stem cell enrichment in luminal and basal models of breast cancer

Claire A. Walsh et al.

PLOS ONE (2020)

Add to Collection

Article Oncology

Estrogen-related receptor alpha directly binds to p53 and cooperatively controls colon cancer growth through the regulation of mitochondrial biogenesis and function

Humberto De Vitto et al.

CANCER & METABOLISM (2020)

Add to Collection

Review Endocrinology & Metabolism

Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities

Binlu Huang et al.

NATURE METABOLISM (2020)

Add to Collection

Article Multidisciplinary Sciences

Estrogen-related receptor alpha induces epithelial-mesenchymal transition through cancer-stromal interactions in endometrial cancer

Kaori Yoriki et al.

SCIENTIFIC REPORTS (2019)

Add to Collection

Article Oncology

PGC1α Suppresses Prostate Cancer Cell Invasion through ERRα Transcriptional Control

Lorea Valcarcel-Jimenez et al.

CANCER RESEARCH (2019)

Add to Collection

Article Oncology

Cancer statistics, 2019

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2019)

Add to Collection

Article Oncology

Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods

J. Ferlay et al.

INTERNATIONAL JOURNAL OF CANCER (2019)

Add to Collection

Review Endocrinology & Metabolism

Cholesterol and Its Metabolites in Tumor Growth: Therapeutic Potential of Statins in Cancer Treatment

Adele Chimento et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

Add to Collection

Article Oncology

Novel endocrine therapeutic strategy in endometrial carcinoma targeting estrogen-related receptor α, by XCT790 and siRNA

PengMing Sun et al.

CANCER MANAGEMENT AND RESEARCH (2018)

Add to Collection

Review Oncology

Key regulator of cellular metabolism, estrogen-related receptor alpha, a new therapeutic target in endocrine-related gynecological tumor

GuiFen Liu et al.

CANCER MANAGEMENT AND RESEARCH (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Mitochondrial cholesterol import

Pia Elustondo et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Dynamin2 GTPase contributes to invadopodia formation in invasive bladder cancer cells

Yubai Zhang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Add to Collection

Review Oncology

Addressing the Role of Obesity in Endometrial Cancer Risk, Prevention, and Treatment

Michaela A. Onstad et al.

JOURNAL OF CLINICAL ONCOLOGY (2016)

Add to Collection

Article Biochemistry & Molecular Biology

There and back again: The journey of the estrogen-related receptors in the cancer realm

Ingrid S. Tam et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2016)

Add to Collection

Article

Cellular Protrusions - Lamellipodia, Filopodia, Invadopodia and Podosomes - and their Roles in Progression of Orofacial Tumours: Current Understanding

Kamila Mohamed Om Alblazi et al.

Asian Pacific Journal of Cancer Prevention (2015)

Add to Collection

Review Endocrinology & Metabolism

Estrogen-related receptors in breast cancer and prostate cancer

Aya Misawa et al.

FRONTIERS IN ENDOCRINOLOGY (2015)

Add to Collection

Article Oncology

Simvastatin, an HMG-CoA reductase inhibitor, exhibits anti-metastatic and anti-tumorigenic effects in endometrial cancer

Monica N. Schointuch et al.

GYNECOLOGIC ONCOLOGY (2014)

Add to Collection

Article Biochemistry & Molecular Biology

Cytoskeleton Modification and Cholesterol Depletion Affect Membrane Properties and Caveolae Positioning of CHO Cells

Maja Grundner et al.

JOURNAL OF MEMBRANE BIOLOGY (2014)

Add to Collection

Article Multidisciplinary Sciences

Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging

Amir Sapir et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Add to Collection

Article Cell Biology

Invadopodia Are Required for Cancer Cell Extravasation and Are a Therapeutic Target for Metastasis

Hon S. Leong et al.

CELL REPORTS (2014)

Add to Collection

Review Biochemistry & Molecular Biology

Controlling Cholesterol Synthesis beyond 3-Hydroxy-3-methylglutaryl-CoA Reductase (HMGCR)

Laura J. Sharpe et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Add to Collection

Article Pathology

Poor prognosis of uterine serous carcinoma compared with grade 3 endometrioid carcinoma in early stage patients

Ji Young Park et al.

VIRCHOWS ARCHIV (2013)

Add to Collection

Article Cell Biology

Invadopodia biogenesis is regulated by caveolin-mediated modulation of membrane cholesterol levels

Giusi Caldieri et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2009)

Add to Collection

Review Medicine, Research & Experimental

The basics of epithelial-mesenchymal transition

Raghu Kalluri et al.

JOURNAL OF CLINICAL INVESTIGATION (2009)

Add to Collection

Review Biochemistry & Molecular Biology

Cholesterol and caveolae: structural and functional relationships

CJ Fielding et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2000)

Add to Collection

Article Cell Biology

Association of mouse actin-binding protein 1 (mAbp1/SH3P7), an Src kinase target, with dynamic regions of the cortical actin cytoskeleton in response to Rac1 activation

MM Kessels et al.

MOLECULAR BIOLOGY OF THE CELL (2000)

Add to Collection

© Peeref 2019-2024. All rights reserved.