4.7 Article

Puerarin Prevents Cadmium-Induced Neuronal Injury by Alleviating Autophagic Dysfunction in Rat Cerebral Cortical Neurons

Related references

Note: Only part of the references are listed.
Article Environmental Sciences

In vivo assessment of molybdenum and cadmium co-induce nephrotoxicity via causing calcium homeostasis disorder and autophagy in ducks (Anas platyrhyncha)

Caiying Zhang et al.

Summary: The study showed that excessive molybdenum and cadmium exposure in duck kidneys caused histological abnormalities and disruptions in calcium homeostasis and autophagy processes, potentially leading to nephrotoxicity.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

Article Engineering, Environmental

Epigenetic regulator BRD4 is involved in cadmium-induced acute kidney injury via contributing to lysosomal dysfunction, autophagy blockade and oxidative stress

Zhong-Gui Gong et al.

Summary: The study demonstrates that BRD4 acts as a transcriptional repressor in mediating lysosomal dysfunction, autophagy blockade, and oxidative stress during Cd exposure, showing its potential as a therapeutic target for Cd-induced AKI.

JOURNAL OF HAZARDOUS MATERIALS (2022)

Article Clinical Neurology

Blood Metal Levels and Amyotrophic Lateral Sclerosis Risk: A Prospective Cohort

Susan Peters et al.

Summary: This study compared metal levels in blood samples from ALS patients and controls, suggesting associations between cadmium and lead concentrations with increased ALS risk, and zinc concentrations with decreased ALS risk. Cadmium and lead may act as intermediates on the pathway from smoking to ALS.

ANNALS OF NEUROLOGY (2021)

Review Environmental Sciences

A review on Cadmium Exposure in the Population and Intervention Strategies Against Cadmium Toxicity

Mei Wang et al.

Summary: Rapid industrial development has led to serious cadmium pollution, posing severe health threats to humans. Cd accumulates in organs like kidneys, liver, and bones, causing irreversible damage and potentially carcinogenic and non-carcinogenic health risks.

BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY (2021)

Article Engineering, Environmental

Cadmium-induced dysfunction of the blood-brain barrier depends on ROS-mediated inhibition of PTPase activity in zebrafish

Tao Zhang et al.

Summary: Accumulation of cadmium in the blood increases the risk of neurological diseases, but the mechanism of how cadmium crosses the blood-brain barrier is unclear. Studies have shown that cadmium chloride can affect the development and function of the BBB in zebrafish, leading to cerebral hemorrhage, increased permeability, and abnormal vascular formation, as well as disrupting cell-cell junctional morphology.

JOURNAL OF HAZARDOUS MATERIALS (2021)

Article Environmental Sciences

Autophagy in Sertoli cell protects against environmental cadmium-induced germ cell apoptosis in mouse testes

Guo-Xiang Zhou et al.

Summary: This study revealed that cadmium triggers germ cell apoptosis in the testes, while autophagy in Sertoli cells can alleviate cadmium-induced germ cell apoptosis.

ENVIRONMENTAL POLLUTION (2021)

Article Biochemistry & Molecular Biology

Puerarin induces Nrf2 as a cytoprotective mechanism to prevent cadmium-induced autophagy inhibition and NLRP3 inflammasome activation in AML12 hepatic cells

Zhao-Ming Yu et al.

Summary: The study found that puerarin can prevent autophagy inhibition and NLRP3 inflammasome activation induced by cadmium by restoring Nrf2 pathway, providing novel insights into the protection of puerarin against cadmium-induced hepatic cell damage.

JOURNAL OF INORGANIC BIOCHEMISTRY (2021)

Article Cell Biology

Simvastatin accelerated motoneurons death in SOD1G93A mice through inhibiting Rab7-mediated maturation of late autophagic vacuoles

Lin Bai et al.

Summary: In ALS model, simvastatin can lead to early onset of disease phenotype, shortened lifespan, and aggravated impairment of autophagic flux in SOD1(G93A) mice, potentially accelerating disease progression.

CELL DEATH & DISEASE (2021)

Article Pharmacology & Pharmacy

Puerarin Restores Autophagosome-Lysosome Fusion to Alleviate Cadmium-Induced Autophagy Blockade via Restoring the Expression of Rab7 in Hepatocytes

Tao Wang et al.

Summary: This study demonstrates that puerarin alleviates cadmium-induced hepatocyte injury by activating autophagy and mitigating autophagy blockade. Through investigating a cell model exposed to cadmium, it was found that puerarin enhanced autophagic activity, strengthened lysosomal degradation capacity, and restored the fusion of autophagosomes and lysosomes by upregulating Rab7 expression.

FRONTIERS IN PHARMACOLOGY (2021)

Review Cell Biology

Machinery, regulation and pathophysiological implications of autophagosome maturation

Yan G. Zhao et al.

Summary: Autophagosome maturation is a crucial process for maintaining cellular homeostasis and autophagic degradation, involving a variety of regulatory factors working together. Its dysregulation is associated with neurodegenerative disorders, muscle diseases, cancer, and the survival of invading pathogens.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Article Cell Biology

Alpha-Synuclein defects autophagy by impairing SNAP29-mediated autophagosome-lysosome fusion

Qilin Tang et al.

