☆ 4.7 Article

Serum Neurofilament Light Chain and Glial Fibrillary Acidic Protein as Potential Diagnostic Biomarkers in Autism Spectrum Disorders: A Preliminary Study

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Related references

Note: Only part of the references are listed.

Article Biochemistry & Molecular Biology

Neuroimmune transcriptome changes in patient brains of psychiatric and neurological disorders

Yu Chen et al.

Summary: Neuroinflammation has been found to play a role in multiple brain disorders, and this study compared the expression changes of immune-related genes across different disorders. The results showed significant alterations in these genes in various brain disorders, mainly related to innate immunity. The study also revealed interactions between the neuroimmune system and neuronal-systems, shedding light on the pathology of these disorders.

MOLECULAR PSYCHIATRY (2023)

Add to Collection

Review Immunology

Innate immune dysfunction and neuroinflammation in autism spectrum disorder (ASD)

H. K. Hughes et al.

Summary: Autism spectrum disorder (ASD) is a diverse neurodevelopmental disorder characterized by deficits in communication and social behavior, often accompanied by restricted and repetitive behaviors. The prevalence of ASD has been increasing in recent decades, and both genetic and environmental factors are believed to contribute to its etiology. This review explores the evidence of innate immune dysfunction in ASD, including abnormal cellular function, neuroinflammation, and microglial activation.

BRAIN BEHAVIOR AND IMMUNITY (2023)

Add to Collection

Article Neurosciences

Association of Amygdala Development with Different Forms of Anxiety in Autism Spectrum Disorder

Derek Sayre Andrews et al.

BIOLOGICAL PSYCHIATRY (2022)

Add to Collection

Review Clinical Neurology

Blood GFAP as an emerging biomarker in brain and spinal cord disorders

Ahmed Abdelhak et al.

Summary: Blood-derived biomarkers, such as glial fibrillary acidic protein (GFAP), hold promise in the diagnosis and prognosis of neurological diseases. However, there are limitations that hinder the widespread clinical use of GFAP as a biomarker.

NATURE REVIEWS NEUROLOGY (2022)

Add to Collection

Article Clinical Neurology

Neurogenetic disorders across the lifespan: from aberrant development to degeneration

Richard A. Hickman et al.

Summary: Intellectual disability and autism spectrum disorder are common, with genetic testing now being used more frequently to provide information. Data on the natural history of neurogenetic conditions in adults are limited, highlighting the need for lifelong studies on affected genes. There is recognition that some neurodegenerative disorders may also involve neurodevelopmental components.

NATURE REVIEWS NEUROLOGY (2022)

Add to Collection

Article Genetics & Heredity

Nonshared environmental factors in the aetiology of autism and other neurodevelopmental conditions: a monozygotic co-twin control study

Johan Isaksson et al.

Summary: This study used a monozygotic co-twin design to investigate the association between perinatal and postnatal risks and neurodevelopmental conditions (NDCs). The findings suggest a link between exposure to these risks and subsequent NDCs, particularly autism.

MOLECULAR AUTISM (2022)

Add to Collection

Article Psychology, Developmental

Early life environmental factors associated with autism spectrum disorder symptoms in children at age 2 years: A birth cohort study

Cindy Pham et al.

Summary: Mounting evidence suggests that early life environmental factors increase the likelihood of autism spectrum disorder. This study found that autism spectrum disorder symptoms at the age of 2 strongly predicted diagnosis by the age of 4. Factors such as lower household income, lone parental status, younger maternal age, maternal pre-pregnancy body mass index, higher gestational weight gain, prenatal maternal stress, prenatal alcohol, environmental air pollutant exposures, secondhand tobacco smoke exposure, dampness/mould, and home heating with oil, kerosene or diesel heaters were associated with autism spectrum disorder symptoms.

AUTISM (2022)

Add to Collection

Article Neurosciences

Decreased Number and Increased Activation State of Astrocytes in Gray and White Matter of the Prefrontal Cortex in Autism

Gelareh Vakilzadeh et al.

Summary: The number of astrocytes is decreased and their activation state is increased in the cerebral cortex of individuals with autism spectrum disorder (ASD). This suggests a potential connection between altered astrocytes, impaired synaptic function, and inflammatory processes in ASD.

CEREBRAL CORTEX (2022)

Add to Collection

Review Immunology

Serum glial fibrillary acidic protein is a body fluid biomarker: A valuable prognostic for neurological disease - A systematic review

Luana Heimfarth et al.

