Improving the Treatment Effect of Carotenoids on Alzheimer's Disease through Various Nano-Delivery Systems

Natural bioactive compounds have recently emerged as a current strategy for Alzheimer's disease treatment. Carotenoids, including astaxanthin, lycopene, lutein, fucoxanthin, crocin and others are natural pigments and antioxidants, and can be used to treat a variety of diseases, including Alzheimer's disease. However, carotenoids, as oil-soluble substances with additional unsaturated groups, suffer from low solubility, poor stability and poor bioavailability. Therefore, the preparation of various nano-drug delivery systems from carotenoids is a current measure to achieve efficient application of carotenoids. Different carotenoid delivery systems can improve the solubility, stability, permeability and bioavailability of carotenoids to a certain extent to achieve Alzheimer's disease efficacy. This review summarizes recent data on different carotenoid nano-drug delivery systems for the treatment of Alzheimer's disease, including polymer, lipid, inorganic and hybrid nano-drug delivery systems. These drug delivery systems have been shown to have a beneficial therapeutic effect on Alzheimer's disease to a certain extent.

Automated summary

Natural bioactive compounds such as carotenoids have been used for the treatment of Alzheimer's disease. However, their low solubility, poor stability, and low bioavailability hinder their effectiveness. Nano-drug delivery systems have been developed to enhance the solubility, stability, permeability, and bioavailability of carotenoids for the treatment of Alzheimer's disease. This review summarizes the recent developments in carotenoid nano-drug delivery systems, including polymer, lipid, inorganic, and hybrid systems, and their therapeutic effects on Alzheimer's disease.