Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 24, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/ijms24043195
Keywords
antiphospholipid syndrome; obstetrical APS; pathogenesis; thrombosis; inflammation
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The antiphospholipid syndrome (APS) is an autoimmune disorder characterized by persistent presence of autoantibodies against phospholipid-binding proteins, leading to thrombosis and/or obstetrical complications. Vascular APS (VAPS) and obstetric APS (OAPS) have been recognized as two distinct clinical entities. VAPS is explained by the interference of antiphospholipid antibodies with the coagulation cascade, while OAPS involves additional mechanisms such as direct damage to trophoblast cells by anti-beta 2 glycoprotein-I.
The antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized, according to the Sydney criteria, by the persistent presence of autoantibodies directed against phospholipid-binding proteins associated with thrombosis and/or obstetrical complications. The most frequent complications in obstetric antiphospholipid syndrome are recurrent pregnancy losses and premature birth due to placental insufficiency or severe preeclampsia. In recent years, vascular APS (VAPS) and obstetric APS (OAPS) have been described as two different clinical entities. In VAPS, antiphospholipid antibodies (aPL) interfere with the mechanisms of coagulation cascade and the 'two hit hypothesis' has been suggested to explain why aPL positivity does not always lead to thrombosis. OAPS seems to involve additional mechanisms, such as the direct action of anti-beta 2 glycoprotein-I on trophoblast cells that can lead to a direct placental functional damage. Furthermore, new actors seem to play a role in the pathogenesis of OAPS, including extracellular vesicles, micro-RNAs and the release of neutrophil extracellular traps. The aim of this review is to investigate the state-of-the-art antiphospholipid syndrome pathogenesis in pregnancy, in order to provide a comprehensive overview of both old and new pathogenetic mechanisms involved in this complex disease.
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