Endotheliopathy in Acute COVID-19 and Long COVID

Article Cardiac & Cardiovascular Systems

Immune-Mediated Glycocalyx Remodeling in Hospitalized COVID-19 Patients

Sascha N. Goonewardena et al.

Summary: The pathobiology of COVID-19 involves immune dysfunction and vascular injury. The disruption of glycocalyx (GAC), which regulates vascular and immune responses, may contribute to the clinical progression of COVID-19.

CARDIOVASCULAR DRUGS AND THERAPY (2023)

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Letter Hematology

Thrombin formation via the intrinsic coagulation pathway and von Willebrand factor reflect disease severity in COVID-19

Matthias H. Busch et al.

HAEMATOLOGICA (2023)

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Article Oncology

Predictive prognostic biomarkers in patients with COVID-19 infection

Shunsuke Fukui et al.

Summary: The present study aimed to identify useful biomarkers to predict deterioration in patients with COVID-19. Several blood markers, including CRP, PSP, LDH, and AST, were found to be reliable indicators for predicting the prognosis of non-severe cases. However, no blood biomarkers were able to predict the outcome in severe cases.

MOLECULAR MEDICINE REPORTS (2023)

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Article Hematology

Effects of convalescent plasma infusion on the ADAMTS13-von Willebrand factor axis and endothelial integrity in patients with severe and critical COVID-19

Quan Zhang et al.

Summary: This study investigates the effects of convalescent plasma infusion (CPI) on the ADAMTS13-VWF axis and vascular endothelial functions in COVID-19 patients. The results show that patients with severe and critical COVID-19 have lower ADAMTS13 activity and increased VWF antigen levels. CPI therapy can modestly improve ADAMTS13 activity and alleviate endothelial damage.

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2023)

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Review Hematology

Hyper-inflammation and complement in COVID-19

Bruno G. Pires et al.

Summary: COVID-19 is a complex disease with a wide range of severity and involvement of various organs and systems. In severe cases, hyperinflammation, caused by complement over-activation, plays a critical role in the pathobiology of the disease, leading to an inflammatory response, microangiopathy, platelet-neutrophil activation, and hypercoagulability. SARS-CoV-2 can directly activate the complement system through multiple pathways, and inhibiting complement activation has been suggested as a potential therapeutic approach. However, the most effective targets and optimal timing for intervention are still unknown, requiring further clinical trials.

AMERICAN JOURNAL OF HEMATOLOGY (2023)

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Review Hematology

Status of major hemostatic components in the setting of COVID-19: the effect on endothelium, platelets, coagulation factors, fibrinolytic system, and complement

Mohammad Sayyadi et al.

Summary: COVID-19 disrupts the balance of the coagulation, fibrinolytic, anticoagulation, and complement systems, leading to coagulopathy. This study investigates the effects of COVID-19 on key hemostatic components, including platelets, endothelial cells, coagulation factors, fibrinolytic system, anticoagulant protein system, and complement system, to enhance understanding of the pathophysiological processes underlying COVID-19 coagulopathy based on evidence.

ANNALS OF HEMATOLOGY (2023)

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Letter Hematology

Increased von Willebrand Factor Platelet-Binding Capacity Is Related to Poor Prognosis in COVID-19 Patients

Lucia Stefanini et al.

THROMBOSIS AND HAEMOSTASIS (2023)

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Article Hematology

Defibrotide mitigates endothelial cell injury induced by plasmas from patients with COVID-19 and related vasculopathies

Sonia Elhadad et al.

Summary: COVID-19 progression is characterized by systemic small vessel arterial and venous thrombosis. This study explored the effect of defibrotide on microvascular endothelial cell (MVEC) activation/injury induced by COVID-19. The results showed that defibrotide suppressed COVID-19-induced caspase 8 activation in MVEC. RNAseq analysis identified potential mechanisms of defibrotide activity in COVID-19-associated MVEC changes.

THROMBOSIS RESEARCH (2023)

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Review Peripheral Vascular Disease

Systematic Review of Endocan as a Potential Biomarker of COVID-19

Amirmohammad Khalaji et al.

Summary: Since the COVID-19 pandemic, several biomarkers have been proposed for diagnosing and predicting the disease. This systematic review evaluated endocan as a potential biomarker for COVID-19. Eight studies were included, showing higher endocan levels in COVID-19 cases compared to controls, and more severe disease was associated with higher endocan levels. Endocan also acted as a diagnostic and prognostic biomarker with different cut-offs. In conclusion, endocan could be a novel biomarker for COVID-19, but further studies are needed.

ANGIOLOGY (2023)

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Review Geriatrics & Gerontology

Mini-review: Angiotensin- converting enzyme 1 (ACE1) and the impact for diseases such as Alzheimer's disease, sarcopenia, cancer, and COVID-19

Valquiria Bueno et al.

Summary: Ageing is associated with comorbidities, inflammation, and immunosenescence. Hypertension is the most common morbidity, and ACE inhibitors and ARBs not only control blood pressure but also have potential benefits in other comorbidities such as Alzheimer's disease, sarcopenia, and cancer.

FRONTIERS IN AGING (2023)

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Article Cell & Tissue Engineering

Increased Circulating CD62E+ Endothelial Extracellular Vesicles Predict Severity and in- Hospital Mortality of COVID-19 Patients

Fariza Mezine et al.

Summary: This study found that measuring levels of CD62E + EVs can help distinguish the severity of COVID-19 in patients upon hospital admission, predict the risk of mortality during hospitalization, and identify individuals at higher risk of fatal outcomes.

STEM CELL REVIEWS AND REPORTS (2023)

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Article Medicine, Research & Experimental

Evaluation of admission levels of P, E and L selectins as predictors for thrombosis in hospitalized COVID-19 patients

Mona M. Watany et al.

Summary: This study aimed to evaluate the levels of soluble selectins P, E, and L as predictors of thrombosis in hospitalized COVID-19 patients. The results showed significantly higher levels of soluble selectins in COVID-19 patients compared to controls, and higher levels were found in patients who developed thrombosis. The elevated selectins were independent predictors of thrombosis, and their levels could predict thrombosis with high sensitivity. Therefore, measuring the levels of selectins at the time of hospital admission can be useful in identifying COVID-19 patients who need prophylactic anticoagulants.

CLINICAL AND EXPERIMENTAL MEDICINE (2022)

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Review Infectious Diseases

Waves and variants of SARS-CoV-2: understanding the causes and effect of the COVID-19 catastrophe

Vikram Thakur et al.

Summary: The coronavirus disease-19 has made a permanent mark in human history, with its variants playing a crucial role in increased transmissibility, infectivity, and immune escape of the virus. The effectiveness of vaccines is severely affected by the new variants.

INFECTION (2022)

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Article Infectious Diseases

Serum levels of laminin and von Willebrand factor in COVID-19 survivors 6 months after discharge

Hongwei Li et al.

Summary: This study evaluated the clinical characteristics, pulmonary diffusion function, chest CT, and serum lung cell damage indicators of COVID-19 survivors 6 months after discharge. The results showed that COVID-19 patients had abnormal lung injury indicators 6 months after discharge, and the recovery time is currently unknown, requiring long-term observation.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2022)

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Article Anesthesiology

Insights into Fibrinogen-Mediated COVID-19 Hypercoagubility in Critically Ill Patients

Andrea Miltiades et al.

Summary: This article describes the mechanisms of hypercoagulability in severe COVID-19 patients and suggests that elevated levels of plasminogen activator inhibitor-1 may inhibit fibrinolysis, leading to hypercoagulability.

JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY (2022)

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Review Infectious Diseases

A clinical case definition of post-COVID-19 condition by a Delphi consensus

Joan B. Soriano et al.

Summary: People with COVID-19 might experience long-term symptoms known as long COVID or long-haul COVID. The lack of a standardized definition hinders the understanding and treatment of this condition. In a WHO-led Delphi process, a consensus definition was developed, stating that post-COVID-19 condition occurs in individuals with a history of SARS-CoV-2 infection, with symptoms lasting for at least 2 months and impacting everyday functioning. This common framework provides a foundation for future studies and therapy.

LANCET INFECTIOUS DISEASES (2022)

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Article Cardiac & Cardiovascular Systems

Current and novel biomarkers of thrombotic risk in COVID-19: a Consensus Statement from the International COVID-19 Thrombosis Biomarkers Colloquium

Diana A. Gorog et al.

Summary: COVID-19 predisposes patients to thrombotic and thromboembolic events. Numerous biomarkers have emerged to assess the thrombotic risk in these patients, informing prognosis and predicting thrombosis.

NATURE REVIEWS CARDIOLOGY (2022)

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Review Immunology

Emerging Role of Platelet-Endothelium Interactions in the Pathogenesis of Severe SARS-CoV-2 Infection-Associated Myocardial Injury

Theresa M. Rossouw et al.

Summary: Cardiovascular dysfunction and disease are common complications of SARS-CoV-2 infection, and acute cardiac injury is the most common cardiac complication. The potential mechanisms of cardiovascular complications include direct viral myocardial injury, systemic inflammation, sepsis, oxygen supply-demand mismatch, electrolyte abnormalities, and hypercoagulability. SARS-CoV-2-induced endotheliitis and platelet activation play a significant role in intravascular inflammation and coagulation, contributing to poor clinical outcomes in severe disease.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Medicine, General & Internal

Endothelial thrombomodulin downregulation caused by hypoxia contributes to severe infiltration and coagulopathy in COVID-19 patient lungs

Taejoon Won et al.

Summary: The article explains the copyright ownership and the license agreement it follows.

EBIOMEDICINE (2022)

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Article Hematology

Hypercoagulability, endotheliopathy, and inflammation approximating 1 year after recovery: Assessing the long-term outcomes in COVID-19 patients

Bingwen Eugene Fan et al.

Summary: Sustained hypercoagulability and endotheliopathy persist in convalescent COVID-19 patients for several months after recovery. Hemostatic, endothelial, and inflammatory abnormalities are still detectable in these patients compared to their pre-recovery state. This finding is important for long-term anticoagulation therapy and follow-up of recovered patients.

AMERICAN JOURNAL OF HEMATOLOGY (2022)

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Article Pathology

Angiopoietin 2 Is Associated with Vascular Necroptosis Induction in Coronavirus Disease 2019 Acute Respiratory Distress Syndrome

David R. Price et al.

Summary: Vascular injury is associated with low platelet levels and increased mortality in COVID-19-induced acute respiratory distress syndrome (ARDS). The vascular injury signature can be used to identify ARDS patients most likely to benefit from vascular targeted therapies.