Summary: The study reveals that alpha-Syn impairs autophagy turnover by reducing the fusion of autophagosomes with lysosomes, leading to a decrease in the formation of autolysosomes. Additionally, alpha-Syn increases the number of extracellular vesicles and the abundance of autophagy-associated proteins in these vesicles. Mechanistically, alpha-Syn decreases the abundance of the v-SNARE protein SNAP29, impacting autophagolysosome fusion and ultimately influencing DA neuronal cell death.

CELL DEATH & DISEASE (2021)

Article Geriatrics & Gerontology

Cadmium, an Environmental Contaminant, Exacerbates Alzheimer's Pathology in the Aged Mice's Brain

Tahir Ali et al.

Summary: The study found that chronic exposure to cadmium may exacerbate memory and synaptic deficits in mice, leading to oxidative stress and the development of oxidative stress-related Alzheimer's disease (AD) pathology. This suggests the need to address the regulation of oxidative stress/ROS and the associated amyloid beta pathology.

FRONTIERS IN AGING NEUROSCIENCE (2021)

Article Biochemistry & Molecular Biology

Puerarin Attenuates Cadmium-Induced Neuronal Injury via Stimulating Cadmium Excretion, Inhibiting Oxidative Stress and Apoptosis

Shuangquan Wen et al.

Summary: This study evaluated the neuroprotective potential of Puerarin against cadmium-induced neuronal injury for the first time, showing that Puerarin ameliorated neuronal injury and oxidative stress induced by cadmium. Additionally, Puerarin stimulated cadmium excretion, thereby reducing apoptosis in cerebral cortical neurons.

BIOMOLECULES (2021)

Article Biochemistry & Molecular Biology

Puerarin plays a protective role in chondrocytes by activating Beclin1-dependent autophagy

Guishuang Li et al.

Summary: Puerarin can protect chondrocytes by promoting autophagy, thereby ameliorating osteoarthritis.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2021)

Review Biochemistry & Molecular Biology

Autophagosome-Lysosome Fusion

Peter Lorincz et al.

JOURNAL OF MOLECULAR BIOLOGY (2020)

Review Neurosciences

Overview of Crosstalk Between Multiple Factor of Transcytosis in Blood Brain Barrier

Marco Tjakra et al.

FRONTIERS IN NEUROSCIENCE (2020)

Article Physiology

Puerarin Attenuates Diabetic Nephropathy by Promoting Autophagy in Podocytes

Xueling Li et al.

FRONTIERS IN PHYSIOLOGY (2020)

Review Biochemistry & Molecular Biology

Autophagy Assays for Biological Discovery and Therapeutic Development

Noboru Mizushima et al.

TRENDS IN BIOCHEMICAL SCIENCES (2020)

Review Medicine, Research & Experimental

A comprehensive review on Pueraria: Insights on its chemistry and medicinal value

Shengguang Wang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Review Pharmacology & Pharmacy

The Role of Natural Antioxidants Against Reactive Oxygen Species Produced by Cadmium Toxicity: A Review

Velid Unsal et al.

ADVANCED PHARMACEUTICAL BULLETIN (2020)

Review Neurosciences

Alzheimer's disease and the autophagic-lysosomal system

Kyung Min Chung et al.

NEUROSCIENCE LETTERS (2019)

Review Environmental Sciences

Cadmium exposure in living organisms: A short review

Hao Zhang et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2019)

Article Biochemistry & Molecular Biology

The in silico and in vivo evaluation of puerarin against Alzheimer's disease

Song Liu et al.

FOOD & FUNCTION (2019)

Review Cell Biology

Autophagy pathway: Cellular and molecular mechanisms

Li Yu et al.

AUTOPHAGY (2018)

Article Biochemistry & Molecular Biology

Restoration of autophagy by puerarin in lead-exposed primary rat proximal tubular cells via regulating AMPK-mTOR signaling

Xiangbin Song et al.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2017)

Review Biochemistry & Molecular Biology

Monitoring and Measuring Autophagy

Saori R. Yoshii et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Multidisciplinary Sciences

Lysosomal adaptation: How cells respond to lysosomotropic compounds

Shuyan Lu et al.

PLOS ONE (2017)

Review Cell Biology

Multiple Roles of the Small GTPase Rab7

Flora Guerra et al.

CELLS (2016)

Article Biochemistry & Molecular Biology

Inactivated Sendai virus induces apoptosis and autophagy via the PI3K/Akt/mTOR/p70S6K pathway in human non-small cell lung cancer cells

Quan Zhang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Article Cell Biology

Interaction of the HOPS complex with Syntaxin 17 mediates autophagosome clearance in Drosophila

Szabolcs Takats et al.

MOLECULAR BIOLOGY OF THE CELL (2014)

Review Chemistry, Medicinal

Puerarin: A Review of Pharmacological Effects

Yan-Xi Zhou et al.

PHYTOTHERAPY RESEARCH (2014)

Editorial Material Cell Biology

Cathepsin-mediated regulation of autophagy in saposin C deficiency

Massimo Tatti et al.

AUTOPHAGY (2013)

Article Biochemistry & Molecular Biology

Induction of cytoprotective autophagy in PC-12 cells by cadmium

Qiwen Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

Review Biochemistry & Molecular Biology

Proteomics of the lysosome

Torben Luebke et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2009)

Review Cell Biology

Maturation of autophagic vacuoles in mammalian cells

Eeva-Liisa Eskelinen

AUTOPHAGY (2005)

Article Cell Biology

Role for Rab7 in maturation of late autophagic vacuoles

S Jäger et al.

JOURNAL OF CELL SCIENCE (2004)