A Compilation of the Diverse miRNA Functions in Caenorhabditis elegans and Drosophila melanogaster Development

MicroRNAs are critical regulators of post-transcriptional gene expression in a wide range of taxa, including invertebrates, mammals, and plants. Since their discovery in the nematode, Caenorhabditis elegans, miRNA research has exploded, and they are being identified in almost every facet of development. Invertebrate model organisms, particularly C. elegans, and Drosophila melanogaster, are ideal systems for studying miRNA function, and the roles of many miRNAs are known in these animals. In this review, we compiled the functions of many of the miRNAs that are involved in the development of these invertebrate model species. We examine how gene regulation by miRNAs shapes both embryonic and larval development and show that, although many different aspects of development are regulated, several trends are apparent in the nature of their regulation.

Automated summary

MicroRNAs play a critical role in regulating post-transcriptional gene expression in various taxa. Their presence has been identified in almost all aspects of development since their discovery in the nematode C. elegans. Invertebrate model organisms, especially C. elegans and Drosophila melanogaster, are ideal for studying miRNA function, and this review compiles the functions of miRNAs in the development of these invertebrate species. The regulation of gene expression by miRNAs shapes both embryonic and larval development, and several trends can be observed in their regulatory nature.