AMERICAN JOURNAL OF PATHOLOGY (2022)

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Article Anesthesiology

Suppression of Fibrinolysis and Hypercoagulability, Severity of Hypoxemia, and Mortality in COVID-19 Patients: A Retrospective Cohort Study

Kristin M. Corey et al.

Summary: This study confirms the association between coagulopathy and hypoxemia in critically ill COVID-19 patients. It identifies several coagulation and inflammatory biomarkers that are associated with severe hypoxemia and major thrombotic events in these patients.

ANESTHESIOLOGY (2022)

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Article Hematology

Endothelial glycocalyx damage in patients with severe COVID-19 on mechanical ventilation - A prospective observational pilot study

David Astapenko et al.

Summary: This study compared endothelial glycocalyx (EG) damage and endotheliopathy in severe COVID-19 patients with bacterial pneumonia patients with septic shock. The results showed more severe EG damage in COVID-19 patients and improvement in sublingual microcirculation on the second day.

CLINICAL HEMORHEOLOGY AND MICROCIRCULATION (2022)

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Article Infectious Diseases

Presepsin as a Novel Biomarker in predicting In-hospital Mortality in Patients With COVID-19 Pneumonia

Hebatallah Hany Assal et al.

Summary: This study found that elevated PSP levels were associated with poor outcomes and in-hospital mortality in hospitalized patients with COVID-19 pneumonia.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2022)

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Article Hematology

SARS-CoV-2 infection induces soluble platelet activation markers and PAI-1 in the early moderate stage of COVID-19

Abaher O. Al-Tamimi et al.

Summary: This study assessed the levels of coagulation and platelet activation markers in COVID-19 patients and found that soluble P-selectin, sCD40L, fibrinogen, and PAI-1 were induced at the moderate stage, suggesting platelet and coagulation system activation before patients required intensive care.

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY (2022)

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Article Biochemistry & Molecular Biology

Levels of Vascular Endothelial Growth Factor and Its Association with Pulmonary Embolism in COVID-19

Jazmin A. Guerra-Lopez et al.

Summary: This study aimed to investigate whether vascular endothelial growth factor (VEGF) levels in COVID-19 patients at hospital admission can predict the occurrence of pulmonary embolism. The study found that VEGF levels were elevated in COVID-19 patients and correlated with inflammatory markers. However, VEGF levels were unable to predict the appearance of pulmonary embolism during hospitalization.

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2022)

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Article Virology

New laboratory evidence for the association between endothelial dysfunction and COVID-19 disease progression

Nan Liu et al.

Summary: There is a strong association between endothelial dysfunction and poor prognosis of COVID-19. COVID-19 patients with poor clinical prognosis tend to be male, elderly, and have coexisting chronic diseases. They also display elevated levels of vascular cell adhesion molecule-1 (VCAM-1), E-selectin, and tissue-type plasminogen activator (tPA), and decreased levels of plasminogen activator inhibitor-1.

JOURNAL OF MEDICAL VIROLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Endothelin-1 is increased in the plasma of patients hospitalised with Covid-19

George R. Abraham et al.

Summary: Virus-induced endothelial dysregulation is a prominent feature of severe Covid-19 infection. Endothelin-1 (ET-1), a highly expressed peptide in endothelial cells with vasoconstrictive properties, shows significantly elevated plasma levels in hospitalized Covid-19 patients during the acute phase of infection. These results support the hypothesis that endothelin receptor antagonists may provide clinical benefit for certain Covid-19 patients.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2022)

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Article Medicine, Research & Experimental

Endothelial dysfunction and altered endothelial biomarkers in patients with post-COVID-19 syndrome and chronic fatigue syndrome (ME/CFS)

Milan Haffke et al.

Summary: A subset of PCS patients exhibit evidence of endothelial dysfunction with altered endothelial biomarkers. Different associations of the RHI with clinical parameters and varying biomarker profiles may suggest distinct pathomechanisms among patient subgroups.

JOURNAL OF TRANSLATIONAL MEDICINE (2022)

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Article Multidisciplinary Sciences

Markers of endothelial cell activation are associated with the severity of pulmonary disease in COVID-19

William O. Osburn et al.

Summary: The severity of COVID-19 lung disease is associated with elevated levels of von Willebrand Factor (VWF) and soluble P-Selectin (sP-Sel), both released by activated endothelial cells. These biomarkers are also correlated with inflammation and vascular inflammation markers.

PLOS ONE (2022)

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Review Virology

COVID-19 infection: an overview on cytokine storm and related interventions

Soheila Montazersaheb et al.

Summary: COVID-19 caused by SARS-CoV-2 poses a significant global health threat, leading to pneumonia and ARDS in patients. Cytokine storm, characterized by elevated levels of pro-inflammatory cytokines, including interleukins and TNF-alpha, contributes to lung damage in ARDS patients. Suppressing the inflammatory response may be a possible strategy for managing COVID-19.

VIROLOGY JOURNAL (2022)

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Review Medicine, Research & Experimental

Clinical challenges of SARS-CoV-2 variants (Review)

Cristian Cojocaru et al.

Summary: This study analyzed the clinical and epidemiological features of different variants of SARS-CoV-2 and made predictions about their potential future evolution. It hypothesized that the mutations were not due to vaccine pressure but rather depended on the natural characteristics of the virus. It is expected that SARS-CoV-2 will become more contagious but less deadly as it adapts to the human body.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2022)

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Article Infectious Diseases

ACE2 and ANGII levels in patients with COVID-19 based on thoracic tomography findings and PCR test results

Afsin Ipekci et al.

Summary: This study analyzed the ACE2 and AngII levels in patients with suspected COVID-19 and examined their relationship with disease severity. The results showed that decreased ACE2 levels were associated with lung damage, while decreased AngII levels were associated with severe diseases such as ARDS and mortality.

JOURNAL OF INFECTION IN DEVELOPING COUNTRIES (2022)

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Review Immunology

Role of triggering receptor expressed on myeloid cells-1 (TREM-1) in COVID-19 and other viral pneumonias: a systematic review and meta-analysis of clinical studies

Yrna Lorena Matos de Oliveira et al.

Summary: This study evaluated the expression of TREM-1 in patients with COVID-19 and other viral pneumonias compared to healthy individuals. The results showed higher levels of sTREM-1 in COVID-19 patients compared to healthy controls, particularly in severe cases. TREM-1 levels were also significantly elevated in patients with other viral pneumonias.

INFLAMMOPHARMACOLOGY (2022)

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Article Hematology

Endothelial Biomarkers in Patients Recovered from COVID-19 One Year after Hospital Discharge: A Cross-Sectional Study

Ming Tong et al.

Summary: In this cross-sectional study, researchers investigated the serum levels of endothelial biomarkers in COVID-19 survivors one year after hospital discharge. The results showed that SARS-CoV-2 infection may not increase the risk of developing long-term cardiovascular events, even for those recovering from severe illness. There were no significant differences in circulatory inflammatory markers and endothelial biomarkers between survivors and healthy controls.

MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES (2022)

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Article Medicine, General & Internal

Relationship Between Endothelial and Angiogenesis Biomarkers Envisage Mortality in a Prospective Cohort of COVID-19 Patients Requiring Respiratory Support

Felipe Maldonado et al.

Summary: This study aimed to evaluate whether early detection of endothelial and angiogenic biomarkers predicts mortality and major cardiovascular events in COVID-19 patients. The results showed that certain biomarkers had significantly increased concentrations in COVID-19 patients and could predict mortality. Furthermore, serum samples from COVID-19 patients enhanced the migration ability of endothelial cells.

FRONTIERS IN MEDICINE (2022)

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Article Biochemistry & Molecular Biology

Adrenomedullin Therapy in Moderate to Severe COVID-19

Toshihiro Kita et al.

Summary: This review discusses the role of adrenomedullin (AM) in severe inflammatory diseases, including COVID-19. While current methods can reduce the severity of COVID-19, there is still a lack of effective treatment for severe cases. Research suggests that exogenous AM administration can reduce inflammation and organ damage. The researchers are conducting a trial to evaluate the efficacy of an AM formulation in treating COVID-19.

BIOMEDICINES (2022)

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Article Hematology

Impaired exercise capacity in post-COVID-19 syndrome: the role of VWF-ADAMTS13 axis

Nithya Prasannan et al.

Summary: Post-COVID syndrome (PCS), also known as long COVID, is a complication of acute SARS-CoV-2 infection characterized by persistent fatigue, reduced exercise tolerance, chest pain, shortness of breath, and cognitive slowing. This study found evidence of a prothrombotic state, as indicated by an elevated VWF(Ag)/ADAMTS13 ratio, in PCS patients. The prothrombotic state was more likely to be present in patients with impaired exercise capacity. These findings suggest a potential role for antithrombotic therapy in the treatment of PCS patients.

BLOOD ADVANCES (2022)

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Review Hematology

Tissue factor in COVID-19-associated coagulopathy

Saravanan Subramaniam et al.

Summary: Micro-and macro-thrombi in arteries and veins of critically ill COVID-19 patients highlight the occurrence of COVID-19-associated coagulopathy. Tissue factor (TF) may play a significant role in COVID-19 patients, with proinflammatory cytokines possibly triggering abnormal TF expression and coagulation activation.

THROMBOSIS RESEARCH (2022)

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Article Immunology

New Avenues to Explore in SARS-CoV-2 Infection: Both TRIM25 and TRIM56 Positively Correlate with VEGF, GAS6, and sAXL in COVID-19 Patients

Gulden Baskol et al.

Summary: This study aimed to reveal the roles of GAS6/sAXL pathway, endothelial dysfunction markers VEGF and HIF-1 alpha, and antiviral effective TRIM25 and TRIM56 proteins in the pathogenesis of COVID-19. The study found that GAS6, sAXL, TRIM56, and VEGF levels were higher, while TRIM25 levels were lower in COVID-19 patients compared to healthy individuals. Other than HIF-1 alpha, none of the research parameters were associated with severity or prognosis.

VIRAL IMMUNOLOGY (2022)

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Review Immunology

Pathophysiological mechanisms of thrombosis in acute and long COVID-19

Haijiao Jing et al.

Summary: This review investigates the crosstalk between inflammation and thrombosis in COVID-19 patients, focusing on the contributions of inflammation to thrombosis pathogenesis and proposing combined use of anti-inflammatory and anticoagulant therapies.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Hematology

The suboptimal fibrinolytic response in COVID-19 is dictated by high PAI-1

Claire S. Whyte et al.