Summary: Astrocytes, as the most abundant cell type in the human central nervous system, play a crucial role in the regulation of neuronal physiology. This systematic review focuses on the potential use of glial fibrillary acidic protein (GFAP) as a blood biomarker for the detection of neurological disorders. The review summarizes studies published between January 2012 and September 2021 and highlights the association between elevated GFAP levels and various neurological diseases, suggesting its potential as a valuable diagnostic biomarker.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

Add to Collection

Review Neurosciences

Genomics, convergent neuroscience and progress in understanding autism spectrum disorder

Helen Rankin Willsey et al.

Summary: This article explores the genes associated with autism spectrum disorder (ASD) and discusses the use of convergent neuroscience approaches to understand the pathobiology of ASD.

NATURE REVIEWS NEUROSCIENCE (2022)

Add to Collection

Review Neurosciences

Virus-Induced Maternal Immune Activation as an Environmental Factor in the Etiology of Autism and Schizophrenia

Aicha Massarali et al.

Summary: Maternal immune activation is a phenomenon that is caused by the activation of inflammatory pathways and affects fetal neural development. Maternal viral infection is one of the significant factors that lead to immune activation in pregnant women. Maternal immune activation and immune abnormalities play key roles in the development of conditions such as autism and schizophrenia. The methods of studying maternal immune activation include animal models and human epidemiological studies, but both have limitations.

FRONTIERS IN NEUROSCIENCE (2022)

Add to Collection

Review Clinical Neurology

Temporal Patterning of Neurofilament Light as a Blood-Based Biomarker for Stroke: A Systematic Review and Meta-Analysis

Jasmin D. Sanchez et al.

Summary: This study investigates the utility of blood neurofilament light chain (NfL) as a biomarker for stroke. Through a systematic review and meta-analysis, the authors create a phasic model of blood NfL values during different time periods of acute stroke and find the potential of NfL as a diagnostic and differentiating biomarker for stroke subtypes.

FRONTIERS IN NEUROLOGY (2022)

Add to Collection

Article Psychiatry

Integration of Urine Proteomic and Metabolomic Profiling Reveals Novel Insights Into Neuroinflammation in Autism Spectrum Disorder

Wenlong Liu et al.

Summary: This study conducted comparative integrated proteomic and metabolomic analyses of urine samples from ASD children and healthy children, and discovered differentially expressed proteins and metabolites related to neuroinflammation. Dysregulated signaling pathways associated with the neuroimmune response were also identified. The study suggests the prominent role of the neuroimmune response in ASD and provides potential biomarkers for diagnosis or early intervention.

FRONTIERS IN PSYCHIATRY (2022)

Add to Collection

Article Neurosciences

Altered Development of Amygdala-Connected Brain Regions in Males and Females with Autism

Joshua K. Lee et al.

Summary: This study investigated the volumetric development of brain regions connected with the amygdala in children with autism. The results showed that there were persistent and increasing differences in the development of these brain regions in children with autism compared to typically developing children. These differences were associated with social impairments and varied between males and females.

JOURNAL OF NEUROSCIENCE (2022)

Add to Collection

Review Psychiatry

Microglia: Synaptic modulator in autism spectrum disorder

Cong Hu et al.

Summary: This review focuses on the role of microglia in ASD, especially their interactions with neurons and synapses, highlighting the essential influence of microglia on normal neural function.

FRONTIERS IN PSYCHIATRY (2022)

Add to Collection

Review Psychiatry

Genetics of autism spectrum disorder: an umbrella review of systematic reviews and meta-analyses

Shuang Qiu et al.

Summary: This article presents an umbrella review of genetic studies on autism spectrum disorder (ASD) and provides a comprehensive overview of the risk genes associated with ASD. The study identifies significant single nucleotide polymorphisms (SNPs) in genes such as CNTNAP2, MTHFR, OXTR, SLC25A12, and VDR that may confer ASD risks. The findings offer evidence-based information for clinicians and healthcare decision-makers, guiding future treatment, prevention, and research.

TRANSLATIONAL PSYCHIATRY (2022)

Add to Collection

Article Neurosciences

Age-dependent white matter microstructural disintegrity in autism spectrum disorder

Clara F. Weber et al.

Summary: This study evaluated the impact of age on white matter microstructure and connectome disruption in patients with Autism Spectrum Disorder (ASD). The findings showed that there is an age-dependent effect on white matter microstructure, with adolescents and young adults exhibiting ASD-related abnormalities. These abnormalities were observed in both diffusion tensor imaging (DTI) metrics and connectome edge density (ED), suggesting a more widespread involvement of the connectome in ASD compared to DTI metrics. Machine learning models were also used to predict ASD diagnoses based on DTI and ED metrics, achieving reasonable accuracy.

