4.7 Article

miR-145 as a Potential Biomarker and Therapeutic Target in Patients with Non-Small Cell Lung Cancer

Related references

Note: Only part of the references are listed.
Article Biotechnology & Applied Microbiology

Overexpression of microRNA-145 enhanced docetaxel sensitivity in breast cancer cells via inactivation of protein kinase B gamma-mediated phosphoinositide 3-kinase -protein kinase B pathway

Ying Zhou et al.

Summary: This study found that miR-145 expression is downregulated in docetaxel-resistant breast cancer cells, and demonstrated that miR-145 can enhance the sensitivity of breast cancer cells to docetaxel by downregulating AKT3 expression and inhibiting the PI3K/AKT signaling pathway.

BIOENGINEERED (2022)

Article Cell Biology

MicroRNA-145 Impairs Classical Non-Homologous End-Joining in Response to Ionizing Radiation-Induced DNA Double-Strand Breaks via Targeting DNA-PKcs

Muddenahalli Srinivasa Sudhanva et al.

Summary: This study demonstrates that miR-145 suppresses DNA-PKcs expression, affecting DNA double-strand break repair and rendering cells sensitive to ionizing radiation. Additionally, miR-145 inhibition is associated with increased Akt1 phosphorylation and upregulation of DNA-PKcs in cancer cells.

CELLS (2022)

Article Immunology

microRNA-145 Inhibition Upregulates SIRT1 and Attenuates Autophagy in a Mouse Model of Lung Ischemia/Reperfusion Injury via NF-κB-dependent Beclin 1

Shao-Hua Dai et al.

Summary: The study demonstrates that miR-145 is upregulated in lung ischemia/reperfusion injury, enhancing autophagy processes and exacerbating the severity of lung damage.

TRANSPLANTATION (2021)

Article Allergy

Developing and evaluating a pediatric asthma severity computable phenotype derived from electronic health records

Anshul Tiwari et al.

Summary: The study developed and evaluated a standardized pediatric asthma severity phenotype based on clinical asthma guidelines for use in EHR-based health initiatives and studies. Findings showed that severity classification based on long-term medication regimen was most effective, leading to better classification of asthma severity in patients.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Biochemistry & Molecular Biology

Identification of Predictive Biomarkers of Response to HSP90 Inhibitors in Lung Adenocarcinoma

Angela Marrugal et al.

Summary: HSP90 plays a crucial role in lung adenocarcinoma, with inhibitors showing promise as therapeutic strategies. iTRAQ-based proteomic techniques identified proteins correlated with response to HSP90 inhibitors, revealing potential targets for improving clinical efficacy in patients with lung adenocarcinoma.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Oncology

Golgi Phosphoprotein 73: The Driver of Epithelial-Mesenchymal Transition in Cancer

Yiming Liu et al.

Summary: GP73, a glycosylated protein highly expressed in various cancer tissues, has been identified as a novel serum biomarker for cancer diagnosis, especially in hepatocellular carcinoma (HCC). Recent studies have shown that GP73 plays multifunctional roles in cancer progression, especially in promoting EMT and cancer metastasis.

FRONTIERS IN ONCOLOGY (2021)

Review Genetics & Heredity

MicroRNA Changes in Gastric Carcinogenesis: Differential Dysregulation during Helicobacter pylori and EBV Infection

Christian Prinz et al.

Summary: Despite medical advances, gastric-cancer mortality remains high in Europe. Infections with H. pylori and EBV are associated with the development of gastric cancer, and miRNAs could serve as promising new tools for early cancer detection. Dysregulation of specific miRNAs, especially miR-155, may potentiate cancer risk in the presence of these infections.

GENES (2021)

Review Oncology

Role of Metastasis-Related microRNAs in Prostate Cancer Progression and Treatment

Su Jung Oh-Hohenhorst et al.

Summary: In this review, the dual roles of microRNAs in promoting and suppressing metastasis in prostate cancer are summarized, focusing on their impact on invasion, migration, and epithelial-to-mesenchymal transition. MicroRNAs have the potential to serve as therapeutic targets for metastatic prostate cancer and as biomarkers for metastasis and therapeutic response.

CANCERS (2021)

Article Medicine, General & Internal

High diagnostic value of miRNAs for NSCLC: quantitative analysis for both single and combined miRNAs in lung cancer

Minhan Yi et al.

Summary: This study conducted a meta-analysis of 80 studies and identified several single miRNAs and combined groups with high diagnostic power for non-small cell lung carcinoma (NSCLC), indicating specific miRNAs as good biomarker candidates for NSCLC, further researches are needed.

ANNALS OF MEDICINE (2021)

Review Oncology

Recent advances of GOLM1 in hepatocellular carcinoma

Jiuliang Yan et al.

HEPATIC ONCOLOGY (2020)

Article Medicine, Research & Experimental

MiR-145 negatively regulates TGFBR2 signaling responsible for sepsis-induced acute lung injury

Xiaohua Cao et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Article Biochemistry & Molecular Biology

miR-145-5p is associated with smoke-related chronic obstructive pulmonary disease via targeting KLF5

Xiaomin Dang et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2019)

Article Oncology

Expression and biological function of rhotekin in gastric cancer through regulating p53 pathway

Meng-Yao Sun et al.

CANCER MANAGEMENT AND RESEARCH (2019)

Review Medicine, Research & Experimental

Regulatory mechanisms of miR-145 expression and the importance of its function in cancer metastasis

Tahereh Zeinali et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Article Medicine, Research & Experimental

Long non-coding RNA HULC interacts with miR-613 to regulate colon cancer growth and metastasis through targeting RTKN

Yan Dong et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Article Medicine, Research & Experimental

DNMT1/miR-200a/GOLM1 signaling pathway regulates lung adenocarcinoma cells proliferation

Longqiu Yang et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Review Oncology

MicroRNAs in regulation of triple-negative breast cancer progression

Dominika Piasecka et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2018)

Review Oncology

A step-by-step microRNA guide to cancer development and metastasis

Georgios S. Markopoulos et al.

CELLULAR ONCOLOGY (2017)

Review Biotechnology & Applied Microbiology

Molecular Biomarkers in Bladder Cancer: Novel Potential Indicators of Prognosis and Treatment Outcomes

Masayoshi Nagata et al.

DISEASE MARKERS (2016)

Article Oncology

Inhibition of rhotekin exhibits antitumor effects in lung cancer cells

Weizhen Zhang et al.

ONCOLOGY REPORTS (2016)

Review Genetics & Heredity

Circulating Plasma MicroRNAs As Diagnostic Markers for NSCLC

Jinpao Hou et al.

FRONTIERS IN GENETICS (2016)

Article Chemistry, Multidisciplinary

Lipid nanoparticle delivery of a microRNA-145 inhibitor improves experimental pulmonary hypertension

Jared M. McLendon et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Article Cell Biology

miRNA profiling along tumour progression in ovarian carcinoma

Olga Vaksman et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2011)

Article Biochemistry & Molecular Biology

MiR-145 inhibits cell proliferation of human lung adenocarcinoma by targeting EGFR and NUDT1

William C. S. Cho et al.

RNA BIOLOGY (2011)

Review Cell Biology

Mammalian Rho GTPases:: new insights into their functions from in vivo studies

Sarah J. Heasman et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

Article Multidisciplinary Sciences

Identification of novel genes coding for small expressed RNAs

M Lagos-Quintana et al.

SCIENCE (2001)