Summary: This study investigates the dysregulation of the fibrinolytic system in COVID-19 disease and finds that elevated levels of PAI-1 suppress plasmin generation, leading to suboptimal fibrinolysis. These findings have important implications for the treatment and prognostic potential of COVID-19 disease.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2022)

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Article Hematology

Sustained VWF-ADAMTS-13 axis imbalance and endotheliopathy in long COVID syndrome is related to immune dysfunction

Helen Fogarty et al.

Summary: This study reveals the mechanisms of sustained EC activation, dysregulated angiogenesis, and VWF/ADAMTS-13 axis imbalance in convalescent COVID-19. Consistent with the pivotal role of immunothrombosis in acute COVID-19, the findings support the hypothesis that abnormal T cell and monocyte populations may be important in the context of persistent EC activation and hemostatic dysfunction during convalescence.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2022)

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Article Cardiac & Cardiovascular Systems

High levels of von Willebrand factor with reduced specific activities in hospitalized patients with or without COVID-19

Monica Bray et al.

Summary: COVID-19 is associated with changes in the activity and quality of VWF, but these changes are not specific to COVID-19. Similar changes in VWF activity and quality are observed in hospitalized patients with or without COVID-19. Further research is needed to understand the mechanisms responsible for qualitative changes in VWF in COVID-19 and other critical illnesses.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2022)

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Article Genetics & Heredity

The role of angiotensin I converting enzyme insertion/deletion polymorphism in the severity and outcomes of COVID-19 patients

Mitra Rezaei et al.

Summary: This study aimed to investigate the correlation between angiotensin I converting enzyme (ACE) insertion/deletion polymorphism and the severity of symptoms in COVID-19 patients. The study found that the ACE D allele was associated with an increased risk of disease severity.

FRONTIERS IN GENETICS (2022)

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Article Medicine, General & Internal

Correlation of Biomarkers of Endothelial Injury and Inflammation to Outcome in Hospitalized COVID-19 Patients

Levy Munguia et al.

Summary: COVID-19 can lead to intense systemic inflammation and a prothrombotic state, causing rapid and disproportionate deterioration of lung function. An observation study found that certain biomarkers are highly correlated with the severity of the disease, and elevated levels of Syndecan-1 are associated with severe cases of COVID-19. Preserving glycocalyx integrity may be a potential treatment for COVID-19.

JOURNAL OF CLINICAL MEDICINE (2022)

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Review Medicine, General & Internal

Circulating angiotensin converting enzyme 2 and COVID-19

Wattana Leowattana et al.

Summary: The SARS-CoV-2 virus enters cells through ACE2 receptors, causing COVID-19 disease. ACE2 and Ang-(1-7) have protective effects in cardiovascular diseases, repairing myocardial damage and reducing inflammation. Increasing ACE2 expression in COVID-19 patients may be a novel treatment approach. hrsACE2 can neutralize SARS-CoV-2 and reduce organ damage.

WORLD JOURNAL OF CLINICAL CASES (2022)

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Article Medicine, General & Internal

Clinical and biochemical characteristics of people experiencing post-coronavirus disease 2019-related symptoms: A prospective follow-up investigation

Assim A. Alfadda et al.

Summary: The study aimed to investigate the clinical and biochemical characteristics of people who recovered from COVID-19 after 6 months of discharge from the hospital. The results showed that half of the followed-up people reported experiencing at least one COVID-19-related symptom, and these individuals had lower lymphocyte count, lower serum calcium levels, and higher blood glucose.

FRONTIERS IN MEDICINE (2022)

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Article Multidisciplinary Sciences

Nitric oxide versus epoprostenol for refractory hypoxemia in Covid-19

Pai B. H. Poonam et al.

Summary: In mechanically ventilated patients with COVID-19, there was no significant difference between inhaled nitric oxide (iNO) and inhaled epoprostenol (iEPO) in terms of change in P/F ratio, duration of mechanical ventilation, ICU stay, and in-hospital mortality.

PLOS ONE (2022)

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Article Hematology

Serum interleukin 1β and sP-selectin as biomarkers of inflammation and thrombosis, could they be predictors of disease severity in COVID 19 Egyptian patients? (a cross-sectional study)

Sara El-Sayed Abd El-Ghani et al.

Summary: IL-1 beta and sP-selectin levels can serve as promising predictors for severe COVID-19 infection and predictable thrombosis.

THROMBOSIS JOURNAL (2022)

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Letter Surgery

Emergence of novel omicron hybrid variants: BA(x), XE, XD, XF more than just alphabets

Pryanka Thakur et al.

INTERNATIONAL JOURNAL OF SURGERY (2022)

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Article Medicine, General & Internal

Plasma Endothelial and Oxidative Stress Biomarkers Associated with Late Mortality in Hospitalized COVID-19 Patients

Arturo Orea-Tejada et al.

Summary: Endothelial dysfunction and oxidative stress are independent indicators of a worse prognosis in hospitalized COVID-19 patients.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Medicine, General & Internal

Von Willebrand Factor and ADAMTS-13 Are Associated with the Severity of COVID-19 Disease

Nataliya Dolgushina et al.

Summary: Coagulopathy in COVID-19 patients is caused by systemic hypercoagulation and inflammation. Endothelial dysfunction leads to the release of tissue factor and von Willebrand factor, resulting in prothrombinase activation. The vWF/ADAMTS-13 ratio can be used to assess the severity of the disease.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Cell Biology

Serum of Post-COVID-19 Syndrome Patients with or without ME/CFS Differentially Affects Endothelial Cell Function In Vitro

Lavinia Flaskamp et al.

Summary: COVID-19 reconvalescent patients may develop post-COVID-19 syndrome (PCS), including a subgroup fulfilling diagnostic criteria of Myalgic encephalomyelitis/Chronic Fatigue Syndrome (PCS/CFS). This study found that PCS/CFS patients had endothelial dysfunction (ED) and increased binding of anti-endothelial cell autoantibodies (AECAs) to endothelial cells (ECs). Additionally, PCS sera showed a pro-angiogenic effect and promoted the release of molecules associated with vascular remodelling, compared to PCS/CFS and healthy controls.

CELLS (2022)

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Review Cell Biology

Vascular Endothelial Glycocalyx Damage and Potential Targeted Therapy in COVID-19

Duoduo Zha et al.

Summary: COVID-19 is a highly infectious respiratory disease caused by SARS-CoV-2. Endothelial cells and the glycocalyx layer play a central role in the pathogenesis of COVID-19. Inflammatory mediators, reactive oxygen species, matrix metalloproteases, glycocalyx fragments, and viral proteins may contribute to endothelial glycocalyx damage in COVID-19. Potential therapeutic strategies targeting the glycocalyx layer are discussed.

CELLS (2022)

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Article Biochemistry & Molecular Biology

Angiopoietin-2 Inhibition of Thrombomodulin-Mediated Anticoagulation-A Novel Mechanism That May Contribute to Hypercoagulation in Critically III COVID-19 Patients

Michael Hultstrom et al.

Summary: Hypercoagulation and endothelial dysfunction play important roles in severe forms of COVID-19 infections. Angiopoietin-2, an inflammatory cytokine and TIE2 receptor antagonist, appears to be involved in the molecular mechanisms underlying COVID-19-associated hypercoagulation. Clinical data, mouse models, and in vitro assays support the hypothesis that Angiopoietin-2 directly inhibits thrombin/thrombomodulin-mediated anticoagulation, leading to increased coagulation in COVID-19 patients.

BIOMEDICINES (2022)

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Article Cardiac & Cardiovascular Systems

Fibrinolytic Proteins and Factor XIII as Predictors of Thrombotic and Hemorrhagic Complications in Hospitalized COVID-19 Patients

Marina Marchetti et al.

Summary: This study provides a comprehensive characterization of hemostatic alterations in hospitalized COVID-19 patients, highlighting the correlation with inflammatory status. Fibrinolytic proteins and NLR may serve as predictors of thrombotic and hemorrhagic complications, respectively.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

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Article Medicine, General & Internal

Admission Levels of Serum P-Selectin and IL-6 Can Predict Development of Deep Venous Thrombosis in Hospitalized Covid-19 Patients

Nehal Farouk et al.

Summary: The present study identified a potential correlation between elevated levels of P-selectin and IL-6 and the development of DVT in hospitalized Covid-19 patients.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2022)

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Review Pharmacology & Pharmacy

Tissue Factor and COVID-19: An Update

Ana Teresa Azevedo Sachetto et al.

Summary: TF plays a central role in thrombosis in COVID-19, as its expression is upregulated during infection with SARS-CoV-2. Increased TF levels are associated with coagulation activation, inflammation, severity of disease, and mortality. TF may serve as a prognostic marker and therapeutic target for reducing thrombosis and inflammation in COVID-19.

CURRENT DRUG TARGETS (2022)

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Article Hematology

Plasma biomarkers associated with survival and thrombosis in hospitalized COVID-19 patients

David Cabrera-Garcia et al.

Summary: This study investigates potential biomarkers of coagulopathy and disease severity in COVID-19, finding that COVID-19 patients have elevated levels of fibrinogen, t-PA, PAI-1, ST2, and vWF compared to controls. Higher levels of t-PA, ST2, and vWF at admission are associated with lower survival rates, and patients with initial higher levels of vWF are more prone to thrombotic events. These findings suggest a predictive role of specific biomarkers in the pathophysiology of COVID-19.

INTERNATIONAL JOURNAL OF HEMATOLOGY (2022)

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Article Pharmacology & Pharmacy

Serum stratifin and presepsin as candidate biomarkers for early detection of COVID-19 disease progression

Noriaki Arakawa et al.

Summary: The prognosis of severe cases of COVID-19 is usually poor, therefore, it is crucial to have biomarkers for early prediction of disease progression. This study identified stratifin and presepsin as potential prognostic biomarkers for severe COVID-19 progression, showing earlier changes compared to other biomarkers and clinical indicators.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2022)

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Article Medicine, Research & Experimental

SARS-CoV-2 infection- induced growth factors play differential roles in COVID-19 pathogenesis

Anamika Gupta et al.

Summary: Growth factors play differential roles in the pathogenesis of COVID-19, with most of them being upregulated at the moderate stage of the disease. The induction of growth factors likely occurs due to endothelial dysfunction and may counter the adverse effects of cytokine storms.

LIFE SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Elevated vascular transformation blood biomarkers in Long-COVID indicate angiogenesis as a key pathophysiological mechanism

Maitray A. Patel et al.