FRONTIERS IN NEUROSCIENCE (2022)

Add to Collection

Review Psychiatry

Re-emerging concepts of immune dysregulation in autism spectrum disorders

Alina Erbescu et al.

Summary: This paper reviews the altered immune landscape in autism spectrum disorder (ASD), highlighting the potential for biomarker discovery and personalized therapeutic approaches. It discusses the interplay of genetic and immune system factors, prenatal and postnatal contributors, oxidative stress response, gastrointestinal inflammation pathways, and epigenetic traits in ASD. Understanding the immune-mediated pathways may lead to the identification of diagnostic or predictive biomarkers and the development of novel therapeutic approaches for individuals with ASD.

FRONTIERS IN PSYCHIATRY (2022)

Add to Collection

Editorial Material Psychiatry

Editorial: Environmental risk factors in autism spectrum disorder

Hideo Matsuzaki et al.

FRONTIERS IN PSYCHIATRY (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

Physiological Effect of Deep Pressure in Reducing Anxiety of Children with ASD during Traveling: A Public Transportation Setting

Ilham Yustar Afif et al.

Summary: This study investigates the physiological effect of deep pressure using an autism hug machine portable seat (AHMPS) in children with autism spectrum disorders (ASD) in public transportation settings. The results demonstrate that the inflatable wrap model can decrease heart rate and skin conductance, thus providing a calming effect.

BIOENGINEERING-BASEL (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

Effect of Short-Term Deep-Pressure Portable Seat on Behavioral and Biological Stress in Children with Autism Spectrum Disorders: A Pilot Study

Ilham Yustar Afif et al.

Summary: This study aimed to evaluate the impact of an autism hug machine portable seat (AHMPS) on behavioral and neurobiological stress in children with ASD. The results showed that children wearing the inflatable wrap experienced behavioral improvement and a reduction in sympathetic stress response, indicating that the inflatable wrap is an effective method for reducing emotional arousal.

BIOENGINEERING-BASEL (2022)

Add to Collection

Review Clinical Neurology

Maternal immune activation and neuroinflammation in human neurodevelopmental disorders

Velda X. Han et al.

Summary: Maternal inflammation during pregnancy can impact fetal neurodevelopment, increasing the risk of neurodevelopmental disorders in offspring. In addition to inflammation, epigenetic factors are also recognized to play a role in NDD pathogenesis.

NATURE REVIEWS NEUROLOGY (2021)

Add to Collection

Review Biochemistry & Molecular Biology

The Role of Maternal Immune Activation in the Pathogenesis of Autism: A Review of the Evidence, Proposed Mechanisms and Implications for Treatment

Aleksandra Zawadzka et al.

Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disease characterized by deficits in social interactions, communication, and repetitive behaviors. Studies suggest a role for immune dysregulation and inflammation in the development of ASD. Infection during pregnancy can lead to oxidative stress, mitochondrial dysfunction, neuroinflammation, and neurodevelopmental pathologies in offspring.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Psychiatry

Prevalence of Autism Spectrum Disorder in a large Italian catchment area: a school-based population study within the ASDEU project

A. Narzisi et al.

EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES (2020)

Add to Collection

Article Neurosciences

Neurofilament Light Chain as a Biomarker, and Correlation with Magnetic Resonance Imaging in Diagnosis of CNS-Related Disorders

Zahra Alirezaei et al.

MOLECULAR NEUROBIOLOGY (2020)

Add to Collection

Article Neurosciences

The Neurodevelopment of Autism from Infancy Through Toddlerhood

Jessica B. Girault et al.

NEUROIMAGING CLINICS OF NORTH AMERICA (2020)

Add to Collection

Review Pharmacology & Pharmacy

Role of Neuroinflammation in Autism Spectrum Disorder and the Emergence of Brain Histaminergic System. Lessons Also for BPSD?

Nermin Eissa et al.

FRONTIERS IN PHARMACOLOGY (2020)

Add to Collection

Review Psychiatry

Microglia mediated neuroinflammation in autism spectrum disorder

Xiaoli Liao et al.

JOURNAL OF PSYCHIATRIC RESEARCH (2020)

Add to Collection

Article Neurosciences

Elevated serum neurofilament light chain in children autism spectrum disorder: A case control study

Wei-chao He et al.