Summary: This study investigated vascular transformation biomarkers in patients with Long-COVID and found that these biomarkers were significantly elevated. Using machine learning, a unique two biomarker profile consisting of ANG-1/P-SEL was developed, providing a classification accuracy for Long-COVID status of 96%.

MOLECULAR MEDICINE (2022)

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Article Medicine, Research & Experimental

Inflammatory markers calprotectin, NETs, syndecan-1 and neopterin in COVID-19 convalescent blood donors

Geir Hetland et al.

Summary: Persistent inflammation has been found in the lungs and other parenchymatous organs of some COVID-19 survivors. The levels of inflammatory markers, such as calprotectin, neutrophil extracellular traps (NETs), syndecan-1, and neopterin, were measured in serum samples of COVID-19 convalescents. It was observed that calprotectin concentrations were significantly increased in the convalescent group, suggesting the presence of low-grade inflammation involving neutrophils.

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION (2022)

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Article Multidisciplinary Sciences

Serum biomarkers associated with SARS-CoV-2 severity

Fabiani de Morais Batista et al.

Summary: This study analyzed the immune response of patients with SARS-CoV-2 infection and identified biomarkers related to disease severity. Some angiogenesis markers were more frequently elevated in severe cases compared to other groups. In terms of cardiovascular diseases, D-dimer, GDF-15, and sICAM-1 were higher in the severe cases. Significant differences in cytokines and chemokines levels were also observed according to the clinical course.

SCIENTIFIC REPORTS (2022)

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Article Immunology

Complement and endothelial cell activation in COVID-19 patients compared to controls with suspected SARS-CoV-2 infection: A prospective cohort study

Flavio Bruni et al.

Summary: This study aimed to evaluate complement and endothelial cell activation in COVID-19 patients compared to controls without SARS-CoV-2 infection. The results showed that complement cascade and endothelium were activated in COVID-19 patients beyond a nonspecific inflammatory trigger, which was not observed in the control group.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Medicine, General & Internal

Mild-to-Moderate COVID-19 Convalescents May Present Pro-Longed Endothelium Injury

Pawel Kozlowski et al.

Summary: This study found that COVID-19 convalescents without other comorbidities related to endothelial impairment only showed slight evidence of endothelial dysfunction at least 6 months after infection.

JOURNAL OF CLINICAL MEDICINE (2022)

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Review Pharmacology & Pharmacy

The Impact of Angiotensin-Converting Enzyme-2/Angiotensin 1-7 Axis in Establishing Severe COVID-19 Consequences

Minela Aida Maranduca et al.

Summary: The COVID-19 pandemic has placed significant stress on the medical community. ACE2, a cellular receptor for the virus, has been identified as a crucial component in the renin-angiotensin-aldosterone system (RAAS) and is responsible for various processes in different organs. Infection with SARS-CoV-2 leads to downregulation of ACE2 and disrupts the balance between ACE and ACE2 in organs, resulting in observed effects of COVID-19 infection.

PHARMACEUTICS (2022)

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Article Infectious Diseases

Mid-Regional Pro-Adrenomedullin as a Prognostic Factor for Severe COVID-19 ARDS

Etienne de Montmollin et al.

Summary: This study aimed to evaluate MR-proADM as a prognostic biomarker and marker of bacterial superinfection in severe SARS-CoV-2 infection. The results showed that MR-proADM is a good predictor of outcome in severe SARS-CoV-2 infection and could be a useful tool to assess bacterial superinfection in COVID-19 patients.

ANTIBIOTICS-BASEL (2022)

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Article Medicine, General & Internal

Utility of Measuring Circulating Bio-Adrenomedullin and Proenkephalin for 30-Day Mortality Risk Prediction in Patients with COVID-19 and Non-COVID-19 Interstitial Pneumonia in the Emergency Department

Ilaria Dafne Papasidero et al.

Summary: The prognostic role of penKid and Bio-ADM in patients with interstitial pneumonia (IP) at ED admission was evaluated. Both biomarkers were found to be good predictors of patient mortality.

MEDICINA-LITHUANIA (2022)

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Article Endocrinology & Metabolism

Hospitalized Patients With COVID-19 Have Higher Plasma Aldosterone-Renin Ratio and Lower ACE Activity Than Controls

Nisha Parikh et al.

Summary: This study aimed to determine the differences in circulating RAAS biomarker levels between COVID-19 patients and non-COVID-19 patients throughout the disease course. The results showed that a high ARR may be a risk marker for COVID-19 hospitalization, independent of BMI. Serum ACE activity was lower in COVID-19 patients compared to controls at the beginning of hospitalization and then increased to similar levels as controls, possibly due to lung injury, which improved with inpatient disease management.

JOURNAL OF THE ENDOCRINE SOCIETY (2022)

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Article Critical Care Medicine

Evaluation of inhaled nitric oxide (iNO) treatment for moderate-to-severe ARDS in critically ill patients with COVID-19: a multicenter cohort study

Khalid Al Sulaiman et al.

Summary: In critically ill COVID-19 patients with moderate-to-severe ARDS, iNO rescue therapy is associated with improved oxygenation parameters but no mortality benefits. Moreover, iNO use is associated with higher odds of AKI, pneumonia, longer LOS, and fewer VFDs.

CRITICAL CARE (2022)

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Review Medicine, Research & Experimental

Long COVID endotheliopathy: hypothesized mechanisms and potential therapeutic approaches

Jasimuddin Ahamed et al.

Summary: SARS-CoV-2 infected individuals may suffer from a multi-organ disorder known as "long COVID" or post-acute sequelae of SARS-CoV-2 infection (PASC). The pathophysiology is unknown and there are no standard treatments available. Acute COVID-19 and PASC have different clinical characteristics, with acute COVID-19 being associated with systemic inflammation, hypercoagulability, and comorbidities, while these features are less prominent in PASC. The involvement of microvascular endotheliopathy and autoimmune responses in PASC is suggested, along with the reactivation of latent pathogens and microvascular thrombosis.

JOURNAL OF CLINICAL INVESTIGATION (2022)

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Article Respiratory System

Efficacy and Safety of LY3127804, an Anti-Angiopoietin-2 Antibody, in a Randomized, Double-Blind, Placebo-Controlled Clinical Trial in Patients Hospitalized with Pneumonia and Presumed or Confirmed COVID-19

Rosie S. Jones et al.

Summary: This study aimed to determine whether the anti-Ang2 monoclonal antibody LY3127804 could reduce the need for mechanical ventilation in pneumonia and COVID-19 patients. However, the results showed that LY3127804 treatment did not decrease the need for ventilator usage in these patients.

CLINICAL MEDICINE INSIGHTS-CIRCULATORY RESPIRATORY AND PULMONARY MEDICINE (2022)

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Article Medicine, General & Internal

Usefulness of monocyte distribution width and presepsin for early assessment of disease severity in COVID-19 patients

Sei Won Kim et al.

Summary: This study found that MDW and presepsin are useful indicators for early assessment of disease severity in COVID-19 patients and can predict the prognosis of patients upon admission.

MEDICINE (2022)

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Article Respiratory System

Heparan sulfate mimetic fucoidan restores the endothelial glycocalyx and protects against dysfunction induced by serum of COVID-19 patients in the intensive care unit

Lushun Yuan et al.

Summary: Accumulating evidence suggests that endothelial dysfunction is involved in the progression of COVID-19. This study found that serum factors of severe COVID-19 patients may affect the glycocalyx and lead to endothelial dysfunction. The study also demonstrated that certain substances circulating in the plasma of COVID-19 patients in intensive care units are associated with endothelial glycocalyx degradation, barrier disruption, inflammation, and increased coagulation.

ERJ OPEN RESEARCH (2022)

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Article Hematology

Platelet-leukocyte interactions in COVID-19: Contributions to hypercoagulability, inflammation, and disease severity

Eugenio D. Hottz et al.

Summary: Platelet-leukocyte interactions play a crucial role in the hypercoagulability and inflammation processes of COVID-19. Understanding the mechanisms behind these interactions is of great importance for understanding disease severity and therapeutic strategies.

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2022)

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Review Medicine, General & Internal

Cytokine Storm in COVID-19: Immunopathogenesis and Therapy

Christian Zanza et al.

Summary: Cytokine storm is an excessive inflammatory state caused by an immune system dysregulation, which can lead to multi-organ failure and death. Initially described in graft-versus-host disease, it has been extended to other diseases such as COVID-19. Various drugs have been tested to mitigate cytokine storm, with some showing effectiveness in reducing mortality, especially in critically ill patients.

MEDICINA-LITHUANIA (2022)

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Article Respiratory System

Elevated plasma levels of epithelial and endothelial cell markers in COVID-19 survivors with reduced lung diffusing capacity six months after hospital discharge

Oriol Sibila et al.

Summary: The study found that about 60% of COVID-19 survivors had reduced DLCO 6 months after discharge, mainly in those over 60 years old, with a history of smoking, hypertension, severe COVID-19 experience, and persistent dyspnea after discharge. In addition, patients with reduced DLCO had higher levels of epithelial and endothelial markers.

RESPIRATORY RESEARCH (2022)

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Article Medical Laboratory Technology

Prognostic Significance of Platelet Activation Marker CD62P in Hospitalized Covid-19 Patients

Magdy Eldahshan et al.

Summary: The expression of CD62P in COVID-19 patients is associated with clinical severity and outcome. Higher levels of CD62P are found in patients who are more likely to die, and CD62P levels are significantly elevated in severe cases. D-dimer and CD62P levels are significant predictors of mortality risk.

CLINICAL LABORATORY (2022)

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Review Virology

The cytokine storm and COVID-19

Biying Hu et al.

Summary: COVID-19, caused by SARS-CoV-2, has become a global pandemic since its emergence in Wuhan, China, in December 2019, posing a serious threat to public health. Close contact and respiratory droplets are the main modes of transmission. The cytokine storm is closely associated with disease severity and mortality, emphasizing the importance of studying and treating the cytokine storm in COVID-19.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Letter Virology

Presepsin as a predictive biomarker of severity in COVID-19: A case series

Ai Fukada et al.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Article Peripheral Vascular Disease

Serum Endocan Levels on Admission Are Associated With Worse Clinical Outcomes in COVID-19 Patients: A Pilot Study

Alpay Medetalibeyoglu et al.

Summary: This study suggests that baseline serum endocan levels may serve as a useful prognostic factor for predicting adverse outcomes in COVID-19 patients, with higher levels associated with a worse prognosis.

ANGIOLOGY (2021)

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Letter Anesthesiology

Inhaled nitric oxide minimally improves oxygenation in COVID-19 related acute respiratory distress syndrome

Alessia Longobardo et al.

BRITISH JOURNAL OF ANAESTHESIA (2021)

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Article Chemistry, Medicinal

Soluble Angiotensin Converting Enzyme 2 (ACE2) Is Upregulated and Soluble Endothelial Nitric Oxide Synthase (eNOS) Is Downregulated in COVID-19-induced Acute Respiratory Distress Syndrome (ARDS)

Alice G. Vassiliou et al.

Summary: The levels of eNOS were significantly lower in COVID-19-ARDS patients, while sACE2 levels were significantly higher. These results suggest the presence of two distinct defense mechanisms in COVID-19-derived ARDS, providing insights for therapeutic applications in COVID-19.

PHARMACEUTICALS (2021)

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Article Hematology

Temporal change in Syndecan-1 as a therapeutic target and a biomarker for the severity classification of COVID-19

Fumihiro Ogawa et al.

Summary: The study suggests that SDC-1, a component of the endothelial glycocalyx, may serve as a biomarker for reflecting the severity of COVID-19 related to endothelial injury.

THROMBOSIS JOURNAL (2021)

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Article Multidisciplinary Sciences

Ephrin-A1 and the sheddase ADAM12 are upregulated in COVID-19

Rachelle Mendoza et al.

Summary: Research has shown that serum levels of ephrin-A1 and ADAM12 are significantly elevated in COVID-19 patients and correlate with disease progression, indicating potential targets for therapeutic development. Conversely, TNF alpha and ADAM17 levels were elevated in a small subset of patients, suggesting a different inflammatory pathway in COVID-19 progression.

HELIYON (2021)

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Letter Immunology

Serum Levels of Soluble Platelet Endothelial Cell Adhesion Molecule 1 in COVID-19 Patients Are Associated With Disease Severity

Linlin Li et al.

JOURNAL OF INFECTIOUS DISEASES (2021)

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Letter Hematology

Plasma P-selectin is an early marker of thromboembolism in COVID-19

Bank G. Fenyves et al.

AMERICAN JOURNAL OF HEMATOLOGY (2021)

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Article Anesthesiology

Effects of inhaled nitric oxide in COVID-19-induced ARDS - Is it worthwhile?

Christopher Lotz et al.

Summary: Inhalation of NO significantly improved oxygenation in COVID-19 ARDS patients. Severe ARDS patients had higher partial pressures of oxygen and reduced pulmonary vascular resistance after receiving iNO. Significant changes in pulmonary shunting were not observed.

ACTA ANAESTHESIOLOGICA SCANDINAVICA (2021)

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Article Immunology

Complement activation and endothelial perturbation parallel COVID-19 severity and activity

Massimo Cugno et al.

Summary: The study found that complement activation is enhanced during the progression of COVID-19 and dampened during remission, indicating its role in the pathophysiology of the disease. The association between complement activation and the biomarkers of endothelial damage suggests that complement may contribute to tissue injury and could be the target of specific therapy.

JOURNAL OF AUTOIMMUNITY (2021)

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Letter Infectious Diseases

Role of endothelial dysfunction in the thrombotic complications of COVID-19 patients

Emanuela Falcinelli et al.

JOURNAL OF INFECTION (2021)

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Review Virology

Potential detrimental role of soluble ACE2 in severe COVID-19 comorbid patients

Mohammad Mahmudur Rahman et al.

Summary: This study discusses the mechanism of SARS-CoV-2 entering host cells, focusing on the role of sACE2 in viral infection, as well as the impact of Ang II and AT1R in disease severity in comorbid patients.

REVIEWS IN MEDICAL VIROLOGY (2021)

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Article Medicine, Research & Experimental

The assessment of serum ACE activity in COVID-19 and its association with clinical features and severity of the disease

Aslihan Avanoglu Guler et al.

Summary: This study investigated the serum ACE activity and its correlation with clinical features and disease severity in patients with COVID-19. The results showed no association between serum ACE activity and COVID-19, and serum ACE activity on admission did not reflect disease severity.

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION (2021)

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Letter Hematology

Circulating Levels of Tissue Plasminogen Activator and Plasminogen Activator Inhibitor-1 Are Independent Predictors of Coronavirus Disease 2019 Severity: A Prospective, Observational Study

Brandon Michael Henry et al.

SEMINARS IN THROMBOSIS AND HEMOSTASIS (2021)

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Article Multidisciplinary Sciences

Plasma tissue plasminogen activator and plasminogen activator inhibitor-1 in hospitalized COVID-19 patients

Yu Zuo et al.

Summary: COVID-19 patients have elevated levels of tPA and PAI-1 in plasma, which are correlated with neutrophil counts and respiratory status. Particularly high levels of tPA are strongly associated with mortality and enhanced fibrinolysis, suggesting a subset of patients may have a favorable balance of factors for fibrinolysis. Further investigation into tPA as a biomarker is warranted.

SCIENTIFIC REPORTS (2021)

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Article Cell Biology

ICU Admission Levels of Endothelial Biomarkers as Predictors of Mortality in Critically Ill COVID-19 Patients

Alice G. Vassiliou et al.

Summary: Endothelial damage markers were found to be significantly elevated in ICU non-survivors compared to survivors upon admission, suggesting their potential use in predicting mortality in COVID-19. The prognostic values of specific endothelial biomarkers were greater than 0.85 according to ROC analysis.

CELLS (2021)

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Article Immunology

Brain injury, endothelial injury and inflammatory markers are elevated and express sex-specific alterations after COVID-19

Jude Savarraj et al.

Summary: COVID-19 can cause brain and endothelial injury, with men showing higher levels of injury markers and inflammatory markers compared to women. Elevated levels of BIMs, CCs, and EIMs in COVID-19 patients suggest brain and endothelial injury, with men being more susceptible to risk factors than women.

JOURNAL OF NEUROINFLAMMATION (2021)

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Article Cell Biology

Soluble ACE2 as a potential therapy for COVID-19

Sudarshan Krishnamurthy et al.

Summary: Soluble angiotensin-converting enzyme 2 (sACE2) is a potential therapeutic option for treating COVID-19 infection by competing with native ACE2 on cell surfaces for binding with the SARS-CoV-2 spike protein, thereby alleviating the inflammatory response.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2021)

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Review Peripheral Vascular Disease

Biomarkers of endothelial dysfunction and outcomes in coronavirus disease 2019 (COVID-19) patients: A systematic review and meta-analysis

Andrianto et al.

Summary: Biomarkers of endothelial dysfunction, including VWF antigen, t-PA, PAI-1, and sTM, are significantly associated with increased composite poor outcomes in patients with COVID-19, indicating the importance of endothelial dysfunction in COVID-19 patients.

MICROVASCULAR RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Syndecan-1, an indicator of endothelial glycocalyx degradation, predicts outcome of patients admitted to an ICU with COVID-19

Dong Zhang et al.

Summary: The study found that COVID-19 patients with high Syndecan-1 levels develop more serious endothelial damage and inflammatory reactions, leading to increased mortality. Syndecan-1 has potential as a marker for disease progression or severity in COVID-19, and protecting the glycocalyx may be a potential treatment for the disease.

MOLECULAR MEDICINE (2021)

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Article Biology

SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung

Alan E. Mast et al.

Summary: In COVID-19 patients, extensive fibrin deposition in the lungs and altered levels of circulating blood coagulation proteins suggest impaired local pathways that limit fibrin formation and promote clearance. Analysis of bronchoalveolar lavage fluid samples revealed decreased transcriptional levels related to fibrinolysis and increased levels related to coagulation, indicating enhanced coagulation propagation and reduced fibrinolysis as drivers of lung coagulopathy in COVID-19 patients.

ELIFE (2021)

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Article Virology

sTREM-1 Predicts Disease Severity and Mortality in COVID-19 Patients: Involvement of Peripheral Blood Leukocytes and MMP-8 Activity

Pedro V. da Silva-Neto et al.

Summary: This study investigated the role of soluble TREM-1 as a biomarker in COVID-19 severity and mortality, finding a significant correlation with disease severity, inflammatory parameters, and negative correlation with lymphocyte counts. The study suggests sTREM-1 could be a predictive tool for disease outcome in COVID-19 patients.

VIRUSES-BASEL (2021)

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Article Virology

Indications of Persistent Glycocalyx Damage in Convalescent COVID-19 Patients: A Prospective Multicenter Study and Hypothesis

Richard Vollenberg et al.

Summary: This study identifies signs of endothelial damage in convalescent COVID-19 patients after mild disease progression without hospitalization, consistent with studies showing evidence of persistent endothelial damage after severe or critical disease progression. Further research should investigate endothelial damage in convalescent COVID-19 patients.

VIRUSES-BASEL (2021)

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Letter Respiratory System

Between inflammation and thrombosis: endothelial cells in COVID-19

Anna Birnhuber et al.

EUROPEAN RESPIRATORY JOURNAL (2021)

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Article Immunology

Soluble Urokinase Plasminogen Activator Receptor (suPAR) as a Biomarker of Systemic Chronic Inflammation

Line Jee Hartmann Rasmussen et al.

Summary: Systemic chronic inflammation (SCI) is a persistent low-grade inflammation that plays a major role in aging and disease development. Despite a lack of standard biomarkers, suPAR has emerged as a potential marker for SCI due to its shared properties and characteristics. SuPAR is associated with inflammation, immune activation, and predicts morbidity and mortality across various conditions.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Medicine, General & Internal

Soluble Urokinase Receptor as a Promising Marker for Early Prediction of Outcome in COVID-19 Hospitalized Patients

Filomena Napolitano et al.

Summary: The study suggests soluble urokinase receptor (suPAR) as a serum biomarker for clinical severity and outcome in COVID-19 patients, prompting increased clinical attention on patients with high suPAR levels.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Immunology

Excessive Matrix Metalloproteinase-1 and Hyperactivation of Endothelial Cells Occurred in COVID-19 Patients and Were Associated With the Severity of COVID-19

Fahim Syed et al.

Summary: The study found that COVID-19 patients exhibit a unique inflammatory profile, with high levels of MMP-1 and hyperactivation of endothelial cells (ECs) associated with disease severity.

JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Medicine, General & Internal

Soluble Urokinase Plasminogen Activator Receptor (suPAR) Independently Predicts Severity and Length of Hospitalisation in Patients With COVID-19

Helena Enocsson et al.

Summary: Admission levels of suPAR were higher in patients with severe/critical COVID-19 and correlated with length of hospital stay. Additionally, suPAR functioned as an independent predictor of COVID-19 disease severity.