NEUROTOXICOLOGY (2020)

Add to Collection

Review Pediatrics

Autism spectrum disorder: definition, epidemiology, causes, and clinical evaluation

Holly Hodges et al.

TRANSLATIONAL PEDIATRICS (2020)

Add to Collection

Review Clinical Neurology

Neurofilament light chain as a biomarker in neurological disorders

Lorenzo Gaetani et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2019)

Add to Collection

Article Clinical Neurology

Plasma and CSF neurofilament light Relation to longitudinal neuroimaging and cognitive measures

Michelle M. Mielke et al.

NEUROLOGY (2019)

Add to Collection

Review Clinical Neurology

Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis

Claire Bridel et al.

JAMA NEUROLOGY (2019)

Add to Collection

Review Neurosciences

Genetic Causes and Modifiers of Autism Spectrum Disorder

Lauren Rylaarsdam et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

Add to Collection

Article Psychology, Multidisciplinary

de novo Blood Biomarkers in Autism: Autoantibodies against Neuronal and Glial Proteins

Mohamed B. Abou-Donia et al.

BEHAVIORAL SCIENCES (2019)

Add to Collection

Article Neuroimaging

Diffusion-weighted imaging evidence of altered white matter development from late childhood to early adulthood in Autism Spectrum Disorder

Fikret Isik Karahanoglu et al.

NEUROIMAGE-CLINICAL (2018)

Add to Collection

Review Clinical Neurology

Neurofilaments as biomarkers in neurological disorders

Michael Khalil et al.

NATURE REVIEWS NEUROLOGY (2018)

Add to Collection

Article Clinical Neurology

Primary olfactory cortex in autism and epilepsy: increased glial cells in autism

David A. Menassa et al.

BRAIN PATHOLOGY (2017)

Add to Collection

Article Developmental Biology

Serum levels of Glial fibrillary acidic protein in Chinese children with autism spectrum disorders

Jingwei Wang et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2017)

Add to Collection

Letter Clinical Neurology

Neurofilament Protein and Antineurofilament Antibodies Following Traumatic Brain Injury Reply

Pashtun Shahim et al.

JAMA NEUROLOGY (2017)

Add to Collection

Review Neurosciences

MeCP2 Deficiency in Neuroglia: New Progress in the Pathogenesis of Rett Syndrome

Xu-Rui Jin et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2017)

Add to Collection

Article Biotechnology & Applied Microbiology

Serum levels of glial fibrillary acidic protein and Nogo-A in children with autism spectrum disorders

Ihsan Cetin et al.

BIOMARKERS (2016)

Add to Collection

Review Biochemistry & Molecular Biology

Clinical Genetic Aspects of ASD Spectrum Disorders

G. Bradley Schaefer

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Add to Collection

Article Clinical Neurology

Neurofilament light in CSF and serum is a sensitive marker for axonal white matter injury in MS

Joakim Bergman et al.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2016)

Add to Collection

Article Behavioral Sciences

Elevated GFAP Protein in Anterior Cingulate Cortical White Matter in Males With Autism Spectrum Disorder

Jessica D. Crawford et al.

AUTISM RESEARCH (2015)

Add to Collection

Review Medicine, Research & Experimental

Characteristics of Brains in Autism Spectrum Disorder: Structure, Function and Connectivity across the Lifespan

Sungji Ha et al.

EXPERIMENTAL NEUROBIOLOGY (2015)

Add to Collection

Article Psychology, Developmental

Prevalence of Parent-Reported ASD and ADHD in the UK: Findings from the Millennium Cohort Study

Ginny Russell et al.

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS (2014)

Add to Collection

Article Clinical Neurology

Elevated glial fibrillary acidic protein levels in the cerebrospinal fluid of patients with narcolepsy

Emily Feneberg et al.

SLEEP MEDICINE (2013)

Add to Collection

Review Neurosciences

Evidence of neurodegeneration in autism spectrum disorder

Janet K. Kern et al.

TRANSLATIONAL NEURODEGENERATION (2013)

Add to Collection

Article Emergency Medicine

Elevated Levels of Serum Glial Fibrillary Acidic Protein Breakdown Products in Mild and Moderate Traumatic Brain Injury Are Associated With Intracranial Lesions and Neurosurgical Intervention

Linda Papa et al.

ANNALS OF EMERGENCY MEDICINE (2012)

Add to Collection

Article Clinical Neurology

Serum glial fibrillary acidic protein as a biomarker for intracerebral haemorrhage in patients with acute stroke

C Foerch et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2006)

Add to Collection

© Peeref 2019-2024. All rights reserved.