FRONTIERS IN MEDICINE (2021)

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Article Hematology

Biomarkers of coagulation, endothelial function, and fibrinolysis in critically ill patients with COVID-19: A single-center prospective longitudinal study

Ganeem K. Juneja et al.

Summary: Immunothrombosis and coagulopathy in the lung microvasculature may lead to lung injury and disease progression in COVID-19. Biomarkers such as elevated D-dimer were associated with disease severity, while clot lysis time, sTM, PAI-1, and plasminogen levels may have predictive ability for mortality.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

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Article Cardiac & Cardiovascular Systems

Effect of Crizanlizumab, a P-Selection inhibitor, in COVID-19 A Placebo-Controlled, Randomized Trial

Thorsten M. Leucker et al.

Summary: The P-selectin inhibitor, crizanlizumab, effectively reduced levels of P-selectin and may induce thrombolysis in COVID-19 patients. However, there were no significant differences in clinical endpoints between crizanlizumab and placebo, and crizanlizumab was well tolerated by patients.

JACC-BASIC TO TRANSLATIONAL SCIENCE (2021)

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Article Critical Care Medicine

Could Soluble Endothelial Protein C Receptor Levels Recognize SARS-CoV2-Positive Patients Requiring Hospitalization?

Alice G. Vassiliou et al.

Summary: The study revealed that plasma levels of sEPCR were significantly elevated in COVID-19 hospitalized patients compared to outpatients, potentially leading to impaired APC activities and contributing to the pro-coagulant phenotype in these patients. Measurement of sEPCR could be useful as a point-of-care test for SARS-CoV2-positive patients.

SHOCK (2021)

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Article Immunology

Antibodies Against Angiotensin II Receptor Type 1 and Endothelin A Receptor Are Associated With an Unfavorable COVID19 Disease Course

Jelle Miedema et al.

Summary: This study found significantly increased levels of auto-antibodies against AT1R and ETAR in COVID-19 patients with an unfavorable disease course. However, levels of antinuclear antibodies (ANA) in patients with unfavorable disease course did not show significant differences compared to patients with favorable disease course and controls.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Medicine, General & Internal

Prognostic Value of Bioactive Adrenomedullin in Critically Ill Patients with COVID-19 in Germany: An Observational Cohort Study

Tim-Philipp Simon et al.

Summary: The plasma levels of bioactive adrenomedullin (bio-ADM) are significantly correlated with disease severity, the need for extracorporeal organ support, and survival rates in COVID-19 patients, demonstrating potential value in early risk stratification and clinical management.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Immunology

Persistent Symptoms and Association With Inflammatory Cytokine Signatures in Recovered Coronavirus Disease 2019 Patients

Sean Wei Xiang Ong et al.

Summary: A study conducted in Singapore involving 288 COVID-19 patients revealed that approximately 10% of recovered patients still experienced persistent symptoms 6 months after the initial infection. The immune cytokine profiles of recovered patients indicated ongoing chronic inflammation and angiogenesis. Monitoring for long-term health consequences in COVID-19 patients is recommended.

OPEN FORUM INFECTIOUS DISEASES (2021)

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Article Biochemistry & Molecular Biology

Increased sTREM-1 plasma concentrations are associated with poor clinical outcomes in patients with COVID-19

Aline H. de Nooijer et al.

Summary: Patients with COVID-19 have elevated plasma concentrations of sTREM-1, which are associated with disease severity and patient outcomes, suggesting that the TREM-1 pathway may be considered as a therapeutic target in severely ill COVID-19 patients.

BIOSCIENCE REPORTS (2021)

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Article Hematology

A mild deficiency of ADAMTS13 is associated with severity in COVID-19: comparison of the coagulation profile in critically and noncritically ill patients

Reyes Maria Martin-Rojas et al.

Summary: This study analyzed the coagulation parameters of critically and noncritically ill patients with COVID-19 bilateral pneumonia and found elevated levels of PAI-1 and vWF activity, as well as a mild reduction of ADAMTS13. These findings suggest that COVID-19 coagulopathy may be related to endothelial cell injury.

BLOOD COAGULATION & FIBRINOLYSIS (2021)

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Article Cardiac & Cardiovascular Systems

Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin

Etheresia Pretorius et al.

Summary: Individuals with Long COVID/PASC may exhibit persistent symptoms due to the presence of persistent circulating plasma microclots that are resistant to fibrinolysis, including fatigue, shortness of breath, sleep issues, and anxiety or depression.

CARDIOVASCULAR DIABETOLOGY (2021)

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Article Emergency Medicine

Predicting outcomes of COVID-19 from admission biomarkers: a prospective UK cohort study

David T. Arnold et al.

Summary: Admission blood biomarkers have only moderate predictive value for predicting COVID-19 outcomes, while simple clinical features such as age and NEWS2 score outperform many biomarkers. IL-6 and suPAR had the best performance, and further studies should focus on the additive value of these biomarkers to routine care.

EMERGENCY MEDICINE JOURNAL (2021)

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Article Immunology

A possible pathogenic role of Syndecan-1 in the pathogenesis of coronavirus disease 2019 (COVID-19)

Sajad Karampoor et al.

Summary: The study investigated the dynamic changes in Syndecan-1 levels in COVID-19 patients. Results showed that COVID-19 patients had significantly higher levels of SDC-1, CRP, IL-6, IL-10, and IL-18 compared to healthy subjects, with lower levels of Vitamin D. ICU patients exhibited higher levels of these markers compared to non-ICU patients. Tracking the markers indicated an initial increase followed by a decrease by day 10, suggesting that SDC-1, IL-6, and IL-18 could be valuable indicators in evaluating COVID-19 activity.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Infectious Diseases

Admission levels of Soluble Urokinase Plasminogen Activator Receptor (suPAR) are Associated with the Development of Severe Complications in Hospitalised COVID-19 Patients: A Prospective Cohort Study

Abderrahim Oulhaj et al.

Summary: The study demonstrated a significant association between plasma levels of suPAR and the incidence of severe complications in COVID-19 patients, with higher suPAR levels correlating with increased risk of adverse outcomes. For every 1 ng/mL increase in suPAR, there was a 58% rise in the hazard of developing the primary outcome. Therefore, suPAR shows promising prognostic utility in predicting severe complications in hospitalized COVID-19 patients.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Virology

The role of angiopoietin-2 and surfactant protein-D levels in SARS-CoV-2-related lung injury: A prospective, observational, cohort study

Handan Alay et al.

Summary: This study investigated the levels of serum surfactant-D (SP-D) and angiopoetin-2 (Ang-2) in predicting the severity of COVID-19 patients. The results showed that SP-D and Ang-2 levels were significantly higher in patients with more severe pneumonia, and they can serve as predictive factors in differentiating COVID-19 patients and determining disease severity.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Article Virology

Soluble angiotensin-converting enzyme 2 is transiently elevated in COVID-19 and correlates with specific inflammatory and endothelial markers

Annika Lundstrom et al.

Summary: The study found that levels of sACE2 were higher in COVID-19 patients compared to healthy controls, but decreased over time while remaining higher than in controls. The correlations of sACE2 and sACE levels with markers of inflammation and endothelial dysfunction were different, suggesting release from different cell types and/or vascular beds.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Article Hematology

Tissue factor upregulation is associated with SARS-CoV-2 in the lungs of COVID-19 patients

Sandeep Subrahmanian et al.

Summary: The upregulation of tissue factor (TF) expression in the lungs of COVID-19 patients may be associated with thrombus formation, which could serve as a key therapeutic target. The correlation of TF expression with SARS-CoV-2 in COVID-19 lungs raises the possibility of direct TF induction by the virus.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

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Article Hematology

Imbalance of von Willebrand factor and ADAMTS13 axis is rather a biomarker of strong inflammation and endothelial damage than a cause of thrombotic process in critically ill COVID-19 patients

Berangere S. Joly et al.

Summary: Clinical features, hemostatic laboratory parameters, VWF/ADAMTS13 axis, and ADAMTS13 conformation were investigated in critically ill COVID-19 patients at admission. The study found that an imbalance between high VWF antigen levels and normal or slightly decreased ADAMTS13 activity levels correlated with mortality, suggesting that these markers may reflect inflammation and endothelial damage rather than driving the thrombotic process of COVID-19.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

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Article Hematology

Persistent endotheliopathy in the pathogenesis of long COVID syndrome

Helen Fogarty et al.

Summary: The study found that endothelial cell activation may persist in convalescent COVID-19 patients and may contribute to the pathogenesis of long COVID. This sustained endotheliopathy was more common in older, comorbid patients, and those requiring hospitalization, indicating a potential link between endothelial dysfunction and long-term COVID symptoms.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

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Article Medicine, Research & Experimental

Heparin prevents in vitro glycocalyx shedding induced by plasma from COVID-19 patients

Simone R. Potje et al.

Summary: Plasma from COVID-19 patients promotes glycocalyx shedding and redox imbalance in endothelial cells, and heparin treatment potentially inhibits glycocalyx disruption.

LIFE SCIENCES (2021)

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Article Peripheral Vascular Disease

Endothelial cell dysfunction, coagulation, and angiogenesis in coronavirus disease 2019 (COVID-19)

Amir Hossein Norooznezhad et al.

Summary: COVID-19 disease involves not only cytokine storm, but also endothelial cell dysfunction and pathologic angiogenesis. These pathological processes may interact with each other through different pathways, and a comprehensive approach is needed in treatment.

MICROVASCULAR RESEARCH (2021)

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Article Multidisciplinary Sciences

Dexamethasone may improve severe COVID-19 via ameliorating endothelial injury and inflammation: A preliminary pilot study

Won-Young Kim et al.

Summary: Dexamethasone showed benefits in severe COVID-19 patients by improving disease severity, oxygenation, and inflammation markers. The study found that patients with severe COVID-19 had significantly higher levels of biomarkers related to endothelial injury and inflammation compared to controls, and dexamethasone treatment was associated with improvements in these markers.

PLOS ONE (2021)

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Article Critical Care Medicine

Platelet activation in critically ill COVID-19 patients

Nader Yatim et al.

Summary: This study found that elevated soluble P-selectin levels at admission were associated with COVID-19 severity and could predict intubation and death. Gene expression analysis indicated that critically ill patients had increased expression of genes related to platelet activation, with specific genes showing grade-dependent upregulation. ROC curve analysis identified PPBP/CXCL7 and SELPLG as biomarkers for intubation.

ANNALS OF INTENSIVE CARE (2021)

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Article Multidisciplinary Sciences

Platelets amplify endotheliopathy in COVID-19

Tessa J. Barrett et al.

Summary: The study reveals an inflammatory hypercoagulable state between platelets and endothelial cells in COVID-19, with platelet-released factors promoting endotheliopathy. S100A8, S100A9, and their protein product MRP8/14 are enriched in COVID-19 platelets and contribute significantly to poor clinical outcomes. Targeting platelet P2Y(12) appears to be a promising strategy for reducing proinflammatory platelet-endothelial interactions in COVID-19.

SCIENCE ADVANCES (2021)

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Article Medicine, General & Internal

Role of Serum E-Selectin as a Biomarker of Infection Severity in Coronavirus Disease 2019

Alessandra Oliva et al.

Summary: This study compared sE-selectin levels in COVID-19 patients and found that higher levels were associated with increased risk of ICU admission, potentially serving as a predictor for disease severity.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Medicine, General & Internal

Endothelial, Immunothrombotic, and Inflammatory Biomarkers in the Risk of Mortality in Critically Ill COVID-19 Patients: The Role of Dexamethasone

Chrysi Keskinidou et al.

Summary: Endothelial dysfunction, coagulation, and inflammation biomarkers are increasingly recognized as prognostic markers for poor outcomes and mortality in severe and critical COVID-19. Our study found that in critically ill COVID-19 patients, certain biomarkers such as sVCAM-1, suPAR, and presepsin can still be reliable prognostic indicators for ICU mortality even after dexamethasone administration. Patients with higher levels of sVCAM-1 or suPAR had a greater risk of mortality.

DIAGNOSTICS (2021)

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Article Immunology

Elevated Serum Levels of Progranulin and Soluble Vascular Cell Adhesion Molecule-1 in Patients with COVID-19

Shifei Yao et al.

Summary: Elevated serum PGRN and sVCAM-1 levels were found in patients with COVID-19, potentially providing insights into the pathogenesis of COVID-19. After successful treatment, serum PGRN and sVCAM-1 levels in COVID-19 patients significantly decreased.

JOURNAL OF INFLAMMATION RESEARCH (2021)

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Article Medicine, General & Internal

Upregulation of pulmonary tissue factor, loss of thrombomodulin and immunothrombosis in SARS-CoV-2 infection

Ivo M. B. Francischetti et al.

Summary: This study found that COVID-19 patients have thrombotic and microvascular complications, and the coagulation abnormalities have a multifactorial etiology. Biomarkers of endothelial cell, neutrophil activation, and fibrinolysis were elevated in severe disease group, correlating with severity. Postmortem specimens demonstrated potential links to immunothrombosis with upregulation of pulmonary TF and loss of thrombomodulin staining.

ECLINICALMEDICINE (2021)

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Article Hematology

Severe COVID-19 is associated with endothelial activation and abnormal glycosylation of von Willebrand factor in patients undergoing hemodialysis

Golzar Mobayen et al.

Summary: Severe COVID-19 in hemodialysis patients is associated with elevated VWF and decreased ADAMTS-13 levels. High soluble Syndecan-1 levels in severely ill patients are related to risk of death. Elevated VWF levels in severely ill patients are correlated with lower VWF sialic acid content, indicating altered VWF processing.

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2021)

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Article Gastroenterology & Hepatology

Elevated plasma ICAM1 levels predict 28-day mortality in cirrhotic patients with COVID-19 or bacterial sepsis

Savneet Kaur et al.

Summary: The study investigated the levels of endothelial injury biomarkers in patients with cirrhosis and severe COVID-19 or bacterial sepsis, revealing that ICAM1 plays an independent role in predicting mortality.

JHEP REPORTS (2021)

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Letter Respiratory System

Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure

Laura Michalick et al.

EUROPEAN RESPIRATORY JOURNAL (2021)

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Article Critical Care Medicine

Markers of endothelial and epithelial pulmonary injury in mechanically ventilated COVID-19 ICU patients

Savino Spadaro et al.

Summary: This study aimed to evaluate the plasma concentration of specific biomarkers in survivors and non-survivors of COVID-19-related ARDS, as well as in COVID-19-related and classical ARDS patients. Results showed that COVID-19 ARDS is characterized by early pulmonary endothelial injury, with differences in expression of biomarkers between COVID-19 ARDS and classical ARDS suggesting different pathological pathways.

CRITICAL CARE (2021)

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Article Peripheral Vascular Disease

Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients

David M. Smadja et al.

ANGIOGENESIS (2020)

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Review Biochemistry & Molecular Biology

COVID-19 cytokine storm: The anger of inflammation

Mehdi Mahmudpour et al.

CYTOKINE (2020)

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Review Biochemistry & Molecular Biology

Therapeutics targeting the fibrinolytic system

Haili Lin et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

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Letter Hematology

Involvement of ADAMTS13 and von Willebrand factor in thromboembolic events in patients infected with SARS-CoV-2

Albert Huisman et al.

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY (2020)

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Article Medical Laboratory Technology

Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases

Cynthia Magro et al.

TRANSLATIONAL RESEARCH (2020)

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Review Hematology

Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID-19

Claire S. Whyte et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Letter Cardiac & Cardiovascular Systems

Platelet and Vascular Biomarkers Associate With Thrombosis and Death in Coronavirus Disease

Tessa J. Barrett et al.

CIRCULATION RESEARCH (2020)

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Article Medical Laboratory Technology

Presepsin in risk stratification of SARS-CoV-2 patients

Martina Zaninotto et al.

CLINICA CHIMICA ACTA (2020)

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Article Medicine, General & Internal

Von Willebrand factor (vWF): marker of endothelial damage and thrombotic risk in COVID-19?

Eleni E. Ladikou et al.

CLINICAL MEDICINE (2020)

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Review Hematology

Coagulation Abnormalities and Thrombosis in Patients Infected With SARS-CoV-2 and Other Pandemic Viruses

Nigel Mackman et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2020)

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Letter Hematology

Anticoagulation with argatroban in patients with acute antithrombin deficiency in severe COVID-19

Deepa J. Arachchillage et al.

BRITISH JOURNAL OF HAEMATOLOGY (2020)

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Letter Medicine, General & Internal

Low ADAMTS 13 plasma levels are predictors of mortality in COVID-19 patients

Mario Bazzan et al.

INTERNAL AND EMERGENCY MEDICINE (2020)

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Article Hematology

Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study

George Goshua et al.

LANCET HAEMATOLOGY (2020)

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Editorial Material Hematology

Endothelial cells orchestrate COVID-19 coagulopathy Comment

Jamie M. O'Sullivan et al.

LANCET HAEMATOLOGY (2020)

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Article Biochemistry & Molecular Biology

Targeting Endothelial Dysfunction in Eight Extreme-Critically Ill Patients with COVID-19 Using the Anti-Adrenomedullin Antibody Adrecizumab (HAM8101)

Mahir Karakas et al.

BIOMOLECULES (2020)

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Article Medicine, General & Internal

ACE/ACE2 Ratio: A Key Also in 2019 Coronavirus Disease (Covid-19)?

Pasquale Pagliaro et al.

FRONTIERS IN MEDICINE (2020)

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Editorial Material Infectious Diseases

Prognostic Role of Soluble Urokinase Plasminogen Activator Receptor at the Emergency Department: A Position Paper by the Hellenic Sepsis Study Group

Dimitrios Velissaris et al.

INFECTIOUS DISEASES AND THERAPY (2020)

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Article Immunology

Elevated Expression of Serum Endothelial Cell Adhesion Molecules in COVID-19 Patients

Ming Tong et al.

JOURNAL OF INFECTIOUS DISEASES (2020)

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Article Hematology

In vitro hypercoagulability and ongoing in vivo activation of coagulation and fibrinolysis in COVID-19 patients on anticoagulation

Annabel Blasi et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Article Cardiac & Cardiovascular Systems

Potential role for tissue factor in the pathogenesis of hypercoagulability associated with in COVID-19

Mario Bautista-Vargas et al.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2020)

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Article Genetics & Heredity

Soluble Urokinase Plasminogen Activator Receptor: A Biomarker for Predicting Complications and Critical Care Admission of COVID-19 Patients

Athanasios Chalkias et al.

MOLECULAR DIAGNOSIS & THERAPY (2020)

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Review Physiology

ELEVATED PLASMIN(OGEN) AS A COMMON RISK FACTOR FOR COVID-19 SUSCEPTIBILITY

Hong-Long Ji et al.

PHYSIOLOGICAL REVIEWS (2020)

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Article Multidisciplinary Sciences

Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2

Kui K. Chan et al.

SCIENCE (2020)

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Letter Hematology

Role of von Willebrand Factor and ADAMTS-13 in the Pathogenesis of Thrombi in SARS-CoV-2 Infection: Time to Rethink

Nuccia Morici et al.

THROMBOSIS AND HAEMOSTASIS (2020)

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Article Immunology

Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID-19

Christophe Guervilly et al.

JOURNAL OF INFECTIOUS DISEASES (2020)

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Article Hematology

Coagulation biomarkers are independent predictors of increased oxygen requirements in COVID-19

Antoine Rauch et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Letter Hematology

Circulating Plasminogen Concentration at Admission in Patients with Coronavirus Disease 2019 (COVID-19)

Brandon Michael Henry et al.

SEMINARS IN THROMBOSIS AND HEMOSTASIS (2020)

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Article Critical Care Medicine

Human recombinant soluble ACE2 in severe COVID-19

Alexander Zoufaly et al.

LANCET RESPIRATORY MEDICINE (2020)

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Review Biochemistry & Molecular Biology

Endothelial glycocalyx damage as a systemic inflammatory microvascular endotheliopathy in COVID-19

Minako Yamaoka-Tojo

BIOMEDICAL JOURNAL (2020)

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Article Critical Care Medicine

Endothelial glycocalyx shedding in the acute respiratory distress syndrome after flu syndrome

Maira Nilson Benatti et al.

JOURNAL OF INTENSIVE CARE (2020)

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Article Infectious Diseases

The potential role of serum angiotensin-converting enzyme in coronavirus disease 2019

Zhe Zhu et al.

BMC INFECTIOUS DISEASES (2020)

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Review Biochemistry & Molecular Biology

Endothelial Damage in Acute Respiratory Distress Syndrome

Alice G. Vassiliou et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Letter Critical Care Medicine

Plasma levels of the active form of suPAR are associated with COVID-19 severity

Mingxiang Huang et al.

CRITICAL CARE (2020)

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Article Biochemistry & Molecular Biology

Erythrocyte, Platelet, Serum Ferritin, and P-Selectin Pathophysiology Implicated in Severe Hypercoagulation and Vascular Complications in COVID-19

Chantelle Venter et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Letter Critical Care Medicine

VEGF-D: a novel biomarker for detection of COVID-19 progression

Yaxian Kong et al.

CRITICAL CARE (2020)

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Letter Critical Care Medicine

RNA-expression of adrenomedullin is increased in patients with severe COVID-19

Julian Hupf et al.

CRITICAL CARE (2020)

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Letter Critical Care Medicine

Soluble urokinase plasminogen activator receptor (suPAR) as an early predictor of severe respiratory failure in patients with COVID-19 pneumonia

Nikoletta Rovina et al.

CRITICAL CARE (2020)

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Article Cardiac & Cardiovascular Systems

Circulating markers of angiogenesis and endotheliopathy in COVID-19

Matthew L. Meizlish et al.

PULMONARY CIRCULATION (2020)

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Review Clinical Neurology

A systematic review of cytokines in chronic fatigue syndrome/myalgic encephalomyelitis/systemic exertion intolerance disease (CFS/ME/SEID)

Matthew Corbitt et al.

BMC NEUROLOGY (2019)

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Article Critical Care Medicine

Vascular endothelial cadherin shedding is more severe in sepsis patients with severe acute kidney injury

Wen-Kuang Yu et al.

CRITICAL CARE (2019)

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Review Cardiac & Cardiovascular Systems

Interaction between platelets and endothelium: from pathophysiology to new therapeutic options

Michalis Hamilos et al.

CARDIOVASCULAR DIAGNOSIS AND THERAPY (2018)

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Review Critical Care Medicine

Endocan, sepsis, pneumonia, and acute respiratory distress syndrome

Nathalie De Freitas Caires et al.

CRITICAL CARE (2018)

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Review Pharmacology & Pharmacy

TREM-1 and its potential ligands in non-infectious diseases: from biology to clinical perspectives

Alessandra Tammaro et al.

PHARMACOLOGY & THERAPEUTICS (2017)

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Article Critical Care Medicine

Endocan as an early biomarker of severity in patients with acute respiratory distress syndrome

Diego Orbegozo et al.

ANNALS OF INTENSIVE CARE (2017)

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Review Hematology

Platelet Interaction with Innate Immune Cells

Julia Barbara Kral et al.

TRANSFUSION MEDICINE AND HEMOTHERAPY (2016)

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Article Medicine, Research & Experimental

Effect of Ivabradine on Endothelial Function in Patients with Stable Angina Pectoris: Assessment with the Endo-PAT 2000 Device

Lucia Jedlickova et al.

ADVANCES IN THERAPY (2015)

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Review Cardiac & Cardiovascular Systems

Selectins: initiators of leucocyte adhesion and signalling at the vascular wall

Rodger P. McEver

CARDIOVASCULAR RESEARCH (2015)

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Review Cardiac & Cardiovascular Systems

The regulation of transendothelial migration: new knowledge and new questions

William A. Muller

CARDIOVASCULAR RESEARCH (2015)

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Article Cardiac & Cardiovascular Systems

Soluble VE-cadherin is involved in endothelial barrier breakdown in systemic inflammation and sepsis

Sven Flemming et al.

CARDIOVASCULAR RESEARCH (2015)

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Article Physiology

Platelets and Their Interactions with Other Immune Cells

Fong W. Lam et al.

COMPREHENSIVE PHYSIOLOGY (2015)

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Review Critical Care Medicine

Pulmonary vascular dysfunction in ARDS

Donal Ryan et al.

ANNALS OF INTENSIVE CARE (2014)

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Review Cardiac & Cardiovascular Systems

Mechanisms regulating endothelial permeability

Sukriti Sukriti et al.

PULMONARY CIRCULATION (2014)

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Article Medicine, General & Internal

Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics

Gerwyn Morris et al.

BMC MEDICINE (2013)

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Review Pathology

Eph/Ephrin Signaling in Injury and Inflammation

Mark G. Coulthard et al.

AMERICAN JOURNAL OF PATHOLOGY (2012)

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Letter Cardiac & Cardiovascular Systems

Large and small artery endothelial dysfunction in chronic fatigue syndrome

David J. Newton et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2012)

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Review Biochemistry & Molecular Biology

Molecular functions of syndecan-1 in disease

Yvonne Hui-Fang Teng et al.

MATRIX BIOLOGY (2012)

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Review Biochemistry & Molecular Biology

Vascular Cell Adhesion Molecule-1 Expression and Signaling During Disease: Regulation by Reactive Oxygen Species and Antioxidants

Joan M. Cook-Mills et al.

ANTIOXIDANTS & REDOX SIGNALING (2011)

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Article Biochemistry & Molecular Biology

Hypoxia down-regulates sFlt-1 (sVEGFR-1) expression in human microvascular endothelial cells by a mechanism involving mRNA alternative processing

Takayuki Ikeda et al.

BIOCHEMICAL JOURNAL (2011)

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Review Biochemistry & Molecular Biology

The plasmin-antiplasmin system: structural and functional aspects

Johann Schaller et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2011)

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Review Obstetrics & Gynecology

Soluble CD14 subtype presepsin (sCD14-ST) and lipopolysaccharide binding protein (LBP) in neonatal sepsis: new clinical and analytical perspectives for two old biomarkers

Michele Mussap et al.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2011)

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Article Cell Biology

PECAM-1 regulates proangiogenic properties of endothelial cells through modulation of cell-cell and cell-matrix interactions

SunYoung Park et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2010)

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Review Cardiac & Cardiovascular Systems

Plasminogen Activator Inhibitor-1 (PAI-1): A Key Factor Linking Fibrinolysis and Age-Related Subclinical and Clinical Conditions

Matteo Cesari et al.

CARDIOVASCULAR THERAPEUTICS (2010)

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Review Biochemistry & Molecular Biology

Regulation of the Protein C Anticoagulant and Antiinflammatory Pathways

A. R. Rezaie

CURRENT MEDICINAL CHEMISTRY (2010)

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Review Medicine, Research & Experimental

Angiotensin II revisited: new roles in inflammation, immunology and aging

Ariela Benigni et al.

EMBO MOLECULAR MEDICINE (2010)

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Article Cell Biology

Soluble CD40L (CD154) is increased in patients with shock

M. Chew et al.

INFLAMMATION RESEARCH (2010)

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Article Hematology

New Developments in Lung Endothelial Heterogeneity: von Willebrand Factor, P-Selectin, and the Weibel-Palade Body

Cristhiaan D. Ochoa et al.

SEMINARS IN THROMBOSIS AND HEMOSTASIS (2010)

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Article Cardiac & Cardiovascular Systems

The Endothelium and Its Role in Regulating Vascular Tone

Aamer Sandoo et al.

OPEN CARDIOVASCULAR MEDICINE JOURNAL (2010)

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Article Physiology

Endothelial EphA receptor stimulation increases lung vascular permeability

Jacqueline Larson et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2008)

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Review Biochemistry & Molecular Biology

Adherens and tight junctions: Structure, function and connections to the actin cytoskeleton

Andrea Hartsock et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2008)

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Review Biochemistry & Molecular Biology

Eph-ephrin bidirectional signaling in physiology and disease

Elena B. Pasquale

CELL (2008)

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Article Hematology

Haplotypes of the EPCR gene, prothrombin levels, and the risk of venous thrombosis in carriers of the prothrombin G20210A mutation

Silvia Navarro et al.

HAEMATOLOGICA (2008)

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Review Hematology

Role of the extrinsic pathway of blood coagulation in hemostasis and thrombosis

Nigel Mackman et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2007)

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Review Physiology

The endothelial glycocalyx: composition, functions, and visualization

Sietze Reitsma et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2007)

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Article Hematology

The role of von Willebrand factor in thrombus formation

Zaverio M. Ruggeri

THROMBOSIS RESEARCH (2007)

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Review Cardiac & Cardiovascular Systems

Signaling and functions of angiopoietin-1 in vascular protection

NPJ Brindle et al.

CIRCULATION RESEARCH (2006)

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Article Hematology

Soluble endothelial protein C receptor (sEPCR) levels and venous thromboembolism in carriers of two dysfunctional protein C variants

P Simioni et al.

THROMBOSIS RESEARCH (2006)

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Article Endocrinology & Metabolism

Angiotensin type 1 receptor is linked to inhibition of nitric oxide production in pulmonary endothelial cells

XM Zhao et al.

REGULATORY PEPTIDES (2005)

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Article Hematology

CD40 ligand influences platelet release of reactive oxygen intermediates

S Chakrabarti et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2005)

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Article Hematology

Soluble thrombomodulin activity and soluble thrombomodulin antigen in plasma

AK Öhlin et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2005)

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Article Hematology

Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses

C Lemieux et al.

BLOOD (2005)

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Article Virology

Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus

S Åkerström et al.

JOURNAL OF VIROLOGY (2005)

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Article Hematology

A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis

B Saposnik et al.

BLOOD (2004)

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Article Hematology

Haplotypes of the EPCR gene, plasma sEPCR levels and the risk of deep venous thrombosis

SU De Willige et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2004)

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Review Critical Care Medicine

Bench-to-bedside review: Acute respiratory distress syndrome how neutrophils migrate into the lung

J Reutershan et al.

CRITICAL CARE (2004)

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Article Hematology

Contribution of polymorphisms in the endothelial protein C receptor gene to soluble endothelial protein C receptor and circulating activated protein C levels, and thrombotic risks

P Medina et al.

THROMBOSIS AND HAEMOSTASIS (2004)

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Article Immunology

TREM-1 (triggering receptor expressed on myeloid cells): A new player in acute inflammatory responses

M Colonna et al.

JOURNAL OF INFECTIOUS DISEASES (2003)

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Article Critical Care Medicine

Soluble thrombomodulin, plasma-derived unactivated protein C, and recombinant human activated protein C in sepsis

JF Dhainaut et al.

CRITICAL CARE MEDICINE (2002)

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Article Biochemistry & Molecular Biology

Endocan is a novel chondroitin sulfate/dermatan sulfate proteoglycan that promotes hepatocyte growth factor/scatter factor mitogenic activity

D Béchard et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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Article Immunology

Biological function of CD40 on human endothelial cells: costimulation with CD40 ligand and interleukin-4 selectively induces expression of vascular cell adhesion molecule-1 and P-selectin resulting in preferential adhesion of lymphocytes

K Kotowicz et al.

IMMUNOLOGY (2000)

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Endotheliopathy in Acute COVID-19 and Long COVID

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